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Abstract As financial derivative products and systemic risk management tools, stock index futures and options have been greatly developed and widely issued in many countries. Taking the Shanghai Stock Exchange 50 (SSE 50) Index and its derivatives as the research objects, we first analyze the lead–lag relationship between stock index, index futures and index options in the Chinese mainland stock market based on a thermal optimal path (TOP) method whose essence is a non-parametric methodology, and compare the results with two mature markets, namely the Hong Kong and US stock markets. We find: (I) In US and Hong Kong stock markets, the index future leads the index. The index option leads the index future when the index remains stable or in an up-trend, but their lead–lag relation reverses when the index collapses; (II) In the Chinese mainland stock market, the index leads the index future, and the index option leads the index future in the whole period of our investigation; (III) In all three markets, the index option leads the index when the index remains stable or in an up-trend, but their lead–lag relation reverses when the index collapses. Our work gives new and strong evidence that the lead–lag relationship varies in different markets and with different market conditions, which has an important contribution to the reveal of the price discovery function of derivative products. Highlights • Dynamic evolution of lead-lag relationship revealed by a non-parametric TOP method. • Index future leads index in US and Hong Kong, but it's opposite in Chinese mainland. • Index option leads the index in general, but it reverses when index collapses. [ABSTRACT FROM AUTHOR]

Background: Identifying and treating tuberculosis infection (TBI) among refugees at elevated risk for developing TB disease is crucial for TB prevention and elimination in the United States (U.S.). However, current evidence is limited by small sample sizes, inclusion of refugees from only a single country, and/or reliance solely on the tuberculin skin test (TST)., Methods: Refugees in a large cohort study from 10 U.S. sites underwent evaluation for TBI using three available tests: the TST and two interferon-gamma release assays (IGRAs). This study calculated TBI prevalence and assessed tuberculosis preventive treatment (TPT) completion among refugees, defining TBI prevalence as positive results on at least two tests., Results: Among 8960 refugees enrolled July 2012 through May 2017, TBI prevalence was 23.2% (95% confidence interval [CI]: 22.4%-24.1%). Completion of TPT was 81.2% (95% CI: 79.6%-82.7%). Shorter treatment regimens of 3 months were associated with higher treatment completion compared to regimens of 6 months or longer., Conclusion: The high TBI prevalence among refugees is a concern, but their high TPT acceptance and completion rates offer an opportunity. IGRA-based tests are preferred in this population; however, limited resources underscore the need for more precise screening approaches to better identify high-risk individuals who truly require TPT., Competing Interests: Declarations of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this article., (Published by Elsevier Ltd.)

In 2023, the U.S. Food and Drug Administration has approved 29 small molecule drugs. These newly approved small molecule drugs possess the distinct scaffolds, thereby exhibiting diverse mechanisms of action and binding modalities. Moreover, the marketed drugs have always been an important source of new drug development and creative inspiration, thereby fostering analogous endeavors in drug discovery that potentially extend to the diverse clinical indications. Therefore, conducting a comprehensive evaluation of drug approval experience and associated information will facilitate the expedited identification of highly potent drug molecules. In this review, we comprehensively summarized the relevant information regarding the clinical applications, mechanisms of action and chemical synthesis of 29 small molecule drugs, with the aim of providing a promising structural basis and design inspiration for pharmaceutical chemists., (© 2024 Wiley Periodicals LLC.)