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The importance of engaging students with complex societal challenges has led to the adoption of various interdisciplinary teaching and learning practices in both K-12 and higher education. However, interdisciplinary learning is one of the most complex domains of contemporary educational practice, and, despite its significance, remains significantly undertheorized and under-researched. This Special Issue highlights empirical research efforts toward understanding interdisciplinary learning in its complexity. It simultaneously aims to (1) advance ecological perspectives that encompass concepts and methodologies for studying complex heterogeneous learning practices and (2) apply these perspectives to the research of interdisciplinary learning - of how people learn across and beyond disciplines. This introduction provides a historical context for interdisciplinary learning, introduces an ecological stance toward researching learning across and beyond disciplines, and reviews critical theoretical and methodological challenges within interdisciplinary learning, arguing that the field of the learning sciences is well-positioned to address these challenges. It discusses how the contributions presented in this special issue shed light on theoretical, methodological, empirical, and design aspects of interdisciplinary learning and offer a basis for further design work and research.

Background: Tubal sterilization is the most commonly used method of contraception in the United States. Because contraceptive effectiveness influences contraceptive selection, we examined typical use failure rates after tubal sterilization in the United States. Methods: We estimated rates of pregnancy after tubal sterilization using data from four waves of the National Survey of Family Growth (NSFG), representative samples of U.S. women aged 15 to 44 years, collected in 2002, 2006 to 2010, 2011 to 2013, and 2013 to 2015. Survey weighting was used in survival analysis to examine time to first pregnancy after tubal sterilization. Data from these participants were censored after a tubal reversal procedure, infertility treatment, hysterectomy, or bilateral oophorectomy. Reported pregnancy rates after tubal sterilization procedures were examined by using Kaplan-Meier curves and then multivariable Cox proportional-hazards models to examine the effects of age at tubal sterilization, race/ethnicity, education, Medicaid funding, and postpartum versus interval procedures. Results: Pregnancy after tubal sterilization was reported by 2.9 to 5.2% of participants across NSFG waves. In the most recent survey wave (2013 to 2015), the estimated percentage of participants with pregnancies within the first 12 months after a tubal sterilization procedure was 2.9%; at 120 months after tubal sterilization, the estimated percentage with a pregnancy was 8.4%. At all the time points examined, pregnancy after tubal sterilization was less common after postpartum procedures than after interval procedures; however, this difference was not evident in multivariable models. In multivariable models, chance of pregnancy decreased with age at time of tubal sterilization. Race/ethnicity, education, and Medicaid funding were not consistently associated with pregnancy after tubal sterilization. Conclusions: These data suggest that there may be nontrivial rates of pregnancy after tubal sterilization. [ABSTRACT FROM AUTHOR]

Introduction: The growth of surgeon burnout is of significant concern. As we work to reimagine the practice of surgery, an accurate understanding of the extent of surgeon burnout is essential. Our goal was to define the current prevalence of burnout and quality of life (QOL) among SAGES surgeons. Methodology: An electronic survey was administered to SAGES members to establish a current baseline for QOL, burnout, depression, and career satisfaction. To assess outcomes, we utilized the validated Maslach Burnout Inventory for Medical Personnel, the Medical Outcomes Study Short Form, and the Primary Care Evaluation of Mental Disorders. All scoring followed validated norm-based methods. Results: Of 4194 active members, 604 responded (14.40%). 69% met burnout threshold, with high levels of emotional exhaustion and depersonalization, and low personal accomplishment. 81% reported "being at the end of their rope", 74% felt emotionally drained, and 65% felt used up daily. Nearly all maintained caring about what happened to their patients (96%), easily understanding how their patients feel (84.3%) and being capable of dealing effectively with their patient's problems (87.6%). However, respondents never, rarely, or occasionally felt energetic (77.5%) or experienced a sense of professional accomplishment (57.8%). The overall QOL score was 69/100, with lower Mental than Physical scores (62.69 (SD 10.20) vs.77.27 (SD 22.24)). More than half of respondents met depression criteria. While 77% supported they would become a physician again, less than half would choose surgery again or recommend surgery to their children. Furthermore, less than a third felt work allowed sufficient time for their personal lives. Conclusions: Participating SAGES surgeons reported alarmingly high rates of burnout and depression. Despite experiencing emotional exhaustion and depersonalization, they maintained a strong commitment to patient care. These findings likely reflect the broader state of surgeons, underscoring the urgent need for action to address this critical issue. [ABSTRACT FROM AUTHOR]

BACKGROUND: Test selection during the return to sport evaluation is an important aspect of ensuring athletes are safe to return to competition. OBJECTIVE: To assess the test-retest and inter-rater reliability of two new single leg hamstring bridge tests (SLHBT) and the relationships between these new tests and isokinetic strength of the quadriceps and hamstrings. METHODS: Thirty healthy college students completed the study. Two testing sessions were held three to seven days apart. Session one, participants performed two SLHBT as well as concentric isokinetic strength tests for the hamstring and quadriceps at 60, 180 and 300∘/sec. The participants performed only the two SLHBT during the second session. The first SLHBT, participants performed as many repetitions as possible of the SLHBT in 30-sec, while the second test measured how quickly the participants could perform five repetitions. Intraclass Correlation Coefficients (ICC2,1) were used to assess test-retest reliability while ICC(3,1) were used to test inter-rater reliability. RESULTS: The test-retest reliability for the SLHBTs was moderate to good, with ICC(2,1) ranging from 0.68 to 0.75, while the inter-rater reliability were excellent with ICC(3,1) all above 0.98. There were significant correlations between the SLHBT and the isokinetic tests, but all correlations were low to moderate. CONCLUSION: This study found good to excellent reliability with the new SLHBT and poor to moderate correlations were noted Therefore, SLHBT may not be an alternative to test hamstring test during the RTS evaluation due to the multiple compensatory strategies athletes may have. [ABSTRACT FROM AUTHOR]

We investigate whether the ideological polarisation of citizens has increased in Western democracies. We propose a novel methodology to identify individual ideologies by applying latent Dirichlet allocation to political survey data. This approach indicates that questions related to confidence in institutions play a leading role in defining citizen ideologies, in addition to the questions associated with the traditional left-right scale. We decompose the shift in ideological positions across the population over time and measure polarisation. This reveals evidence of a 'disappearing centre' in a sub-group of countries with citizens shifting away from centrist ideologies into anti-establishment 'anarchist' ideologies. This trend is especially pronounced for the United States. [ABSTRACT FROM AUTHOR]

Background: Diabetes self-management education (DSME) is generally considered to be a key determinant of the treatment outcomes and related costs of diabetes mellitus. While DSME programmes generally have positive outcomes, their effects may depend on certain factors, such as the type of programmes provided and patients' level of health literacy (HL). Low HL has been associated with poorer self-management behaviours and poor medication adherence in diabetic patients, but its impact on the effects of DSME has not yet been systematically investigated. This study aimed to investigate the influence of HL on the self-reported effects of DSME programmes while taking the type of programme into consideration. Method: A total of 366 diabetic patients from nine countries completed a questionnaire measuring HL, self-management behaviours, problem perception, coping, perceived general health and well-being, before and after participating in a DSME programme. Results: DSME programmes were found to have positive effects on self-reported self-management behaviours and almost all psychological and health outcomes, regardless of HL level. Patients with high HL scored better on several diabetes outcomes than those with low HL, but all patients described benefiting from DSME. Individual and group-based programmes resulted in more positive effects on several diabetes outcomes than self-help groups, but no interaction with HL was found. Conclusion: Our findings confirm those of previous studies showing that DSME programmes have positive effects and that low HL is associated with lower diabetes outcomes but do not support the assumption that the effects of DSME programmes are influenced by the patient's HL. However, due to the limitations of this study, further investigation is necessary to support these findings and improve our understanding about the impact of HL on DSME programmes' effectiveness.

This article investigates whether parents in the United States and Canada send their children to schools that are similar to the schools they attended. Intergenerational continuity in the type of high school attended may be generated by social status or religious socialization concerns, or simply through familiarity, identity, and network ties built through parents' high school experiences. Social reproduction as well as social identity processes, we argue, explain intergenerational continuity in schooling choices for children. Findings reveal that public schools are the most likely destination for children regardless of the type of school a parent attended. We also find intergenerational continuity in school sector among parents who opt out of traditional public schools. The school sector boundaries vary by educational context, however, with much higher boundaries between most sectors in the United States than in Canada. A notable exception is the very high levels of intergenerational continuity in the public Catholic sector in Canada, which reflects social identities built within the historical nexus of family, community, and religion. We conclude by discussing implications for researchers who study sector effects and school choice as well as practitioners vying for students in an increasingly competitive educational market.

Objectives: Effective health communication can increase intent to vaccinate. We compared 8 messages that may influence parents' intent to vaccinate their children against COVID-19. Methods: In a cross-sectional survey of adults in the United States administered online in August 2021, 1837 parents and legal guardians were exposed to 8 messages (individual choice, gain/practical benefits, nonexpert, health care provider recommendation, altruism/community good, safety/effectiveness, safety, and effectiveness) to determine message reception and influence on intent to vaccinate their children. Parents responded to 10 questions using a Likert scale. We computed odds ratios (ORs) for each message, with an OR >1.0 indicating greater observed odds of participant agreement with the follow-up statement as compared with a reference message. We compared outcomes individually across messages with ordinal logistic regression fit using generalized estimating equations. Results: The individual choice message had the highest odds of agreement for understanding intent (OR = 2.10; 95% CI, 1.94-2.27), followed by the health care provider recommendation message (OR = 1.58; 95% CI, 1.46-1.71). The individual choice message had the highest odds of memorability, relatability, and trustworthiness. The altruism/community good message was at or near second best. The altruism/community good message had the highest or near-highest odds of increasing parents' intent to vaccinate their children, asking friends and family for their thoughts, and searching for additional information. The message that most motivated parents to vaccinate their children depended on parental intent to vaccinate prior to being exposed to the tested messages. Conclusions: Messages with themes of individual choice, health care provider recommendation, and altruism/community good may be used in future message campaigns. Further research is needed to refine message concepts related to altruism/community good. [ABSTRACT FROM AUTHOR]

An editorial is presented on critical need for enhanced postpartum care to mitigate long-term cardiovascular disease risks in women. Topics include especially those with hypertensive disorders of pregnancy and gestational diabetes; and prevalence of pregnancy-related cardiovascular conditions, gaps in postpartum care, and the impact of extending Medicaid coverage postpartum.

Objective: Public health agencies have a critical role in providing effective messaging about mitigation strategies during a public health emergency. The objectives of this study were (1) to understand perceptions of COVID-19 vaccines, including concerns about side effects, safety, and effectiveness and how these perceptions influence vaccine decision-making among US adults and (2) to learn what messages might motivate vaccine uptake. Methods: In April and May 2021, we conducted 14 online focus groups with non-Hispanic English-speaking and English- and Spanish-speaking Hispanic adults (N = 99) not vaccinated against COVID-19. We oversampled adults aged 18-39 years and rural residents and systematically assessed 10 test messages. Researchers used a standardized guide and an a priori codebook for focus group discussions, coding transcripts, and thematic analysis. Results: Vaccine hesitancy factors included fear of the unknown; long-term side effects, including infertility; and beliefs that the vaccines were developed too quickly and were not sufficiently effective. Motivating factors for receiving vaccination included the ability to safely socialize and travel. Health care providers were considered important trusted messengers. Participants were critical of most messages tested. Messages that came across as "honest" about what is not yet known about COVID-19 vaccines were perceived more positively than other messages tested. Messages were seen as ineffective if perceived as vague or lacking in data and specificity. Conclusions: Messages that were simple and transparent about what is unknown about vaccines relative to emerging science were viewed most favorably. Health care providers, friends, and family were considered influential in vaccination decision-making. Findings underscore the benefits of research-informed strategies for developing and disseminating effective messages addressing critical issues in a public health emergency. [ABSTRACT FROM AUTHOR]

Introduction: Adverse childhood experiences (ACEs) are common and have been associated with poor developmental outcomes. We aimed to investigate the relationship between early ACE exposure, subsequent diagnosis of developmental delay, and receipt of developmental delay services by young children. In addition, we aimed to assess the impact of health-promoting behaviors such as breastfeeding and daily reading on these relationships. Methods: In this cross-sectional analysis of nationally-representative data from the 2017–2018 National Survey of Children's Health, we examined the relationship between ACEs, prior breastfeeding, daily reading, and developmental delay diagnosis among 7837 children aged 3–5 years, using multivariate logistic regression to adjust for family, personal, and sociodemographic characteristics. Results: We found a dose-dependent relationship between ACEs and developmental delay diagnosis; compared to those without ACEs, developmental delay was more common among those with either one ACE (aOR = 2.03, 95% CI 1.17–3.52) or two or more ACEs (aOR = 2.34, 95% CI 1.25–4.37). Neither breastfeeding (exclusively breastfed for 6 months vs. never breastfed aOR = 0.70, 95% CI 0.33–1.46) nor daily reading (no reading versus daily reading aOR = 1.15, CI 0.57–2.33) were associated with incidence of developmental delay among study participants. There was no significant difference in receipt of services intended to meet developmental needs between children with and without ACEs. Discussion: Children with very early ACE exposure are at increased risk for diagnosis of developmental delay. Early screening for ACEs and developmental delay may mitigate the early developmental manifestations of ACE exposure in vulnerable children. Significance: As poor developmental outcomes are related to ACEs, children aged 3–5 years should be routinely screened for ACE exposure. Although breastfeeding and daily reading have multiple benefits to children, they do not adequately mitigate the developmental delays associated with ACE exposure. [ABSTRACT FROM AUTHOR]

COVID-19 profoundly shaped how service providers in the antiviolence sector interact with clients, coworkers, and community stakeholders. In addition to stressors inherent in antiviolence work, service providers negotiated new, challenging social distancing and remote communication strategies. In this paper, we analyze interviews with 23 antiviolence workers in the US Great Plains region, focusing on participants' descriptions of workplace boundaries and intimacy. We demonstrate how COVID-19 both expanded and contracted public/private boundaries and formal/informal connections in antiviolence workers' daily experiences. Pandemic conditions revealed the pressing need for frontline workers to exercise discretion over levels of intimate engagement with coworkers and clients. [ABSTRACT FROM AUTHOR]

Anal cancer incidence is significantly higher in people living with HIV as HIV increases the oncogenic potential of human papillomavirus. The incidence of anal cancer in the United States has recently increased, with diagnosis and treatment hampered by high loss-to-follow-up rates. Novel methods for the automated, real-time diagnosis of AIN 2+ could enable "see and treat" strategies, reducing loss-to-follow-up rates. A previous retrospective study demonstrated that the accuracy of a high-resolution microendoscope (HRME) coupled with a deep learning model was comparable to expert clinical impression for diagnosis of AIN 2+ (sensitivity 0.92 [P = 0.68] and specificity 0.60 [P = 0.48]). However, motion artifacts and noise led to many images failing quality control (17%). Here, we present a high frame rate HRME (HF-HRME) with improved image quality, deployed in the clinic alongside a deep learning model and evaluated prospectively for detection of AIN 2+ in real-time. The HF-HRME reduced the fraction of images failing quality control to 4.6% by employing a high frame rate camera that enhances contrast and limits motion artifacts. The HF-HRME outperformed the previous HRME (P < 0.001) and clinical impression (P < 0.0001) in the detection of histopathologically confirmed AIN 2+ with a sensitivity of 0.91 and specificity of 0.87. [ABSTRACT FROM AUTHOR]

BACKGROUND: Neuroendocrine tumor liver metastases (NELM) are a major source of morbidity and mortality in neuroendocrine tumor patients and can be treated with hepatic debulking surgery (HDS). This study aims to identify variables associated with postoperative morbidity in NELM HDS. STUDY DESIGN: This analysis uses the American College of Surgeons NSQIP targeted hepatectomy-specific Participant User File from 2014 to 2020. Surgeries were grouped by number of hepatic resections performed (1 to 5, 6 to 10, greater than 10). Multivariable logistic regression and matching were used to identify prognostic factors of morbidity. RESULTS: A total of 1,163 patients were included. A total of 1,011 (87%) had 1 to 5 hepatic resections, 101 (8.7%) had 6 to 10 resections, and 51 (4.4%) had greater than 10 resections. The overall complication rate was 35%, and surgical and medical complications reached 30% and 13%, respectively. Mortality occurred in 11 patients (0.9%). Significantly higher rates of any (34% vs 35% vs 53%, p = 0.021) and surgical complications (29% vs 28% vs 49%, p = 0.007) were noted for those undergoing greater than 10 resections (1 to 5 resections, 6 to 10, greater than 10). “Bleeding requiring transfusion” (p < 0.0001) occurred more frequently in the greater than 10 resection group. On multivariable logistic regression, greater than 10 resections were an independent risk factor for any (odds ratio [OR] 2.53, p = 0.002; OR 2.52, p =. 0013) and surgical (OR 2.53, p = 0.003; OR 2.88, p = 0.005) complications compared with 1 to 5 resections and 6 to 10 resections, respectively. Medical complications (OR 2.34, p = 0.020) and length of stay greater than 5 days (OR 1.98, p = 0.032) were also increased with greater than 10 vs 1 to 5 resections. CONCLUSIONS: As reported by NSQIP, NELM HDS were performed safely with low mortality. However, more hepatic resections, especially greater than 10, were associated with increased postoperative morbidity and length of stay. [ABSTRACT FROM AUTHOR]

Intensive longitudinal designs (e.g., experience sampling methods [ESMs]) hold promise for examining the dynamic interplay between daily adversity, coping strategies, and behavioral and mental health issues among marginalized populations. However, few studies have used intensive longitudinal designs with sexual minority women (SMW), an understudied and at-risk population. We assessed feasibility and acceptability of using once-daily, interval-contingent ESM with 161 trauma-exposed SMW (M age = 29.1, SD = 7.57); 20.5% nonbinary; 32.3% queer; 52.2% people of color; 14.3% with annual incomes ≤$9,999; and 30.4% in Southern United States (U.S.). SMW completed one comprehensive online baseline assessment and once-daily brief online assessments for 14 days. Daily surveys assessed past-24-hour stressors, stress responses, and behavioral and mental health symptoms. At the end of the 14-day ESM period, SMW answered three open-ended questions about participating in this study and about research with SMW. Regarding feasibility, 151 participants (94.0%) initiated the post-baseline ESM study portion and 72 (45.0%) completed all 14 daily surveys. An average of 11.70 (median = 13, SD = 3.31) daily surveys (83.5%) were completed by those who initiated the ESM. ESM completion level varied by race/ethnicity and U.S. region. Qualitative acceptability data revealed several themes, namely that SMW (1) enjoyed participating and felt positively about the ESM experience, (2) felt supported to reflect on impacts of early and ongoing stressors, (3) appreciated the chance to self-reflect and challenge existing thought patterns and coping behaviors, (4) recognized their capacity to tolerate trauma-related distress, (5) recommended that researchers focus on SMW's diverse stressors and daily experiences, (6) wanted a rationale for providing sensitive information and more space to narrate their experiences, and (7) recognized the need for affirmative treatment and policies. Findings could inform modifications to ESM protocols to improve their feasibility and acceptability among trauma-exposed SMW and promote ongoing utility of this valuable method. [ABSTRACT FROM AUTHOR]

This study investigated whether the associations between (a) the quality of the parent-child relationship and peer acceptance and (b) early adolescents' life satisfaction differed depending on the importance of family values in the respective culture. As part of the Value of Children Study, data from a subsample of N = 1,034 adolescents (58% female, M age = 13.62 years, SD = 0.60 years) from 11 cultures was analyzed. Multilevel analyses revealed a positive relation between parental admiration and adolescents' life satisfaction independent of cultural membership. Further, the higher the importance of family values in a culture, the weaker was the positive effect of peer acceptance on adolescents' life satisfaction. The results highlight the universal importance of parental warmth and support in adolescence and underline the effect of culturally shared family values on the role of peer acceptance for adolescent development. (Contains 3 tables and 1 note.)

The United States produces the most media--film, television, and music--in the world; yet, media literacy is still a new concept to most Americans, including educators. What media literacy is, why it matters, and how it can be implemented--especially in the schools--constitute the subject of this yearbook. The answers are diverse, as the chapters will show. There is a growing sense of urgency about media literacy in K-college education. Although the definition of media literacy remains contentious, as do different approaches to the field, many scholars, educators, parents, and community activists agree that media literacy is essential in the 21st century. This chapter offers a brief history of the field along with an attempt to define media literacy and offer a rationale for its inclusion in the American public school curriculum. Part I of the yearbook, on the whole, deals with why media literacy can make a difference in American schools. Part II, on the whole, deals with the implementation of media literacy, in and outside the public schools, and the problems facing those who aim to implement it. Media literacy is not without its opponents and its issues. Still, despite differences in theory, focus, and experiences, the contributors to this volume demonstrate their belief in the power of media literacy to transform curriculum, teaching, and even society.

A rich literature shows that early-life conditions shape later-life outcomes, including health and migration events. However, analyses of geographic disparities in mortality outcomes focus almost exclusively on contemporaneously measured geographic place (e.g., state of residence at death), thereby potentially conflating the role of early-life conditions, migration patterns, and effects of destinations. We employ the newly available Mortality Disparities in American Communities data set, which links respondents in the 2008 American Community Survey to official death records, and estimate consequential differences based on the method of aggregation we use: the unweighted mean absolute deviation of the difference in life expectancy at age 50 measured by state of birth versus state of residence is 0.58 years for men and 0.40 years for women. These differences are also spatially clustered, and we show that regional inequality in life expectancy is higher based on life expectancies by state of birth, implying that interstate migration mitigates baseline geographic inequality in mortality outcomes. Finally, we assess how state-specific features of in-migration, out-migration, and nonmigration together shape measures of mortality disparities by state (of residence), further demonstrating the difficulty of clearly interpreting these widely used measures. [ABSTRACT FROM AUTHOR]

Illicit opioids, consisting largely of fentanyl, novel synthetic opioids, and adulterants, are the primary cause of drug overdose fatality in the United States. Xylazine, an alpha-2 adrenergic agonist and veterinary tranquilizer, is being increasingly detected among decedents following illicit opioid overdose. Clinical outcomes in non-fatal overdose involving xylazine are unexplored. Therefore, among emergency department patients with illicit opioid overdose, we evaluated clinical outcome differences for patients with and without xylazine exposures. This multicenter, prospective cohort study enrolled adult patients with opioid overdose who presented to one of nine United States emergency departments between 21 September 2020, and 17 August 2021. Patients with opioid overdose were screened and included if they tested positive for an illicit opioid (heroin, fentanyl, fentanyl analog, or novel synthetic opioid) or xylazine. Patient serum was analyzed via liquid chromatography quadrupole time-of-flight mass spectroscopy to detect current illicit opioids, novel synthetic opioids, xylazine and adulterants. Overdose severity surrogate outcomes were: (a) cardiac arrest requiring cardiopulmonary resuscitation (primary); and (b) coma within 4 h of arrival (secondary). Three hundred and twenty-one patients met inclusion criteria: 90 tested positive for xylazine and 231 were negative. The primary outcome occurred in 37 patients, and the secondary outcome occurred in 111 patients. Using multivariable regression analysis, patients positive for xylazine had significantly lower adjusted odds of cardiac arrest (adjusted OR 0.30, 95% CI 0.10–0.92) and coma (adjusted OR 0.52, 95% CI 0.29–0.94). In this large multicenter cohort, cardiac arrest and coma in emergency department patients with illicit opioid overdose were significantly less severe in those testing positive for xylazine. [ABSTRACT FROM AUTHOR]

Reviews the definition of standards in general, and proposes a definition of standards and global minimum essential requirements for use in medical education. Aims to serve as a tool for the improvement of quality and international comparisons of basic medical programs. Explains the IIME (Institute for International Medical Education) project established by the China Medical Board. Includes 12 references. (Author/YDS)

Background Clinical differences between critical illness from influenza infection vs coronavirus disease 2019 (COVID-19) have not been well characterized in pediatric patients. Methods We compared demographics, clinical characteristics, and outcomes of US children (aged 8 months to 17 years) admitted to the intensive care or high-acuity unit with influenza or COVID-19. Using mixed-effects models, we assessed the odds of death or requiring life support for influenza vs COVID-19 after adjustment for age, sex, race and Hispanic origin, and underlying conditions including obesity. Results Children with influenza (n = 179) were younger than those with COVID-19 (n = 381; median, 5.2 years vs 13.8 years), less likely to be non-Hispanic Black (14.5% vs 27.6%) or Hispanic (24.0% vs 36.2%), and less likely to have ≥1 underlying condition (66.4% vs 78.5%) or be obese (21.4% vs 42.2%), and a shorter hospital stay (median, 5 days vs 7 days). They were similarly likely to require invasive mechanical ventilation (both 30.2%), vasopressor support (19.6% and 19.9%), or extracorporeal membrane oxygenation (2.2% and 2.9%). Four children with influenza (2.2%) and 11 children with COVID-19 (2.9%) died. The odds of death or requiring life support in children with influenza vs COVID-19 were similar (adjusted odds ratio, 1.30; 95% confidence interval,.78–2.15; P =.32). Conclusions Despite differences in demographics and clinical characteristics of children with influenza or COVID-19, the frequency of life-threatening complications was similar. Our findings highlight the importance of implementing prevention measures to reduce transmission and disease severity of influenza and COVID-19. [ABSTRACT FROM AUTHOR]

Global production of marine finfish has grown in total volume of production and the number of species farmed commercially, but there has been little production in the United States of marine finfish other than salmon and red drum. For most species considered to be ready for commercialization, there are few or no farms from which to evaluate the size of the market or to estimate revenues and costs necessary to assess economic feasibility. This present study takes a first step to fill this gap with an analysis of the existing supply of 20 marine finfish species identified as candidates for commercialization in the United States, as a proxy for effective demand (the volume of a product sold at the market equilibrium price). Secondary data from 1950 (where available) through 2019 were compiled on each species, including (1) global aquaculture production, (2) US aquaculture production, (3) US commercial landings, (4) US recreational landings, and (5) imports. Current effective market demand (measured as the sum of commercial landings, farmed production, and imports) was low, totaling 36.6 million kg across the 20 species, which is equivalent to less than 23% of the annual volume sold of US farmed catfish. Commercial landings for 17 of the 20 species exhibited declines, potentially offering opportunities for farmed product to capture market share by filling the increasing gaps in supply. The variability in commercial landings provides opportunities for farms to capitalize on their advantage in supplying product with a high degree of consistency of volume, size, delivery frequency, and quality. Several unknown factors suggest the need for follow‐up studies on consumer preferences, degree of substitutability among finfish species, and effects of recreational landings on demand. An important limitation to prospective producers is the lack of species‐specific import data for the generic categories of "flounder," "bass," and "snapper." This supply analysis provides a foundational analysis for prospective producers, investors, and researchers interested in commercialization of these marine species. [ABSTRACT FROM AUTHOR]

Background: Non-native snake envenomations in the United States are uncommon with much unknown about a patient's presenting signs and symptoms. Antivenoms for non-native snake envenomations are not typically available in hospital pharmacies which may limit their administration. What are the clinical presentations, treatments, and outcomes of non-native snake envenomation cases reported to the North American Snakebite Registry (NASBR) of the Toxicology Investigators Consortium (ToxIC)? Methods: This is a descriptive review of all non-native envenomations reported to the NASBR from 2013 to March 2022. Data abstracted included snake species, patient history, clinical signs, diagnostics, treatment (including antivenom usage), follow-up, and final outcome. Results: We identified 19 non-native snake envenomations resulting from encounters with eleven different species, eight of which belonged to the Viperidae family. The most common presenting symptoms were edema (18 patients), ecchymosis (seven patients), and necrosis (six patients). Systemic effects and hematologic abnormalities were less common. The most common treatments were extremity elevation and analgesia, with two patients receiving mechanical ventilation. Ten patients received antivenom. No patients died. Three patients had loss of mobility in a digit at the last follow-up visit. One patient had permanent tissue loss of a small area on a finger. Conclusions: The results of this study suggest that non-native snake envenomations in the United States frequently cause local soft tissue effects and less frequently cause systemic or hematologic effects. Most patients received antivenom, although several patients envenomated by snakes for which a specific antivenom exists did not receive any. Sequelae at the last follow-up of such encounters consisted of local mobility deficits. [ABSTRACT FROM AUTHOR]

We trace the evolution of extreme illiquidity discounts among Treasury securities during the financial crisis, when bond prices fell more than 6% below more liquid but otherwise identical notes. Using high-resolution data on market quality and trader identities and characteristics, we find that the discounts amplify through feedback loops, where cheaper, less-liquid securities flow to longer-horizon investors, thereby increasing their illiquidity and thus their appeal to these investors. The effect of the widened liquidity gap on transactions costs is further amplified by a surge in the price liquidity providers charge for access to their balance sheets in the crisis. Received September 28, 2016; editorial decision January 2, 2018 by Editor Philip Strahan. Authors have furnished an Internet Appendix , which is available on the Oxford University Press Web site next to the link to the final published paper online. [ABSTRACT FROM AUTHOR]

Background: High-quality contraceptive counseling is critical to support Veterans' reproductive autonomy and promote healthy outcomes.Objective: To describe perceived quality of contraceptive counseling in Veterans Health Administration (VA) primary care and assess factors associated with perceived high- and low-quality contraceptive counseling.Design: Cross-sectional study using data from the Examining Contraceptive Use and Unmet Need in women Veterans (ECUUN) national telephone survey.Participants: Veterans aged 18-44 who received contraceptive services from a VA primary care clinic in the past year (N=506).Main Measures: Perceived quality of contraceptive counseling was captured by assessing Veterans' agreement with 6 statements regarding provider counseling adapted from the Consumer Assessment of Healthcare Providers and Systems (CAHPS) survey. High-quality counseling was defined as a top score of strongly agreeing on all 6 items; low-quality counseling was defined as not agreeing (neutral, disagreeing, or strongly disagreeing) with >3 items. We constructed two multivariable models to assess associations between patient-, provider-, and system-level factors and perceived high-quality (Model 1) and perceived low-quality counseling (Model 2).Key Results: Most participants strongly agreed that their providers listened carefully (74%), explained things clearly (77%), and spent enough time discussing things (71%). Lower proportions strongly agreed that their provider discussed more than one option (54%), discussed pros/cons of various methods (44%), or asked which choice they thought was best for them (62%). In Model 1, Veterans who received care in a Women's Health Clinic (WHC) had twice the odds of perceiving high-quality counseling (aOR=1.99; 95%CI=1.24-3.22). In Model 2, Veterans who received care in a WHC (aOR=0.49; 95%CI=0.25-0.97) or from clinicians who provide cervical cancer screening (aOR=0.49; 95%CI=0.26-0.95) had half the odds of perceiving low-quality counseling.Conclusions: Opportunities exist to improve the quality of contraceptive counseling within VA primary care settings, including more consistent efforts to seek patients' perspectives with respect to contraceptive decisions. [ABSTRACT FROM AUTHOR]

Background: Women worldwide face risks from pregnancy, HIV, and other sexually transmitted infections (STIs). To date, highly effective contraceptive methods provide no HIV/STI protection, and HIV prevention products, excluding condoms, provide no pregnancy protection. Intravaginal rings (IVRs) delivering antiretrovirals and contraceptives are a promising multipurpose prevention technology (MPT). Methods: Embedded within a Phase I randomized, placebo-controlled trial, we examined acceptability of continuous versus interrupted use of a 90-day MPT IVR among 47 low-risk women in Norfolk, Virginia and the Dominican Republic. A baseline survey assessed menstruation attitudes, risk perceptions and trial-related motivations. Follow-up surveys (M1/M3) examined user experiences with and preferences for IVR attributes; 18 women also participated in two in-depth interviews. Results: Most women rated the IVR's flexibility and smoothness (86%) and ease of insertion/removal (76%) as very acceptable. Fewer women similarly rated the IVR size (57%) and changes in color from menstruation (52%). Most participants experienced no changes or less bleeding. Those reporting more/heavier bleeding (20% M1, 15% M3) disliked the change. Overall, women preferred a 3-month (75%) to a 1-month IVR (7.5%) or a bimonthly injectable (10%). In qualitative interviews, women were willing to continuously use an IVR for 6–12 months, providing it did not "degrade" inside the body. Reasons for trial participation and prevention preferences, menstrual attitudes, and perceived IVR benefits and doubts varied by site. Conclusions: Findings provide strong evidence of demand for an MPT IVR that protects from pregnancy and HIV/STIs, lasts longer than 1 month, minimally disrupts menstrual bleeding, and is in women's control. numberClinicalTrials.gov : #NCT03279120. [ABSTRACT FROM AUTHOR]

Background Predominance of 2 antigenically drifted influenza viruses during the 2019–2020 season offered an opportunity to assess vaccine effectiveness against life-threatening pediatric influenza disease from vaccine-mismatched viruses in the United States. Methods We enrolled children aged <18 years admitted to the intensive care unit with acute respiratory infection across 17 hospitals. Respiratory specimens were tested using reverse-transcription polymerase chain reaction for influenza viruses and sequenced. Using a test-negative design, we estimated vaccine effectiveness comparing odds of vaccination in test-positive case patients vs test-negative controls, stratifying by age, virus type, and severity. Life-threating influenza included death or invasive mechanical ventilation, vasopressors, cardiopulmonary resuscitation, dialysis, or extracorporeal membrane oxygenation. Results We enrolled 159 critically ill influenza case-patients (70% ≤8 years; 51% A/H1N1pdm09 and 25% B-Victoria viruses) and 132 controls (69% were aged ≤8 years). Among 56 sequenced A/H1N1pdm09 viruses, 29 (52%) were vaccine-mismatched (A/H1N1pdm09/5A+156K) and 23 (41%) were vaccine-matched (A/H1N1pdm09/5A+187A,189E). Among sequenced B-lineage viruses, majority (30 of 31) were vaccine-mismatched. Effectiveness against critical influenza was 63% (95% confidence interval [CI], 38% to 78%) and similar by age. Effectiveness was 75% (95% CI, 49% to 88%) against life-threatening influenza vs 57% (95% CI, 24% to 76%) against non-life-threating influenza. Effectiveness was 78% (95% CI, 41% to 92%) against matched A(H1N1)pdm09 viruses, 47% (95% CI, –21% to 77%) against mismatched A(H1N1)pdm09 viruses, and 75% (95% CI, 37% to 90%) against mismatched B-Victoria viruses. Conclusions During a season when vaccine-mismatched influenza viruses predominated, vaccination was associated with a reduced risk of critical and life-threatening influenza illness in children. [ABSTRACT FROM AUTHOR]

Brown carbon (BrC) associated with aerosol particles in western United States wildfires was measured between July and August 2019 aboard the NASA DC-8 research aircraft during the Fire Influence on Regional to Global Environments and Air Quality (FIREX-AQ) study. Two BrC measurement methods are investigated, highly spectrally resolved light absorption in solvent (water and methanol) extracts of particles collected on filters and in situ bulk aerosol particle light absorption measured at three wavelengths (405, 532 and 664 nm) with a photoacoustic spectrometer (PAS). A light-absorption closure analysis for wavelengths between 300 and 700 nm was performed. The combined light absorption of particle pure black carbon material, including enhancements due to internally mixed materials, plus soluble BrC and a Mie-predicted factor for conversion of soluble BrC to aerosol particle BrC, was compared to absorption spectra from a power law fit to the three PAS wavelengths. For the various parameters used, at a wavelength of roughly 400 nm they agreed, at lower wavelengths the individual component-predicted particle light absorption significantly exceeded the PAS and at higher wavelengths the PAS absorption was consistently higher but more variable. Limitations with extrapolation of PAS data to wavelengths below 405 nm and missing BrC species of low solubility that more strongly absorb at higher wavelengths may account for the differences. Based on measurements closest to fires, the emission ratio of PAS-measured BrC at 405 nm relative to carbon monoxide (CO) was on average 0.13 Mm -1 ppbv -1 ; emission ratios for soluble BrC are also provided. As the smoke moved away from the burning regions, the evolution over time of BrC was observed to be highly complex; BrC enhancement, depletion or constant levels with age were all observed in the first 8 h after emission in different plumes. Within 8 h following emissions, 4-nitrocatechol, a well-characterized BrC chromophore commonly found in smoke particles, was largely depleted relative to the bulk BrC. In a descending plume where temperature increased by 15 K, 4-nitrocatechol dropped, possibly due to temperature-driven evaporation, but bulk BrC remained largely unchanged. Evidence was found for reactions with ozone, or related species, as a pathway for secondary formation of BrC under both low and high oxides of nitrogen (NO x) conditions, while BrC was also observed to be bleached in regions of higher ozone and low NO x , consistent with complex behaviors of BrC observed in laboratory studies. Although the evolution of smoke in the first hours following emission is highly variable, a limited number of measurements of more aged smoke (15 to 30 h) indicate a net loss of BrC. It is yet to be determined how the near-field BrC evolution in smoke affects the characteristics of smoke over longer timescales and spatial scales, where its environmental impacts are likely to be greater. [ABSTRACT FROM AUTHOR]

Supplemental Digital Content is Available in the Text. Introduction.: Workplace bullying and incivility have been recognized as significant problems in both clinical and academic environments. These negative behaviors can lead to disengagement, stress, and lost productivity. The purposes of this study were to 1) identify predictors of bullying experiences and 2) assess the prevalence of being bullied among faculty and staff working in physical therapist education programs across the United States. Review of Literature.: More than one-third of US workers are bullied or have witnessed bullying in the workplace. When these disruptive behaviors occur within the context of physical therapist education, the impact can be detrimental to teaching and learning, clinical practice, and individual well-being. Subjects.: Participants included 529 Doctor of Physical Therapy faculty and staff. Methods.: Respondents completed the uncivil workplace behavior questionnaire—revised and negative acts questionnaire—revised. Results.: Survey results revealed that 32.5% of academic faculty had experienced bullying within the last 6 months. Discussion and Conclusion.: The prevalence of bullying and incivility in academic physical therapy programs approaches that of the general workforce in the United States. Physical Therapy education programs must take an active role in preventing, recognizing, and managing uncivil behaviors in the academic environment. [ABSTRACT FROM AUTHOR]

After decades of criminalization, psychedelic substances such as psilocybin and LSD are experiencing their comeback in science and Western culture more broadly. While psychedelic plants and fungi have a long history of use in Indigenous cultures, the Western prohibitionist reality instantiated around 1970 has stigmatized psychedelics as medically useless and a threat to society. Yet studies are increasingly demonstrating their potential to treat widespread mental health conditions such as PTSD, depression, or anxiety in combination with psychotherapy. Most of this research is currently taking place in the US, where additionally decriminalization and legalization efforts and religious exemptions have paved the way to make psychedelics legally accessible. Based on 3 years of ethnographic research in the US (both in-person and virtual), this article explores contemporary US-American socio-psychedelic imaginaries, i.e., collective visions articulated and enacted to reintegrate psychedelics legally and responsibly into society. Four socio-psychedelic imaginaries are identified, described, and interpreted: the biomedicalization imaginary, decriminalization imaginary, legalization imaginary, and sacramental imaginary. These imaginaries diverge and converge around several politics: politics of access, politics of responsibility, politics of naming, politics of assimilation and social change, and politics of epistemic credibility. Contemporary socio-psychedelic imaginaries are co-evolving, mutually shaping, and amplifying each other. Together they function as societal corrective to the politically motivated prohibition of psychedelics. Although enacted by humans, the radical imagination expressed in socio-psychedelic imaginaries has its roots in human-psychedelics entanglements. [ABSTRACT FROM AUTHOR]

Lehavot et al. identified the unique health care needs of women Veterans with lower-extremity amputation, and Dhruva et al. identify persistent gender-based disparities in guideline-directed medical therapy among younger women Veterans. Ahuja et al. provide an example of how VA facilities can improve care for pregnant Veterans through a VA facility quality improvement project which, after assessing primary care provider comfort with caring for pregnant Veterans, led to a new local education series. [Extracted from the article]

Purpose: This paper aims to extend the consideration of distributed leadership in health-care settings. Leadership is typically studied from the classical notion of the place of single leaders and continues to examine distributed leadership within small teams or horizontally. The purpose is to develop a practical understanding of how distributed leadership may occur vertically, between different layers of the health-care leadership hierarchy, examining its influence on health-care outcomes across two hospitals. Design/methodology/approach: Using semi-structured interviews, data were collected from 107 hospital employees (including executive leadership, clinical management and clinicians) from two hospitals in Australia and the USA. Using thematic content analysis, an iterative process was adopted characterized by alternating between social identity and distributed leadership literature and empirical themes to answer the question of how the practice of distributed leadership influences performance outcomes in hospitals? Findings: The perceived social identities of leadership groups shaped communication and performance both positively and negatively. In one hospital a moderating structure emerged as a leadership dyad, where leadership was distributed vertically between hospital hierarchal layers, observed to overcome communication limitations. Findings suggest dyad creation is an effective mechanism to overcome hospital hierarchy-based communication issues and ameliorate health-care outcomes. Originality/value: The study demonstrates how current leadership development practices that focus on leadership relational and social competencies can benefit from a structural approach to include leadership dyads that can foster these same competencies. This approach could help develop future hospital leaders and in doing so, improve hospital outcomes. [ABSTRACT FROM AUTHOR]

In the absence of systematic data collection by the state and federal governments, efforts to collect information on officer-involved shootings (OIS) have been assumed by the public and news agencies. In a combination of journalistic reporting and what is known as crowdsourcing, media and masses of individuals volunteer their time to identify OIS incidents and enter them into online databases. These efforts are invaluable in describing interpersonal violence between citizens and law enforcement, but it is not well known to what extent the media-based datasets are comprehensive. In the present study, we compared data from three major media-based websites to official data from five police departments that made their data available—Dallas, Denver, Jacksonville, Orlando, and Knoxville. We found a higher rate of matches than discrepancies with regard to fatalities but a much lower rate with regard to non-fatal shootings. Systematically recording and reporting OIS incidents should be the function of the government. Before—and if—that happens, our findings add to the growing evidence that media-based efforts, combined with crowdsourcing, can be useful though limited alternatives. [ABSTRACT FROM AUTHOR]

Employment discrimination against lesbian, gay, bisexual, and transgender ( LGBT) individuals remains a persistent problem not addressed by federal and most state equal employment opportunity laws in the United States. Despite this lack of regulation, a growing number of organizations are voluntarily adding sexual orientation and gender identity to their nondiscrimination statements, providing domestic partner benefits, sponsoring affinity groups, and establishing other ' LGBT-friendly' policies. This article incorporates institutional theory and organizational demography to explore the antecedents to these policies to understand why some organizations seek to be at the forefront of this trend while others do only the minimum to embrace this element of diversity. The analysis of a sample of Fortune 1000 firms reveals that state law dealing with gay rights in non-employment-related areas for the state where each company is headquartered, the number of women serving on each firm's board of directors, and whether other companies in the same industry have adopted progressive policies are all related to company policy toward its LGBT employees. Sexual orientation of employees by industry does not seem to influence company policy. © 2014 Wiley Periodicals, Inc. [ABSTRACT FROM AUTHOR]

We address an apparent paradox that the market shares of four ENERGY STAR appliances in the United States do not respond to within-state changes in electricity prices. We resolve the paradox by showing that market shares do respond to between-state variation in electricity prices. We also suggest an economic explanation for the paradox through the timing of appliance purchases. Using the estimation results, we find that the four ENERGY STAR appliances reduce carbon emissions by 1.9 million megawatt-hours per year, equivalent to removing 0.1% of all U.S. vehicles, and that the addition of a $100/ton CO2 price would increase these figures to 2.1 million megawatt-hours and 0.11%. [ABSTRACT FROM AUTHOR]

In the US, beef cattle feedlots commonly use antibiotic feed additives, such as tylosin and virginiamycin, to prevent liver abscesses, which can cause significant economic losses and animal welfare concerns. However, growing public and regulatory pressure to curb the proliferation of antibiotic resistant bacteria has prompted a need to reduce or eliminate their use. As an alternative, our group is working on a bacteriophage-based feed additive that targets Fusobacterium necrophorum, the primary cause of bovine liver abscesses, with the aim of reducing or eliminating the dependence on antibiotic feed additives. Using a combination of phage isolation techniques, we identified and characterized fifteen new F. necrophorum phages belonging to six genetically distinct groups. These phages exhibited a broad intraspecific host range and could infect various contemporary F. necrophorum strains isolated from different regions of the United States. All the phages were temperate, with dsDNA genomes ranging from around 36 kbp to 114 kbp. Almost all contemporary F. necrophorum isolates were found to have one or more active prophages upon bacterial genome sequencing and prophage induction. In vitro evolution resulted in the recovery of a potential virulent mutant, fBB37, which inhibited the growth of the high leukotoxin-producing F. necrophorum 8L1 strain for over 40 hours in vitro. Phage cocktails proved effective for up to 60 hours. After minimal optimization, most phages demonstrated high productivity (> 109 PFU/mL) and little yield variation during scale-up, highlighting their commercial potential. Unexpectedly, we discovered a previously unrecognized Fusobacterium species, Fusobacterium varium, is widely prevalent and frequently the most abundant member of the genus in cattle rumen. Previous studies on liver abscess control in cattle have almost exclusively focused on F. necrophorum, which may explain the lack of effectiveness observed. To elucidate the ecological role and potential pathogenicity of ruminal F. varium, we conducted genome sequencing and found these bovine strains to have multiple virulence factors and high similarity to human clinical isolates. However, phages with the ability to infect F. varium were plentiful in rumen fluid, with several demonstrating purely lytic activity. To assess the safety and in vivo dynamics of F. necrophorum and F. varium phage cocktails, a smallscale animal trial was recently conducted with ten cannulated cattle. [ABSTRACT FROM AUTHOR]

For d/Deaf and hard-of-hearing prereaders who communicate predominately in spoken and/or signed English (DHH-English), Teachers of the d/Deaf (TODs) read books aloud to increase English skills, auditory-verbal comprehension, sequencing skills, verbal reasoning, background knowledge, and sight word recognition. Teachers struggle to select appropriate books for read alouds. Unfortunately, the only available book selection system for TODs serving DHH-English was developed for a different purpose than identifying storybooks to increase English skills and was based on a methodology difficult to evaluate. To help teachers select books, we created an empirically-derived difficulty-level system based on the judgments of 69 experienced TODs serving DHH-English preschoolers and kindergartener across the United States. We used 14 storybooks and asked the TODs to group these books and order these groups based on how difficult the storybooks would be for DHH-English prereaders to understand when the books were read aloud. Additionally, TODs described the groups they created and why they assigned the books in their groups. We used these descriptions in a content analysis to derive a glossary of book characteristics. Finally, we analysed these results with a multivariate technique that simultaneously analysed the glossary and ranking data to create a difficulty-level scale and to identify exemplar books. The book selection system includes a two-tiered glossary, a six-point difficulty-level scale and exemplar books for each scale level. We discuss how this empirically-derived book selection system for read alouds with DHH-English prereaders can be paired with the three existing evidence-based read-aloud interventions designed to increase oral language skills. [ABSTRACT FROM AUTHOR]

Drawing on a feminist surveillance and social control framework, we conduct a manifest and latent content analysis of anti‐abortion policies passed in the United States in either a state's House or Senate from 2010 to 2015 to systematically assess the scope, content, and implicit meaning of 282 anti‐abortion bills. We find that out of the 727 anti‐abortion measures contained in this legislation, 622 incorporate surveillance, and social control mechanisms that operate together to socially construct women as a dependent population in need of government protection on two fronts: protection for women and their "unborn," and protection from abortion providers. Fusing together womanhood and motherhood, these policies essentialize motherhood, depicting women as an uninformed group in need of protection from their own ignorance and the practices of abortion providers who are constructed as an unethical group of health‐care practitioners. Related Articles: Hussey, Laura S. 2013. "Crisis Pregnancy Centers, Poverty, and the Expanding Frontiers of American Abortion Politics." Politics & Policy 41 (6): 985‐1011. https://doi.org/10.1111/polp.12054 Medoff, Marshall H. 2010. "State Abortion Policy and the Long‐Term Impact of Parental Involvement Laws." Politics & Policy 38 (2): 193‐221. https://doi.org/10.1111/j.1747-1346.2010.00235.x Wolff, Kristina B. 2011. "Panic in the ER: Maternal Drug Use, the Right to Bodily Integrity, Privacy, and Informed Consent." Politics & Policy 39 (5): 679‐714. https://doi.org/10.1111/j.1747-1346.2011.00313.x [ABSTRACT FROM AUTHOR]

Despite considerable progress in hydrological modeling, challenges remain in the interpretation and accurate transfer of hydrological information across watersheds and scales. In the conterminous United States (CONUS), these limitations are related to spatial inconsistencies and constraints in hydrological model structures, including a lack of spatially explicit process components (streams, reservoirs, and watershed development) and restricted estimation of model parameters across watersheds. Collectively, such limitations can impede identification of the causes of streamflow variations across the diversity of watershed sizes and land uses in the CONUS and contribute to model imprecision and spatial inconsistencies in prediction uncertainties. We addressed these concerns with a new approach, the first hybrid (statistical‐mechanistic) SPARROW (SPAtially Referenced Regression On Watershed attributes) model of long‐term mean annual streamflow, applied across diverse environmental settings of the CONUS. The hybrid model coupled previous catchment‐scale (1 km) water balance predictions of "natural" unit area runoff, which are inclusive of major water cycling processes, with additional explanatory variables (e.g., soils, vegetation, land use, topography, water losses in streams, and reservoirs) that account for the effects of natural and cultural water supply and demand processes that operate over large spatial scales and explain streamflow variability across CONUS river basins. Accounting for these statistically unique effects, including a nonlinear surface area‐dependent scaling of water loss in river networks, significantly improved the accuracy of mean streamflow predictions in CONUS basins. Our hybrid modeling approach provides new methods for transferring hydrological information to ungauged locations in river networks, especially those in larger and more culturally diverse CONUS watersheds. Key Points: Integration of water balance methods with a spatially explicit statistical model improves accuracy of streamflow prediction across the USAStudy identifies large‐scale natural and human controls on water delivery from the land to river networks and quantifies in‐stream lossesApproach improves understanding and parameterization of large‐scale hydrological processes and scaling properties to support prediction [ABSTRACT FROM AUTHOR]

The precise estimation of process effects in hydrological models requires applying models to large scales with extensive spatial variability in controlling factors. Despite progress in large‐scale applications of hydrological models in conterminous United States (CONUS) river basins, spatial constraints in model parameters have prevented the interbasin sharing of data, complicating quantification of process effects and limiting the accuracy of model predictions and uncertainties. Hierarchical Bayesian methods enable data sharing between basins and the identification of the causes of model uncertainties, which can improve model accuracy and interpretability; however, computational inefficiencies have been an obstacle to their large‐scale application. We used a new generation of Bayesian methods to develop a hierarchical version of a previous hybrid (statistical‐mechanistic) SPAtially Referenced Regression On Watershed attributes model of long‐term mean annual streamflow in the CONUS. We identified hierarchical (regional) variations in model coefficients and uncertainties and evaluated their effects on model accuracy and interpretability across diverse environments in 16 major CONUS regions. Hierarchical coefficients significantly improved spatial accuracy of model predictions, with the largest improvements in humid eastern regions, where uncertainties were approximately one third of those in arid western regions. Half of the coefficients varied regionally, with the largest variations in coefficients associated with water losses in streams and reservoirs. Our unraveling of the causes of model uncertainties identified a small latent process component of runoff that varies inversely with river size in most CONUS regions. Our study advances the use of hierarchical Bayesian methods to improve the predictive capabilities of hydrological models. Key Points: Use of hierarchical Bayesian methods with a spatially explicit statistical model improves accuracy of streamflow prediction across the United StatesThe study identifies regionally varying model coefficients for natural and human controls on water transport and losses in watershedsHierarchical models show promise for reducing uncertainties in transfers of hydrological information from gauged to ungauged watersheds [ABSTRACT FROM AUTHOR]

Mandatory disclosure is a regulatory tool intended to allow market participants to assess operational risk. We examine the value of disclosure through the controversial SEC requirement, since overturned, which required major hedge funds to register as investment advisors and file Form ADV disclosures. Leverage and ownership structures suggest that lenders and equity investors were already aware of operational risk. However, operational risk does not mediate flow-performance relationships. Investors either lack this information or regard it as immaterial. These findings suggest that regulators should account for the endogenous production of information and the marginal benefit of disclosure to different investment clienteles. [ABSTRACT FROM AUTHOR]

The COVID-19 pandemic challenged the public health system to respond to an emerging, difficult-to-understand pathogen through demanding behaviors, including staying at home, masking for long periods, and vaccinating multiple times. We discuss key challenges of the pandemic health communication efforts deployed in the United States from 2020 to 2022 and identify research priorities. One priority is communicating about uncertainty in ways that prepare the public for disagreement and likely changes in recommendations as scientific understanding advances: How can changes in understanding and recommendations foster a sense that "science works as intended" rather than "the experts are clueless" and prevent creating a void to be filled by misinformation? A second priority concerns creating a culturally fluent framework for asking people to engage in difficult and novel actions: How can health messages foster the perception that difficulties of behavior change signal that the change is important rather than that the change "is not for people like me?" A third priority entails a shift from communication strategies that focus on knowledge and attitudes to interventions that focus on norms, policy, communication about policy, and channel factors that impair behavior change: How can we move beyond educating and correcting misinformation to achieving desired actions? [ABSTRACT FROM AUTHOR]

Esophageal adenocarcinoma (EAC) has become the dominant type of esophageal cancer in United States. The 5-year survival rate of EAC is below 20% and most patients present with locally advanced or widespread metastatic disease, where current treatment is largely ineffective. Therefore, new therapeutic approaches are urgently needed. Improvement of EAC patient outcome requires well-characterized animal models in which to evaluate novel therapeutics. In this study we aimed to establish a peritoneal dissemination xenograft mouse model of EAC that would support survival outcome analyses. To find the best candidate cell line from 7 human EAC cell lines of different origin named ESO26, OE33, ESO51, SK-GT-2, OE19, OACM5.1C and Flo-1 were injected intraperitoneally/subcutaneously into SCID mice. The peritoneal/xenograft tumor formation and mouse survival were compared among different groups. All cell lines injected subcutaneously formed tumors within 3 months at variable rates. All cell lines except OACM5.1C formed intraperitoneal tumors within 3 months at variable rates. Median animal survival with peritoneal dissemination was 108 days for ESO26 cells (5X106), 65 days for OE33 cells (5X106), 88 days for ESO51 cells (5X106), 76 days for SK-GT-2 cells (5X106), 55 days for OE19 cells (5X106), 45 days for OE19 cells (10X106) and 82 days for Flo-1 cells (5X106). Interestingly, only in the OE19 model all mice (7/7 for 5X106 and 5/5 for10X106) developed bloody ascites with liver metastasis after intraperitoneal injection. The median survival time of these animals was the shortest (45 days for 10X106 cells). In addition, median survival was significantly increased after paclitaxel treatment compared with the control group (57 days versus 45 days, p = 0.0034) along with a significant decrease of the relative subcutaneous tumor volume (p = 0.00011). Thus peritoneal dissemination mouse xenograft model for survival outcome assessment after intraperitoneal injection of OE19 cells will be very useful for the evaluation of cancer therapeutics. [ABSTRACT FROM AUTHOR]

Across the United States, street-level bureaucrats increasingly engage exploited or trafficked persons. While a great deal of their frontline work remains the same, the terminology used to define their trafficked clients is a critical new addition to their caseloads. In this article, I use the Midwest as a case study for understanding how encounters between service providers and trafficked persons hinge on which definitions are mobilized. Using qualitative data from 42 interviews, I argue that frontline workers use definitions of human trafficking that utilize legal frames or normative judgments to make meaning of their clients' experiences. While service providers articulated the utility of these definitions, they also addressed moments of friction, when the legal frames they use are in direct tension with their normative judgments. These moments highlight antitrafficking workplace challenges and expose the issues of resource accessibility survivors face when their exploitation does not fit dominant understandings of trafficking. [ABSTRACT FROM AUTHOR]

Objectives: To investigate the occurrence, the genetic environment and the functionality of novel variants of the MDR gene cfr(C) in Campylobacter from China.Methods: A total of 370 Campylobacter isolates of porcine and chicken origin collected from three regions of China in 2015 were screened for cfr(C) by PCR. The phenotypes and genotypes of cfr(C)-positive isolates were investigated by antimicrobial susceptibility testing, PFGE, MLST, S1-PFGE, Southern blotting and WGS. Quantitative RT-PCR was used to compare the expression levels of the cfr(C) variants in their original isolate and clone constructs in Campylobacter jejuni NCTC 11168.Results: Four (1.1%) porcine Campylobacter coli isolates were positive for cfr(C). They failed to show elevated MICs of phenicols. The deduced Cfr(C) sequences identified exhibited 2-6 amino acid changes compared with the original Cfr(C) reported in the USA. Cloning of the cfr(C) variant genes into C. jejuni NCTC 11168 resulted in ≥32-fold increases in the MICs of phenicols, indicating that the cfr(C) variant genes are functional. The cfr(C)-carrying isolates belonged to three genotypes and WGS analysis revealed the cfr(C) genes were chromosomally located in MDR genomic islands, which contained multiple antibiotic resistance genes of Gram-positive origin.Conclusions: This study identified chromosomal cfr(C) genes in C. coli isolates from China. They appeared functionally dormant in the original isolates but were fully functional when cloned and expressed in C. jejuni. The cfr(C) genes were co-transferred with other antibiotic resistance genes, possibly from Gram-positive bacteria. These findings reveal new insights into the function and transmission of cfr(C) in Campylobacter. [ABSTRACT FROM AUTHOR]

Objectives. To describe policies related to parental leave, breastfeeding, and childcare for faculty and staff at top schools of public health in the United States. Methods. We identified the top 25 schools of public health from the US News and World Report rankings. We reviewed each institutional Web site to identify publicly available policies as of July 2018. Results. For birth mothers, 80% (20/25) of the schools provided paid childbearing leave to faculty (mean = 8.2 weeks), and 48% (12/25) provided paid childbearing leave for staff (mean = 5.0 weeks). For nonbirth parents, 68% (17/25) provided paid parental leave for faculty and 52% (13/25) for staff (range = 1–15 weeks). We found that 64% (16/25) of the schools had publicly available lactation policies, and 72% (18/25) of the schools had at least 1 university-run on-campus childcare center. Conclusions. The majority of top US schools of public health provide paid leave to faculty birth mothers. However, most schools fall short of the 14 weeks recommended by the American Public Health Association. [ABSTRACT FROM AUTHOR]

Biofilm‐associated implant‐related bone and joint infections are clinically important due to the extensive morbidity, cost of care and socioeconomic burden that they cause. Research in the field of biofilms has expanded in the past two decades, however, there is still an immense knowledge gap related to many clinical challenges of these biofilm‐associated infections. This subject was assigned to the Biofilm Workgroup during the second International Consensus Meeting on Musculoskeletal Infection held in Philadelphia USA (ICM 2018) (https://icmphilly.com). The main objective of the Biofilm Workgroup was to prepare a consensus document based on a review of the literature, prepared responses, discussion, and vote on thirteen biofilm related questions. The Workgroup commenced discussing and refining responses prepared before the meeting on day one using Delphi methodology, followed by a tally of responses using an anonymized voting system on the second day of ICM 2018. The Working group derived consensus on information about biofilms deemed relevant to clinical practice, pertaining to: (1) surface modifications to prevent/inhibit biofilm formation; (2) therapies to prevent and treat biofilm infections; (3) polymicrobial biofilms; (4) diagnostics to detect active and dormant biofilm in patients; (5) methods to establish minimal biofilm eradication concentration for biofilm bacteria; and (6) novel anti‐infectives that are effective against biofilm bacteria. It was also noted that biomedical research funding agencies and the pharmaceutical industry should recognize these areas as priorities. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res [ABSTRACT FROM AUTHOR]