1. Association of Fitness With Incident Dyslipidemias Over 25 Years in the Coronary Artery Risk Development in Young Adults Study.
- Author
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Sarzynski, Mark A., Jr.Schuna, John M., Carnethon, Mercedes R., Jr.Jacobs, David R., Lewis, Cora E., Jr.Quesenberry, Charles P., Sidney, Stephen, Schreiner, Pamela J., Sternfeld, Barbara, Schuna, John M Jr, Jacobs, David R Jr, and Quesenberry, Charles P Jr
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DYSLIPIDEMIA , *PHYSICAL fitness , *CORONARY heart disease risk factors , *DISEASES in young adults , *DISEASE incidence , *PROPORTIONAL hazards models , *EXERCISE tests , *HYPERLIPIDEMIA , *LONGITUDINAL method , *LOW density lipoproteins , *MULTIVARIATE analysis , *RESEARCH funding - Abstract
Introduction: Few studies have examined the longitudinal associations of fitness or changes in fitness on the risk of developing dyslipidemias. This study examined the associations of (1) baseline fitness with 25-year dyslipidemia incidence and (2) 20-year fitness change on dyslipidemia development in middle age in the Coronary Artery Risk Development in Young Adults Study (CARDIA).Methods: Multivariable Cox proportional hazards regression models were used to test the association of baseline fitness (1985-1986) with dyslipidemia incidence over 25 years (2010-2011) in CARDIA (N=4,898). Modified Poisson regression models were used to examine the association of 20-year change in fitness with dyslipidemia incidence between Years 20 and 25 (n=2,487). Data were analyzed in June 2014 and February 2015.Results: In adjusted models, the risk of incident low high-density lipoprotein cholesterol (HDL-C); high triglycerides; and high low-density lipoprotein cholesterol (LDL-C) was significantly lower, by 9%, 16%, and 14%, respectively, for each 2.0-minute increase in baseline treadmill endurance. After additional adjustment for baseline trait level, the associations remained significant for incident high triglycerides and high LDL-C in the total population and for incident high triglycerides in both men and women. In race-stratified models, these associations appeared to be limited to whites. In adjusted models, change in fitness did not predict 5-year incidence of dyslipidemias, whereas baseline fitness significantly predicted 5-year incidence of high triglycerides.Conclusions: Our findings demonstrate the importance of cardiorespiratory fitness in young adulthood as a risk factor for developing dyslipidemias, particularly high triglycerides, during the transition to middle age. [ABSTRACT FROM AUTHOR]- Published
- 2015
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