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Aim: The aim of the study was to identify sociodemographic, disease-related, physical and mental health-related determinants of fatigue at 2-year follow-up in individuals with symptomatic knee osteoarthritis (OA)., Methods: A longitudinal analysis of participants with symptomatic knee OA from the Multicenter Osteoarthritis Study (MOST) was conducted to identify predictors of fatigue at 2-year follow-up. Participants self-reported fatigue at baseline for the first time in the MOST cohort and at follow-up using a 0-10 visual analog scale. At baseline, questionnaires on sociodemographics, disease-related symptoms, physical and mental health factors were completed. Data were analyzed using linear regressions with a backwards elimination approach., Results: Of the 2330 individuals in the MOST cohort at baseline, 576 had symptomatic knee OA and of these, 449 with complete fatigue values at baseline and follow-up were included in this analysis. Minimally important fatigue change (ie, worsening [≥1.13], no change [<0.82 or <1.13] and improvement [≥-0.82]) from baseline to follow-up were unequal within the population (34.5%, 26.9%, 38.5%; χ 2 [2, N = 449] = 9.32, P = .009). The multiple linear regression showed that baseline fatigue (unstandardized coefficient [Β] = 0.435; 95% confidence interval [CI] 0.348-0.523, P < .001), slow gait speed (Β = -1.124; 95% CI -1.962 to -0.285, P = .009), depressive symptoms (Β = 0.049; 95% CI 0.024-0.075, P < .001) and higher numbers of comorbidities (Β = 0.242; 95% CI 0.045-0.439, P = .016) were significant predictors of greater fatigue at follow-up., Conclusion: Fatigue is strongly associated with physical- and mental-related health factors. Individualized treatments that include combined psychological and physical function rehabilitation might be modalities for fatigue management., (© 2020 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd.)

Background: Pain is a significant burden within the U.S. adult population, but little is known regarding epidemiology of pain, particularly with respect to race, ethnicity, and socioeconomic position (SEP)., Objective: The purpose of this study was to describe and evaluate prevalence and distribution of pain in the United States., Methods: With data from the population-based 2003-2004 National Health and Nutrition Examination Survey, prevalence of acute (<3 months) and chronic (≥ 3 months) pain was evaluated, including subgroup analyses of race, ethnicity, and SEP, with SEP defined by the poverty-to-income ratio, a ratio derived from the federal poverty level, accounting for household income and number of household members., Results: Prevalence of acute pain was 12.2% (95% confidence interval: 11.2-13.3%). Non-Hispanic black as well as Hispanic and Mexican-American individuals had higher rates of acute pain than non-Hispanic white people, and a higher prevalence was noted in those with higher SEP. Chronic pain prevalence was 15.6% (13.4-17.7%), with non-Hispanic white people having a higher prevalence than those in other racial and ethnic groups., Conclusion: Trends of chronic pain by SEP were opposite of acute pain as those in the highest SEP group tended to have less chronic pain than those in lower SEP groups. These findings suggest that SEP, in addition to race and ethnicity, may play a role in the development of pain as well as its treatment and management., (Wiley Periodicals, Inc.)