44 results on '"Rathore, Saif S."'
Search Results
2. Differences in Patient Survival After Acute Myocardial Infarction by Hospital Capability of Performing Percutaneous Coronary Intervention.
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Chen, Jersey, Krumholz, Harlan M., Wang, Yun, Curtis, Jeptha P., Rathore, Saif S., Ross, Joseph S., Nonnand, Sharon-Lise T., Schreiner, Geoffrey C., Mulvey, Gregory, and Nallamothu, Brahmajee K.
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MYOCARDIAL infarction-related mortality ,INFARCTION ,CARDIOVASCULAR services in hospitals ,CORONARY heart disease treatment ,REGIONAL medical programs ,PREVENTION - Abstract
The article presents a study which investigates the survival impact of regionalization of acute myocardial infarction (AMI) care on percutaneous coronary intervention (PCI) hospitals in the U.S. Risk-standardized mortality rates (RSMRs) between PCI hospitals and non-PCI hospitals within the same health care regions were analyzed. The study suggests that regionalizing AMI care to PCI hospitals can reduce mortality rates, however, survival outcomes varies across the regions.
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- 2010
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3. Mortality and Readmission for Patients With Heart Failure Among U.S. News & World Report's Top Heart Hospitals.
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Mulvey, Gregory K., Yun Wang, Zhenqiu Lin, Wang, Oliver J., Chen, Jersey, Keenan, Patricia S., Drye, Elizabeth E., Rathore, Saif S., Normand, Sharon-Lise T., and Krumholz, Harlan M.
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REGRESSION analysis ,HEART disease related mortality ,HOSPITAL admission & discharge ,RATINGS of hospitals ,HEART failure - Abstract
The article discusses a study on the use of hierarchical regression models in assessing the rates of risk-standardized mortality and readmission of patients with heart failure in hospitals identified in the "America's Best Hospitals" ranking by the periodical "U.S. News & World Report" and in those non-ranked facilities. The study noted there was a reduced mean rate of in-hospital mortality in ranked hospitals, compared to non-ranked ones. It is said that ranked hospitals have not shown enough evidence of superiority for readmission.
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- 2009
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4. Regionalization of Care for Acute Coronary Syndromes: More Evidence Is Needed.
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Rathore, Saif S., Epstein, Andrew J., Volpp, Kevin G. M., and Krumholz, Harlan M.
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CORONARY disease , *MEDICAL centers , *PATIENT safety , *MEDICAL care costs , *MEDICAL economics , *MEDICAL care cost shifting , *MEDICAL care , *PATIENTS , *PLANNING - Abstract
Comments on the push for regional treatment centers for patients with acute coronary syndromes. Planning for regionalized care begun by the State of Maryland; Presentation of concerns for this approach to patient care and possible unintended consequences; Arguments for the benefits of the ACS centers, which are based on studies with notable limitations; Lack of clear consensus on the specific nature of ACS regionalization; Risks to patients; Concerns about how the direct admission of ACS patients will be handled; Economic implications; Concern that regionalization may be the end of quality care at non-ACS facilities; Conclusion and belief there is not enough data to support the value of these centers at this time.
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- 2005
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5. Regional variations in racial differences in the treatment of elderly patients hospitalized with acute myocardial infarction
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Rathore, Saif S., Masoudi, Frederick A., Havranek, Edward P., and Krumholz, Harlan M.
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MYOCARDIAL infarction , *CORONARY disease , *MEDICAL care for older people ,CARDIAC surgery patients - Abstract
Purpose: Racial differences in the treatment of patients with myocardial infarction are often presented as nationally consistent patterns of care, despite known regional variations in quality of care. We sought to determine whether racial differences in myocardial infarction treatment vary by U.S. census region.Methods: We conducted a retrospective analysis of medical record data from 138,938 elderly fee-for-service Medicare beneficiaries hospitalized with myocardial infarction between 1994 and 1996. Patients were evaluated for the use (admission, discharge) of aspirin and beta-blockers, and cardiac procedures (cardiac catheterization, any coronary revascularization) within 60 days of admission.Results: Nationally, black patients had lower crude rates of aspirin and beta-blocker use, cardiac catheterization, and coronary revascularization than did white patients. Racial differences in treatment, however, varied by region. Black patients in the Northeast had rates of aspirin use that were similar to those of white patients on admission (50.6% vs. 49.8%, P = 0.58) and at discharge (77.5% vs. 74.2%, P = 0.07), whereas racial differences were observed in the South (admission: 43.7% vs. 48.8%, P <0.001; discharge: 69.5% vs. 73.2%, P <0.001), Midwest (admission: 48.4% vs. 52.3%, P = 0.004), and West (admission: 49.2% vs. 56.2%, P <0.001; discharge: 70.7% vs. 76.2%, P = 0.02). Racial differences in beta-blocker use were comparable across regions (admission: P = 0.59, discharge: P = 0.89). There were no differences in cardiac catheterization use among black and white patients in the Northeast (38.9% vs. 40.5%, P = 0.24), as opposed to the Midwest (43.3% vs. 48.9%, P <0.001), South (39.2% vs. 48.5%, P <0.001), and West (38.3% vs. 48.6%, P <0.001). Similarly, racial differences in any coronary revascularization use were smallest in the Northeast (22.1% vs. 26.7%, P <0.001), greater in the Midwest (24.7% vs. 33.5%, P <0.001), and largest in the South (20.7% vs. 32.0%, P <0.001) and West (22.9% vs. 33.7%, P <0.001). Regional variations in racial differences persisted after multivariable adjustment for aspirin on admission (P = 0.09) and any coronary revascularization (P = 0.10).Conclusion: Racial differences in the use of some therapies for myocardial infarction in patients hospitalized between 1994 and 1996 varied by region, suggesting that national evaluations of racial differences in health care use may obscure potentially important regional variations. [ABSTRACT FROM AUTHOR]- Published
- 2004
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6. JCAHO Accreditation And Quality Of Care For Acute Myocardial Infarction.
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Chen, Jersey, Rathore, Saif S., Radford, Martha J., and Krumholz, Harlan M.
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HOSPITAL accreditation , *MEDICARE , *MYOCARDIAL infarction , *MEDICAL care , *PATIENTS - Abstract
Examines the association between U.S. Joint Commission on Accreditation of Healthcare Organizations (JCAHO) accreditation of hospitals, quality of care and survival among Medicare patients hospitalized for acute myocardial infarction (AMI). Requirements under the JCAHO accreditation program; Quality of AMI care and outcomes; Mortality rates of hospitals accredited with commendation.
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- 2003
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7. Treatment of patients with myocardial infarction who present with a paced rhythm.
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Rathore, Saif S., Weinfurt, Kevin P., Gersh, Bernard J., Oetgen, William J., Schulman, Kevin A., Solomon, Allen J., Rathore, S S, Weinfurt, K P, Gersh, B J, Oetgen, W J, Schulman, K A, and Solomon, A J
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MYOCARDIAL infarction , *CARDIAC pacemakers , *PATIENTS - Abstract
Background: A paced rhythm can mask the electrocardiographic features of an acute myocardial infarction, complicating timely recognition and treatment.Objective: To evaluate characteristics, treatment, and outcomes among patients presenting with paced rhythms during myocardial infarction.Design: Retrospective cohort study.Setting: U.S. acute care hospitals.Patients: 102 249 Medicare beneficiaries at least 65 years of age who were treated for acute myocardial infarction between 1994 and 1996.Measurements: Provision of three treatments for acute myocardial infarction (emergent reperfusion, aspirin, and beta-blockers), death at 30 days, and long-term follow-up.Results: 1954 patients (1.9%) presented with paced rhythms during myocardial infarction. These patients were older; were predominantly male; and had higher rates of congestive heart failure, diabetes, and previous infarction. They were significantly less likely to receive emergent reperfusion (relative risk [RR], 0.27 [95% CI, 0.22 to 0.33]), aspirin (RR at admission, 0.91 [CI, 0.88 to 0.94]; RR at discharge, 0.87 [CI, 0.83 to 0.92]), and beta-blockers at admission (RR, 0.89 [CI, 0.82 to 0.96]). In addition, there was a trend toward decreased use of beta-blockers at discharge (RR, 0.91 [CI, 0.76 to 1.06]). Crude mortality rates were higher among patients with paced rhythms than among those without at 30 days (25.8% vs. 21.3%; P = 0.001) and at 1 year (47.1% vs. 36.1%; P = 0.001). Among patients with paced rhythms, risk for death at 30 days decreased after adjustment for illness severity and decreased use of therapy (RR, 1.03 [CI, 0.93 to 1.14]). Patients with paced rhythms remained at additional risk for long-term mortality (hazard ratio, 1.12 [CI, 1.06 to 1.18]).Conclusions: Patients with paced rhythms were less likely than those without to receive treatment for acute myocardial infarction and had poorer short- and long-term outcomes. However, this mortality risk diminished after adjustment for treatment. This suggests that improved recognition and treatment of myocardial infarction may improve outcomes, particularly in the short term. [ABSTRACT FROM AUTHOR]- Published
- 2001
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8. Residency application statements can predict postresidency training.
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Adams, Michael, Rathore, Saif S., Mitchell, S. Ray, Eisenberg, John M., Adams, M, Rathore, S S, Mitchell, S R, and Eisenberg, J M
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VOCATIONAL guidance , *MEDICAL specialties & specialists , *FAMILY medicine , *INTERNSHIP programs , *MEDICAL education , *MEDICINE , *ACQUISITION of data - Abstract
We sought to evaluate whether residency application statements regarding expected career paths are accurate predictors of early postresidency career paths. We evaluated 162 residents who completed a categorical medicine residency at Georgetown University Hospital between 1990 and 1998 to determine if their stated career plans (generalist practice, subspecialization, or undecided) at application predicted activity immediately after residency. Of 130 residents with defined postresidency plans at application, most 78 (60%) followed those career paths after graduation; 18 (67%) of 27 pursued their initial interest in generalist practice, and 60 (58%) of 103 pursued their stated interest in subspecialty training. We also noted a movement of residents toward generalism (79 [49%] of 162), despite low initial interest (27 [17%] of 162). [ABSTRACT FROM AUTHOR]
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- 1999
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9. Acute Coronary Syndromes and Regionalization of Care—Reply.
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Rathore, Saif S., Epstein, Andrew J., Volpp, Kevin G. M., and Krumholz, Harlan M.
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LETTERS to the editor , *CORONARY heart disease treatment , *MEDICAL care - Abstract
Presents a reply to a letter to the editor of "The Journal of the American Medical Association" regarding acute coronary syndromes and regionalization of care. Discussion of an article by Rathore and colleagues found in a previous issue of the journal.
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- 2005
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10. Sex and Racial Differences in the Management of Acute Myocardial Infarction, 1994 through 2002.
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Vaccarino, Viola, Rathore, Saif S., Wenger, Nanette K., Frederick, Paul D., Abramson, Jerome L., Barron, Hal V., Manhapra, Ajay, Mallik, Susmita, and Krumholz, Harlan M.
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DISEASE management , *MYOCARDIAL infarction , *HEART diseases , *HEALTH & race , *MEDICAL anthropology , *RACIAL differences ,SEX differences (Biology) - Abstract
Background: Although increased attention has been paid to sex and racial differences in the management of myocardial infarction, it is unknown whether these differences have narrowed over time. Methods: With the use of data from the National Registry of Myocardial Infarction, we examined sex and racial differences in the treatment of patients who were deemed to be “ideal candidates†for particular treatments and in deaths among 598,911 patients hospitalized with myocardial infarction between 1994 and 2002. Results: In the unadjusted analysis, sex and racial differences were observed for rates of reperfusion therapy (for white men, white women, black men, and black women: 86.5, 83.3, 80.4, and 77.8 percent, respectively; P<0.001), use of aspirin (84.4, 78.7, 83.7, and 78.4 percent, respectively; P<0.001), use of beta-blockers (66.6, 62.9, 67.8, and 64.5 percent; P<0.001), and coronary angiography (69.1, 55.9, 64.0, and 55.0 percent; P<0.001). After multivariable adjustment, racial and sex differences persisted for rates of reperfusion therapy (risk ratio for white women, black men, and black women: 0.97, 0.91, and 0.89, respectively, as compared with white men) and coronary angiography (relative risk, 0.91, 0.82, and 0.76) but were attenuated for the use of aspirin (risk ratio, 0.97, 0.98, and 0.94) and beta-blockers (risk ratio, 0.98, 1.00, and 0.96); all risks were unchanged over time. Adjusted in-hospital mortality was similar among white women (risk ratio, 1.05; 95 percent confidence interval, 1.03 to 1.07) and black men (risk ratio, 0.95; 95 percent confidence interval, 0.89 to 1.00), as compared with white men, but was higher among black women (risk ratio, 1.11; 95 percent confidence interval, 1.06 to 1.16) and was unchanged over time. Conclusions: Rates of reperfusion therapy, coronary angiography, and in-hospital death after myocardial infarction, but not the use of aspirin and beta-blockers, vary according to race and sex, with no evidence that the differences have narrowed in recent years. N Engl J Med 2005;353:671-82. [ABSTRACT FROM AUTHOR]
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- 2005
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11. US Cardiologist Workforce From 1995 To 2007: Modest Growth, Lasting Geographic Maldistribution Especially In Rural Areas.
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Aneja, Sanjay, Ross, Joseph S., Wang, Yongfei, Matsumoto, Masatoshi, Rodgers, George P., Bernheim, Susannah M., Rathore, Saif S., and Krumholz, Harlan M.
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CARDIOVASCULAR disease treatment , *PHYSICIANS , *RURAL Americans , *ANALYSIS of variance , *CARDIOLOGY , *STATISTICAL correlation , *HEALTH services accessibility , *LONGITUDINAL method , *MAPS , *RESEARCH methodology , *MEDICALLY underserved areas , *MEDICAL specialties & specialists , *MULTIVARIATE analysis , *POPULATION geography , *RESEARCH funding , *REWARD (Psychology) , *TELEMEDICINE , *DESCRIPTIVE statistics - Abstract
A sufficient cardiology workforce is necessary to ensure access to cardiovascular care. Specifically, access to cardiologists is important in the management and treatment of chronic cardiovascular disease. Given this, we examined the supply and distribution of the cardiologist workforce. In doing so, we mapped the ratios of cardiologists, primary care physicians, and total physicians to the population age sixty-five or older within different Hospital Referral Regions from the years 1995 and 2007. We found that within the twelve-year span of our study, the cardiology workforce grew modestly compared with the primary care physician and total physician workforces. Also, despite increases in the number of cardiologists, there was a persistent geographic maldistribution of the workforce. For example, approximately 60 percent of the elderly population had access to only 38 percent of the cardiologists. Our results suggest that large segments of the US population, specifically in rural and socioeconomically disadvantaged areas, continue to have a lower concentration of cardiologists. This maldistribution could be addressed through a variety of strategies, including the use of telemedicine and economic incentives. [ABSTRACT FROM AUTHOR]
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- 2011
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12. Delay in reperfusion with transradial percutaneous coronary intervention for ST-elevation myocardial infarction: Might some delays be acceptable?
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Wimmer NJ, Cohen DJ, Wasfy JH, Rathore SS, Mauri L, and Yeh RW
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- Aged, Humans, Male, Middle Aged, Myocardial Infarction mortality, Risk Factors, Survival Rate trends, Time Factors, Treatment Outcome, United States epidemiology, Coronary Care Units statistics & numerical data, Decision Support Techniques, Electrocardiography, Myocardial Infarction surgery, Percutaneous Coronary Intervention methods
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Background: Randomized clinical trials (RCTs) suggest benefits for the transradial approach to percutaneous coronary intervention (PCI) for ST-elevation myocardial infarction (STEMI). However, transradial PCI may delay reperfusion, leading to its avoidance. We sought to quantify the delay in reperfusion from transradial PCI ("transradial delay") that would need to be introduced to offset the potential mortality benefit of transradial PCI, compared with transfemoral, observed in RCTs., Methods: We developed a decision-analytic model to compare transfemoral and transradial PCI in STEMI. Thirty-day mortality rates were estimated by pooling STEMI patients from 2 RCTs comparing transfemoral and transradial PCI. We projected the impact of transradial delay using estimates of the increase in mortality associated with door-to-balloon time delays. Sensitivity analyses were performed to understand the impact of uncertainty in assumptions., Results: In the base case, a transradial delay of 83.0 minutes was needed to offset the mortality benefit of transradial PCI. When the mortality benefit of transradial PCI was one-quarter that observed in RCTs, the delay associated with equivalent mortality was 20.9 minutes. In probabilistic sensitivity analyses, transradial PCI was preferred over transfemoral PCI in 97.5% of simulations when transradial delay was 30 minutes and in 79.0% of simulations when delay was 60 minutes., Conclusions: A substantial transradial delay is required to eliminate even a fraction of the mortality benefit observed with transradial PCI in RCTs. Results were robust to changing multiple assumptions and have implications for operators reluctant to transition to transradial PCI in STEMI because of concern for delaying reperfusion., (Copyright © 2014 Mosby, Inc. All rights reserved.)
- Published
- 2014
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13. Transfer rates from nonprocedure hospitals after initial admission and outcomes among elderly patients with acute myocardial infarction.
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Barreto-Filho JA, Wang Y, Rathore SS, Spatz ES, Ross JS, Curtis JP, Nallamothu BK, Normand SL, and Krumholz HM
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- Aged, Fee-for-Service Plans economics, Female, Hospital Mortality trends, Hospitals, Special economics, Humans, Male, Medicare economics, Myocardial Infarction economics, Myocardial Infarction mortality, Myocardial Revascularization economics, Patient Transfer economics, Survival Rate trends, United States epidemiology, Hospitals, Special statistics & numerical data, Myocardial Infarction therapy, Myocardial Revascularization methods, Patient Admission, Patient Transfer statistics & numerical data
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Importance: It is unknown whether hospital transfer rates for patients with acute myocardial infarction admitted to nonprocedure hospitals (facilities that do not provide catheterization) vary and whether these rates further influence revascularization rates, length of stay, and mortality., Objectives: To examine hospital differences in transfer rates for elderly patients with acute myocardial infarction across nonprocedure hospitals and to determine whether these rates are associated with revascularization rates, length of stay, and mortality., Design, Setting, and Participants: We used Medicare claims data from January 1, 2006, to December 31, 2008, to assess transfer rates in nonprocedure hospitals, stratified according to transfer rates as low (≤ 20%), mid-low (>20%-30%), mid-high (>30%-40%), or high (>40%). Data were analyzed for 55,962 Medicare fee-for-service patients admitted to 901 nonprocedure US hospitals with more than 25 admissions per year for acute myocardial infarction., Main Outcomes and Measures: We compared rates of catheterization, percutaneous coronary intervention, and coronary artery bypass graft surgery during hospitalization and within 60 days, as well as hospital total length of stay, across groups. We measured risk-standardized mortality rates at 30 days and 1 year. RESULTS The median transfer rate was 29.4% (interquartile range [25th-75th percentile], 21.8%-37.8%). Higher transfer rates were associated with higher rates of catheterization (P < .001), percutaneous coronary intervention (P < .001), and coronary artery bypass graft surgery (P < .001). Median length of stay was not meaningfully different across the groups. There was no meaningful evidence of associations between transfer rates and risk-standardized mortality at 30 days (mean [SD], 22.3% [2.6%], 22.1% [2.3%], 22.3% [2.4%], and 21.7% [2.1%], respectively; P = .054) or 1 year (43.9% [2.3%], 43.6% [2.2%], 43.5% [2.4%], and 42.8% [2.2%], respectively; P < .001) for low, mid-low, mid-high, and high transfer groups., Conclusions and Relevance: Nonprocedure hospitals vary substantially in their use of the transfer process for elderly patients admitted with acute myocardial infarction. High-transfer hospitals had greater use of invasive cardiac procedures after admission compared with low-transfer hospitals. However, higher transfer rates were not associated with a significantly lower risk-standardized mortality rate at 30 days. Moreover, at 1 year there was only a 1.1% difference (42.8% vs 43.9%) between hospitals with higher and lower transfer rates. These findings suggest that, as a single intervention, promoting the transfer of patients admitted with acute myocardial infarction may not improve hospital outcomes.
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- 2014
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14. Body mass index and mortality in acute myocardial infarction patients.
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Bucholz EM, Rathore SS, Reid KJ, Jones PG, Chan PS, Rich MW, Spertus JA, and Krumholz HM
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- Aged, Comorbidity, Female, Health Surveys, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Proportional Hazards Models, Prospective Studies, Risk Factors, Smoking adverse effects, Survival Analysis, Translational Research, Biomedical, United States, Body Mass Index, Cause of Death, Myocardial Infarction mortality, Obesity mortality, Overweight mortality
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Background: Previous studies have described an "obesity paradox" with heart failure, whereby higher body mass index (BMI) is associated with lower mortality. However, little is known about the impact of obesity on survival after acute myocardial infarction., Methods: Data from 2 registries of patients hospitalized in the US with acute myocardial infarction between 2003-2004 (PREMIER) and 2005-2008 (TRIUMPH) were used to examine the association of BMI with mortality. Patients (n=6359) were categorized into BMI groups (kg/m(2)) using baseline measurements. Two sets of analyses were performed using Cox proportional hazards regression with fractional polynomials to model BMI as categorical and continuous variables. To assess the independent association of BMI with mortality, analyses were repeated, adjusting for 7 domains of patient and clinical characteristics., Results: Median BMI was 28.6. BMI was inversely associated with crude 1-year mortality (normal, 9.2%; overweight, 6.1%; obese, 4.7%; morbidly obese; 4.6%; P <.001), which persisted after multivariable adjustment. When BMI was examined as a continuous variable, the hazards curve declined with increasing BMI and then increased above a BMI of 40. Compared with patients with a BMI of 18.5, patients with higher BMIs had a 20% to 68% lower mortality at 1 year. No interactions between age (P=.37), sex (P=.87), or diabetes mellitus (P=.55) were observed., Conclusions: There appears to be an "obesity paradox" among patients after acute myocardial infarction such that higher BMI is associated with lower mortality, an effect that was not modified by patient characteristics and was comparable across age, sex, and diabetes subgroups., (Copyright © 2012 Elsevier Inc. All rights reserved.)
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- 2012
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15. Effect of living alone on patient outcomes after hospitalization for acute myocardial infarction.
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Bucholz EM, Rathore SS, Gosch K, Schoenfeld A, Jones PG, Buchanan DM, Spertus JA, and Krumholz HM
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- Female, Follow-Up Studies, Humans, Male, Middle Aged, Myocardial Infarction mortality, Myocardial Infarction therapy, Prospective Studies, Risk Factors, Surveys and Questionnaires, Survival Rate trends, United States epidemiology, Health Status, Hospitalization, Myocardial Infarction psychology, Outcome Assessment, Health Care, Quality of Life
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Considerable attention has been devoted to the effect of social support on patient outcomes after acute myocardial infarction (AMI). However, little is known about the relation between patient living arrangements and outcomes. Thus, we used data from PREMIER, a registry of patients hospitalized with AMI at 19 United States centers from 2003 through 2004, to assess the association of living alone with outcomes after AMI. Outcome measurements included 4-year mortality, 1-year readmission, and 1-year health status using the Seattle Angina Questionnaire (SAQ) and the Short Form-12 Physical Health Component scales. Patients who lived alone had higher crude 4-year mortality (21.8% vs 14.5%, p <0.001) but comparable rates of 1-year readmission (41.6% vs 38.3%, p = 0.79). Living alone was associated with lower unadjusted quality of life (mean SAQ -2.40, 95% confidence interval [CI] -4.44 to -0.35, p = 0.02) but had no impact on Short Form-12 Physical Health Component (-0.45, 95% CI -1.65 to 0.76, p = 0.47) compared to patients who did not live alone. After multivariable adjustment, patients who lived alone had a comparable risk of mortality (hazard ratio 1.35, 95% CI 0.94 to 1.93) and readmission (hazard ratio 0.99, 95% CI 0.76 to 1.28) as patients who lived with others. Mean quality-of-life scores remained lower in patients who lived alone (SAQ -2.91, 95% CI -5.56 to -0.26, p = 0.03). In conclusion, living alone may be associated with poorer angina-related quality of life 1 year after MI but is not associated with mortality, readmission, or other health status measurements after adjusting for other patient and treatment characteristics., (Copyright © 2011 Elsevier Inc. All rights reserved.)
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- 2011
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16. Who is missing from the measures? Trends in the proportion and treatment of patients potentially excluded from publicly reported quality measures.
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Bernheim SM, Wang Y, Bradley EH, Masoudi FA, Rathore SS, Ross JS, Drye E, and Krumholz HM
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- Aged, Cross-Sectional Studies, Female, Hospitalization statistics & numerical data, Humans, Male, Medicaid, Medicare, Myocardial Infarction epidemiology, Prognosis, Retrospective Studies, United States epidemiology, Adrenergic beta-Antagonists therapeutic use, Angiotensin-Converting Enzyme Inhibitors therapeutic use, Myocardial Infarction drug therapy, Outcome and Process Assessment, Health Care methods, Platelet Aggregation Inhibitors therapeutic use, Quality Improvement, Quality Indicators, Health Care
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Background: The Centers for Medicare and Medicaid Services provides public reporting on the quality of hospital care for patients with acute myocardial infarction (AMI). The Centers for Medicare and Medicaid Services Core Measures allow discretion in excluding patients because of relative contraindications to aspirin, β-blockers, and angiotensin-converting enzyme inhibitors. We describe trends in the proportion of patients with AMI with contraindications that could lead to discretionary exclusion from public reporting., Methods: We completed cross-sectional analyses of 3 nationally representative data cohorts of AMI admissions among Medicare patients in 1994-1995 (n = 170,928), 1998-1999 (n = 27,432), and 2000-2001 (n = 27,300) from the national Medicare quality improvement projects. Patients were categorized as ineligible (eg, transfer patients), automatically excluded (specified absolute medical contraindications), discretionarily excluded (potentially excluded based on relative contraindications), or "ideal" for treatment for each measure., Results: For 4 of 5 measures, the percentage of discretionarily excluded patients increased over the 3 periods (admission aspirin 15.8% to 16.9%, admission β-blocker 14.3% to 18.3%, discharge aspirin 10.3% to 12.3%, and angiotensin-converting enzyme inhibitors 2.8% to 3.9%; P < .001). Of patients potentially included in measures (those who were not ineligible or automatically excluded), the discretionarily excluded represented 25.5% to 69.2% in 2000-2001. Treatment rates among patients with discretionary exclusions also increased for 4 of 5 measures (all except angiotensin-converting enzyme inhibitors)., Conclusions: A sizeable and growing proportion of patients with AMI have relative contraindications to treatments that may result in discretionary exclusion from publicly reported quality measures. These patients represent a large population for which there is insufficient evidence as to whether measure exclusion or inclusion and treatment represents best care., (Copyright © 2010 Mosby, Inc. All rights reserved.)
- Published
- 2010
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17. Racial differences in survival after in-hospital cardiac arrest.
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Chan PS, Nichol G, Krumholz HM, Spertus JA, Jones PG, Peterson ED, Rathore SS, and Nallamothu BK
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- Aged, Aged, 80 and over, Cardiopulmonary Resuscitation, Cohort Studies, Electric Countershock, Female, Heart Arrest ethnology, Heart Arrest therapy, Hospitalization, Humans, Male, Middle Aged, Registries, Socioeconomic Factors, Tachycardia, Ventricular, United States, Ventricular Fibrillation, Black or African American, Black People statistics & numerical data, Heart Arrest mortality, Hospitals statistics & numerical data, White People statistics & numerical data
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Context: Racial differences in survival have not been previously studied after in-hospital cardiac arrest, an event for which access to care is not likely to influence treatment., Objectives: To estimate racial differences in survival for patients with in-hospital cardiac arrests and examine the association of sociodemographic and clinical factors and the admitting hospital with racial differences in survival., Design, Setting, and Patients: Cohort study of 10,011 patients with cardiac arrests due to ventricular fibrillation or pulseless ventricular tachycardia enrolled between January 1, 2000, and February 29, 2008, at 274 hospitals within the National Registry of Cardiopulmonary Resuscitation., Main Outcome Measures: Survival to hospital discharge; successful resuscitation from initial arrest and postresuscitation survival (secondary outcome measures)., Results: Included were 1883 black patients (18.8%) and 8128 white patients (81.2%). Rates of survival to discharge were lower for black patients (25.2%) than for white patients (37.4%) (unadjusted relative rate [RR], 0.73; 95% confidence interval [CI], 0.67-0.79). Unadjusted racial differences narrowed after adjusting for patient characteristics (adjusted RR, 0.81 [95% CI, 0.75-0.88]; P < .001) and diminished further after additional adjustment for hospital site (adjusted RR, 0.89 [95% CI, 0.82-0.96]; P = .002). Lower rates of survival to discharge for blacks reflected lower rates of both successful resuscitation (55.8% vs 67.4% for whites; unadjusted RR, 0.84 [95% CI, 0.81-0.88]) and postresuscitation survival (45.2% vs 55.5% for whites; unadjusted RR, 0.85 [95% CI, 0.79-0.91]). Adjustment for the hospital site at which patients received care explained a substantial portion of the racial differences in successful resuscitation (adjusted RR, 0.92 [95% CI, 0.88-0.96]; P < .001) and eliminated the racial differences in postresuscitation survival (adjusted RR, 0.99 [95% CI, 0.92-1.06]; P = .68)., Conclusions: Black patients with in-hospital cardiac arrest were significantly less likely to survive to discharge than white patients, with lower rates of survival during both the immediate resuscitation and postresuscitation periods. Much of the racial difference was associated with the hospital center in which black patients received care.
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- 2009
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18. Association of door-to-balloon time and mortality in patients admitted to hospital with ST elevation myocardial infarction: national cohort study.
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Rathore SS, Curtis JP, Chen J, Wang Y, Nallamothu BK, Epstein AJ, and Krumholz HM
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- Aged, Cohort Studies, Emergency Treatment mortality, Female, Hospital Mortality, Hospitalization statistics & numerical data, Humans, Male, Middle Aged, Myocardial Infarction mortality, Time Factors, Transportation of Patients, United States, Angioplasty, Balloon mortality, Myocardial Infarction therapy
- Abstract
Objective: To evaluate the association between door-to-balloon time and mortality in hospital in patients undergoing primary percutaneous coronary intervention for ST elevation myocardial infarction to assess the incremental mortality benefit of reductions in door-to-balloon times of less than 90 minutes., Design: Prospective cohort study of patients enrolled in the American College of Cardiology National Cardiovascular Data Registry, 2005-6., Setting: Acute care hospitals., Participants: 43 801 patients with ST elevation myocardial infarction undergoing primary percutaneous coronary intervention., Main Outcome Measure: Mortality in hospital., Results: Median door-to-balloon time was 83 minutes (interquartile range 6-109, 57.9% treated within 90 minutes). Overall mortality in hospital was 4.6%. Multivariable logistic regression models with fractional polynomial models indicated that longer door-to-balloon times were associated with a higher adjusted risk of mortality in hospital in a continuous non-linear fashion (30 minutes=3.0%, 60 minutes=3.5%, 90 minutes=4.3%, 120 minutes=5.6%, 150 minutes=7.0%, 180 minutes=8.4%, P<0.001). A reduction in door-to-balloon time from 90 minutes to 60 minutes was associated with 0.8% lower mortality, and a reduction from 60 minutes to 30 minutes with a 0.5% lower mortality., Conclusion: Any delay in primary percutaneous coronary intervention after a patient arrives at hospital is associated with higher mortality in hospital in those admitted with ST elevation myocardial infarction. Time to treatment should be as short as possible, even in centres currently providing primary percutaneous coronary intervention within 90 minutes.
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- 2009
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19. Association of physician certification and outcomes among patients receiving an implantable cardioverter-defibrillator.
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Curtis JP, Luebbert JJ, Wang Y, Rathore SS, Chen J, Heidenreich PA, Hammill SC, Lampert RI, and Krumholz HM
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- Aged, Aged, 80 and over, Female, Humans, Intraoperative Complications epidemiology, Logistic Models, Male, Middle Aged, Physicians standards, Physicians statistics & numerical data, Postoperative Complications epidemiology, Prosthesis Implantation adverse effects, Prosthesis Implantation standards, Registries, Retrospective Studies, Treatment Outcome, United States, Cardiac Electrophysiology, Certification, Clinical Competence, Defibrillators, Implantable adverse effects, Defibrillators, Implantable standards, Medicine, Outcome and Process Assessment, Health Care, Specialization
- Abstract
Context: Allowing nonelectrophysiologists to perform implantable cardioverter-defibrillator (ICD) procedures is controversial. However, it is not known whether outcomes of ICD implantation vary by physician specialty., Objective: To determine the association of implanting physician certification with outcomes following ICD implantation., Design, Setting, and Patients: Retrospective cohort study using cases submitted to the ICD Registry performed between January 2006 and June 2007. Patients were grouped by the certification status of the implanting physician into mutually exclusive categories: electrophysiologists, nonelectrophysiologist cardiologists, thoracic surgeons, and other specialists. Hierarchical logistic regression models were developed to determine the independent association of physician certification with outcomes., Main Outcome Measures: In-hospital procedural complication rates and the proportion of patients meeting criteria for a defibrillator with cardiac resynchronization therapy (CRT-D) who received that device., Results: Of 111,293 ICD implantations included in the analysis, 78,857 (70.9%) were performed by electrophysiologists, 24,399 (21.9%) by nonelectrophysiologist cardiologists, 1862 (1.7%) by thoracic surgeons, and 6175 (5.5%) by other specialists. Compared with patients whose ICD was implanted by electrophysiologists, patients whose ICD was implanted by either nonelectrophysiologist cardiologists or thoracic surgeons were at increased risk of complications in both unadjusted (electrophysiologists, 3.5% [2743/78,857]; nonelectrophysiologist cardiologists, 4.0% [970/24,399]; thoracic surgeons, 5.8% [108/1862]; P < .001) and adjusted analyses (relative risk [RR] for nonelectrophysiologist cardiologists, 1.11 [95% confidence interval {CI}, 1.01-1.21]; RR for thoracic surgeons, 1.44 [95% CI, 1.15-1.79]). Among 35,841 patients who met criteria for CRT-D, those whose ICD was implanted by physicians other than electrophysiologists were significantly less likely to receive a CRT-D device compared with patients whose ICD was implanted by an electrophysiologist in both unadjusted (electrophysiologists, 83.1% [21 303/25,635]; nonelectrophysiologist cardiologists, 75.8% [5950/7849]; thoracic surgeons, 57.8% [269/465]; other specialists, 74.8% [1416/1892]; P < .001) and adjusted analyses (RR for nonelectrophysiologist cardiologists, 0.93 [95% CI, 0.91-0.95]; RR for thoracic surgeons, 0.81 [95% CI, 0.74-0.88]; RR for other specialists, 0.97 [95% CI, 0.94-0.99])., Conclusions: In this registry, nonelectrophysiologists implanted 29% of ICDs. Overall, implantations by a nonelectrophysiologist were associated with a higher risk of procedural complications and lower likelihood of receiving a CRT-D device when indicated compared with patients whose ICD was implanted by an electrophysiologist.
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- 2009
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20. Mental disorders, quality of care, and outcomes among older patients hospitalized with heart failure: an analysis of the national heart failure project.
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Rathore SS, Wang Y, Druss BG, Masoudi FA, and Krumholz HM
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- Comorbidity, Female, Heart Failure epidemiology, Heart Failure rehabilitation, Hospitalization statistics & numerical data, Humans, International Classification of Diseases, Male, Mental Disorders diagnosis, Middle Aged, Retrospective Studies, Severity of Illness Index, United States epidemiology, Ventricular Dysfunction, Left physiopathology, Angiotensin-Converting Enzyme Inhibitors therapeutic use, Mental Disorders epidemiology, Quality of Health Care standards, Ventricular Dysfunction, Left drug therapy, Ventricular Dysfunction, Left epidemiology
- Abstract
Objective: To evaluate the effect of a mental illness diagnosis on quality of care and outcomes among patients with heart failure., Design: Retrospective, national, population-based sample of patients with heart failure hospitalized from April 1, 1998, through March 31, 1999, and July 1, 2000, through June 30, 2001., Setting: Nonfederal US acute care hospitals., Patients: A total of 53 314 Medicare beneficiaries., Main Outcome Measures: Quality of care measures, including left ventricular ejection fraction (LVEF) assessment, prescription of an angiotensin-converting enzyme (ACE) inhibitor at discharge among patients without treatment contraindications, and 1-year readmission and 1-year mortality., Results: Of the patients included in the study, 17.0% had a mental illness diagnosis. Compared with patients without mental illness diagnoses, eligible patients with mental illness diagnoses had lower rates of LVEF evaluation (53.0% vs 47.3%; P < .001) but comparable rates of ACE inhibitor prescription (71.3% vs 69.7%; P = .40). Findings were unchanged after multivariate adjustment: patients with mental illness had lower odds of LVEF evaluation (odds ratio [OR], 0.81; 95% confidence interval [CI], 0.76-0.87) but comparable rates of ACE inhibitor prescription (0.96; 0.80-1.14). Patients with mental illness diagnoses had higher crude rates of 1-year all-cause readmission (73.7% vs 68.5%; P < .001), which persisted after multivariate adjustment (OR, 1.30; 95% CI, 1.21-1.39). Crude 1-year mortality was higher among patients with a mental illness diagnosis (41.0% vs 36.2%; P < .001). Presence of a comorbid mental illness diagnosis was associated with 1-year mortality after multivariate adjustment (OR, 1.20; 95% CI, 1.12-1.28)., Conclusions: Mental illness is commonly diagnosed among elderly patients hospitalized with heart failure. This subgroup receives somewhat poorer care during hospitalization and has a greater risk of death and readmission to the hospital.
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- 2008
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21. Primary care physicians' views of Medicare Part D.
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Epstein AJ, Rathore SS, Alexander GC, and Ketcham JD
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- Female, Health Services Accessibility, Humans, Male, Middle Aged, Prescription Drugs economics, United States, Attitude of Health Personnel, Medicaid, Medicare Part D, Physicians, Family
- Abstract
Objective: To examine physicians' attitudes about the impact of Medicare Part D and how it varied among seniors, particularly Medicare-Medicaid dual-eligible enrollees., Study Design: Web-based survey of primary care physicians in North Carolina (generous Medicaid formulary) and Florida, Massachusetts, and Texas (restrictive Medicaid formularies)., Methods: Of 5141 eligible primary care physicians, 716 (14%) responded between November 2007 and March 2008. We examined Part D's effects on access overall and for selected populations. We used descriptive and regression analyses to assess physicians' views about Part D's effects on dual-eligible enrollees and how those views differed between North Carolina and the other states. All analyses were weighted for nonresponse., Results: More respondents had a favorable (48%) than an unfavorable (37%) view of Part D overall, and 55% reported Part D improved access to prescription drugs in general. However, 44% reported access declined for individuals with prior drug coverage, and 64% reported Part D formularies were insufficient for their patients' needs. Nearly half (49%) reported dual-eligible enrollees' access was worse under Part D in 2007 relative to Medicaid before 2006; 63% reported higher administrative burden. Physicians reported Part D lowered dual-eligible enrollees' access and increased providers' burden more in North Carolina than in the 3 restrictive Medicaid states., Conclusion: Primary care physicians held generally positive but widely varying views of Part D. Respondents expressed concerns about access to prescription drugs under Part D, particularly for dual-eligible enrollees. Improving the transparency and generosity of Part D formulary coverage may improve access.
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- 2008
22. Regional variation in cardiac catheterization appropriateness and baseline risk after acute myocardial infarction.
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Ko DT, Wang Y, Alter DA, Curtis JP, Rathore SS, Stukel TA, Masoudi FA, Ross JS, Foody JM, and Krumholz HM
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- Aged, Female, Guideline Adherence, Hospitalization statistics & numerical data, Humans, Male, Medicare, Myocardial Infarction classification, Myocardial Infarction mortality, Practice Guidelines as Topic, Regression Analysis, Risk Assessment, United States, Cardiac Catheterization statistics & numerical data, Myocardial Infarction therapy, Practice Patterns, Physicians' statistics & numerical data, Process Assessment, Health Care statistics & numerical data
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Objectives: We evaluated whether appropriateness and baseline risk of cardiac catheterization varied according to regional intensity of invasive therapy after acute myocardial infarction (AMI), and whether AMI mortality varied according to invasive intensity regions., Background: Marked regional variations exist in cardiac invasive procedure use after AMI within the U.S., Methods: We performed an analysis of 44,639 Medicare fee-for-service beneficiaries hospitalized with AMI between 1998 and 2001. Invasive procedure intensity was determined based on overall cardiac catheterization rates for Medicare enrollees. Cardiac catheterization appropriateness was determined by the American College of Cardiology/American Heart Association classification and baseline risk was estimated using the GRACE (Global Registry of Acute Coronary Events) risk score. The primary outcomes of the study were cardiac catheterization use within 60 days and 3-year mortality after hospital admission., Results: Higher invasive intensity regions were more likely to perform cardiac catheterizations on class I patients (appropriate) (RR 1.38, 95% confidence interval [CI] 1.27 to 1.48), class II patients (equivocal) (RR 1.42, 95% CI 1.31 to 1.53), and class III patients (inappropriate) (RR 1.29, 95% 0.97 to 1.67) compared with low-intensity regions after adjusting for patient and physician characteristics. The overall cardiac catheterization use was 5.2% lower for each increase in GRACE risk decile, and this relationship was observed similarly in all regions. Risk-standardized mortality rates of AMI patients at 3 years were not substantially different between regions., Conclusions: Although higher-risk patients and those with more appropriate indications may have the most to benefit from an invasive strategy after AMI, we found that higher-invasive regions do not differentiate procedure selection based on the patients' appropriateness or their baseline risks.
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- 2008
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23. Socioeconomic status, treatment, and outcomes among elderly patients hospitalized with heart failure: findings from the National Heart Failure Project.
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Rathore SS, Masoudi FA, Wang Y, Curtis JP, Foody JM, Havranek EP, and Krumholz HM
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- Aged, Angiotensin-Converting Enzyme Inhibitors therapeutic use, Comorbidity, Female, Heart Failure complications, Heart Failure drug therapy, Hospitalization, Humans, Male, Medicare, Patient Readmission, Quality Indicators, Health Care, Retrospective Studies, United States, Ventricular Dysfunction, Left etiology, White People, Heart Failure economics, Heart Failure mortality, Outcome Assessment, Health Care, Social Class
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Background: Prior studies have reported conflicting findings concerning the association of socioeconomic status (SES), treatment, and outcomes in patients hospitalized with heart failure (HF)., Methods: We conducted a retrospective analysis of medical record data from a national sample of Medicare beneficiaries hospitalized with HF between March 1998 and April 1999 (n = 25,086) to assess the association of patient SES, treatment, and outcomes. Patients' SES was designated as lower, lower-middle, higher-middle, and higher using residential ZIP code characteristics. Patients were evaluated for left ventricular systolic function assessment, prescription of angiotensin-converting enzyme inhibitors at discharge, readmission within 1 year of discharge, and mortality within 30 days and 1 year of admission. Hierarchical logistic regression models were used to assess the association of SES, quality of care, and outcomes adjusting for patient, physician, and hospital characteristics., Results: Lower SES patients (relative risk [RR] 0.92, 95% CI 0.87-0.96) were modestly less likely to have had a left ventricular systolic function assessment, but had a similar adjusted likelihood of being prescribed angiotensin-converting enzyme inhibitors (RR 1.03, 95% CI 0.93-1.11) compared with higher SES patients after multivariable adjustment. Socioeconomic status was not associated with 30-day mortality after multivariable adjustment, but lower SES patients had a higher risk of 1-year mortality (RR 1.10, 95% CI 1.02-1.19) and readmission within 1 year of discharge (RR 1.08, 95% CI 1.03-1.12) compared with higher SES patients., Conclusions: Socioeconomic status in patients hospitalized with HF was not strongly associated with quality of care or 30-day mortality. However, the increased risk of 1-year mortality and readmission among patients of lower SES suggest SES may influence outcomes after hospitalization for HF.
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- 2006
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24. Serum urea nitrogen, creatinine, and estimators of renal function: mortality in older patients with cardiovascular disease.
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Smith GL, Shlipak MG, Havranek EP, Foody JM, Masoudi FA, Rathore SS, and Krumholz HM
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- Aged, Cardiovascular Diseases blood, Cardiovascular Diseases physiopathology, Disease Progression, Female, Follow-Up Studies, Humans, Male, Retrospective Studies, Risk Factors, Survival Rate, United States epidemiology, Blood Urea Nitrogen, Cardiovascular Diseases mortality, Creatinine blood, Glomerular Filtration Rate physiology
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Background: Renal dysfunction predicts increased mortality in cardiovascular patients, but the best renal estimator for quantifying risks is uncertain. We compared admission serum urea nitrogen (SUN) level, creatinine level, Modification of Diet in Renal Disease (MDRD) rate, and Mayo estimated glomerular filtration rate (eGFR) for predicting mortality., Methods: In a retrospective cohort of Medicare patients (aged > or = 65 years) hospitalized for myocardial infarction (n = 44,437) and heart failure (n = 56,652), renal estimators were compared for linearity with 1-year mortality risk, magnitude of risk, and relative importance for predicting risk (percentage variance explained) in proportional hazards models., Results: The SUN level, creatinine level, and Mayo eGFR had linear associations with mortality. These measures predicted steadily increased risk in patients who experienced a myocardial infarction with a SUN level greater than 17 mg/dL (> 6.1 mmol/L), a creatinine level greater than 1.0 mg/dL (> 88.4 micromol/L), and a Mayo eGFR of less than 100 mL/min per 1.73 m2; and in patients who experienced heart failure with a SUN level greater than 16 mg/dL (> 5.7 mmol/L), a creatinine level greater than 1.1 mg/dL (> 97.2 micromol/L), and a Mayo eGFR of 90 mL/min per 1.73 m2 or less. In contrast, the MDRD eGFR had a J-shaped association and failed to identify increased risks in 50.0% of patients who experienced a myocardial infarction (with an MDRD eGFR > 55 mL/min per 1.73 m2) and 60.0% of patients who experienced heart failure (with an MDRD eGFR > 44 mL/min per 1.73 m2). The SUN level and Mayo eGFR had the greatest magnitude of risks. In myocardial infarction and heart failure patients, adjusted mortality increased by 3% and 7%, respectively, per 5-U increase in SUN, and by 3% and 9%, respectively, per 10-U decrease in Mayo eGFR (P<.001), based on models including both renal measures. Of all the measures, SUN had the greatest magnitude of relative importance for predicting mortality., Conclusions: In older cardiovascular patients, SUN- and creatinine-based measures were powerful predictors of postdischarge mortality. Only MDRD eGFR was less adequate in quantifying risks for patients with mild impairment. Novel estimators, such as the Mayo eGFR, may play an important role in outcomes' prognostication for these patients.
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- 2006
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25. Physician board certification and the care and outcomes of elderly patients with acute myocardial infarction.
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Chen J, Rathore SS, Wang Y, Radford MJ, and Krumholz HM
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- Aged, Connecticut, Female, Hospitalization, Humans, Male, Medicare, Patient Selection, Quality Assurance, Health Care, Treatment Outcome, United States, Certification, Myocardial Infarction therapy, Physicians standards
- Abstract
Background: Patients and purchasers prefer board-certified physicians, but whether these physicians provide better quality of care and outcomes for hospitalized patients is unclear., Objective: We evaluated whether care by board-certified physicians after acute myocardial infarction (AMI) was associated with higher use of clinical guideline recommended therapies and lower 30-day mortality., Subjects and Methods: We examined 101,251 Medicare patients hospitalized for AMI in the United States and compared use of aspirin, beta-blockers, and 30-day mortality according to the attending physicians' board certification in family practice, internal medicine, or cardiology., Results: Board-certified family practitioners had slightly higher use of aspirin (admission: 51.1% vs 46.0%; discharge: 72.2% vs 63.9%) and beta-blockers (admission: 44.1% vs 37.1%; discharge: 46.2% vs 38.7%) than nonboard-certified family practitioners. There was a similar pattern in board-certified Internists for aspirin (admission: 53.7% vs 49.6%; discharge: 78.2% vs 68.8%) and beta-blockers (admission: 48.9% vs 44.1%; discharge: 51.2% vs 47.1). Board-certified cardiologists had higher use of aspirin compared with cardiologists certified in internal medicine only or without any board certification (admission: 61.3% vs 53.1% vs 52.1%; discharge: 82.2% vs 71.8% vs 71.5%) and beta-blockers (admission: 52.9% vs 49.6% vs 41.5%; discharge: 54.7% vs 50.6% vs 42.5%). In multivariate regression analyses, board certification was not associated with differences in 30-day mortality., Conclusions: Treatment by a board-certified physician was associated with modestly higher quality of care for AMI, but not differences in mortality. Regardless of board certification, all physicians had opportunities to improve quality of care for AMI.
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- 2006
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26. Standards for statistical models used for public reporting of health outcomes: an American Heart Association Scientific Statement from the Quality of Care and Outcomes Research Interdisciplinary Writing Group: cosponsored by the Council on Epidemiology and Prevention and the Stroke Council. Endorsed by the American College of Cardiology Foundation.
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Krumholz HM, Brindis RG, Brush JE, Cohen DJ, Epstein AJ, Furie K, Howard G, Peterson ED, Rathore SS, Smith SC Jr, Spertus JA, Wang Y, and Normand SL
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- American Heart Association, Humans, Outcome Assessment, Health Care statistics & numerical data, Public Health Informatics standards, Public Health Informatics statistics & numerical data, Quality of Health Care statistics & numerical data, Risk Assessment statistics & numerical data, Stroke prevention & control, United States epidemiology, Models, Statistical, Outcome Assessment, Health Care standards, Quality of Health Care standards, Risk Assessment standards, Stroke epidemiology
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With the proliferation of efforts to report publicly the outcomes of healthcare providers and institutions, there is a growing need to define standards for the methods that are being employed. An interdisciplinary writing group identified 7 preferred attributes of statistical models used for publicly reported outcomes. These attributes include (1) clear and explicit definition of an appropriate patient sample, (2) clinical coherence of model variables, (3) sufficiently high-quality and timely data, (4) designation of an appropriate reference time before which covariates are derived and after which outcomes are measured, (5) use of an appropriate outcome and a standardized period of outcome assessment, (6) application of an analytical approach that takes into account the multilevel organization of data, and (7) disclosure of the methods used to compare outcomes, including disclosure of performance of risk-adjustment methodology in derivation and validation samples.
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- 2006
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27. Quality of care and outcomes of older patients with heart failure hospitalized in the United States and Canada.
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Ko DT, Tu JV, Masoudi FA, Wang Y, Havranek EP, Rathore SS, Newman AM, Donovan LR, Lee DS, Foody JM, and Krumholz HM
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- Aged, Aged, 80 and over, Canada epidemiology, Female, Heart Failure mortality, Heart Failure physiopathology, Humans, Male, Prognosis, Retrospective Studies, Severity of Illness Index, Stroke Volume physiology, Survival Rate trends, United States epidemiology, Heart Failure therapy, Hospitalization statistics & numerical data, Inpatients, Outcome Assessment, Health Care, Quality Assurance, Health Care
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Background: Health care expenditure per person is significantly higher in the United States compared with Canada, but whether there are differences in quality of care of many conditions is unknown. We compared the process of care and outcomes of patients with heart failure, the most common cause of hospitalization for individuals 65 years and older in both countries., Methods: We compared processes of care and 30-day and 1-year risk-standardized mortality rates among 28,521 US Medicare beneficiaries and 8180 similarly aged patients in Ontario, Canada, hospitalized with heart failure from 1998 to 2001., Results: More US patients underwent left ventricular ejection fraction assessment during hospitalization compared with Canadian patients (61.2% vs 41.7%, P<.001). At discharge, patients in the United States were prescribed beta-blockers more frequently (28.7% vs 25.4%, P<.001) but angiotensin-converting enzyme inhibitors less frequently (54.3% vs 63.4%, P<.001). Among ideal candidates, prescription of beta-blockers (32.5% vs 29.7%, P = .08) or angiotensin-converting enzyme inhibitors (78.3% vs 77.6%, P = .68) was not significantly different between the 2 countries. The US patients had lower risk characteristics on admission and lower crude mortality rates at 30 days and 1 year. Thirty-day risk-standardized mortality was significantly lower for the US patients (8.9% vs 10.7%, P<.001), but 1-year risk-standardized mortality was no longer significantly different (32.2% vs 32.3%, P = .98)., Conclusion: Patients with heart failure who are hospitalized in the United States had lower short-term mortality at 30 days, but 1-year mortality rates were not significantly different between the United States and Canada.
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- 2005
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28. Physician specialty and mortality among elderly patients hospitalized with heart failure.
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Foody JM, Rathore SS, Wang Y, Herrin J, Masoudi FA, Havranek EP, and Krumholz HM
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- Age Distribution, Aged, Aged, 80 and over, Databases as Topic, Female, Hospitals, Teaching, Hospitals, Urban, Humans, Male, Medicare statistics & numerical data, Referral and Consultation statistics & numerical data, United States epidemiology, Heart Failure mortality, Hospital Mortality, Medicine statistics & numerical data, Specialization
- Abstract
Background: Whether specialty care improves survival among patients with heart failure remains controversial., Methods: We evaluated specialty care and outcomes in 25869 Medicare beneficiaries hospitalized with heart failure in the United States from 1998 through 1999. Patients were classified based on the specialty of their attending physician: cardiologist, internist, general physician, or family physician. The primary outcome of interest was all-cause mortality within 30 days of admission., Results: Cardiologists were attending physicians for 26%, internists for 50%, and general and family physicians cared for the remainder. Mortality at 30 days was lowest for patients cared for by cardiologists (8.8%), higher for patients cared for by internists (10.0%, relative risk [RR] = 1.07; 95% confidence interval [CI]: 0.97 to 1.19; P = 0.059) and general physicians (11.1%, RR = 1.26; 95% CI: 0.99 to 1.58; P = 0.086), and highest for patients cared for by family physicians (12.0%, RR = 1.31; 95% CI: 1.15 to 1.49; P <0.001). Patients cared for by family physicians remained at higher 30-day mortality rates whether with (RR = 1.30; 95% CI: 1.11 to 1.52) or without consultation with cardiologists (RR = 1.31; 95% CI: 1.13 to 1.52)., Conclusion: Hospitalized patients with heart failure had lower 30-day mortality when treated by cardiologists than when they were treated by other physicians. Although these differences were modest (RR = 1.07) for internists, they were substantial for general physicians (RR = 1.26) and family physicians (RR = 1.31); of note was that inpatient cardiology consultation did not appear to change this relation.
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- 2005
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29. Adoption of spironolactone therapy for older patients with heart failure and left ventricular systolic dysfunction in the United States, 1998-2001.
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Masoudi FA, Gross CP, Wang Y, Rathore SS, Havranek EP, Foody JM, and Krumholz HM
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- Aged, Aged, 80 and over, Cohort Studies, Creatinine blood, Diuretics therapeutic use, Drug Prescriptions statistics & numerical data, Female, Follow-Up Studies, Humans, Male, Mineralocorticoid Receptor Antagonists therapeutic use, Patient Selection, Potassium blood, Randomized Controlled Trials as Topic statistics & numerical data, Risk Assessment, United States, Heart Failure drug therapy, Spironolactone therapeutic use, Ventricular Dysfunction, Left drug therapy
- Abstract
Background: Concerns have been raised about the appropriateness of spironolactone use in some patients with heart failure. We studied the adoption of spironolactone therapy after publication of the Randomized Aldactone Evaluation Study (RALES) in national cohorts of older patients hospitalized for heart failure., Methods and Results: This is a study of serial cross-sectional samples of Medicare beneficiaries > or =65 years old discharged after hospitalization for the primary diagnosis of heart failure and with left ventricular systolic dysfunction. The first sample was discharged before (April 1998 to March 1999, n=9758) and the second sample after (July 2000 to June 2001, n=9468) publication of RALES in September 1999. We assessed spironolactone prescriptions at hospital discharge in patient groups defined by enrollment criteria for the trial. Using multivariable logistic regression, we identified factors independently associated with prescriptions not meeting these criteria. Spironolactone use increased >7-fold (3.0% to 21.3% P<0.0001) after RALES. Of patients meeting enrollment criteria, 24.1% received spironolactone, as compared with 17.4% of those not meeting the criteria. Of all prescriptions after RALES, 30.9% were provided to patients not meeting enrollment criteria. Spironolactone was prescribed to 22.8% of patients with a serum potassium value > or =5.0 mmol/L, to 14.1% with a serum creatinine value > or =2.5 mg/dL, and to 17.3% with severe renal dysfunction (estimated glomerular filtration rate <30 mL.min(-1).1.73 m(-2)). In multivariable analyses, factors associated with prescriptions not meeting enrollment criteria included advanced age, noncardiovascular comorbidities, discharge to skilled nursing facilities, and care provided by physicians without board certification., Conclusions: Spironolactone prescriptions increased markedly after the publication of RALES, and many treated patients were at risk for hyperkalemia. Simultaneously, many patients who might have benefited were not treated. These findings demonstrate the importance of balancing efforts to enhance use among appropriate patients and minimizing use in patients at risk for adverse events.
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- 2005
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30. Racial differences in reperfusion therapy use in patients hospitalized with myocardial infarction: a regional phenomenon.
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Rathore SS, Frederick PD, Every NR, Barron HV, and Krumholz HM
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- Aged, Female, Humans, Male, Middle Aged, United States, Black or African American, Hospitalization statistics & numerical data, Myocardial Infarction therapy, Myocardial Reperfusion statistics & numerical data, White People
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Background: Racial differences in reperfusion therapy use among patients hospitalized with myocardial infarction (MI) have been previously reported as national phenomenon. However, it is unclear whether racial differences in treatment vary by region., Methods: Using data from the National Registry of Myocardial Infarction-2 and -3, a cohort of patients hospitalized with MI in the United States between 1994 and 2000, we sought to determine whether racial differences in reperfusion therapy use varied by geographic region in patients eligible for reperfusion therapy with no clinical contraindications to treatment (n = 204 230)., Results: Black patients had lower crude rates of reperfusion therapy than white patients (66.5% vs 69.9%, -3.3% racial difference, 99% CI -4.4% to -2.2%) overall. However, racial differences in reperfusion therapy use varied by geographic region. Reperfusion therapy rates were similar for black patients and white patients in the Northeast (67.9% black vs 65.3% white, +2.7% racial difference, 99% CI -0.5% to 5.8%) and statistically comparable for patients in the Midwest (68.3% black vs 69.0% white, -0.7% racial difference, 99% CI -2.9% to 1.5%) and West (70.7% black vs 72.6% white, -1.9% racial difference, 99% CI -5.1% to 1.2%). Racial differences in reperfusion therapy use were greatest for patients hospitalized in the South (64.5% black vs 71.7% white, -7.1% racial difference, 99% CI -8.7% to -5.6%). Racial differences were reduced, but geographic variations in racial differences persisted after multivariable adjustment., Conclusions: Lower rates of reperfusion therapy use among black patients with MI do not reflect a national pattern of racial differences in treatment, but a practice pattern predominantly attributable to the South.
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- 2005
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31. Sex, quality of care, and outcomes of elderly patients hospitalized with heart failure: findings from the National Heart Failure Project.
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Rathore SS, Foody JM, Wang Y, Herrin J, Masoudi FA, Havranek EP, Ordin DL, and Krumholz HM
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- Aged, Aged, 80 and over, Chi-Square Distribution, Cohort Studies, Female, Heart Failure mortality, Hospitalization, Humans, Logistic Models, Male, Medicare, Sex Factors, Stroke Volume, United States, Angiotensin-Converting Enzyme Inhibitors therapeutic use, Heart Failure therapy, Outcome and Process Assessment, Health Care, Quality of Health Care
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Background: Previous studies have demonstrated that women hospitalized for heart failure receive poorer quality of care and have worse outcomes than men. However, these studies were based upon selected patient populations and lacked quality of care measures., Methods: We used data from the National Heart Failure Project, a national sample of fee-for-service Medicare patients hospitalized with heart failure in the United States in 1998-1999, to evaluate differences in quality of care and patient outcomes between men and women. Multivariable hierarchical logistic regression models and chi2 analyses were used to examine sex differences in the documentation of left ventricular systolic function (LVSF), prescription of angiotensin-converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARBs) for patients with left ventricular dysfunction, and mortality within 30 days and 1 year of admission in the study cohort (n = 30,996)., Results: Women had lower overall rates of LVSF assessment than men (64.9% vs 69.5%, P < .001). Among patients classified as candidates for ACE inhibitor prescription, women had lower crude rates of ACE inhibitor prescription than men (70.1% vs 74.2%, P = .015), but treatment rates were similar when evaluating the prescription of ACE inhibitors or ARBs (78.9% women vs 81.3% men, P = .11). Despite lower rates of treatment, women had lower mortality rates than men at 30 days (9.2% vs 11.4%, P < .001) and 1 year (36.2% vs 43.0%, P < .001) after admission. Results were similar after multivariable adjustment., Conclusions: There were small sex differences in the quality of care provided to fee-for-service Medicare patients hospitalized with heart failure, although women had higher rates of survival than men up to 1 year after hospitalization.
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- 2005
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32. Differences, disparities, and biases: clarifying racial variations in health care use.
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Rathore SS and Krumholz HM
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- Humans, Prejudice, United States, Delivery of Health Care statistics & numerical data, Racial Groups, Terminology as Topic
- Abstract
Studies documenting racial differences in health care use are common in the medical literature. However, observational studies of racial differences in health care use lack a framework for interpreting reports of variations in health care use, leading to various terms, ranging from "variations" to "bias," that suggest different causes, consequences, and, ultimately, remedies for such variations in treatment. We propose criteria to assess racial differences in health care use by using a clinical equity (equal treatment based on equal clinical need) framework. This framework differentiates between initial reports of racial differences and subsequent classifications of their findings as racial disparities or racial bias in health care use. Racial variations in health care use may be considered disparities after demonstrating that racial differences are not attributable to treatment eligibility, clinical contraindications, patient preferences, or confounding by other clinical factors and are associated with adverse consequences. Racial bias with adverse consequences in health care may be inferred if a racial variation in treatment that has been characterized as a disparity persists after accounting for health care system factors (for example, type of hospital at which the patient was treated). We apply this framework to published reports of racial differences in treatment to determine which studies provide evidence of differences, disparities, and bias. We discuss the use of such a framework in directing policy interventions for alleviating inappropriate racial variations in health care use.
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- 2004
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33. National patterns of use and effectiveness of angiotensin-converting enzyme inhibitors in older patients with heart failure and left ventricular systolic dysfunction.
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Masoudi FA, Rathore SS, Wang Y, Havranek EP, Curtis JP, Foody JM, and Krumholz HM
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- Aged, Aged, 80 and over, Cohort Studies, Comorbidity, Creatinine blood, Drug Prescriptions statistics & numerical data, Drug Utilization, Female, Heart Failure blood, Heart Failure mortality, Humans, Male, Patient Discharge statistics & numerical data, Stroke Volume, United States epidemiology, Ventricular Dysfunction, Left blood, Ventricular Dysfunction, Left mortality, Angiotensin-Converting Enzyme Inhibitors therapeutic use, Heart Failure drug therapy, Ventricular Dysfunction, Left drug therapy
- Abstract
Background: Although ACE inhibitors are underprescribed for heart failure, factors associated with their use are not well described. Furthermore, the effectiveness of ACE inhibitors has been questioned in some populations, potentially contributing to underuse. Our objectives were to assess the correlates of ACE inhibitor use and the relationship between ACE inhibitor prescription and mortality in older patients with heart failure., Methods and Results: We studied a national sample aged > or =65 years who had survived hospitalization for heart failure between April 1998 and March 1999 or July 2000 and June 2001, restricting the analysis to patients with left ventricular systolic dysfunction and without a documented contraindication to use of ACE inhibitors (n=17 456). Factors associated with ACE inhibitor prescription at discharge and the relationship between ACE inhibitor prescription and death within 1 year were assessed with hierarchical logistic models. Secondary analyses assessed therapeutic substitution with angiotensin receptor blockers (ARBs). ACE inhibitors were prescribed to only 68% of this ideal cohort, and 76% received either an ACE inhibitor or an ARB. Patient, physician, and hospital factors were weak predictors of prescription, except for serum creatinine (RR for 133 to 221 micromol/L=0.87, 95% CI 0.85 to 0.89; RR for > or =222 micromol/L=0.53, 95% CI 0.49 to 0.57 compared with < or =132 micromol/L). ACE inhibitor prescription was associated with lower crude 1-year mortality (33.0% versus 42.1%, P<0.001), lower risk of death after adjustment (RR 0.86, 95% CI 0.82 to 0.90), and lower mortality regardless of patient gender, age, race, or serum creatinine level., Conclusions: ACE inhibitors were widely underprescribed despite evidence of a favorable impact on survival in a broad range of patients with heart failure. These results emphasize the importance of ongoing efforts to translate clinical trial results into practice.
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- 2004
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34. Hospital percutaneous coronary intervention volume and patient mortality, 1998 to 2000: does the evidence support current procedure volume minimums?
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Epstein AJ, Rathore SS, Volpp KG, and Krumholz HM
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- Female, Health Planning Guidelines, Humans, Male, Outcome Assessment, Health Care, Retrospective Studies, United States, Angioplasty, Balloon, Coronary mortality, Angioplasty, Balloon, Coronary statistics & numerical data, Hospitals statistics & numerical data, Quality of Health Care
- Abstract
Objectives: The aim of this study was to evaluate current American College of Cardiology/American Heart Association (ACC/AHA) hospital percutaneous coronary intervention (PCI) volume minimum recommendations., Background: In order to reduce procedure-associated mortality, ACC/AHA guidelines recommend that hospitals offering PCIs perform at least 400 PCIs annually. It is unclear whether this volume standard applies to current practice., Methods: We conducted a retrospective analysis of the Agency for Healthcare Research and Quality's Nationwide In-patient Sample hospital discharge database to evaluate in-hospital mortality among patients (n = 362748) who underwent PCI between 1998 and 2000 at low (5 to 199 cases/year), medium (200 to 399 cases/year), high (400 to 999 cases/year), and very high (1000 cases or more/year) PCI volume hospitals., Results: Crude in-hospital mortality rates were 2.56% in low-volume hospitals, 1.83% in medium-volume hospitals, 1.64% in high-volume hospitals, and 1.36% in very high-volume hospitals (p < 0.001 for trend). Compared with patients treated in high-volume hospitals (odds ratio [OR] 1.00, referent), patients treated in low-volume hospitals remained at increased risk for mortality after adjustment for patient characteristics (OR 1.21, 95% confidence interval [CI] 1.06 to 1.28). However, patients treated in medium-volume hospitals (OR 1.02, 95% CI 0.92 to 1.14) and patients treated in very high-volume hospitals (OR 0.94, 95% CI 0.85 to 1.03) had a comparable risk of mortality. Findings were similar when high- and very high-volume hospitals were pooled together., Conclusions: We found no evidence of higher in-hospital mortality in patients undergoing PCI at medium-volume hospitals compared with patients treated at hospitals with annual PCI volumes of 400 cases of more, suggesting current ACC/AHA PCI hospital volume minimums may merit reevaluation.
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- 2004
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35. Hospital coronary artery bypass graft surgery volume and patient mortality, 1998-2000.
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Rathore SS, Epstein AJ, Volpp KG, and Krumholz HM
- Subjects
- Age Distribution, Aged, Analysis of Variance, Coronary Disease mortality, Coronary Disease surgery, Female, Humans, Incidence, Male, Middle Aged, Odds Ratio, Probability, Registries, Retrospective Studies, Risk Assessment, Sampling Studies, Sex Distribution, Total Quality Management, United States, Cause of Death, Coronary Artery Bypass mortality, Coronary Artery Bypass statistics & numerical data, Hospital Mortality trends, Outcome Assessment, Health Care
- Abstract
Objective: To evaluate the association between annual hospital coronary artery bypass graft (CABG) surgery volume and in-hospital mortality., Summary Background Data: The Leapfrog Group recommends health care purchasers contract for CABG services only with hospitals that perform >or=500 CABGs annually to reduce mortality; it is unclear whether this standard applies to current practice., Methods: We conducted a retrospective analysis of the National Inpatient Sample database for patients who underwent CABG in 1998-2000 (n = 228738) at low (12-249 cases/year), medium (250-499 cases/year), and high (>or=500 cases/year) CABG volume hospitals. Crude in-hospital mortality rates were 4.21% in low-volume hospitals, 3.74% in medium-volume hospitals, and 3.54% in high-volume hospitals (trend P < 0.001). Compared with patients at high-volume hospitals (odds ratio 1.00, referent), patients at low-volume hospitals remained at increased risk of mortality after multivariable adjustment (odds ratio 1.26, 95% confidence interval = 1.15-1.39). The mortality risk for patients at medium-volume hospitals was of borderline significance (odds ratio 1.11, 95% confidence interval = 1.01-1.21). However, 207 of 243 (85%) of low-volume and 151 of 169 (89%) of medium-volume hospital-years had risk-standardized mortality rates that were statistically lower or comparable to those expected. In contrast, only 11 of 169 (6%) of high-volume hospital-years had outcomes that were statistically better than expected., Conclusions: Patients at high-volume CABG hospitals were, on average, at a lower mortality risk than patients at lower-volume hospitals. However, the small size of the volume-associated mortality difference and the heterogeneity in outcomes within all CABG volume groups suggest individual hospital CABG volume is not a reliable marker of hospital CABG quality.
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- 2004
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36. Sex differences in use of coronary revascularization in elderly patients after acute myocardial infarction: a tale of two therapies.
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Rathore SS, Foody JM, Radford MJ, and Krumholz HM
- Subjects
- Aged, Aged, 80 and over, Comorbidity, Confidence Intervals, Female, Health Services for the Aged, Humans, Male, Medicare, Retrospective Studies, Sex Factors, United States, Angioplasty, Balloon, Coronary, Coronary Artery Bypass, Myocardial Infarction therapy
- Abstract
Objectives: To determine if there are sex differences in the use of coronary revascularization in elderly patients after acute myocardial infarction (AMI), and if sex differences vary by type of revascularization therapy., Design: Retrospective analysis of medical record data., Setting: US acute-care nongovernment hospitals., Patients: A total of 66,830 Medicare patients > or =65 years old hospitalized with AMI., Interventions: None., Measurements and Results: We assessed sex differences in the use of coronary revascularization within 60 days of hospital admission among patients who had undergone cardiac catheterization. Multivariable logistic regression models were used to derive risk-standardized rates of any coronary revascularization, coronary artery bypass graft (CABG) surgery, and percutaneous coronary intervention (PCI) adjusted for patient and hospital characteristics. Women had lower crude overall rates of coronary revascularization compared with men (65.2% vs 68.7%, p < 0.001). Multivariable adjustment reduced the sex difference in the overall coronary revascularization rate from 3.5 to 2.1% (66.0% women vs 68.1% men, p = 0.001). Sex differences in coronary revascularization use, however, varied by type of revascularization therapy. Women had lower risk-standardized rates of CABG surgery compared with men (27.0% vs 32.9%, p < 0.001), but had higher risk-standardized rates of PCI (42.0% vs 38.2%, p < 0.001), particularly among patients > 85 years old (45.8% vs 38.9%, p = 0.011)., Conclusions: Among Medicare patients hospitalized with AMI, women are slightly less likely to undergo coronary revascularization after cardiac catheterization; however, sex differences in coronary revascularization vary by type of therapy.
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- 2003
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37. Most hospitalized older persons do not meet the enrollment criteria for clinical trials in heart failure.
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Masoudi FA, Havranek EP, Wolfe P, Gross CP, Rathore SS, Steiner JF, Ordin DL, and Krumholz HM
- Subjects
- Adrenergic beta-Antagonists therapeutic use, Age Factors, Aged, Aged, 80 and over, Angiotensin-Converting Enzyme Inhibitors therapeutic use, Cross-Sectional Studies, Female, Heart Failure complications, Hospitalization, Humans, Male, Mineralocorticoid Receptor Antagonists therapeutic use, Spironolactone therapeutic use, United States, Ventricular Dysfunction, Left complications, Heart Failure drug therapy, Patient Selection, Randomized Controlled Trials as Topic standards
- Abstract
Background: Although it is widely accepted that clinical trials in heart failure may not apply to older populations, the magnitude of the discrepancy between trial populations and patients seen in community-based practice are not known. Our objective was to determine the proportion of older persons meeting enrollment criteria of randomized controlled trials of agents that prolong life in heart failure., Methods: We conducted a cross-sectional study of Medicare beneficiaries >64 years old with the principal diagnosis of heart failure who were discharged from acute care hospitals in the United States between April 1998 and March 1999. Enrollment criteria of the Studies of Left Ventricular Dysfunction (SOLVD), Metroprolol CR/LX Randomized Intervention Trial in Congestive Heart Failure (MERIT-HF), and Randomized Aldactone Evaluation Study (RALES) trials were applied to the population, and the proportions meeting the criteria were determined by subgroups of age and sex., Results: Of the 20,388 patients studied, 18%, 13%, and 25% met the enrollment criteria of the SOLVD, MERIT-HF, and RALES trials, respectively. Although trial eligibility was less than a third for any sex or age group, significantly fewer women than men met trial criteria (13% vs 23% for SOLVD, 11% vs 17% for MERIT-HF, and 21% vs 32% for RALES, P <.0001 for all). The oldest patients were also less likely to fulfill enrollment criteria. The proportion of all patients not included because of preserved left ventricular systolic function was twice as large as the proportion meeting the inclusion criteria for any trial., Conclusions: A minority of hospitalized older persons with heart failure fit the profile of populations of clinical trials. There is an urgent need for research in heart failure for typical heart failure patients, including the very old, women, and patients with preserved left ventricular systolic function.
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- 2003
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38. Regional variation in the treatment and outcomes of myocardial infarction: investigating New England's advantage.
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Krumholz HM, Chen J, Rathore SS, Wang Y, and Radford MJ
- Subjects
- Adrenergic beta-Antagonists therapeutic use, Aged, Angioplasty, Balloon, Coronary statistics & numerical data, Aspirin therapeutic use, Coronary Artery Bypass statistics & numerical data, Female, Fibrinolytic Agents therapeutic use, Hospitalization, Humans, Logistic Models, Male, Myocardial Infarction drug therapy, New England epidemiology, Practice Patterns, Physicians' statistics & numerical data, Quality of Health Care, Thrombolytic Therapy statistics & numerical data, United States epidemiology, Myocardial Infarction mortality, Myocardial Infarction therapy, Outcome Assessment, Health Care
- Abstract
Background: Previous studies have reported that myocardial infarction (MI) treatment in New England differs from that of other regions of the United States. We sought to determine whether regional differences in MI treatment were independent of regional differences in patient, hospital, or physician characteristics, and whether the New England region's practice pattern was associated with better outcomes than those of patients in other regions., Methods: We evaluated 167,180 patients aged > or =65 years who were hospitalized with MI between 1994 to 1996 to assess regional variations in quality of care. Patients were evaluated for the use of reperfusion therapy, aspirin, and beta-blockers on admission and 30-day mortality rate. Hierarchical logistic regression models were used to determine whether practice patterns specific to New England were independent of regional variations in patient, physician, hospital, or other geographic characteristics., Results: New England had the highest use of beta-blockers (72% vs 52% other regions, P <.001), and aspirin (80% vs 76% other regions, P <.001), a lower use of reperfusion therapy (61% vs 67% other regions, P <.001), and the lowest risk-standardized 30-day mortality rate (15% vs 19% other regions, P <.001). These differences persisted after adjusting for patient, physician, and hospital characteristics., Conclusions: Patients with MI in New England have higher rates of medical therapy use and lower 30-day mortality rates than patients in other US regions. This pattern is independent of patient or provider characteristics, suggesting other factors likely contribute to better short-term outcomes in New England.
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- 2003
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39. Race, quality of care, and outcomes of elderly patients hospitalized with heart failure.
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Rathore SS, Foody JM, Wang Y, Smith GL, Herrin J, Masoudi FA, Wolfe P, Havranek EP, Ordin DL, and Krumholz HM
- Subjects
- Aged, Angiotensin-Converting Enzyme Inhibitors therapeutic use, Fee-for-Service Plans standards, Female, Humans, Male, Medicare standards, Multivariate Analysis, Patient Readmission statistics & numerical data, Quality of Health Care, Retrospective Studies, Survival Analysis, United States, Ventricular Function, Left, Black or African American statistics & numerical data, Heart Failure ethnology, Heart Failure therapy, Hospitals standards, Outcome Assessment, Health Care, White People statistics & numerical data
- Abstract
Context: Black patients hospitalized with heart failure reportedly receive poorer quality of care and have worse outcomes than white patients. Because previous studies have been based on selected patient populations treated more than a decade ago, it is unclear if racial differences in quality of care and outcomes currently exist in the United States., Objective: To evaluate differences in quality of care and patient outcomes between black and white Medicare beneficiaries hospitalized with heart failure., Design: Retrospective analysis of medical record data systematically collected for the National Heart Failure Project., Setting and Patients: Nationwide US sample of 29 732 fee-for-service Medicare beneficiaries hospitalized with heart failure in 1998 and 1999., Main Outcome Measures: Prescription of angiotensin-converting enzyme (ACE) inhibitors, measurement of left ventricular ejection fraction (LVEF), readmission within 1 year of discharge, and mortality within 30 days and 1 year of admission., Results: Black patients and white patients had similar crude rates of LVEF assessment (67.8% black vs 66.6% white; P =.29). Among patients classified as ideal for ACE inhibitor use, black patients had higher crude rates of ACE inhibitor use than white patients (81.0% vs 73.8% white; P<.001) but had similar rates of ACE inhibitor or angiotensin receptor blocker (ARB) use (85.7% black vs 82.5% white; P =.08). After multivariable adjustment, black patients had comparable rates of LVEF assessment (risk ratio [RR], 0.99; 95% confidence interval [CI], 0.95-1.03). Black patients remained more likely to be prescribed ACE inhibitors (RR, 1.22; 95% CI, 1.14-1.28) than were white patients in an adjusted analysis, but there were no significant racial differences in the prescription of ACE inhibitors or ARBs (black vs white, RR, 1.03; 95% CI, 0.97-1.07). Black patients had higher rates of readmission within 1 year of discharge (68.2% vs 63.0%; P<.001) but had lower crude 30-day (6.3% vs 10.7%; P<.001) and 1-year (31.5% vs 40.1%; P<.001) mortality rates than white patients. After multivariable adjustment, black patients had a slightly higher rate of readmission than white patients (RR, 1.09; 95% CI, 1.06-1.13) but remained at lower risk of 30-day mortality (RR, 0.78; 95% CI, 0.68-0.91) and 1-year mortality (RR, 0.93; 95% CI, 0.88-0.98)., Conclusions: Black Medicare patients hospitalized with heart failure received comparable quality of care and had slightly higher rates of readmission but had lower mortality rates up to 1 year after hospitalization than did white patients.
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- 2003
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40. Quality of care of Medicare beneficiaries with acute myocardial infarction: who is included in quality improvement measurement?
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Rathore SS, Wang Y, Radford MJ, Ordin DL, and Krumholz HM
- Subjects
- Adrenergic beta-Antagonists adverse effects, Adrenergic beta-Antagonists therapeutic use, Aged, Aged, 80 and over, Analysis of Variance, Angiotensin-Converting Enzyme Inhibitors adverse effects, Angiotensin-Converting Enzyme Inhibitors therapeutic use, Aspirin adverse effects, Aspirin therapeutic use, Female, Humans, Male, Retrospective Studies, United States, Geriatrics, Hospitalization, Medicare, Myocardial Infarction drug therapy, Quality of Health Care
- Abstract
Objectives: To determine the proportion of older patients hospitalized with acute myocardial infarction (AMI) incorporated in a commonly used set of AMI quality indicators., Design: Retrospective analysis of a medical record database., Setting: Nongovernmental U.S. acute care hospitals., Participants: Medicare patients hospitalized for AMI between January 1994 and February 1996., Measurements: Proportion of patients aged 65 and older classified as ideal candidates (without absolute or relative contraindications) for six Centers for Medicare & Medicaid Services AMI quality indicators: aspirin (admission, discharge), beta-blocker (admission, discharge), angiotensin-converting enzyme (ACE) inhibitors at discharge, and time to reperfusion therapy., Results: Of the 149,996 patients eligible for admission therapies, 10.1% were ideal candidates for reperfusion therapy, 65.0% for aspirin, and 34.7% for beta-blockers. Of the 116,919 patients eligible for discharge therapies, 47.7% were ideal candidates for aspirin, 17.6% for beta-blockers, and 15.2% for ACE inhibitors. More than one-quarter (26.8%) of all patients were ineligible for any of the six quality indicators; this proportion increased with age, ranging from 23.7% of patients aged 65 to 69 to 30.2% of patients aged 85 and older., Conclusion: A substantial proportion of older patients were not included in AMI process quality measurement, with the proportion excluded higher in successively older age groups. The data highlight the need for additional research to determine effective treatment strategies for patients for whom the evidence base for clinical decision-making remains weak.
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- 2003
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41. Effects of age on the quality of care provided to older patients with acute myocardial infarction.
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Rathore SS, Mehta RH, Wang Y, Radford MJ, and Krumholz HM
- Subjects
- Age Factors, Aged, Aged, 80 and over, Attitude of Health Personnel, Cohort Studies, Combined Modality Therapy methods, Critical Care trends, Drug Utilization, Female, Health Services Accessibility, Humans, Logistic Models, Male, Medicare standards, Myocardial Infarction diagnosis, Myocardial Infarction mortality, Odds Ratio, Practice Patterns, Physicians' statistics & numerical data, Risk Assessment, Survival Analysis, United States, Adrenergic beta-Antagonists administration & dosage, Coronary Care Units standards, Critical Care standards, Guideline Adherence statistics & numerical data, Health Services for the Aged standards, Myocardial Infarction therapy, Quality of Health Care, Thrombolytic Therapy methods
- Abstract
Purpose: Older patients are less likely to receive guideline-recommended medical therapies during acute myocardial infarction. However, it is unclear whether the lower rates of treatment reflect elderly patients' increased number of comorbid conditions, physician or hospital effects, or true age-associated variation. Furthermore, it is unclear whether age-associated variations in care are similar or vary among treatments., Methods: We evaluated 146,718 Medicare patients from the Cooperative Cardiovascular Project aged > or =65 years who were hospitalized between 1994 and 1996 with a confirmed myocardial infarction, to ascertain whether rates of acute reperfusion therapy and use of aspirin (admission, discharge), beta-blockers (admission, discharge), and angiotensin-converting enzyme (ACE) inhibitors varied among patients aged 65 to 69 years, 70 to 74 years, 75 to 79 years, 80 to 84 years, and > or =85 years. We identified patients who were considered eligible for each therapy and who had no treatment contraindications. Associations between age and use of therapy were assessed, adjusting for patient, physician, hospital, and geographic factors., Results: Adjusted treatment rates were higher for patients aged 65 to 69 years than for patients aged > or =85 years for acute reperfusion therapy (54.4% vs. 31.2%, P <0.0001 for trend), beta-blockers (admission: 52.2% vs. 43.8%, P <0.0001 for trend; discharge: 61.8% vs. 55.3%, P <0.0001 for trend), aspirin at admission (73.8% vs. 71.0%, P <0.0001 for trend), and ACE inhibitors (61.6% vs. 57.1%, P = 0.02 for trend); there were no differences in the prescription of aspirin at discharge (76.0% vs. 73.6%, P = 0.05)., Conclusion: Elderly patients are less likely to receive guideline-indicated therapies when hospitalized with myocardial infarction. The effects of age were largest for acute reperfusion and smallest for aspirin.
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- 2003
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42. Race and sex differences in the refusal of cardiac catheterization among elderly patients hospitalized with acute myocardial infarction.
- Author
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Rathore SS, Ordin DL, and Krumholz HM
- Subjects
- Aged, Female, Hospitalization, Humans, Logistic Models, Male, Myocardial Infarction ethnology, Sex Factors, Socioeconomic Factors, Treatment Refusal ethnology, United States epidemiology, Black or African American statistics & numerical data, Cardiac Catheterization statistics & numerical data, Myocardial Infarction epidemiology, Myocardial Infarction therapy, Treatment Refusal statistics & numerical data, White People statistics & numerical data
- Abstract
Background: Prior studies have reported race and sex differences in cardiac catheterization use after acute myocardial infarction (AMI). It is unclear whether race or sex differences in procedure refusal may contribute to this difference. We sought to determine whether cardiac catheterization refusal rates differ by patient race or sex., Methods: We evaluated medical records of 74,745 Medicare beneficiaries hospitalized for AMI between January 1994 and February 1996 to ascertain refusal of cardiac catheterization during hospitalization. Patient race and sex were evaluated for their association with cardiac catheterization refusal adjusting for patient, physician, and hospital characteristics., Results: The cardiac catheterization refusal rate in the overall cohort was 2.92% (95% CI 2.80%-3.04%). Race and sex differences in cardiac catheterization were observed after multivariate adjustment, with white women (odds ratio [OR] 1.28), black men (OR 1.34), and black women (OR 1.37) more likely to refuse cardiac catheterization than white men (OR 1.00). Relative differences in refusal were associated with only modest absolute differences in risk-standardized rates of cardiac catheterization refusal; rates were lowest for white men (2.55%), and higher for white women (3.21%), black men (3.36%), and black women (3.38%, P <.001 for global comparison)., Conclusions: Patient race and sex were associated with cardiac catheterization refusal among elderly patients hospitalized with AMI. However, absolute race and sex differences in rates of procedure refusal were small, suggesting that race and sex differences in cardiac catheterization refusal provide only a partial explanation of observed differences in cardiac procedure use.
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- 2002
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43. Characterization of incident stroke signs and symptoms: findings from the atherosclerosis risk in communities study.
- Author
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Rathore SS, Hinn AR, Cooper LS, Tyroler HA, and Rosamond WD
- Subjects
- Black People, Brain Ischemia diagnosis, Brain Ischemia epidemiology, Causality, Cerebral Hemorrhage diagnosis, Cerebral Hemorrhage epidemiology, Cohort Studies, Comorbidity, Female, Follow-Up Studies, Gait Disorders, Neurologic epidemiology, Headache epidemiology, Humans, Incidence, Male, Middle Aged, Paresis epidemiology, Risk, Seizures epidemiology, Sex Factors, Speech Disorders epidemiology, Stroke classification, United States epidemiology, Vertigo epidemiology, Vision Disorders epidemiology, White People, Black or African American, Arteriosclerosis epidemiology, Stroke diagnosis, Stroke epidemiology
- Abstract
Background and Purpose: Although patterns of stroke occurrence and mortality have been well studied, few epidemiological data are available regarding the clinical characteristics of stroke events., Methods: We evaluated hospitalized stroke events reported in the Atherosclerosis Risk in Communities (ARIC) Study to describe the clinical characteristics of incident stroke. Confirmed stroke cases (n=474) were evaluated for stroke symptoms (headache, vertigo, gait disturbance, convulsions) and stroke signs (hemianopia, diplopia, speech deficits, paresis, paresthesia/sensory deficits) and their univariate associations with race, sex, and stroke subtype., Results: Over 9.2 years of follow-up, 402 (85%) ischemic and 72 (15%) hemorrhagic strokes occurred. Frequency of stroke symptoms (95% CIs) were as follows: headache (27.4%; 23.4% to 31.4%), gait disturbance (10.8%; 7.9% to 13.6%), convulsions (4.4%; 2.6% to 6.3%), and vertigo (2.1%; 0.8% to 3.4%). Speech deficits occurred in 24.0% (20.2% to 27.9%), hemianopia in 14.6% (11.4% to 17.7%), and diplopia in 5.5% (3.4% to 7.5%) of cases. Most cases involved paresis (81.6%; 78.1% to 85.1%), while fewer cases experienced sensory deficits (44.5%; 40.0% to 49.0%). Blacks were more likely than whites to experience paresis (85.4% versus 78.2%; P=0.044). Men were more likely than women to experience a gait disturbance (14.4% versus 6.7%; P=0.007). Persons with hemorrhagic strokes had a higher proportion of headaches (55.6% versus 22.4%; P=0.001) and convulsions (11.1% versus 3.2%; P=0.003) than those with ischemic events, while speech and sensory deficits were more common in ischemic strokes (26.1% versus 12.5%, P=0.013, and 49.0% versus 19.4%, P=0.001, respectively)., Conclusions: We present epidemiological data concerning the clinical characteristics of incident stroke in a population-based cohort. Although minor differences by race, sex, and stroke subtype were observed, data from additional follow-up are required to confirm observed variations.
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- 2002
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44. Evaluation of a consumer-oriented internet health care report card: the risk of quality ratings based on mortality data.
- Author
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Krumholz HM, Rathore SS, Chen J, Wang Y, and Radford MJ
- Subjects
- Aged, Fee-for-Service Plans standards, Female, Hospital Mortality, Humans, Logistic Models, Male, Medicare Part A standards, Myocardial Infarction mortality, Survival Analysis, United States epidemiology, Hospitals standards, Information Services standards, Internet, Myocardial Infarction therapy, Outcome and Process Assessment, Health Care, Quality Indicators, Health Care
- Abstract
Context: Health care "report cards" have attracted significant consumer interest, particularly publicly available Internet health care quality rating systems. However, the ability of these ratings to discriminate between hospitals is not known., Objective: To determine whether hospital ratings for acute myocardial infarction (AMI) mortality from a prominent Internet hospital rating system accurately discriminate between hospitals' performance based on process of care and outcomes., Design, Setting, and Patients: Data from the Cooperative Cardiovascular Project, a retrospective systematic medical record review of 141 914 Medicare fee-for-service beneficiaries 65 years or older hospitalized with AMI at 3363 US acute care hospitals during a 4- to 8-month period between January 1994 and February 1996 were compared with ratings obtained from HealthGrades.com (1-star: worse outcomes than predicted, 5-star: better outcomes than predicted) based on 1994-1997 Medicare data., Main Outcome Measures: Quality indicators of AMI care, including use of acute reperfusion therapy, aspirin, beta-blockers, angiotensin-converting enzyme inhibitors; 30-day mortality., Results: Patients treated at higher-rated hospitals were significantly more likely to receive aspirin (admission: 75.4% 5-star vs 66.4% 1-star, P for trend =.001; discharge: 79.7% 5-star vs 68.0% 1-star, P =.001) and beta-blockers (admission: 54.8% 5-star vs 35.7% 1-star, P =.001; discharge: 63.3% 5-star vs 52.1% 1-star, P =.001), but not angiotensin-converting enzyme inhibitors (59.6% 5-star vs 57.4% 1-star, P =.40). Acute reperfusion therapy rates were highest for patients treated at 2-star hospitals (60.6%) and lowest for 5-star hospitals (53.6% 5-star, P =.008). Risk-standardized 30-day mortality rates were lower for patients treated at higher-rated than lower-rated hospitals (21.9% 1-star vs 15.9% 5-star, P =.001). However, there was marked heterogeneity within rating groups and substantial overlap of individual hospitals across rating strata for mortality and process of care; only 3.1% of comparisons between 1-star and 5-star hospitals had statistically lower risk-standardized 30-day mortality rates in 5-star hospitals. Similar findings were observed in comparisons of 30-day mortality rates between individual hospitals in all other rating groups and when comparisons were restricted to hospitals with a minimum of 30 cases during the study period., Conclusion: Hospital ratings published by a prominent Internet health care quality rating system identified groups of hospitals that, in the aggregate, differed in their quality of care and outcomes. However, the ratings poorly discriminated between any 2 individual hospitals' process of care or mortality rates during the study period. Limitations in discrimination may undermine the value of health care quality ratings for patients or payers and may lead to misperceptions of hospitals' performance.
- Published
- 2002
- Full Text
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