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Paraprofessionals are critical members of instructional teams for students with autism; however, little is known about their job preparation and professional development needs. This study addressed the gap in the literature by surveying 325 paraprofessionals in public school settings in the United States and Guam who reported working with students with autism. Data were gathered on paraprofessionals' (a) roles and responsibilities, (b) applied knowledge from different types of professional development, (c) perceived barriers to professional development, and (d) types and timing of communication with their supervising teachers. The results of this study have direct implications for individuals interested in developing a model of professional development that will meet the unique needs of paraprofessionals who work with students with autism.

While researchers have suggested that mentorship positively affects academic and learning outcomes in higher education, little is known about the impact of peer mentoring on graduate students' academic experiences. We conducted a systematic review to explore the impact of peer mentorship on graduate students' learning, and formal approaches to enhancing these relationships. We searched eight multidisciplinary databases to identify relevant studies. Studies were included if they reported on graduate students' peer mentoring, or evaluated initiatives to further the development of these relationships. Forty-seven studies were included in this review. The majority of students who participate in formal peer-mentoring programs benefit from these experiences. Peer mentorship positively affects developmental outcomes across four domains of graduate learning: academic, social, psychological, and career. While group-mentoring may be an effective means of delivering peer-mentorship support, further evaluative research is required to determine how academic institutions can promote positive peer mentoring relationships in graduate education.

The occurrence of pesticide mixtures is common in stream waters of the United States, and the impact of multiple compounds on aquatic organisms is not well understood. Watershed Regressions for Pesticides (WARP) models were developed to predict Pesticide Toxicity Index (PTI) values in unmonitored streams in the Midwest and are referred to as WARP-PTI models. The PTI is a tool for assessing the relative toxicity of pesticide mixtures to fish, benthic invertebrates, and cladocera in stream water. One hundred stream sites in the Midwest were sampled weekly in May through August 2013, and the highest calculated PTI for each site was used as the WARP-PTI model response variable. Watershed characteristics that represent pesticide sources and transport were used as the WARP-PTI model explanatory variables. Three WARP-PTI models-fish, benthic invertebrates, and cladocera - were developed that include watershed characteristics describing toxicity-weighted agricultural use intensity, land use, agricultural management practices, soil properties, precipitation, and hydrologic properties. The models explained between 41 and 48% of the variability in the measured PTI values. WARP-PTI model evaluation with independent data showed reasonable performance with no clear bias. The models were applied to streams in the Midwest to demonstrate extrapolation for a regional assessment to indicate vulnerable streams and to guide more intensive monitoring. [ABSTRACT FROM AUTHOR]

Presents information about United States Institute for Theatre Technology Inc. Activities of the institute; Promotion and tenure evaluation; Pressure endured by faculty and staff technologists and designers.

Pyrethroids are a class of widely-used insecticides that can be transported from terrestrial applications to aquatic systems via runoff and tend to sorb to organic carbon in sediments. Pyrethroid occurrence is detrimental to stream ecosystems due to toxicity to sediment-dwelling invertebrates which are particularly at risk of pyrethroid exposure in urban streams. In this work, 49 streams located in watersheds in the northeastern United States were surveyed for nine current-use pyrethroids using two extraction methods. Total sediment concentrations were determined by exhaustive chemical extraction, while bioaccessible concentrations were determined by single-point Tenax extraction. Total and bioaccessible pyrethroid concentrations were detected in 76% and 67% of the sites, and the average sum of pyrethroids was 232 ng/g organic carbon (OC) for total and 43.8 ng/g OC for bioaccessible pyrethroids. Bifenthrin was the most commonly detected pyrethroid in streambed sediments. Sediment toxicity was assessed using 10-d Hyalella azteca bioassays, and 28% and 15% of sediments caused a decrease in H. azteca biomass and survival, respectively. A temperature-based focused toxicity identification evaluation was used to assess pyrethroids as the causal factor for toxicity. The concentrations of pyrethroids was only weakly correlated with the degree of urban land use. Sediment toxicity was predicted by total and bioaccessible pyrethroid concentrations expressed as toxic units. This work suggests that bioaccessibility-based methods, such as Tenax extraction, can be a valuable tool in assessing sediment toxicity. Image 1 • 49 sediments were sampled in the northeastern U.S. for the presence of pyrethroids. • Total and bioaccessible pyrethroids were detected in 76% and 67% of the sediments. • 28% of the sediments sampled were toxic to Hyalella azteca in 10-d bioassays. • Bioaccessible and total pyrethroids both predicted sediment toxicity. • Pyrethroids were weakly correlated with urban land use. A survey of urban streambed sediments collected from the northeastern U.S. showed that pyrethroid insecticides were present and bioaccessible at the majority of sites, and most of the sediments were not toxic according to 10-d amphipod bioassays. [ABSTRACT FROM AUTHOR]

Epipodophyllotoxins are associated with leukemias characterized by translocations of the MLL gene at chromosome band 11q23 and other translocations. Cytochrome P450 (CYP) 3A metabolizes epipodophyllotoxins and other chemotherapeutic agents. CYP3A metabolism generates epipodophyllotoxin catechol and quinone metabolites, which could damage DNA. There is a polymorphism in the 5' promoter region of the CYP3A4 gene (CYP3A4-V) that might alter the metabolism of anticancer drugs. We examined 99 de novo and 30 treatment-related leukemias with a conformation-sensitive gel electrophoresis assay for the presence of the CYP3A4-V. In all treatment-related cases, there was prior exposure to one or more anticancer drugs metabolized by CYP3A. Nineteen of 99 de novo (19%) and 1 of 30 treatment-related (3%) leukemias carried the CYP3A4-V (P = 0.026; Fisher's Exact Test, FET). Nine of 42 de novo leukemias with MLL gene translocations (21%), and 0 of 22 treatment-related leukemias with MLL gene translocations carried the CYP3A4-V (P = 0. 016, FET). This relationship remained significant when 19 treatment-related leukemias with MLL gene translocations that followed epipodophyllotoxin exposure were compared with the same 42 de novo cases (P = 0.026, FET). These data suggest that individuals with CYP3A4-W genotype may be at increased risk for treatment-related leukemia and that epipodophyllotoxin metabolism by CYP3A4 may contribute to the secondary cancer risk. The CYP3A4-W genotype may increase production of potentially DNA-damaging reactive intermediates. The variant may decrease production of the epipodophyllotoxin catechol metabolite, which is the precursor of the potentially DNA-damaging quinone.