1. Distribution and outcomes of infection of Mycobacterium avium complex species in cystic fibrosis.
- Author
-
Azar M, Zimbric M, Shedden K, and Caverly LJ
- Subjects
- Adult, Female, Humans, Male, Mycobacterium Infections, Nontuberculous epidemiology, Mycobacterium Infections, Nontuberculous therapy, Outcome Assessment, Health Care methods, Outcome Assessment, Health Care statistics & numerical data, Prognosis, Respiratory Function Tests methods, Retrospective Studies, United States epidemiology, Anti-Bacterial Agents therapeutic use, Cystic Fibrosis diagnosis, Cystic Fibrosis microbiology, Cystic Fibrosis physiopathology, Mycobacterium Infections, Nontuberculous classification, Mycobacterium avium Complex classification, Mycobacterium avium Complex drug effects, Mycobacterium avium Complex genetics, Mycobacterium avium Complex pathogenicity, Mycobacterium avium-intracellulare Infection epidemiology, Mycobacterium avium-intracellulare Infection physiopathology, Mycobacterium avium-intracellulare Infection therapy
- Abstract
Background: The majority of nontuberculous mycobacterial (NTM) pulmonary infections in people with cystic fibrosis (CF) are caused by Mycobacterium avium complex (MAC) species. Data on MAC species distribution and outcomes of infection in CF are lacking., Methods: This was a single center, retrospective study. MAC isolates had species identification with MLSA of rpoB and the 16S23S ITS region. Clinical data were compared between species., Results: Twenty-three people with CF and 57 MAC isolates were included. Infection with M. avium was the most common (65.2%). M. intracellulare was associated with higher rates of NTM disease, younger age, and steeper decline in lung function prior to infection., Conclusions: We observed worse clinical outcomes in people with M. intracellulare infection relative to other MAC species. Further investigation of clinical outcomes of MAC infection among CF patients is warranted to better define the utility of species-level identification of MAC isolates in CF., Competing Interests: Declaration of Competing Interest The authors have no conflicts of interest., (Copyright © 2019 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.)
- Published
- 2020
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