1. Chronic myeloid leukemia – some topical issues.
- Author
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Mughal, T, Cortes, J, Cross, N C P, Donato, N, Hantschel, O, Jabbour, E, Kantarjian, H, Melo, J V, Skorski, T, Silver, R T, and Goldman, J M
- Subjects
- *
MYELOID leukemia , *IMATINIB , *PROTEIN-tyrosine kinases , *TUMOR suppressor genes , *HEART failure - Abstract
The article presents an editorial looking at chronic myeloid leukemia. The article discusses the part genomic instability plays in causing the BCR-ABL fusion, the PP2A tumor suppressor gene, resistance to imatinib mesylate, the possible association between imatinib mesylate and cardiac failure, the U.S. Food and Drug Administration's approval of dasatinib, and the therapeutic use of tyrosine kinase.
- Published
- 2007
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