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Experiencing everyday discrimination can have a significant negative impact on an individual's wellbeing. While much attention has been paid to the physical and mental health consequences of discrimination, less is known about how discrimination can affect cognitive health, and most existing work has been conducted in laboratory settings where participants recall discrimination retrospectively. Given the artificial environment and susceptibility to recall bias in such procedures, the current study utilised two daily diary studies, consisting of young adults in Singapore (Study 1; N = 484) and midlife adults from the US (Study 2; N = 3577), to examine the association between discrimination and cognitive failures in daily life. Multilevel modelling revealed consistent evidence that experiencing discrimination was associated with poorer cognitive health at both the within- and between-person levels. These associations between discrimination and cognitive health remained robust even after controlling for demographic covariates previously found to affect cognitive health, as well as daily stressor exposure. These findings suggest that the experiences of everyday discrimination may lead to poorer daily cognitive functioning regardless of whether discrimination was experienced in a daily context or across the lifespan, and indicate importance of raising awareness on the harmful cognitive consequences of discrimination. [ABSTRACT FROM AUTHOR]

Background: The association between sex and the survival of patients with esophageal cancer (EC) remains controversial. We sought to systematically investigate sex-based disparities in EC survival using the Surveillance, Epidemiology, and End Results (SEER) registry data from the United States., Methods: Patients with EC diagnosed from 2004 to 2015 registered in the SEER database were selected. The association between sex and cancer-specific survival (CSS) was evaluated using survival analysis. The Inverse Probability Weighting (IPW) approach was applied to reduce the observed bias between males and females. Subgroup analyses were used to investigate the robustness of the sex-based disparity and to explore potential interaction effects with other variables., Results: Overall, 29,312 eligible EC patients were analyzed, of whom 5,781 were females, and 23,531 were males. Females had higher crude CSS compared to males (10-year CSS: 24.5 vs. 21.3%; P < 0.001). Similar results were obtained after adjusting for selection bias using the IPW approach and multivariate regression. Subgroup analyses confirmed the relative robustness of sex as a prognostic factor. However, significant interactions were observed between sex and other variables, such as age, race, tumor grade, histology, and treatment modality. In particular, there was no survival advantage for premenopausal females compared to their male counterparts, but the association between sex and EC survival was prominent in 46-55-year-old patients., Conclusions: Female EC patients had better long-term survival than males. The association between sex and EC survival vary according to age, race, tumor grade, histology, and treatment modality. Sex-based disparity in EC-specific survival was age-related in the United States population., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Xiang, Xiong, Hu, Li, Zhang, Mao and Shen.)