26 results on '"Mehta, C."'
Search Results
2. Incident Non-AIDS Comorbidity Burden Among Women With or at Risk for Human Immunodeficiency Virus in the United States.
- Author
-
Collins, Lauren F, Sheth, Anandi N, Mehta, C Christina, Naggie, Susanna, Golub, Elizabeth T, Anastos, Kathryn, French, Audrey L, Kassaye, Seble, Taylor, Tonya N, Fischl, Margaret A, Adimora, Adaora A, Kempf, Mirjam-Colette, Palella, Frank J, Tien, Phyllis C, and Ofotokun, Ighovwerha
- Subjects
HIV infection risk factors ,DISEASE clusters ,HIV-positive persons ,HIV seronegativity ,CONFIDENCE intervals ,COMPARATIVE studies ,DESCRIPTIVE statistics ,AIDS ,COMORBIDITY ,POISSON distribution - Abstract
Background Human immunodeficiency virus (HIV) infection may accelerate development of aging-related non-AIDS comorbidities (NACMs). The incidence of NACMs is poorly characterized among women living with HIV (WLWH). Methods WLWH and HIV-seronegative participants followed in the Women's Interagency HIV Study (WIHS) through 2009 (when >80% of WLWH used antiretroviral therapy) or onward were included, with outcomes measured through 31 March 2018. Sociodemographics, clinical covariates, and prevalent NACM were determined at enrollment. We used Poisson regression models to determine incident NACM burden (number of NACMs accrued through most recent WIHS visit out of 10 total NACMs assessed) by HIV serostatus and age. Results There were 3129 participants (2239 WLWH, 890 HIV seronegative) with 36 589 person-years of follow-up. At enrollment, median age was 37 years, 65% were black, and 47% currently smoked. In fully adjusted analyses, WLWH had a higher incident NACM rate compared with HIV-seronegative women (incidence rate ratio, 1.36 [95% confidence interval (CI), 1.02–1.81]). Incident NACM burden was higher among WLWH vs HIV-seronegative women in most age strata (HIV × age interaction: P = .0438), and women <25 years old had the greatest incidence rate ratio by HIV serostatus at 1.48 (95% CI, 1.19–1.84) compared with those in older age groups. Incident NACM burden was associated with traditional comorbidity risk factors but not HIV-specific indices. Conclusions Incident NACM burden was higher among WLWH than HIV-seronegative women. This difference was most dramatic among women aged <25 years, a group for whom routine comorbidity screening is not prioritized. Established non-HIV comorbidity risk factors were significantly associated with incident NACM burden. More data are needed to inform best practices for NACM screening, prevention, and management among WLWH, particularly young women. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
3. The Prevalence and Burden of Non-AIDS Comorbidities Among Women Living With or at Risk for Human Immunodeficiency Virus Infection in the United States.
- Author
-
Collins, Lauren F, Sheth, Anandi N, Mehta, C Christina, Naggie, Susanna, Golub, Elizabeth T, Anastos, Kathryn, French, Audrey L, Kassaye, Seble, Taylor, Tonya, Fischl, Margaret A, Adimora, Adaora A, Kempf, Mirjam-Colette, Palella, Frank J, Tien, Phyllis C, and Ofotokun, Ighovwerha
- Subjects
HIV infection epidemiology ,COMORBIDITY ,HIV infection complications ,HIV infection risk factors ,MENTAL illness risk factors ,KIDNEY disease risk factors ,HIV-positive persons ,HIV seronegativity ,HIV infections ,BONE diseases ,AGE distribution ,BLACK people ,ANTIRETROVIRAL agents ,RACE ,REGRESSION analysis ,RISK assessment ,HYPERLIPIDEMIA ,LIVER diseases ,SEX distribution ,INCOME ,DESCRIPTIVE statistics ,DISEASE prevalence ,COCAINE ,TOBACCO products ,BODY mass index ,STATISTICAL models ,WOMEN'S health ,AIDS ,DISEASE risk factors - Abstract
Background The prevalence and burden of age-related non-AIDS comorbidities (NACMs) are poorly characterized among women living with HIV (WLWH). Methods Virologically suppressed WLWH and HIV-seronegative participants followed in the Women's Interagency HIV Study (WIHS) through at least 2009 (when >80% of WLWH used antiretroviral therapy) were included, with outcomes measured through 31 March 2018. Covariates, NACM number, and prevalence were summarized at most recent WIHS visit. We used linear regression models to determine NACM burden by HIV serostatus and age. Results Among 3232 women (2309 WLWH, 923 HIV-seronegative) with median observation of 15.3 years, median age and body mass index (BMI) were 50 years and 30 kg/m
2 , respectively; 65% were black; 70% ever used cigarettes. WLWH had a higher mean NACM number than HIV-seronegative women (3.6 vs 3.0, P < .0001) and higher prevalence of psychiatric illness, dyslipidemia, non-AIDS cancer, kidney, liver, and bone disease (all P < .01). Prevalent hypertension, diabetes, and cardiovascular and lung disease did not differ by HIV serostatus. Estimated NACM burden was higher among WLWH versus HIV-seronegative women in those aged 40–49 (P < .0001) and ≥60 years (P = .0009) (HIV × age interaction, P = .0978). In adjusted analyses, NACM burden was associated with HIV, age, race, income, BMI, alcohol abstinence, cigarette, and crack/cocaine use; in WLWH, additional HIV-specific indices were not associated, aside from recent abacavir use. Conclusions Overall, NACM burden was high in the cohort, but higher in WLWH and in certain age groups. Non-HIV traditional risk factors were significantly associated with NACM burden in WLWH and should be prioritized in clinical guidelines for screening and intervention to mitigate comorbidity burden in this high-risk population. [ABSTRACT FROM AUTHOR]- Published
- 2021
- Full Text
- View/download PDF
4. adaptive population enrichment phase III trial of TRC105 and pazopanib versus pazopanib alone in patients with advanced angiosarcoma (TAPPAS trial).
- Author
-
Mehta, C R, Liu, L, and Theuer, C
- Subjects
- *
ANGIOSARCOMA , *VASCULAR endothelial growth factors , *KINASE inhibitors , *VASCULAR endothelial growth factor receptors - Abstract
Background Major challenges in clinical trials of ultra-orphan oncology diseases include limited patient availability and paucity of reliable prior data for estimating the treatment effect and, therefore, determining optimal sample size. Angiosarcoma (AS), a particularly aggressive form of soft tissue sarcoma with an incidence of about 2000 cases per year in the United States and Europe is poorly addressed by current systemic therapies. Pazopanib, an inhibitor of vascular endothelial growth factor receptor (VEGFR) is approved for the treatment of AS, with modest benefit. TRC105 (carotuximab) is a monoclonal antibody to endoglin, an essential angiogenic target highly expressed on proliferating endothelium and both tumor vessels and tumor cells in AS, that has the potential to complement VEGFR tyrosine kinase inhibitors. In a phase I/II study of soft tissue sarcoma, TRC105 combined safely with pazopanib and the combination demonstrated durable complete responses and encouraging progression-free survival (PFS). In addition, there was a suggestion of superior benefit in patients with cutaneous lesions versus those with the non-cutaneous lesions. Patients and methods This article describes the design of a recently initiated phase III trial of TRC105 And Pazopanib versus Pazopanib alone in patients with advanced AngioSarcoma (TAPPAS trial). Given the ultra-orphan status of the disease and the paucity of reliable prior data on PFS or overall survival (end points required for regulatory approval as a pivotal trial), an adaptive design incorporating population enrichment and sample size re-estimation was implemented. The design incorporated regulatory input from the Food and Drug Administration (FDA) and European Medicines Agency and proceeded following special protocol assessment designation by the FDA. Conclusions It is shown that the benefit of the adaptive design as compared with a conventional single-look design arises from the learning and subsequent improvements in power that occur after an unblinded analysis of interim data. Registered on Clinicaltrials.gov NCT02979899. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
5. Perceptions of Cancer-related Information Among Cancer Survivors.
- Author
-
McInnes, D. Keith, Cleary, Paul D., Stein, Kevin D., Lin Ding, Mehta, C. Christina, and Ayanian, John Z.
- Subjects
CANCER patient psychology ,MEDICAL care ,GENDER differences (Psychology) ,HEALTH outcome assessment ,HEALTH surveys - Abstract
The article discusses the study on the perceptions of cancer-related information among cancer survivors in Massachusetts. It gives details on how the study was done. The study emphasized the importance of providing information more effectively to cancer survivors to improve their care and health outcomes. Furthermore, effort should be made to understand the differences by sex in terms of perception of cancer-related information.
- Published
- 2008
- Full Text
- View/download PDF
6. Power and sample size for ordered categorical data.
- Author
-
Rabbee, N, Coull, B.A., Mehta, C, Patel, N, and Senchaudhuri, P
- Subjects
STATISTICS ,MEDICAL research ,BIOMETRY ,EXPERIMENTAL design ,REGRESSION analysis ,SAMPLE size (Statistics) ,STATISTICAL models - Abstract
We propose a new method for computing power and sample size for linear rank tests of differences between two ordered multinomial populations. The method is flexible in that it is applicable to any general alternative hypothesis and for any choice of rank scores. We show that the method, though asymptotic, closely approximates existing exact methods. At the same time it overcomes the computational limitations of the exact methods. This advantage makes our asymptotic approach more practical for sample size computations at the planning stages of a large study. We illustrate the method with data arising from both proportional and non-proportional odds models in the two ordered multinomial setting. [ABSTRACT FROM AUTHOR]
- Published
- 2003
- Full Text
- View/download PDF
7. Policy- and county-level associations with HIV pre-exposure prophylaxis use, the United States, 2018.
- Author
-
Siegler, Aaron J., Mehta, C. Christina, Mouhanna, Farah, Giler, Robertino Mera, Castel, Amanda, Pembleton, Elizabeth, Jaggi, Chandni, Jones, Jeb, Kramer, Michael R., McGuinness, Pema, McCallister, Scott, and Sullivan, Patrick S.
- Subjects
- *
PRE-exposure prophylaxis , *POISSON regression , *CENSUS , *MEDICAID , *CONFIDENCE intervals , *HIV , *HIV infection epidemiology , *HIV prevention , *ANTI-HIV agents , *HEALTH policy , *LOCAL government , *PREVENTIVE health services , *POLICY sciences , *RESIDENTIAL patterns ,MEDICAID statistics - Abstract
Purpose: HIV pre-exposure prophylaxis (PrEP) is highly efficacious, and yet most individuals indicated for it are not currently using it. To provide guidance for health policymakers, researchers, and community advocates, we developed county-level PrEP use estimates and assessed locality and policy associations.Methods: Using data from a national aggregator, we applied a validated crosswalk procedure to generate county-level estimates of PrEP users in 2018. A multilevel Poisson regression explored associations between PrEP use and (1) state policy variables of Medicaid expansion and state Drug Assistance Programs (PrEP-DAPs) and (2) county-level characteristics from the U.S. Census Bureau. Outcomes were PrEP per population (prevalence) and PrEP-to-need ratio (PnR), defined as the ratio of PrEP users per new HIV diagnosis. Higher levels of PrEP prevalence or PnR indicate more PrEP users relative to the total population or estimated need, respectively.Results: Our 2018 county-level data set included a total of 188,546 PrEP users in the United States. Nationally, PrEP prevalence was 70.3/100,000 population and PnR was 4.9. In an adjusted model, counties with a 5% higher proportion of black residents had 5% lower PnR (rate ratio (RR): 0.95, 95% confidence interval (CI): 0.93, 0.96). Similarly, counties with higher concentration of residents uninsured or living in poverty had lower PnR. Relative to states without Medicaid expansion or PrEP-DAPs, states with only one of those programs had 25% higher PrEP prevalence (RR: 1.25, 95% CI: 1.09, 1.45), and states with both programs had 99% higher PrEP prevalence (RR: 1.99, 95% CI: 1.60, 2.48). There was a significant linear trend across the three policy groups, and similar findings for the relation between PnR and the policy groups.Conclusions: In a data set comprising approximately 80% of PrEP users in the United States, we found that Medicaid expansion and PrEP-DAPs were associated with higher PrEP use in states that adopted those policies, after controlling for potential confounders. Future research should identify which components of PrEP support programs have the most success and how to best promote PrEP among groups most impacted by the epidemic. States should support the admirable health decisions of their residents to get on PrEP by implementing policies that facilitate access. [ABSTRACT FROM AUTHOR]- Published
- 2020
- Full Text
- View/download PDF
8. Miscarriage among women in the United States Women's Interagency HIV Study, 1994-2017.
- Author
-
Wall, Kristin M., Haddad, Lisa B., Mehta, C. Christina, Golub, Elizabeth T., Rahangdale, Lisa, Dionne-Odom, Jodie, Karim, Roksana, Wright, Rodney L., Minkoff, Howard, Cohen, Mardge, Kassaye, Seble G., Cohan, Deborah, Ofotokun, Igho, and Cohn, Susan E.
- Subjects
MISCARRIAGE ,HIV-positive women ,HIV infections ,CHILDBIRTH ,VIRAL load - Abstract
Background: Relatively little is known about the frequency and factors associated with miscarriage among women living with HIV.Objective: The objective of the study was to evaluate factors associated with miscarriage among women enrolled in the Women's Interagency HIV Study.Study Design: We conducted an analysis of longitudinal data collected from Oct. 1, 1994, to Sept. 30, 2017. Women who attended at least 2 Women's Interagency HIV Study visits and reported pregnancy during follow-up were included. Miscarriage was defined as spontaneous loss of pregnancy before 20 weeks of gestation based on self-report assessed at biannual visits. We modeled the association between demographic, behavioral, and clinical covariates and miscarriage (vs live birth) for women overall and stratified by HIV status using mixed-model logistic regression.Results: Similar proportions of women living with and without HIV experienced miscarriage (37% and 39%, respectively, P = .638). In adjusted analyses, smoking tobacco (adjusted odds ratio, 2.0), alcohol use (adjusted odds ratio, 4.0), and marijuana use (adjusted odds ratio, 2.0) were associated with miscarriage. Among women living with HIV, low HIV viral load (<4 log10 copies/mL) (adjusted odds ratio, 0.5) and protease inhibitor (adjusted odds ratio, 0.4) vs the nonuse of combination antiretroviral therapy use were protective against miscarriage.Conclusion: We did not find an increased odds of miscarriage among women living with HIV compared with uninfected women; however, poorly controlled HIV infection was associated with increased miscarriage risk. Higher miscarriage risk among women exposed to tobacco, alcohol, and marijuana highlight potentially modifiable behaviors. Given previous concern about antiretroviral therapy and adverse pregnancy outcomes, the novel protective association between protease inhibitors compared with non-combination antiretroviral therapy and miscarriage in this study is reassuring. [ABSTRACT FROM AUTHOR]- Published
- 2019
- Full Text
- View/download PDF
9. Body Image Dissatisfaction in Cancer Survivors.
- Author
-
DeFrank, Jessica T., Mehta, C. Christina Bahn, Stein, Kevin D., and Baker, Frank
- Subjects
- *
BODY image , *CANCER patients , *DISCONTENT , *MULTIPLE regression analysis , *ONCOLOGY nursing - Abstract
Purpose/Objectives: To explore medical and psychosocial factors associated with body image dissatisfaction in male and female cancer survivors. Design: Secondary data analysis from the American Cancer Society's Study of Cancer Survivors-II pilot survey. Setting: Cancer survivors were identified through two state cancer registry databases. Sample: 165 male and 234 female cancer survivors of six cancer types (bladder, female breast, colorectal, endometrial, prostate, and melanoma) who were 2, 5, and 10 years beyond diagnosis. Methods: Researchers notified physicians prior to participant recruitment. State cancer registries contacted potential participants via mailed letters. Participants who gave their informed consent completed a written survey. Main Research Variables: Current body image dissatisfaction, mental and physical health, sexual functioning, and basic medical and demographic information. Findings: Results of multiple regression analysis indicated that male survivors of prostate cancer were more likely to express positive body images than men who had other types of cancer. A composite variable that included a history of cancer recurrence, multiple cancers, or metastatic cancer was the strongest predictor of body image dissatisfaction for female survivors. Body image was not associated with age, length of time since diagnosis, or general treatment type for either gender. Conclusions: Body image was associated with various medical and psychosocial factors, and the factors differed for male and female cancer survivors. Implications for Nursing: An understanding of factors associated with body image is essential for the nursing care of patients with cancer. [ABSTRACT FROM AUTHOR]
- Published
- 2007
- Full Text
- View/download PDF
10. Contraception methods used among women with HIV starting antiretroviral therapy in a large United States clinical trial, 2009-2011.
- Author
-
Sheth, Anandi N., Angert, Christine D., Haddad, Lisa B., Mehta, C. Christina, and Cohn, Susan E.
- Subjects
- *
ANTIRETROVIRAL agents , *CONTRACEPTION , *CLINICAL trials , *FAMILY planning services , *HIV , *HIV infections , *FAMILY planning , *RESEARCH funding , *CONDOMS - Abstract
Objective(s): We describe contraception and dual method use among women with HIV initiating antiretroviral therapy (ART) in a U.S. clinical trial and examine associated factors.Study Design: We analyzed data from ART-naïve women aged 45 years and under initiating one of 3 regimens as part of A5257 (May 2009-June 2011) which required that women at risk for pregnancy use contraception. We classified self-reported methods as more effective (Tier 1 [intrauterine device, hysterectomy, permanent contraception] and Tier 2 [hormonal rings, patches, injections, pills]) versus less effective (Tier 3 [condoms alone] and Tier 4 [withdrawal, none]). We used logistic regression models to assess associations with use of (a) more effective, and (b) dual methods (condoms with a more effective method).Results: Of 285 women, majority were Black (59%), had annual income <$20,000 (54%), and had government insurance (68%). The most common contraceptive methods reported at baseline were permanent contraception (37%), male condoms alone (31%), and injectable progestin (8%); 41% and 16% reported Tier 1 and 2 use, respectively; 36% reported dual method use. Use of more effective and dual methods did not change 48 and 96 weeks after ART initiation (p > 0.05). In multivariable analyses, baseline use of more effective and dual methods was associated with age at least 40 years versus 18 to 29 years (odds ratio [OR] 4.46, 95% confidence interval [CI] 2.12, 9.35) and having at least one child (OR 2.31, 95%CI 1.27, 4.20).Conclusions: In women initiating modern ART in a clinical trial, permanent contraception was common, while use of other more effective contraceptive methods was low and did not change after ART initiation. Efforts are needed to improve integration of family planning services for women within the context of HIV clinical trials.Implications: The findings highlight the importance of improving integration of HIV and family planning services, including in the context of clinical trials. [ABSTRACT FROM AUTHOR]- Published
- 2021
- Full Text
- View/download PDF
11. Consequences of low-level viremia among women with HIV in the United States.
- Author
-
Aldredge A, Mehta CC, Lahiri CD, Schneider MF, Alcaide ML, Anastos K, Plankey M, French AL, Floris-Moore M, Tien PC, Dionne J, Dehovitz J, Collins LF, and Sheth AN
- Subjects
- Humans, Female, Adult, United States epidemiology, Middle Aged, HIV-1 isolation & purification, CD4 Lymphocyte Count, Prevalence, Viremia epidemiology, HIV Infections drug therapy, HIV Infections epidemiology, HIV Infections virology, Viral Load
- Abstract
Objective: Investigate the outcomes of women with HIV (WWH) with low-level viremia (LLV)., Design: The prevalence of LLV and potential clinical sequelae, such as virologic failure and non-AIDS comorbidity (NACM) development, are poorly characterized among WWH., Methods: We analyzed data from the Women's Interagency HIV Study among WWH enrolled from 2003 to 2020 who reported antiretroviral therapy use at least 1 year followed by an HIV-1 viral load less than 200 copies/ml. Consecutive viral load measurements from four semi-annual visits were used to categorize women at baseline as having: virologic suppression (all viral load undetectable), intermittent LLV (iLLV; nonconsecutive detectable viral load up to 199 copies/ml), persistent LLV (pLLV; at least two consecutive detectable viral load up to 199 copies/ml), or virologic failure (any viral load ≥200 copies/ml). Adjusted hazard ratios quantified the association of virologic category with time to incident virologic failure and multimorbidity (≥2 of 5 NACM) over 5-year follow-up., Results: Of 1598 WWH, baseline median age was 47 years, 64% were Black, 21% Hispanic, and median CD4 + cell count was 621 cells/μl. After excluding 275 women (17%) who had virologic failure at baseline, 58, 19, and 6% were categorized as having virologic suppression, iLLV, and pLLV, respectively. Compared with WWH with virologic suppression, the adjusted hazard ratio [aHR; 95% confidence interval (CI)] for incident virologic failure was 1.88 (1.44-2.46) and 2.51 (1.66-3.79) for iLLV and pLLV, respectively; and the aHR for incident multimorbidity was 0.81 (0.54-1.21) and 1.54 (0.88-2.71) for iLLV and pLLV, respectively., Conclusion: Women with iLLV and pLLV had an increased risk of virologic failure. Women with pLLV had a trend towards increased multimorbidity risk., (Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.)
- Published
- 2024
- Full Text
- View/download PDF
12. Brief Report: Substance Use Care Continuum in Women With and Without HIV in the Southern United States.
- Author
-
Ramakrishnan A, Fujita AW, Mehta CC, Wilson TE, Shoptaw S, Carrico A, Adimora AA, Eaton EF, Jones DL, Chandran A, and Sheth AN
- Subjects
- United States epidemiology, Humans, Female, HIV, Self Report, Continuity of Patient Care, HIV Infections drug therapy, HIV Infections epidemiology, Substance-Related Disorders complications, Substance-Related Disorders epidemiology
- Abstract
Background: Substance use (SU) contributes to poor outcomes among persons living with HIV. Women living with HIV (WWH) in the United States are disproportionately affected in the South, and examining SU patterns, treatment, and HIV outcomes in this population is integral to addressing HIV and SU disparities., Methods: WWH and comparable women without HIV (WWOH) who enrolled 2013-2015 in the Women's Interagency HIV Study Southern sites (Atlanta, Birmingham/Jackson, Chapel Hill, and Miami) and reported SU (self-reported nonmedical use of drugs) in the past year were included. SU and treatment were described annually from enrollment to the end of follow-up. HIV outcomes were compared by SU treatment engagement., Results: At enrollment, among 840 women (608 WWH, 232 WWOH), 18% (n = 155) reported SU in the past year (16% WWH, 24% WWOH); 25% (n = 38) of whom reported SU treatment. Over time, 30%, 21%, and 18% reported SU treatment at 1, 2, and 3 years, respectively, which did not significantly differ by HIV status. Retention in HIV care did not differ by SU treatment. Viral suppression was significantly higher in women who reported SU treatment only at enrollment ( P = 0.03)., Conclusions: We identified a substantial gap in SU treatment engagement, with only a quarter reporting treatment utilization, which persisted over time. SU treatment engagement was associated with viral suppression at enrollment but not at other time points or with retention in HIV care. These findings can identify gaps and guide future strategies for integrating HIV and SU care for WWH., Competing Interests: The authors have no funding or conflicts of interest to disclose., (Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.)
- Published
- 2024
- Full Text
- View/download PDF
13. Factors influencing the indication of coronary angiography in patients presenting with chest pain unspecified: an analysis of two decades (1994-2014).
- Author
-
Moreyra AE, Mehta C, Cosgrove NM, Zinonos S, Sargsyan D, Gold A, Trivedi M, Kostis JB, Cabrera J, and Kostis WJ
- Subjects
- Aged, Humans, United States, Coronary Angiography, Retrospective Studies, Medicare, Chest Pain diagnostic imaging, Chest Pain epidemiology, Coronary Artery Disease diagnostic imaging, Myocardial Infarction
- Abstract
Guidelines for cardiac catheterization in patients with non-specific chest pain (NSCP) provide significant room for provider discretion, which has resulted in variability in the utilization of invasive coronary angiograms (CAs) and a high rate of normal angiograms. The overutilization of CAs in patients with NSCP and discharged without a diagnosis of coronary artery disease is an important issue in medical care quality. As a result, we sought to identify patient demographic, socioeconomic, and geographic factors that influenced the performance of a CA in patients with NSCP who were discharged without a diagnosis of coronary artery disease. We intended to establish reference data points for gauging the success of new initiatives for the evaluation of this patient population. In this 20-year retrospective cohort study (1994-2014), we examined 107 796 patients with NSCP from the Myocardial Infarction Data Acquisition System, a large statewide validated database that contains discharge data for all patients with cardiovascular disease admitted to every non-federal hospital in NJ. Patients were partitioned into two groups: those offered a CA (CA group; n = 12 541) and those that were not (No-CA group; n = 95 255). Geographic, demographic, and socioeconomic variables were compared between the two groups using multivariable logistic regression, which determined the predictive value of each categorical variable on the odds of receiving a CA. Whites were more likely than Blacks and other racial counterparts (19.7% vs. 5.6% and 16.5%, respectively; P < .001) to receive a CA. Geographically, patients who received a CA were more likely admitted to a large hospital compared to small- or medium-sized ones (12.5% vs. 8.9% and 9.7%, respectively; P < .05), a primary teaching institution rather than a teaching affiliate or community center (16.1 % vs. 14.3% and 9.1%, respectively; P < .001), and at a non-rural facility compared to a rural one (12.1% vs. 6.5%; P < .001). Lastly from a socioeconomic standpoint, patients with commercial insurance more often received a CA compared to those having Medicare or Medicaid/self-pay (13.7% vs. 9.5% and 6.0%, respectively; P < .001). The utilization of CA in patients with NSCP discharged without a diagnosis of coronary artery disease in NJ during the study period may be explained by differences in geographic, demographic, and socioeconomic factors. Patients with NSCP should be well scrutinized for CA eligibility, and reliable strategies are needed to reduce discretionary medical decisions and improve quality of care., (© The Author(s) 2024. Published by Oxford University Press on behalf of International Society for Quality in Health Care. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
- Published
- 2024
- Full Text
- View/download PDF
14. Co-Utilization of HIV, Substance Use, Mental Health Services Among Women With Current Substance Use: Opportunities for Integrated Care?
- Author
-
Fujita AW, Ramakrishnan A, Mehta CC, Yusuf OB, Thompson AB, Shoptaw S, Carrico AW, Adimora AA, Eaton E, Cohen MH, Jain JP, Adedimeji A, Plankey M, Jones DL, Chandran A, Colasanti JA, and Sheth AN
- Subjects
- Humans, Female, Adult, Middle Aged, Mental Disorders epidemiology, Mental Disorders therapy, Delivery of Health Care, Integrated, Patient Acceptance of Health Care statistics & numerical data, United States epidemiology, Young Adult, HIV Infections epidemiology, Substance-Related Disorders epidemiology, Substance-Related Disorders therapy, Mental Health Services statistics & numerical data
- Abstract
Background: The syndemic of HIV, substance use (SU), and mental illness has serious implications for HIV disease progression among women. We described co-utilization of HIV care, SU treatment, and mental health treatment among women with or at risk for HIV., Methods: We included data from women with or at risk for HIV (n = 2559) enrolled in all 10 sites of the Women's Interagency HIV Study (WIHS) from 2013 to 2020. Current SU was defined as self-reported, non-medical use of drugs in the past year, excluding use of only marijuana. Tobacco and alcohol were assessed separately. We described co-utilization of SU treatment, tobacco and alcohol use treatment, HIV care, and mental health care in the past year among women who were eligible for each service. We compared service utilization by those who did/did not utilize SU treatment using Wald Chi-square tests., Results: Among women with current SU (n = 358), 42% reported utilizing SU treatment. Among those with current SU+HIV (n = 224), 84% saw their HIV provider, and 34% saw a mental health provider. Among women with current SU+heavy alcohol use (n = 95), 18% utilized alcohol use treatment; among current SU+tobacco use (n = 276), 8% utilized tobacco use treatment. Women who utilized SU treatment had higher utilization of alcohol use treatment (59% vs. 5%; P < .001) and tobacco use treatment (12% vs. 5%; P = .028). HIV care engagement was high regardless of SU treatment., Conclusions: We found high engagement in SU and HIV care, but low engagement in alcohol and tobacco use treatment. Integrated SU treatment services for women, including tobacco/alcohol treatment and harm reduction, are needed to optimize treatment engagement and HIV care continuum outcomes., Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
- Published
- 2024
- Full Text
- View/download PDF
15. Aging-Related Comorbidity Burden Among Women and Men With or At-Risk for HIV in the US, 2008-2019.
- Author
-
Collins LF, Palella FJ Jr, Mehta CC, Holloway J, Stosor V, Lake JE, Brown TT, Topper EF, Naggie S, Anastos K, Taylor TN, Kassaye S, French AL, Adimora AA, Fischl MA, Kempf MC, Koletar SL, Tien PC, Ofotokun I, and Sheth AN
- Subjects
- United States epidemiology, Humans, Male, Female, Cross-Sectional Studies, Sex Factors, Comorbidity, Cohort Studies, Adult, Middle Aged, Aged, HIV Infections epidemiology, Aging pathology
- Abstract
Importance: Despite aging-related comorbidities representing a growing threat to quality-of-life and mortality among persons with HIV (PWH), clinical guidance for comorbidity screening and prevention is lacking. Understanding comorbidity distribution and severity by sex and gender is essential to informing guidelines for promoting healthy aging in adults with HIV., Objective: To assess the association of human immunodeficiency virus on the burden of aging-related comorbidities among US adults in the modern treatment era., Design, Setting, and Participants: This cross-sectional analysis included data from US multisite observational cohort studies of women (Women's Interagency HIV Study) and men (Multicenter AIDS Cohort Study) with HIV and sociodemographically comparable HIV-seronegative individuals. Participants were prospectively followed from 2008 for men and 2009 for women (when more than 80% of participants with HIV reported antiretroviral therapy use) through last observation up until March 2019, at which point outcomes were assessed. Data were analyzed from July 2020 to April 2021., Exposures: HIV, age, sex., Main Outcomes and Measures: Comorbidity burden (the number of total comorbidities out of 10 assessed) per participant; secondary outcomes included individual comorbidity prevalence. Linear regression assessed the association of HIV status, age, and sex with comorbidity burden., Results: A total of 5929 individuals were included (median [IQR] age, 54 [46-61] years; 3238 women [55%]; 2787 Black [47%], 1153 Hispanic or other [19%], 1989 White [34%]). Overall, unadjusted mean comorbidity burden was higher among women vs men (3.4 [2.1] vs 3.2 [1.8]; P = .02). Comorbidity prevalence differed by sex for hypertension (2188 of 3238 women [68%] vs 2026 of 2691 men [75%]), psychiatric illness (1771 women [55%] vs 1565 men [58%]), dyslipidemia (1312 women [41%] vs 1728 men [64%]), liver (1093 women [34%] vs 1032 men [38%]), bone disease (1364 women [42%] vs 512 men [19%]), lung disease (1245 women [38%] vs 259 men [10%]), diabetes (763 women [24%] vs 470 men [17%]), cardiovascular (493 women [15%] vs 407 men [15%]), kidney (444 women [14%] vs 404 men [15%]) disease, and cancer (219 women [7%] vs 321 men [12%]). In an unadjusted model, the estimated mean difference in comorbidity burden among women vs men was significantly greater in every age strata among PWH: age under 40 years, 0.33 (95% CI, 0.03-0.63); ages 40 to 49 years, 0.37 (95% CI, 0.12-0.61); ages 50 to 59 years, 0.38 (95% CI, 0.20-0.56); ages 60 to 69 years, 0.66 (95% CI, 0.42-0.90); ages 70 years and older, 0.62 (95% CI, 0.07-1.17). However, the difference between sexes varied by age strata among persons without HIV: age under 40 years, 0.52 (95% CI, 0.13 to 0.92); ages 40 to 49 years, -0.07 (95% CI, -0.45 to 0.31); ages 50 to 59 years, 0.88 (95% CI, 0.62 to 1.14); ages 60 to 69 years, 1.39 (95% CI, 1.06 to 1.72); ages 70 years and older, 0.33 (95% CI, -0.53 to 1.19) (P for interaction = .001). In the covariate-adjusted model, findings were slightly attenuated but retained statistical significance., Conclusions and Relevance: In this cross-sectional study, the overall burden of aging-related comorbidities was higher in women vs men, particularly among PWH, and the distribution of comorbidity prevalence differed by sex. Comorbidity screening and prevention strategies tailored by HIV serostatus and sex or gender may be needed.
- Published
- 2023
- Full Text
- View/download PDF
16. Gender Segregation and Its Correlates at Midlife and Beyond.
- Author
-
Mehta C, Wilson J, and Smirles KE
- Subjects
- Age Factors, Aged, Communication, Female, Humans, Male, Masculinity, Middle Aged, Peer Group, Sex Factors, United States, Friends
- Abstract
We investigated gender segregation and its correlates in the friendships of U.S. adults aged 50-74 years (177 women; 52 men). Gender segregation existed in our midlife sample such that 74% of friend nominations were same gender. Similar to research on other periods of the adult lifespan we found that for women, gender segregation was negatively correlated with competitive activity orientation, positively correlated with beliefs about same-gender peers' communicative responsiveness and negatively correlated with beliefs about other-gender peers' communicative responsiveness. Women's gender segregation was also negatively correlated with masculinity and positively correlated with gender-reference group identity. For men, gender segregation was negatively correlated with beliefs about other-gender peers' communicative responsiveness and positively correlated with gender-reference group identity. Our results suggest that gender segregation continues to exist at midlife and that there is some continuity in the correlates of gender segregation across adulthood.
- Published
- 2021
- Full Text
- View/download PDF
17. The cost of rhinitis in the United States: a national insurance claims analysis.
- Author
-
Roland LT, Wise SK, Wang H, Zhang P, Mehta C, and Levy JM
- Subjects
- Humans, Insurance Claim Review, United States epidemiology, Rhinitis epidemiology, Rhinitis, Allergic, Perennial, Rhinitis, Allergic, Seasonal
- Published
- 2021
- Full Text
- View/download PDF
18. Utility of a US Food and Drug Administration (FDA) label indication for condoms for anal sex.
- Author
-
Siegler AJ, Ahlschlager L, Rosenthal EM, Sullivan PS, Kelley CF, Rosenberg ES, Sanchez TH, Moore RH, Mehta CC, and Cecil MP
- Subjects
- Adult, Humans, Male, Middle Aged, United States, United States Food and Drug Administration, Young Adult, Condoms standards, Equipment Failure Analysis statistics & numerical data, Guidelines as Topic, Product Labeling standards, Sexual Behavior
- Abstract
Condoms are highly effective for HIV prevention, yet are not currently indicated by the US Food and Drug Administration (FDA) for anal sex. We surveyed a national sample of men who have sex with men to assess whether FDA label indication could affect anticipated condom use, and to determine levels of perceived condom failure for anal sex. We found that 69% of respondents anticipated that a label indication change would increase their likelihood of condom use. Median perceived failure was 15%. We anticipate that these results may aid the FDA in developing standards for a label indication for anal sex.
- Published
- 2020
- Full Text
- View/download PDF
19. Development of a US trust measure to assess and monitor parental confidence in the vaccine system.
- Author
-
Frew PM, Murden R, Mehta CC, Chamberlain AT, Hinman AR, Nowak G, Mendel J, Aikin A, Randall LA, Hargreaves AL, Omer SB, Orenstein WA, and Bednarczyk RA
- Subjects
- Adult, Female, Health Care Surveys, Humans, Internet, Male, Patient Acceptance of Health Care, Reproducibility of Results, United States, Vaccination Coverage, Vaccines administration & dosage, Vaccines adverse effects, Health Knowledge, Attitudes, Practice, Parents psychology, Trust, Vaccination psychology
- Abstract
Objective: To develop a Vaccine Confidence Index (VCI) that is capable of detecting variations in parental confidence towards childhood immunizations centered on trust and concern issues that impact vaccine confidence., Methods: We used a web-based national poll of 893 parents of children <7 years in 2016 to assess the measures created for the Emory VCI (EVCI). EVCI measures were developed using constructs related to vaccine confidence identified by the U.S. National Vaccine Advisory Committee (i.e., "Information Environment", "Trust", "Healthcare Provider", "Attitudes and Beliefs", and "Social Norms"). Reliability for EVCI was assessed using Cronbach's alpha. Using the variables related to each of the constructs, we calculated an overall EVCI score that was then assessed against self-reported childhood vaccine receipt using chi-square and the Cochrane-Armitage trend tests., Results: Respondents' EVCI scores could range from 0 to 24, and the full range of values was observed in this sample (Mean = 17.5 (SD 4.8)). EVCI scores were significantly different (p ≤ 0.006 for all comparisons) between parents who indicated their child(ren) received routinely recommended vaccines compared with parents who indicated they had delayed or declined recommended immunizations. There was also a significant, consistent association between higher EVCI scores and greater reported vaccine receipt., Conclusions: We developed EVCI to reliably measure parental vaccine confidence, with individuals' scores linked to parental vaccine-related attitudes, intentions, and behaviors. As such, EVCI may be a useful tool for future monitoring of both population and individual confidence in childhood immunization., (Copyright © 2018. Published by Elsevier Ltd.)
- Published
- 2019
- Full Text
- View/download PDF
20. Average Clinician-Measured Blood Pressures and Cardiovascular Outcomes in Patients With Type 2 Diabetes Mellitus and Ischemic Heart Disease in the EXAMINE Trial.
- Author
-
White WB, Jalil F, Cushman WC, Bakris GL, Bergenstal R, Heller SR, Liu Y, Mehta C, Zannad F, and Cannon CP
- Subjects
- Aged, Analysis of Variance, Cause of Death, Diabetes Mellitus, Type 2 drug therapy, Diabetes Mellitus, Type 2 mortality, Diabetic Cardiomyopathies drug therapy, Diabetic Cardiomyopathies mortality, Double-Blind Method, Female, Heart Failure etiology, Hospitalization statistics & numerical data, Humans, Hypertension diagnosis, Hypertension mortality, Hypertension physiopathology, Hypoglycemic Agents therapeutic use, Male, Middle Aged, Myocardial Ischemia drug therapy, Myocardial Ischemia mortality, Piperidines therapeutic use, Prognosis, Prospective Studies, United States epidemiology, Uracil analogs & derivatives, Uracil therapeutic use, Blood Pressure Determination statistics & numerical data, Diabetes Mellitus, Type 2 physiopathology, Diabetic Cardiomyopathies physiopathology, Myocardial Ischemia physiopathology
- Abstract
Background Blood pressure ( BP ) treatment goals in patients with diabetes mellitus and increased cardiovascular risk remain controversial. Our study objective was to determine cardiovascular outcomes according to achieved BP s over the average follow-up period in the EXAMINE (Examination of Cardiovascular Outcomes With Alogliptin Versus Standard of Care) trial. Methods and Results EXAMINE was a cardiovascular outcomes trial in 5380 patients with type 2 diabetes mellitus and recent acute coronary syndromes. Risks of major adverse cardiac events and cardiovascular death or heart failure were analyzed using a Cox proportional hazards model with adjustment for baseline covariates in 10-mm Hg increments of clinician-measured systolic BP from ≤100 to >160 mm Hg and diastolic BP from ≤60 to >100 mm Hg averaged during the 24 months after randomization. Based on 2015 guidelines from the American College of Cardiology, the American Heart Association and the American Society of Hypertension and 2017 American Diabetes Association guidelines, systolic BP s of 131 to 140 mm Hg and diastolic BP s of 81 to 90 mm Hg were the reference groups. A U-shaped relationship between cardiovascular outcomes and BP s was observed. Importantly, compared with the systolic BP reference group, adjusted hazard ratios for major adverse cardiac events and cardiovascular death or heart failure were significantly higher in patients with systolic BP s <130 mm Hg. Similarly, compared with the diastolic BP reference group, adjusted hazard ratios for major adverse cardiac events and for cardiovascular death or heart failure were significantly higher for diastolic BP s <80 mm Hg. Conclusions In patients with type 2 diabetes mellitus and recent acute coronary syndrome, average BP s <130/80 mm Hg were associated with worsened cardiovascular outcomes. These data suggest that intensive control of BP in patients with type 2 diabetes mellitus and ischemic heart disease should be evaluated in a prospective randomized trial. Clinical Trial Registration URL : https://www.clinicaltrials.gov . Unique identifier: NCT 00968708.
- Published
- 2018
- Full Text
- View/download PDF
21. 10-Year Resource Utilization and Costs for Cardiovascular Care.
- Author
-
Shaw LJ, Goyal A, Mehta C, Xie J, Phillips L, Kelkar A, Knapper J, Berman DS, Nasir K, Veledar E, Blaha MJ, Blumenthal R, Min JK, Fazel R, Wilson PWF, and Budoff MJ
- Subjects
- Asymptomatic Diseases economics, Asymptomatic Diseases epidemiology, Asymptomatic Diseases therapy, Female, Humans, Male, Mass Screening methods, Mass Screening statistics & numerical data, Middle Aged, Needs Assessment, Prevalence, Risk Factors, United States epidemiology, Cardiovascular Diseases economics, Cardiovascular Diseases epidemiology, Cardiovascular Diseases therapy, Health Care Costs statistics & numerical data, Health Care Rationing organization & administration, Patient Care Management economics, Patient Care Management methods
- Abstract
Background: Cardiovascular disease (CVD) imparts a heavy economic burden on the U.S. health care system. Evidence regarding the long-term costs after comprehensive CVD screening is limited., Objectives: This study calculated 10-year health care costs for 6,814 asymptomatic participants enrolled in MESA (Multi-Ethnic Study of Atherosclerosis), a registry sponsored by the National Heart, Lung, and Blood Institute, National Institutes of Health., Methods: Cumulative 10-year costs for CVD medications, office visits, diagnostic procedures, coronary revascularization, and hospitalizations were calculated from detailed follow-up data. Costs were derived by using Medicare nationwide and zip code-specific costs, inflation corrected, discounted at 3% per year, and presented in 2014 U.S. dollars., Results: Risk factor prevalence increased dramatically and, by 10 years, diabetes, hypertension, and dyslipidemia was reported in 19%, 57%, and 53%, respectively. Self-reported symptoms (i.e., chest pain or shortness of breath) were common (approximately 40% of enrollees). At 10 years, approximately one-third of enrollees reported having an echocardiogram or exercise test, whereas 7% underwent invasive coronary angiography. These utilization patterns resulted in 10-year health care costs of $23,142. The largest proportion of costs was associated with CVD medication use (78%). Approximately $2 of every $10 were spent for outpatient visits and diagnostic testing among the elderly, obese, those with a high-sensitivity C-reactive protein level >3 mg/l, or coronary artery calcium score (CACS) ≥400. Costs varied widely from <$7,700 for low-risk (Framingham risk score <6%, 0 CACS, and normal glucose measurements at baseline) to >$35,800 for high-risk (persons with diabetes, Framingham risk score ≥20%, or CACS ≥400) subgroups. Among high-risk enrollees, CVD costs accounted for $74 million of the $155 million consumed by MESA participants., Conclusions: Longitudinal patterns of health care resource use after screening revealed new evidence on the economic burden of treatment and testing patterns not previously reported. Maintenance of a healthy population has the potential to markedly reduce the economic burden of CVD among asymptomatic individuals., (Copyright © 2018 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.)
- Published
- 2018
- Full Text
- View/download PDF
22. "Sex isn't something you do with someone you don't care about": young women's definitions of sex.
- Author
-
Mehta CM, Sunner LE, Head S, Crosby R, and Shrier LA
- Subjects
- Adolescent, Adult, Female, Humans, Interviews as Topic, Sexual Partners, United States, Young Adult, Interpersonal Relations, Sexual Behavior psychology
- Abstract
Study Objective: How young women define sexual intercourse has implications for their sexually transmitted infection (STI) risk. This study investigated young women's (1) definitions of sex, (2) understanding of a unique sex event, and (3) definitions of when a sex event begins and ends., Design: Using semi-structured interviews, young women were asked to define sex, define when a sex event began and ended, and were asked whether they thought their partners would agree. Interview transcripts were analyzed using thematic analysis., Setting: Participants were recruited from an urban adolescent health clinic in the Northeastern United States., Participants: Twenty-four heterosexual, sexually active young women contributed data for analysis., Interventions: None., Results: Young women's definitions of sex varied. Some included anal and oral sex while others did not. Time between sex events, new condom use, and new erection were used to define unique sex events. Some believed sex began with foreplay. Others believed sex began when the penis entered the vagina. Some believed sex ended when the penis was withdrawn from the vagina. Others believed sex ended with orgasm for one or both partners. Young women talked about the influence of relationship type on their definitions of sex., Conclusions: Variations in young women's definitions of sex may influence their responses to clinical questions about sexual activity and their understanding of their STI risk. As such, our findings have important implications for clinical counseling regarding sexual behavior and correct condom use and for researchers investigating young women's sexual behavior., (Copyright © 2011 North American Society for Pediatric and Adolescent Gynecology. Published by Elsevier Inc. All rights reserved.)
- Published
- 2011
- Full Text
- View/download PDF
23. The rationale, design, and implementation of the American Cancer Society's studies of cancer survivors.
- Author
-
Smith T, Stein KD, Mehta CC, Kaw C, Kepner JL, Buskirk T, Stafford J, and Baker F
- Subjects
- Adolescent, Adult, American Cancer Society, Cross-Sectional Studies, Female, Humans, Longitudinal Studies, Male, Middle Aged, Minority Groups, Patient Selection, Quality of Life, Racial Groups, Registries, Surveys and Questionnaires, United States epidemiology, Neoplasms mortality, Survivors
- Abstract
The American Cancer Society (ACS) defines cancer survivorship as beginning at diagnosis with cancer and continuing for the balance of life and views quality of life (QOL) as a key outcome. In this article, the authors describe the rationale, methodology, and sample characteristics of the 2 ACS Studies of Cancer Survivors (SCS): 1) a longitudinal study identifying and surveying survivors approximately 1 year postdiagnosis that includes plans to resurvey the panel at 2 years, 7 years, and 12 years postdiagnosis to identify predictors of QOL; and 2) a cross-sectional study of QOL among 3 separate cohorts of survivors who were approximately 3 years, 6 years, and 11 years postdiagnosis at the time of data collection. Survivors of prostate, breast, lung, colorectal, bladder, skin, kidney, ovarian, and uterine cancers and of non-Hodgkin lymphoma were sampled from 25 different central cancer registries, with African-American and Hispanic survivors over sampled. Survivors completed either mail or telephone surveys that described their physical, psychological, social, and spiritual functioning. The overall recruitment rate was 34.0%; 15411 participants completed surveys, of whom 40.1% had a high school education or less and 19.4% were racial/ethnic minorities. The SCS surveys provide a large diagnostically, geographically, and demographically diverse database on cancer survivorship that was designed to overcome some of the limitations of past research. Future reports will compare QOL of survivors at different well-defined times postdiagnosis, investigate the issues of understudied populations and diagnostic groups, and describe survivor QOL at state levels. Insights valuable to those considering registry-based studies are offered on issues of ascertainment, sampling, and recruitment., ((c) 2006 American Cancer Society.)
- Published
- 2007
- Full Text
- View/download PDF
24. The American Cancer Society's Studies of Cancer Survivors: the largest, most diverse investigation of long-term cancer survivors so far.
- Author
-
Stein K, Smith T, Kim Y, Mehta CC, Stafford J, Spillers RL, and Baker F
- Subjects
- Adult, American Cancer Society, Caregivers psychology, Female, Humans, Longitudinal Studies, Male, Middle Aged, Research Design, United States, Health Status, Neoplasms, Quality of Life, Survivors
- Published
- 2006
- Full Text
- View/download PDF
25. The American Cancer Society's Studies of Cancer Survivors.
- Author
-
Stein K, Smith T, Kim Y, Mehta CC, Stafford J, Spillers RL, and Baker F
- Subjects
- Adaptation, Psychological, Attitude to Health, Caregivers psychology, Cost of Illness, Cross-Sectional Studies, Family psychology, Female, Health Services Needs and Demand, Health Status, Humans, Longitudinal Studies, Male, Registries, Sickness Impact Profile, United States, American Cancer Society, Neoplasms complications, Neoplasms psychology, Neoplasms therapy, Research organization & administration, Survivors psychology, Survivors statistics & numerical data
- Published
- 2006
- Full Text
- View/download PDF
26. Cancer mortality among beekeepers.
- Author
-
McDonald JA, Li FP, and Mehta CR
- Subjects
- Bee Venoms toxicity, Female, Humans, Male, Neoplasms chemically induced, United States, Bees, Insect Bites and Stings complications, Neoplasms mortality, Occupational Diseases mortality
- Abstract
Carcinogenic effects of bee venom were evaluated in a mortality study of 580 occupationally exposed beekeepers. The subjects were identified through obituary notices published between 1949 and 1978 in three journals of the U.S. beekeeping industry. Death certificates of beekeepers were examined for causes of mortality, and proportionate mortality ratios were compared with those for the general U.S. population. Beekeepers had a slightly lower than expected fraction of deaths from cancer. The deficit of lung cancers in male beekeepers was significant (p less than 0.05) and may indicate that fewer beekeepers were cigarette smokers. The frequencies of other cancers did not differ significantly from expectation. Non-Hodgkin lymphoma developed in four persons, and was expected in two. Mortality from diseases other than cancer showed no unusual patterns. At least two persons died from accidents directly related to the care of beehives. Analysis of a subgroup of 377 males with major roles in the beekeeping industry showed no substantial differences in distribution of causes of death. This study of beekeepers reveals neither adverse nor beneficial effects of intense exposure to bee stings.
- Published
- 1979
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.