10 results on '"Maes, Hermine H"'
Search Results
2. The Genetic and Environmental Influences Contributing to the Association between Electronic and Conventional Cigarette Initiation.
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Prom-Wormley, Elizabeth C, Clifford, James S, Cooke, Megan E, Cecilione, Jennifer, Maes, Hermine H, Do, Elizabeth, and Roberson-Nay, Roxann
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ELECTRONIC cigarettes ,YOUNG adults ,BIVARIATE analysis ,CONFIDENCE intervals ,TEENAGERS - Abstract
Introduction: As the use of electronic cigarette (EC) continues to rise in the United States, especially among adolescents and young adults, it is necessary to better understand the factors associated with EC initiation. Specifically, it is unclear how genetic and environmental contributions influence the initiation of EC. Furthermore, the degree to which genetic and environmental influences are shared between EC initiation and conventional cigarette (CC) initiation is unknown.Methods: A sample of young adult twins ages 15-20 (N = 858 individuals; 421 complete twin pairs) was used to estimate the genetic and environmental influences on the liability of initiation unique to EC and CC as well as the degree to which these factors are shared between the two. Approximately 24% of participants initiated the use of EC, 19% initiated the use of CC, and 11% initiated the dual use.Results: Combined contributions of additive genetic and shared environmental influences were significant for CC (ACC = 0.19 [95% confidence interval {CI} = 0-0.79], p = 0.57; CCC = 0.42 [95% CI = 0-0.70], p = 0.13) and EC (AEC = 0.25 [95% CI = 0-0.83, p = 0.44; CEC = 0.42 [95% CI = 0-0.73], p = 0.12), whereas unique environmental influences were significant (ECC = 0.39 [95% CI = 0.18-0.57], p < 0.001; EEC = 0.32 [95% CI = 0.14-0.56], p < 0.001). Results also demonstrated a significant overlap of the unique environmental (rE = 0.87, p < 0.001) and familial influences contributing to correlation between the two phenotypes in the bivariate analysis.Conclusions: These preliminary results suggest that both genes and environmental influences are potential drivers of EC initiation among adolescents and young adults.Implications: This article is the first to use a sample of twin to estimate the contributions of genetic and environmental influences toward EC initiation and estimate the potential for overlapping influences with CC initiation. This study has implications for future debate about the etiology of EC and CC use with respect to potential overlapping genetic and environmental influences. [ABSTRACT FROM AUTHOR]- Published
- 2021
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3. Cross-Cultural Comparison of Genetic and Cultural Transmission of Smoking Initiation Using an Extended Twin Kinship Model.
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Maes, Hermine H., Morley, Kate, Neale, Michael C., Kendler, Kenneth S., Heath, Andrew C., Eaves, Lindon J., and Martin, Nicholas G.
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SMOKING , *TWIN psychology , *KINSHIP , *ASSORTATIVE mating , *GENDER differences (Psychology) , *GENE expression , *AGE distribution , *BIOLOGICAL models , *COMPARATIVE studies , *CULTURE , *RESEARCH methodology , *MEDICAL cooperation , *RESEARCH , *RESEARCH funding , *EVALUATION research - Abstract
Background: Considerable evidence from twin and adoption studies indicates that genetic and shared environmental factors play a role in the initiation of smoking behavior. Although twin and adoption designs are powerful to detect genetic and environmental influences, they do not provide information on the processes of assortative mating and parent-offspring transmission and their contribution to the variability explained by genetic and/or environmental factors.Methods: We examined the role of genetic and environmental factors in individual differences for smoking initiation (SI) using an extended kinship design. This design allows the simultaneous testing of additive and non-additive genetic, shared and individual-specific environmental factors, as well as sex differences in the expression of genes and environment in the presence of assortative mating and combined genetic and cultural transmission, while also estimating the regression of the prevalence of SI on age. A dichotomous lifetime 'ever' smoking measure was obtained from twins and relatives in the 'Virginia 30,000' sample and the 'Australian 25,000'.Results: Results demonstrate that both genetic and environmental factors play a significant role in the liability to SI. Major influences on individual differences appeared to be additive genetic and unique environmental effects, with smaller contributions from assortative mating, shared sibling environment, twin environment, cultural transmission, and resulting genotype-environment covariance. Age regression of the prevalence of SI was significant. The finding of negative cultural transmission without dominance led us to investigate more closely two possible mechanisms for the lower parent-offspring correlations compared to the sibling and DZ twin correlations in subsets of the data: (1) age × gene interaction, and (2) social homogamy. Neither of the mechanism provided a significantly better explanation of the data.Conclusions: This study showed significant heritability, partly due to assortment, and significant effects of primarily non-parental shared environment on liability to SI. [ABSTRACT FROM AUTHOR]- Published
- 2018
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4. A Genetic Epidemiological Mega Analysis of Smoking Initiation in Adolescents.
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Maes, Hermine H., Prom-Wormley, Elizabeth, Eaves, Lindon J., Soo Hyun Rhee, Hewitt, John K., Susan Young, Corley, Robin, McGue, Matt, Iacono, William G., Legrand, Lisa, Samek, Diana R., Murrelle, E. Lenn, Silberg, Judy L., Miles, Donna R., Schieken, Richard M., Beunen, Gaston P., Thomis, Martine, Rose, Richard J., Dick, Danielle M., and Boomsma, Dorret I.
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GENETIC epidemiology , *TEENAGERS , *TOBACCO use , *SMOKING , *GENETICS , *COMPARATIVE studies , *EPIDEMIOLOGICAL research , *RESEARCH methodology , *MEDICAL cooperation , *RESEARCH , *RESEARCH funding , *TWINS , *EVALUATION research ,ENVIRONMENTAL aspects - Abstract
Introduction: Previous studies in adolescents were not adequately powered to accurately disentangle genetic and environmental influences on smoking initiation (SI) across adolescence.Methods: Mega-analysis of pooled genetically informative data on SI was performed, with structural equation modeling, to test equality of prevalence and correlations across cultural backgrounds, and to estimate the significance and effect size of genetic and environmental effects according to the classical twin study, in adolescent male and female twins from same-sex and opposite-sex twin pairs (N = 19 313 pairs) between ages 10 and 19, with 76 358 longitudinal assessments between 1983 and 2007, from 11 population-based twin samples from the United States, Europe, and Australia.Results: Although prevalences differed between samples, twin correlations did not, suggesting similar etiology of SI across developed countries. The estimate of additive genetic contributions to liability of SI increased from approximately 15% to 45% from ages 13 to 19. Correspondingly, shared environmental factors accounted for a substantial proportion of variance in liability to SI at age 13 (70%) and gradually less by age 19 (40%).Conclusions: Both additive genetic and shared environmental factors significantly contribute to variance in SI throughout adolescence. The present study, the largest genetic epidemiological study on SI to date, found consistent results across 11 studies for the etiology of SI. Environmental factors, especially those shared by siblings in a family, primarily influence SI variance in early adolescence, while an increasing role of genetic factors is seen at later ages, which has important implications for prevention strategies.Implications: This is the first study to find evidence of genetic factors in liability to SI at ages as young as 12. It also shows the strongest evidence to date for decay of effects of the shared environment from early adolescence to young adulthood. We found remarkable consistency of twin correlations across studies reflecting similar etiology of liability to initiate smoking across different cultures and time periods. Thus familial factors strongly contribute to individual differences in who starts to smoke with a gradual increase in the impact of genetic factors and a corresponding decrease in that of the shared environment. [ABSTRACT FROM AUTHOR]- Published
- 2017
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5. Polygenic score for cigarette smoking is associated with ever electronic-cigarette use in a college-aged sample.
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Cooke ME, Clifford JS, Do EK, Gilman JM, Maes HH, Peterson RE, Prom-Wormley EC, Evins AE, and Schuster RM
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- Adolescent, Electronics, Genome-Wide Association Study, Humans, Longitudinal Studies, United States, Young Adult, Cigarette Smoking epidemiology, Cigarette Smoking genetics, Electronic Nicotine Delivery Systems, Tobacco Products, Vaping epidemiology
- Abstract
Background and Aims: Electronic cigarette use has escalated rapidly in recent years, particularly among youth. Little is known about the genetic influences on e-cigarette use. This study aimed to determine whether genetic risk for regular use of combustible cigarettes or for number of cigarettes smoked per day confers risk for ever e-cigarette use or frequency of e-cigarette use., Design, Setting, Participants, and Measurements: We used data from 9541 young adults from the Spit for Science longitudinal cohort study (2011-2019). Polygenic scores (PGS) of regular combustible cigarette use (PGS-RCU) and cigarettes per day (PGS-CPD) were constructed using summary statistics from the two largest available genome-wide association study (GWAS) meta-analysis of European ancestry and East Asian ancestry of combustible cigarette use and used to test whether the PGS of RCU or CPD predicted lifetime e-cigarette use and frequency of past 30-day e-cigarette use in a diverse sample of young adults of African (AFR), Admixed American (AMR), East Asian (EAS), European (EUR), and South Asian (SAS) ancestry., Findings: The PGS-RCU was associated with lifetime e-cigarette use in the EUR sample (OR = 1.27, 95% CI = 1.19-1.36, P = 7.53 × 10
-12 ), but not in the other subsamples (ps > 0.12). This association remained significant after excluding regular combustible cigarette smokers (OR = 1.21, 95% CI = 1.12-1.31, P = 3.36 × 10-6 ). There was no statistically significant association between PGS-CPD and lifetime e-cigarette use and neither the PGS-RCU nor the PGS-CPD were associated with frequency of e-cigarette use in the past 30 days in any of the subsamples., Conclusions: Genetic factors associated with regular combustible cigarette use appear to be associated with ever e-cigarette use in young adults. We did not find evidence for shared genetic factors influencing heaviness of use of combustible cigarettes and current e-cigarette use frequency., (© 2021 Society for the Study of Addiction.)- Published
- 2022
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6. Lindon J. Eaves, Ph.D., M.A. (Oxon), D.Sc. Theory-model-data.
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Maes HH, Hatemi PK, and Neale MC
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- Adolescent, Adolescent Behavior history, History, 20th Century, History, 21st Century, Humans, United States, Genetic Association Studies history, Genetics, Behavioral history, Twin Studies as Topic history
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We begin this special issue by providing a glimpse into the career of Dr. Lindon J. Eaves, from the perspectives of a student, postdoc, instructor, assistant to associate and full professor over the last 20 odd years. We focus primarily on Lindon's contributions to methodological issues and research designs to address them, in particular those related to models for extended twin-family designs, for the development of adolescent behavior, for genotype-environment covariation and interaction, and their application to the Virginia 30,000 and the Virginia Twin Study of Adolescent Behavioral Development. We then introduce the collection of papers in this special festschrift issue of Behavior Genetics, celebrating Dr. Eaves achievements over the last 40 years.
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- 2014
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7. Genes, environments, and developmental research: methods for a multi-site study of early substance abuse.
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Costello EJ, Eaves L, Sullivan P, Kennedy M, Conway K, Adkins DE, Angold A, Clark SL, Erkanli A, McClay JL, Copeland W, Maes HH, Liu Y, Patkar AA, Silberg J, and van den Oord E
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- Adolescent, Adult, Child, Child, Preschool, Developmental Disabilities genetics, Developmental Disabilities psychology, Diseases in Twins genetics, Diseases in Twins psychology, Female, Genotype, Humans, Life Change Events, Longitudinal Studies, Male, Risk Factors, Social Environment, Substance-Related Disorders genetics, Substance-Related Disorders psychology, Twins, Dizygotic psychology, Twins, Monozygotic psychology, United States epidemiology, Young Adult, Developmental Disabilities epidemiology, Diseases in Twins epidemiology, Environment, Gene-Environment Interaction, Substance-Related Disorders epidemiology, Twins, Dizygotic genetics, Twins, Monozygotic genetics
- Abstract
The importance of including developmental and environmental measures in genetic studies of human pathology is widely acknowledged, but few empirical studies have been published. Barriers include the need for longitudinal studies that cover relevant developmental stages and for samples large enough to deal with the challenge of testing gene-environment-development interaction. A solution to some of these problems is to bring together existing data sets that have the necessary characteristics. As part of the National Institute on Drug Abuse-funded Gene-Environment-Development Initiative, our goal is to identify exactly which genes, which environments, and which developmental transitions together predict the development of drug use and misuse. Four data sets were used of which common characteristics include (1) general population samples, including males and females; (2) repeated measures across adolescence and young adulthood; (3) assessment of nicotine, alcohol, and cannabis use and addiction; (4) measures of family and environmental risk; and (5) consent for genotyping DNA from blood or saliva. After quality controls, 2,962 individuals provided over 15,000 total observations. In the first gene-environment analyses, of alcohol misuse and stressful life events, some significant gene-environment and gene-development effects were identified. We conclude that in some circumstances, already collected data sets can be combined for gene-environment and gene-development analyses. This greatly reduces the cost and time needed for this type of research. However, care must be taken to ensure careful matching across studies and variables.
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- 2013
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8. Mechanisms underlying the lifetime co-occurrence of tobacco and cannabis use in adolescent and young adult twins.
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Agrawal A, Silberg JL, Lynskey MT, Maes HH, and Eaves LJ
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- Adolescent, Adult, Child, Comorbidity, Female, Humans, Longitudinal Studies, Male, Marijuana Abuse epidemiology, Marijuana Abuse genetics, Models, Statistical, Sex Factors, Social Environment, Tobacco Use Disorder epidemiology, Tobacco Use Disorder genetics, Twins, United States epidemiology, Young Adult, Marijuana Abuse complications, Tobacco Use Disorder complications
- Abstract
Using twins assessed during adolescence (Virginia Twin Study of Adolescent Behavioral Development: 8-17 years) and followed up in early adulthood (Young Adult Follow-Up, 18-27 years), we tested 13 genetically informative models of co-occurrence, adapted for the inclusion of covariates. Models were fit, in Mx, to data at both assessments allowing for a comparison of the mechanisms that underlie the lifetime co-occurrence of cannabis and tobacco use in adolescence and early adulthood. Both cannabis and tobacco use were influenced by additive genetic (38-81%) and non-shared environmental factors with the possible role of non-shared environment in the adolescent assessment only. Causation models, where liability to use cannabis exerted a causal influence on the liability to use tobacco fit the adolescent data best, while the reverse causation model (tobacco causes cannabis) fit the early adult data best. Both causation models (cannabis to tobacco and tobacco to cannabis) and the correlated liabilities model fit data from the adolescent and young adult assessments well. Genetic correlations (0.59-0.74) were moderate. Therefore, the relationship between cannabis and tobacco use is fairly similar during adolescence and early adulthood with reciprocal influences across the two psychoactive substances. However, our study could not exclude the possibility that 'gateways' and 'reverse gateways', particularly within a genetic context, exist, such that predisposition to using one substance (cannabis or tobacco) modifies predisposition to using the other. Given the high addictive potential of nicotine and the ubiquitous nature of cannabis use, this is a public health concern worthy of considerable attention., (Copyright 2009 Elsevier Ireland Ltd. All rights reserved.)
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- 2010
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9. Provision of genetic services for hearing loss: results from a national survey and comparison to insights obtained from previous focus group discussions.
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Withrow KA, Tracy KA, Burton SK, Norris VW, Maes HH, Arnos KS, and Pandya A
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- Adult, Deafness diagnosis, Deafness epidemiology, Deafness genetics, Female, Hearing Disorders epidemiology, Humans, Male, United States epidemiology, Genetic Testing methods, Hearing Disorders diagnosis, Hearing Disorders genetics, Surveys and Questionnaires
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Hearing loss is a common sensory deficit and more than 50% of affected individuals have a genetic etiology. The discovery of 40 genes and more than 100 loci involved in hearing loss has made genetic testing for some of these genes widely available. Genetic services for deafness are also being sought more often due to the early identification of hearing loss through newborn screening services. The motivations for pursuing genetic testing, and how genetic services are provided to the client may differ among individuals. Additionally, information obtained through genetic testing can be perceived and used in different ways by parents of deaf children and deaf adults. This study aimed to follow up on focus group studies published earlier with a quantitative survey instrument and assess the preference of consumers for provision of genetic services. We conducted a national survey of hearing and deaf parents of children with hearing loss and of deaf adults. Data was compared and analyzed by hearing status of the participant, their community affiliation and the genetic testing status using nominal logistic regression. Consistent with our focus group results, the survey participants thought that a genetic counselor/geneticist would be the most appropriate professional to provide genetics services. Statistically significant differences were noted in the preferred choice of provider based on the genetic testing status. Parents preferred that genetic evaluation, including testing, occur either immediately at or a few months after the audiologic diagnosis of hearing loss. This data should help providers in clinical genetics keep patient preferences at the helm and provide culturally competent services.
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- 2009
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10. Impact of genetic advances and testing for hearing loss: results from a national consumer survey.
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Withrow KA, Tracy KA, Burton SK, Norris VW, Maes HH, Arnos KS, and Pandya A
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- Adolescent, Adult, Child, Cultural Characteristics, Data Collection, Female, Humans, Logistic Models, Male, Middle Aged, Parents psychology, Surveys and Questionnaires, United States, Young Adult, Attitude to Health, Deafness genetics, Genetic Testing psychology, Hearing Loss genetics, Motivation
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Hearing loss is a common neuro-sensory deficit; nearly 50% of children with hearing loss have a genetic etiology. With the discovery of 40 genes and more than 100 loci involved in hearing loss, genetic testing is becoming more widely available. The information obtained through genetic testing can be perceived and used in different ways by parents of deaf children and deaf adults, based on their prior knowledge and understanding of these advances. It is therefore important to clarify the feelings of these potential consumers towards genetic services for hearing loss and understand their goals for genetic testing. The present study evaluates the feelings of consumers towards the advances in the genetics of hearing loss, the motivations for pursuing testing, and the perceived impact testing may have on their lives. We surveyed 808 parents of children with hearing loss nationally and 156 young deaf adults at Gallaudet University. In this study, learning the etiology of the hearing loss was the most commonly cited motivation for pursuing genetic testing and for parents was the most commonly cited outcome that genetic testing may have on their children's lives. Culturally Deaf respondents were less likely to believe that genetic testing will impact their lives or their children's lives and were less likely to report positive feelings about advances in the genetics of hearing loss. Cultural affiliation and genetic testing status, rather than hearing status, contributed more to the participants' responses., ((c) 2009 Wiley-Liss, Inc.)
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- 2009
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