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Purpose: To determine if corneal hysteresis (CH) was associated with increased central corneal thickness (CCT) induced by wearing soft contact lenses during eye closure. Design: A prospective laboratory investigation. Methods: CCT was measured with a modified optical coherence tomography (OCT), and CH was measured with a Reichert Ocular Response Analyzer (ORA) [Reichert Ophthalmic Instruments, Depew, New York, USA]. The ORA also determined values for intraocular pressure (IOP), corneal compensated IOP (IOPcc), and corneal resistance factor (CRF). One randomly selected eye of 20 non–contact lens wearers (four males and 16 females, age 19.7 ± 1.1 years) was patched during three hours of soft contact lens wear. Measurements were made before lens insertion, immediately upon removal, and every 20 minutes thereafter for 100 minutes. Results: Immediately after contact lens removal, CCT was increased by 13.1 ± 2.2% (mean ± SD) compared with baseline (post hoc, P = .001). After 100 minutes, it remained elevated by 2.4 ± 1.6% (post hoc, P = .001). However, there were no significant differences of CH at any time after lens wear (analysis of variance [ANOVA], P = .9). Immediately after lens removal, there were significant increases in IOP (post hoc, P = .003) and corneal resistance factor (CRF) (post-hoc, P = .015), but not in IOPcc (post hoc, P = .07). After lens wear, there were significant but weak correlations between the percentage change of CCT (CCT%) and IOP (r = 0.32, P = .001) and IOPcc (r = 0.29, P = .001). However, there was no significant correlation between CCT% and CH (r = 0.07, P = .458). Conclusion: CH as measured by ORA was not associated with corneal swelling induced by soft contact lens wear in this study group. [Copyright &y& Elsevier]

Objective: To evaluate the risk factors for uterine clear-cell carcinoma (UCCC) and construct nomograms predicting 1-, 3-, and 5-year overall survival rates of patients with UCCC., Methods: The demographic and clinical information of 1674 patients diagnosed with UCCC between 2004 and 2015, including age, race, marital status, tumor size, American Joint Committee on Cancer (AJCC) stage, and details of surgery and radiotherapy/chemotherapy, was collected from the Surveillance, Epidemiology, and End Results (SEER) database. After excluding patients with unknown AJCC stage, race, marital status, or lymph node information, 1469 patients remained. Risk factors were determined using univariate and multivariate analyses, and nomograms were developed to predict 1-, 3-, and 5-year overall survival of UCCC. Various indicators were used to evaluate the performance of the nomogram, such as the C-index, net classification improvement (NRI) and decision curve analysis (DCA)., Results: Age, log odds of positive lymph nodes, AJCC stage, surgery status, and chemotherapy status were independent risk factors for UCCC. The C-indexes of the training group and AJCC stage groups were 0.771 and 0.697, respectively. The results for the area under the receiver operating characteristics curve, NRI, and calibration curves indicated that the nomogram had good predictive ability. DCA revealed that the nomogram had greater clinical applicability than AJCC stage alone. Internal validation using the validation cohort also demonstrated that this nomogram had good predictive performance., Conclusion: A new nomogram comprising a combination of demographic and clinical characteristics provided better survival predictions than the AJCC staging system alone, which will facilitate prognostic assessments and clinical decision-making., (© 2024 International Federation of Gynecology and Obstetrics.)