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1. Cell-Free Hemoglobin-Based Blood Substitutes and Risk of Myocardial Infarction and Death.

Author

Natanson, Charles, Kern, Steven J., Lurie, Peter, Banks, Steven M., and Wolfe, Sidney M.

Subjects
*BLOOD substitutes, *MYOCARDIAL infarction, *CORONARY disease, *BLOOD transfusion, *PATIENTS, *SAFETY
Abstract

The article presents a study assessing the safety of hemoglobin-based substitutes (HBBSs) used in surgical, stroke and trauma patients. The study involved a review of data of patients who received HBBSs therapeutically between 1980 and 2008 as well as the results from a U.S. Food and Drug Administration review and two clinical trials. Among the outcomes measured were mortality and myocardial infarction (MI). Researchers concluded that the use of HBBSs was linked to a significant increase in the risk of death and MI.

Published
2008
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