1. The rates of septicemia in older adults with prostate cancer treated with abiraterone or enzalutamide: A population-based study.
- Author
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Nikita N, Gandhi K, Keith SW, Sharma S, Kelly WK, and Lu-Yao G
- Subjects
- Humans, Male, Aged, Aged, 80 and over, United States epidemiology, Hospitalization statistics & numerical data, SEER Program, Prostatic Neoplasms drug therapy, Antineoplastic Agents therapeutic use, Antineoplastic Agents adverse effects, Incidence, Medicare, Phenylthiohydantoin therapeutic use, Phenylthiohydantoin analogs & derivatives, Phenylthiohydantoin adverse effects, Nitriles therapeutic use, Benzamides therapeutic use, Sepsis epidemiology, Sepsis chemically induced, Androstenes therapeutic use, Androstenes adverse effects
- Abstract
Introduction: Prostate cancer (PCa) is the most common non-cutaneous tumor among American men. Androgen receptor signaling inhibitors such as abiraterone and enzalutamide have been approved for similar disease states among patients with advanced PCa. Existing data suggest using steroids is associated with an increased risk of infection. Because abiraterone is usually prescribed with prednisone, we sought to compare the risk of septicemia in patients using abiraterone vs. enzalutamide., Materials and Methods: We utilized the SEER-Medicare-linked data and used negative binomial regression models to compare the changes in the rates of septicemia-related hospitalizations six months pre- and post-abiraterone and enzalutamide initiation., Results: We found that the incidence of septicemia-related hospitalizations increased 2.77 fold within six months of initiating abiraterone (incidence rate ratio [IRR]: 2.77, 95% confidence interval [CI]: 2.17-3.53) 1.97 fold within six months of starting enzalutamide (IRR: 1.97, 95% CI: 1.43-2.72). However, the difference in the changes did not reach statistical significance (interaction IRR: 0.71, 95% CI: 0.48-1.06)., Discussion: The findings suggest that both abiraterone and enzalutamide are associated with an increased risk of septicemia-related hospitalizations. However, the difference in the increase of septicemia risk following the two treatments did not reach statistical significance. Further studies are warranted to understand the mechanisms at play., Competing Interests: Declaration of Competing Interest The authors declare no competing interests., (Copyright © 2024 Elsevier Ltd. All rights reserved.)
- Published
- 2024
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