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• Reference intervals were derived from LabCorp's large database of patient test results. • Reference intervals are age and gender based inclusive of neonatal and geriatric populations. • The modified indirect method of Hoffmann was used to determine the reference intervals. • The population used for the calculation was diverse and distributed across the United States. • Patient test results were pulled from a nation-wide system of laboratories. • The patient population is unbiased with respect to age, gender, race or geography. • Assays used in the calculations are standardized to instrument, method, and calibration. • The reference intervals include 266 analytes representing over 2700 age bracket. • Age brackets are calculated with significant N values utilizing 72 M test results. • Reference intervals tabulated represent multiple laboratory disciplines. For many years, clinical laboratories have either verified or estimated reference intervals (RI) for laboratory tests. Those calculations have largely been performed by direct sampling analysis of ostensibly healthy individuals or by post-analysis biochemical screening. Recently however, indirect calculations have come to the forefront as an IFCC endorsed method by using normal and abnormal patient data. Using a large database of patient test results from Laboratory Corporation of America, age and gender based RIs, inclusive of neonatal, pediatric, and geriatric populations, were determined using a modified indirect method of Hoffmann, and represent a diverse population distributed across the United States from a nation-wide system of laboratories and is unbiased with respect to age, gender, race or geography. The tabulation of RIs using big data by an indirect method represent 72 M patient test results. The table includes 266 individual analytes consisting of approximately 2,700 age categories, including tests across multiple medical disciplines. To our knowledge, this is the largest collection of RIs that were calculated by an indirect method representing clinical chemistry, endocrinology, coagulation, and hematology analytes that have been derived with very powerful "Ns" for each age bracket. This process provides more robust RIs and allows for the determination of pediatric and geriatric RIs that would otherwise be difficult to obtain using traditional direct RI determinations. [ABSTRACT FROM AUTHOR]