1. Inactivating mutations of the chromatin remodeling gene ARID2 in hepatocellular carcinoma.
- Author
-
Li, Meng, Zhao, Hong, Zhang, Xiaosong, Wood, Laura D., Anders, Robert A., Choti, Michael A., Pawlik, Timothy M., Daniel, Hubert D., Kannangai, Rajesh, Offerhaus, G Johan A., Velculescu, Victor E., Wang, Linfang, Zhou, Shibin, Vogelstein, Bert, Hruban, Ralph H, Papadopoulos, Nick, Cai, Jianqiang, Torbenson, Michael S., and Kinzler, Kenneth W.
- Subjects
- *
CHROMATIN , *LIVER cancer , *NUCLEOTIDE sequence , *HEPATITIS C virus , *GENETIC mutation , *HEPATITIS B virus , *GENETICS - Abstract
Through exomic sequencing of ten hepatitis C virus (HCV)-associated hepatocellular carcinomas (HCC) and subsequent evaluation of additional affected individuals, we discovered novel inactivating mutations of ARID2 in four major subtypes of HCC (HCV-associated HCC, hepatitis B virus (HBV)-associated HCC, alcohol-associated HCC and HCC with no known etiology). Notably, 18.2% of individuals with HCV-associated HCC in the United States and Europe harbored ARID2 inactivation mutations, suggesting that ARID2 is a tumor suppressor gene that is relatively commonly mutated in this tumor subtype. [ABSTRACT FROM AUTHOR]
- Published
- 2011
- Full Text
- View/download PDF