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Hepatitis E virus (HEV) RNA was detected in 6.3% and HEV IgG in 40% of 5,033 serum samples from market-weight pigs at 25 slaughterhouses in 10 US states. The prevalent HEV genotype was zoonotic genotype 3, group 2. Blood of HEV-viremic pigs from slaughterhouses may contaminate pork supply chains. [ABSTRACT FROM AUTHOR]

The article presents a study which conducted a blinded interlaboratory assessment of the diagnostic agreement and accuracy of serologic tests for routine detection of antibodies against Porcine circovirus-2 (PCV-2) in several North American laboratories. The study found that kappa analysis revealed differences among the laboratories. The indirect fluorescent antibody tests (IFAT) in the first two laboratories and the in-house enzyme-linked immunosorbent assays (ELISA) used in the fifth laboratory detected the highest number of positive samples.

Hepatitis E virus (HEV) is a single-strand positivesense RNA virus in the family Hepeviridae. The disease caused by HEV, hepatitis E, is an important public health problem in developing countries of Asia and Africa and is also endemic in many industrialized countries, including the United States. HEV has been identified from several other animal species in addition to humans, including the pig, chicken, mongoose, deer, rabbit, ferret, bat, and fish. Here we report the complete genome sequence of the first strain of HEV from rabbits in the United States. Sequence and phylogenetic analyses revealed that the U.S. rabbit HEV is a distant member of the zoonotic genotype 3 HEV, thus raising a concern for potential zoonotic human infection. A unique 90-nucleotide insertion within the X domain of the ORF1 was identified in the rabbit HEV, and this insertion may play a role in the species tropism of HEV. [ABSTRACT FROM AUTHOR]

Indocyanine green (ICG) is a diagnostic dye commonly used in medical imaging and liver function monitoring. Given its widespread use, there is a need for detailed evaluations of its adverse drug reactions in real-world settings. As the comprehensive overview of its safety profile is very limited, this study aimed to analyze the adverse events (AEs) associated with ICG using data from the Food and Drug Administration Adverse Event Reporting System (FAERS). Data between 2004Q1 and 2023Q4 were extracted from the FAERS database. Signal detection was performed using various disproportionality analysis algorithms, including reporting odds ratio (ROR), proportional reporting ratio, Bayesian confidence propagation neural network, and multiitem gamma Poisson shrinker. During the study period, a total of 62 ICG-related AEs were reported in the FAERS database. Significant clinical adverse reactions included anaphylactic shock (ROR: 92.10, 95% confidence interval (CI): 37.71-224.96), procedural hypotension (ROR: 1397.27, 95% CI: 443.31-4404.08), and urticaria (ROR: 10.88, 95% CI: 4.02-29.42). This study provides valuable insights into the safety profile of ICG, highlighting the need for further monitoring to ensure its safe clinical use in clinical practice. Ongoing pharmacovigilance and large-scale studies are warranted to fully understand the potential risks associated with ICG., Competing Interests: Declarations. Competing interests: The authors declare no competing interests. Data sharing statement: The FAERS database, utilized for this research, is publicly accessible through the FDA’s official website. The datasets used and analyzed during the current study are available from the corresponding author upon reasonable request. Ethics statement: No ethical approval is required for studies using publicly available data from FAERS., (© 2024. The Author(s).)

Purpose: The benefits of leisure-time physical activity (LTPA) in reducing mortality are well-known, while the relationship between work-related physical activity (WRPA) and mortality remains controversial. The study aimed to investigate the association between WRPA and mortality, and to determine whether LTPA should be recommended in a population with a high level of WRPA., Method: Data were obtained from a sample of adults aged 20-80 years included in the National Health and Nutrition Examination Survey (NHANES) cohort from 2007 to 2018. Hazard ratios (HRs) for the association between WRPA and all-cause mortality were estimated using Cox proportional regression models. All analyses were performed in accordance with NHANES guidelines, in which data were complex-weighted first and then analyzed in the next step, Statistical significance was defined as a two-sided P-value < 0.05., Results: A total of 27,567 participants were included in the study. Over a median follow-up period of 78 months, a total of 2,553 (weighted ratio, 6.5%) participants were assumed dead. The mean age (SD) of this cohort was 47.5 (16.7), and 48.5% were men. Compared to participants without WRPA (as the reference group), participants engaged in WRPA exhibited a significantly reduced risk of all-cause mortality over different time periods. Specifically, the HR for participants with less than 17.5 h of weekly participation were 0.70 (95% CI: 0.62-0.78). For those participating between 17.5 and 35 h per week, the HR was 0.80 (95% CI: 0.64-1.00), while participants engaging in more than 35 h of weekly participation had an HR of 0.71 (95% CI: 0.56-0.91)., Conclusions: WRPA is a protective factor that reduces the risk of all-cause death, especially in people without LTPA., Competing Interests: Declarations. Ethics approval and consent to participate: All data has been approved by the NCHS Ethics Committee. Consent for publication: Not applicable. Competing interests: The authors declare no conflicts of interest., (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)