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The purpose of the study was to compare United States and Polish university women in regard to demographics, victimization experiences, sensation seeking, fear of dangerous situations, perceived likelihood of victimization, and confidence about managing dangerous situations. A total of 520 women completed the online instruments, which consisted of Perceptions of Dangerous Situations Scale (PDSS), Brief Sensation-Seeking Scale (BSSS), and a demographic questionnaire. Overall, in regard to Fear, Likelihood, and Confidence about dangerous situations, Polish women scored significantly higher in Fear and Likelihood than U. S. women. Differences in Confidence between the two groups were not statistically significant. The two groups differed in the frequency of victimizations in terms of violent crimes, rape, and abusive relationships. The groups also differed in Likelihood scores depending on prior victimization. U. S. women made less of a distinction than Polish women between their emotional (Fear) and their cognitive (Likelihood) appraisals of dangerous situations. Neither group of women scored higher in Fear if they had been previously victimized. The researchers found differences between Polish and U.S. university women in Fear and Likelihood scores, some of which may be related to cultural differences. Sensation seeking did not differ between the two groups. Regardless of country membership, women did not acknowledge rape by a known person to be as likely as rape by a stranger, nor did they acknowledge the greater likelihood of being beaten up by a known person than by a stranger. It is clear that more education is still needed. Plain language summary: Fear of Crime, Perception of Risk, and Confidence About Dangerous Situations Among Women in the United States and Poland Security is a basic human need, connected with stability, freedom from fear, anxiety and chaos, and a feeling that there is no threat or risk of losing essential goods. A sense of security depends on numerous objective factors: scope of real danger, gender, age, and place of residence, but also on subjective perceptions– resources, social support, and individual personality features. Thus, it follows that a sense of safety and a sense of danger result from a way of thinking, as well as the temperament and personality of a particular individual. The purpose of our study was to compare United States and Polish university women regarding demographics, victimization experiences, sensation seeking, fear of dangerous situations, perceived likelihood of victimization, and confidence about managing hazardous situations. A total of 520 women from Poland and the United States completed the online instruments: the Perceptions of Dangerous Situations Scale (PDSS), a Brief Sensation-Seeking Scale (BSSS), and a demographic questionnaire. In our study, we found differences between the groups. Polish women scored significantly higher in Fear and Likelihood than U. S. women. Differences in Confidence between the two groups were not statistically significant. The two groups differed in the frequency of victimizations in terms of violent crimes, rape, and abusive relationships. Our results show that cultural diversity might affect the perception of dangerous situations. [ABSTRACT FROM AUTHOR]

Charitable giving in the United States provides a major source of funding for nonprofit organizations, but it is also a highly variable source of funding. A possible explanation for the substantial variability in giving lies in the measurement of income. In addition to permanent and transitory income, this article introduces the variability of income as a factor affecting charitable donations. The variability of income increases with the level of household income and varies by the source of income. In distinguishing types of income the authors are also able to shed some light on decision making by married couples. The effect of changes in permanent household income on charitable giving is significantly larger than that of transitory household income. Greater variability in the flow of annual household income has a negative effect on total giving. In addition, the authors find some significant differences in the impact on giving between the husband's and wife's earnings. [ABSTRACT FROM AUTHOR]

Presents a study that analyzed women's fear of crime and confidence about crime in the U.S. Background on women's fear of crime; Investigation on the women's confidence for managing dangerous situations; Discussion on the implications of the study for self-defense and rape prevention curricula.

Analyzes the interrelationship among funding sources of art and history museums in the United States. Data from the 1989 survey of museums; Impact of changes in funding sources on each other; Effects of increased developmental efforts to revenues; Description of funding sources models.

Examines the effects of taxation on the equitable distribution property transfers in the United States. Transformation of family law; Distribution of property between divorcing spouses; Existence of an ownership interest to avoid taxation by the Davis Rule.

In this paper we present a new approach to measuring government efficiency, based on the theory that communities that allocate resources efficiently in the local public sector maximize property values. We use Data Envelopment Analysis (DEA) to identify the counties in Minnesota that are characterized by property-value maximization and hence an efficient public sector. The results indicate that the dominant source of public sector inefficiency is an inappropriate scale of operations. It appears that some county jurisdictions are too large to service the population efficiently. The size and concentration of government power are also responsible in part for observed inefficiencies. [ABSTRACT FROM AUTHOR]

Abstract: Background: Relationships of sugar intakes with indicators of metabolic syndrome are important concerns for public health and safety. For individuals, dietary intake data for fructose and other sugars are limited. Method: Descriptive statistics. The data from 25,506 subjects, aged 12–80yr, contained in the NHANES 1999–2006 databases were analyzed for sugar intakes and health parameters. Results: Dietary fructose was almost always consumed with other sugars. On average, fructose provided 37% of total simple sugar intake and 9% of energy intake. In more than 97% of individuals studied, fructose caloric contribution was lower than that of non-fructose sugars. Fructose and non-fructose sugar intakes had no positive association with blood concentrations of TG, HDL cholesterol, glycohemoglobin, uric acid, blood pressure, waist circumference, and BMI in the adults studied (aged 19 to 80yr, n =17,749). Conclusion: Daily fructose intakes with the American diet averaged approximately 37% of total sugars and 9% of daily energy. Fructose was rarely consumed solely or in excess over non-fructose sugars. Fructose and non-fructose sugar ordinary consumption was not positively associated with indicators of metabolic syndrome, uric acid and BMI. [Copyright &y& Elsevier]

Microbial challenge in-use studies are performed to evaluate the potential for microbial proliferation in preservative-free single-dose biological products after first puncture and potential accidental contamination during dose preparation (e.g., reconstitution or dilution) and storage. These studies, in addition to physicochemical in-use stability assessments, are used as part of product registration to define in-use hold times in Prescribing Information and in the pharmacy manual in the case of clinical products. There are no formal guidance documents describing regulator expectations on how to conduct microbial challenge in-use studies and interpret microbial data to assign in-use storage hold times. In lieu of guidance, US Food and Drug Administration (FDA) regulators have authored publications and presentations describing regulator expectations. Insufficient or unavailable microbial challenge data can result in shortened in-use hold times, thus microbial challenge data enables flexibility for health care providers (HCPs) and patients while ensuring patient safety. A cross-industry/FDA in-use microbial working group was formed through the Innovation & Quality (IQ) Consortium to gain alignment among industry practice and regulator expectations. The working group assessed regulatory guidance, current industry practice via a blinded survey of IQ Consortium member companies, and scientific rationale to align on recommendations for experimental design, execution of microbial challenge in-use studies, and a decision tree for microbial data interpretation to assign in-use hold times. Besides the study execution and data interpretation, additional considerations are discussed including the use of platform data for clinical stage products, closed system transfer devices (CSTDs), transport of dose solutions, long infusion times, and the use of USP <797> by HCPs for preparing sterile drugs for administration. The recommendations provided in this article will help streamline biological product development, ensure consistency on assignment of in-use hold times in biological product labels across industry, and provide maximum allowable flexibility to HCPs and patients while ensuring patient safety., (© PDA, Inc. 2024.)

On February 22, 2013, the FDA licensed ado-trastuzumab emtansine (Kadcyla; Genentech, Inc.) for use as a single agent for the treatment of patients with human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer (MBC) who previously received trastuzumab and a taxane, separately or in combination. The clinical basis for licensure was a phase III trial in 991 patients with HER2-positive MBC that randomly allocated patients to receive ado-trastuzumab emtansine (n=495) or lapatinib in combination with capecitabine (n=496). The coprimary endpoints were progression-free survival (PFS) based on tumor assessments by an independent review committee and overall survival (OS). Statistically significant improvements in PFS and OS were observed in patients receiving ado-trastuzumab emtansine compared with patients receiving lapatinib plus capecitabine [difference in PFS medians of 3.2 months, HR, 0.65 (95% confidence interval, CI, 0.55-0.77), P<0.0001 and difference in OS medians of 5.8 months, HR, 0.68 (95% CI, 0.55-0.85), P=0.0006]. The most common adverse reactions in patients receiving ado-trastuzumab emtansine were fatigue, nausea, musculoskeletal pain, thrombocytopenia, headache, increased aminotransferase levels, and constipation. Other significant adverse reactions included hepatobiliary disorders and left ventricular dysfunction. Given the PFS and OS results, the benefit-risk profile was considered favorable., (©2014 American Association for Cancer Research.)

There is a major need for an effective vaccine against serogroup B disease. The long-term efficacy of the serogroups A, C, Y and W135 conjugate vaccines and the need for booster vaccines has to be determined, as does the effect of changing epidemiology in the United States and worldwide. Control of serogroup A disease in sub-Saharan Africa is a major challenge.