1. Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice.
- Author
-
Kogan SC, Ward JM, Anver MR, Berman JJ, Brayton C, Cardiff RD, Carter JS, de Coronado S, Downing JR, Fredrickson TN, Haines DC, Harris AW, Harris NL, Hiai H, Jaffe ES, MacLennan IC, Pandolfi PP, Pattengale PK, Perkins AS, Simpson RM, Tuttle MS, Wong JF, and Morse HC 3rd
- Subjects
- Animals, Hematologic Neoplasms pathology, Humans, Leukemia classification, Leukemia pathology, Myeloproliferative Disorders classification, Myeloproliferative Disorders pathology, National Institutes of Health (U.S.), Neural Tube Defects classification, Neural Tube Defects pathology, Sarcoma classification, Sarcoma pathology, United States, Hematologic Neoplasms classification, Mice
- Abstract
The hematopathology subcommittee of the Mouse Models of Human Cancers Consortium recognized the need for a classification of murine hematopoietic neoplasms that would allow investigators to diagnose lesions as well-defined entities according to accepted criteria. Pathologists and investigators worked cooperatively to develop proposals for the classification of lymphoid and nonlymphoid hematopoietic neoplasms. It is proposed here that nonlymphoid hematopoietic neoplasms of mice be classified in 4 broad categories: nonlymphoid leukemias, nonlymphoid hematopoietic sarcomas, myeloid dysplasias, and myeloid proliferations (nonreactive). Criteria for diagnosis and subclassification of these lesions include peripheral blood findings, cytologic features of hematopoietic tissues, histopathology, immunophenotyping, genetic features, and clinical course. Differences between murine and human lesions are reflected in the terminology and methods used for classification. This classification will be of particular value to investigators seeking to develop, use, and communicate about mouse models of human hematopoietic neoplasms.
- Published
- 2002
- Full Text
- View/download PDF