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Background Human papilloma virus (HPV) is the most common sexually transmitted infection (STI) in the United States (US) and is associated with the development of cervical and anal dysplasia; however, little is known about the epidemiology of HPV in transgender persons. The objective of this study was to conduct a systematic review of the literature to evaluate the existing epidemiologic data on HPV infection prevalence as well as anal and cervical dysplasia in transgender persons. Methods The PubMed and Scopus databases were queried using the keyword "transgender" in combination with one of the following: PAP, cervical cancer, anogenital warts. The search generated 86 articles, when accounting for duplicates across searches. We included original research articles published from January 1969 to March 2019. Excluded were non-English articles, studies that did not have HPV or cytology testing data, and studies that did not have disaggregated transgender data. Results In total, 13 articles were included in the review, of which 9 focused on transgender women (TW), 3 on transgender men (TM), and 1 on both TW and TM. HPV DNA testing was performed in 10 studies, with 7 of those offering prevalence data for specific HPV genotypes. Overall, HPV prevalence in TW ranged from 15%-97.4%, with High Risk-HPV (HR-HPV) prevalence ranging from 13%-82.5%. Anal cytology data for TW was presented in 2 studies, both of which cited a 42% prevalence of abnormal cytology. Cervical or vaginal cytology was evaluated in 4 articles, 3 of which involved TM and 1 of which involved TW with neovaginas. Among TM, the prevalence of abnormal cervical cytology ranged from 6%-42%. Conclusion Our review highlights the lack of HPV research and the high variability of the existing data about the transgender population. Further study is needed to better understand not only the epidemiology of HPV and resultant dysplastic sequelae, but also to inform the development of transgender sensitive diagnostic methods for this infection. The diverse genital anatomy represented in the transgender community as well as the gender dysphoria these patient's experience during testing pose myriad diagnostic challenges that will need to be considered in the development of screening and diagnostic practices. Disclosures All authors: No reported disclosures. [ABSTRACT FROM AUTHOR]