1. Across-the-World Automated Optimization and Continuous-Flow Synthesis of Pharmaceutical Agents Operating Through a Cloud-Based Server.
- Author
-
Fitzpatrick DE, Maujean T, Evans AC, and Ley SV
- Subjects
- Chemistry Techniques, Synthetic economics, Chemistry Techniques, Synthetic instrumentation, Cloud Computing economics, Drug Industry economics, Drug Industry instrumentation, Drug Industry methods, Equipment Design, Japan, United Kingdom, United States, Analgesics, Opioid chemical synthesis, Anesthetics, Local chemical synthesis, Antidepressive Agents, Second-Generation chemical synthesis, Bupropion chemical synthesis, Chemistry Techniques, Synthetic methods, Lidocaine chemical synthesis, Tramadol chemical synthesis
- Abstract
The power of the Cloud has been harnessed for pharmaceutical compound production with remote servers based in Tokyo, Japan being left to autonomously find optimal synthesis conditions for three active pharmaceutical ingredients (APIs) in laboratories in Cambridge, UK. A researcher located in Los Angeles, USA controlled the entire process via an internet connection. The constituent synthetic steps for Tramadol, Lidocaine, and Bupropion were thus optimized with minimal intervention from operators within hours, yielding conditions satisfying customizable evaluation functions for all examples., (© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.)
- Published
- 2018
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