1. Celiac disease is uncommon in irritable bowel syndrome in the USA.
- Author
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Almazar AE, Talley NJ, Larson JJ, Atkinson EJ, Murray JA, and Saito YA
- Subjects
- Adolescent, Adult, Aged, Case-Control Studies, Celiac Disease blood, Celiac Disease diagnosis, Comorbidity, Female, GTP-Binding Proteins immunology, Genotype, HLA Antigens blood, Humans, Immunoglobulin A blood, Irritable Bowel Syndrome genetics, Male, Middle Aged, Prevalence, Protein Glutamine gamma Glutamyltransferase 2, Transglutaminases immunology, United States epidemiology, Young Adult, Celiac Disease epidemiology, Irritable Bowel Syndrome epidemiology
- Abstract
Background and Aims: Routine serologic testing for celiac disease (CD) may be useful in irritable bowel syndrome (IBS) patients, but this is controversial. We aimed to compare the prevalence of unrecognized CD in a large cohort of patients with and without IBS., Participants and Methods: This is a family case-control IBS study conducted at a single US academic medical center. Stored serum and DNA were available. Tissue transglutaminase (TTg) immunoglobulin A was performed, followed by indirect immunofluorescence testing for endomysial antibodies with positive or weakly positive TTg results. Individuals were considered to have CD if both results were positive. χ and Fisher's exact tests were used to compare prevalence between the two groups., Results: Serum samples were studied from 533 cases and 531 controls. In all, 80% of participants were female, with a median age of 50 years; 65% of cases and 0% controls met the Rome criteria for IBS. Previous serological testing for CD had occurred in 142 (27%) cases and 13 (2%) controls, but none had CD on subsequent testing. Six (1.1%) cases versus five (0.9%) controls had positive or weakly positive TTg test. Six cases (1.1%) versus three (0.6%) controls were confirmed to have CD by endomysial antibody (P=0.51)., Conclusion: No difference in the prevalence of CD between patients with IBS and patients without IBS at a tertiary medical center was observed. Our findings do not support routine celiac serologic or genetic testing in patients with IBS in all US populations.
- Published
- 2018
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