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OBJECTIVE: To assess the feasibility of sterile water application to the skin of the extremely low birth weight (ELBW) newborns in the first week of life and examine its effects on their skin integrity and outcomes. DESIGN: Pilot randomized controlled trial. SETTING: Open-bay, 18 bed Level III NICU in the Eastern United States. PARTICIPANTS: Twenty-eight ELBW neonates. Two newborns expired, sixteen newborns remained in the intervention group and twelve newborns in the control group. METHODS: ELBW neonates were either assigned to receive frequent sterile water wash to skin or not during care for the first week of life. Using the Neonatal Skin Condition Scale (NSCS), assessments were performed twice a day during the first week. Fluid intake, serum electrolytes, culture proven sepsis and other morbidities, and length of stay (LOS) were compared while controlling for confounding variables using multiple regression analysis. RESULTS: There was no difference in the demographic or clinical characteristics between both groups. Sterile water wash application to skin was not associated with differences in skin health indices or fluid intake. However, it was associated with higher median sodium level and with early regression of bilirubin level when compared to controls. CONCLUSION: Frequent skin washes with sterile water are feasible and safe. However, they may not be associated with improved skin integrity or fluid intake. [ABSTRACT FROM AUTHOR]

Objective: The NICHD and SIBEN assessments are adapted from the Sarnat grade, and used to determine severity of neonatal encephalopathy (NE). We compare NICHD and SIBEN methods, and their ability to define a minimum threshold associated with significant cerebral injury., Study Design: Between 2016 and 2019, 145 infants with NE (77-mild; 65-moderate; 3-severe) were included. NICHD and SIBEN grade and numerical scores were assigned. Kappa scores described agreement between methods, and ROC curves their ability to predict MR injury., Results: Good agreement existed between grading systems (K = 0.86). SIBEN defined more infants as moderate, and less as mild, than NICHD (p < 0.001). Both numerical scores were superior to standard grades in predicting MR injury., Conclusion: Despite good agreement between methods, SIBEN defines more infants as moderate NE. Both numerical scores were superior to standard grade, and comparable to each other, in defining a minimum threshold for cerebral injury. Further assessment contrasting their predictive ability for long-term outcome is required., (© 2021. The Author(s).)

Objectives: Late preterm infants are the fastest growing segment of the premature infant population in the United States. However, it is not known if demographic and clinical factors can impact the length of hospital stay (LOS) in this population. The objectives of this study are to determine the following: (a) factors associated with a LOS > 3 d and (b) whether there is any difference in risks between infants born at 33-34 versus 35-36 weeks., Methods: Utilizing the Nationwide Inpatient Sample Database, a de-identified dataset produced by the Healthcare Cost and Utilization Project, analysis of 81 913 infants born at 33-36 weeks from 2007 to 2008 was conducted. LOS outcome was defined as ≤3 and >3 d. Bivariable and multivariable logistic regression was used to evaluate predictors of LOS among this population., Results: Only 42.7% of infants were discharged home within three days. Factors associated with a LOS > 3 d included gestational age of <35 weeks (RR = 1.63; CI: 1.58-1.68), birth weight of < 2500 g (RR = 1.36; CI: 1.33-1.39), male sex (RR = 1.06; CI: 1.05-1.07), delivery via C-section (RR = 1.46; CI: 1.41-1.51) and multiple gestation (RR = 1.08; 95% CI: 1.06-1.09). Other significant factors included race, birth region, primary insurance payer and clinical complications. In the adjusted interaction model, these variables have more impact on longer LOS in the 35-36 weeks group (p < 0.0001)., Conclusion: Birth region in addition to gestational age, birth weight, gender, mode of delivery, multiple gestation and primary insurance payer affect LOS in late preterm infants. These variables are more critical for the 35-36 week population.