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Importance: Consumers have reported skin rash/irritation and hair loss/breakage with Wen by Chaz Dean Sweet Almond Mint Cleansing Conditioner (WCDSAMCC), however epidemiologic, toxicologic and clinical hair loss studies have not provided an explanation. Contact dermatitis has been hypothesized. Objective: To assess the tolerability of six products: WCDSAMCC, three other hair cleansing conditioners, and two controls [salicylic acid shampoo (SAS) and baby shampoo (BS)]. Design: Double-blind, randomized, controlled trial. Setting: Single-site study. Population: General population volunteers. Intervention: Standard semi-open patch tests (SOPTs) and duration-escalation repeat open application tests (ROATs) over 5 weeks. Main Outcome Measures: Primary outcome measure was "stopping point" [ROAT total component score ≥6 (maximum 10) or global ≥4 (maximum 5)]. Secondary outcomes included "any reaction" (ROAT component score ≥1) and SOPT ≥ doubtful. Results: Two hundred of 298 volunteers were enrolled. There were no significant differences in the tolerability of WCDSAMCC and any of the other three hair cleansing conditioners as assessed by SOPT or ROAT. WCDSAMCC was significantly better tolerated than SAS ("stopping point", or "any reaction", p values<0.0001) as well as BS ( p  = 0.01). The frequency of doubtful SOPT reactions was lowest for WCD (2.2%) and highest for SAS (7.1%, p  = 0.04). Conclusions: As assessed by both ROAT and SOPTs, WCDSAMCC was similar in tolerability to three other hair cleansing conditioners and significantly better tolerated than both controls (SAS and BS). Summary: This double-blind, randomized, controlled study found that WCDSAMCC was similar in tolerability to three other HCCs and was significantly better tolerated than both SAS and BS. This study provides critical clinical evidence on the comparative lack of cutaneous effects with use of WCDSAMCC. Trial Registration: NCT03483025 ClinicalTrials.gov.

Background: Children are as likely as adults to be sensitized and reactive to contact allergens. However, the prevailing data on pediatric allergic contact dermatitis are quantitatively and qualitatively limited because of a narrow geographic localization of data-reporting providers., Objective: The aim of the study was to present the first quarter results from the Loma Linda Pediatric Contact Dermatitis Registry focused on registered providers who self-identified as providing care for pediatric allergic contact dermatitis (ACD) within the United States., Methods: The US providers were invited to join the registry via completion of an online, secure, 11-question registration survey addressing demographics and clinical practice essentials. The presented results reflect data gathered within the first quarter of registry recruitment; registration is ongoing., Results: Of 169 responders from 48 states, the majority of providers were female (60.4%), academic (55.6%), and dermatologists (76.3%). Based on individual provider averages, the minimum cumulative number of pediatric patch-test evaluations performed each year ranged between 1372 and 3468 children., Conclusions: The Pediatric Contact Dermatitis Registry provides a description of the current leaders in the realm of pediatric ACD and gaps, which are in need of attention. The registry allows for a collaborative effort to exchange information, educate providers, and foster investigative research with the hope of legislation that can reduce the disease burden of ACD in US children.

Background: The state of allergic contact dermatitis (ACD) education has not been formally examined since the original study done by High and Cruz (Am J Contact Dermat. 2003;14(4):195-199)., Objective: The objectives of the study were to characterize the current state of ACD and patch-testing education in US dermatology residency programs and to determine if there has been any significant improvement over the past 8 years., Method: This was a survey of ACD education and patch-testing practices in US dermatology residency programs., Results: Surveys were sent to program directors and chief residents at all 112 US dermatology residency programs. Of the 224 surveys sent out, 105 (46.88%) were returned. There were several statistically significant changes from the 2002 survey. More faculty members who are designated as ACD experts are now members of the American Contact Dermatitis Society. Fewer programs now routinely review contact dermatitis-specific journals. Residents are now more likely to receive didactic lectures on ACD. Program directors estimated graduating residents will now be less likely to perform the TRUE Test in practice, and although not statistically significant, program directors also estimated an increase in the number of residents who will use expanded tests., Conclusions: Although some areas of ACD education have improved over the past 8 years, opportunities to further improve remain.