1. Respiratory Health Associated With Systemic Metal Exposure in Post-9/11 Veterans in the Department of Veterans Affairs Toxic Embedded Fragment Registry.
- Author
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Hines, Stella E., Gaitens, Joanna M., Brown, Clayton H., Glick, Danielle R., Reback, Maxwell, Chin, Katherine H., Lawrence, Emma, Cavanaugh, Kerri L., Lawson, William E., Sriram, Peruvemba, Beck, Lisa, Duch, John, Aguayo, Samuel M., Permana, Paska, and McDiarmid, Melissa A.
- Subjects
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AMERICAN veterans , *PULMONARY function tests , *RESEARCH funding , *SPIROMETRY , *QUESTIONNAIRES , *TERRORISM , *DEPLOYMENT (Military strategy) , *DESCRIPTIVE statistics , *OCCUPATIONAL exposure , *RESPIRATORY organ physiology , *DISASTERS , *FORCED expiratory volume , *METALS , *INDUSTRIAL hygiene - Abstract
Objective: Adverse respiratory outcomes in post-9/11 veterans with elevated urinary metal measures and enrolled in the VA's Toxic Embedded Fragment registrywere compared to thosewithout elevated urinary metals. Methods: Veterans completed questionnaires, underwent pulmonary physiology tests (pulmonary function and oscillometry), and provided urine samples for analysis of 13 metals. Respiratory symptoms, diagnoses, and physiology measures were compared in veterans with ≥1 urine metal elevation to those without metal elevations, adjusted for covariates, including smoking. Results: Among 402 study participants, 24% had elevated urinemetals, often just exceeding upper limits of reference values. Compared to veterans without elevated metals, those with elevated metals had had higher FEV1 values but similar frequencies of respiratory symptoms and diagnoses and abnormalities on pulmonary physiology tests. Conclusions: Mild systemic metal elevations in post-9/11 veterans are not associated with adverse respiratory health outcomes. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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