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The topic of this academic review is settler slogans that mandate colonial school policy in North America. Also discussed is Indigenous futurity as a strategy for transforming education and countering the educational harm that comes from weaponized language. Beginning in 1887, the US federal government authorized colonial schooling, using the dangerous educational cliché "Kill the Indian in him, and save the man." The purpose of this article was to illuminate this weaponizing rhetoric in education, which served as a guiding principle for imposing Indigenous assimilation that manifested as federal policy in the Americas. Research questions were, How did the kill-and-save slogan shape US and Canadian education and policy? How can the concept of Indigenous futurity improve Indigenous education? Colonial settler efforts to control tribal nations with weaponizing rhetoric leveled at education policy, public perception, and compulsory boarding/residential schools are exposed. Peer-reviewed studies were read, with analysis of 51 sources, many authored by Indigenous academics. Resultant cultural genocide, systemic discrimination, and educational disparity are described. Indigenous resistance to settler ideologies, policies, and settlements, as well as assertions of tribal rights, freedom, and sovereignty, reflect patterns in the material analyzed. Modern-day empowerment of society's most vulnerable ethnic group requires a deep rethinking of schooling processes. Debunking settler futurity, the lesser-known Indigenous view of futurity looks to sustaining Indigenous communities and calls on society for amends.

Critical friendship is an innovative method used to strengthen an individual's professional skills, including critical reflection, thinking, and problem-solving abilities in educational settings. Critical friendships can occur through one-on-one relationships or in groups known as critical friendship groups (CFGs). Literature on CFGs examines the benefits of structured CFGs integrated into teacher preparation programs. CFGs that form beyond university walls, like a study abroad context, have not been discussed in the literature even though these experiences can be the catalyst for CFGs. This case study illustrates how a CFG was formed during a study abroad trip to Belize with undergraduate and graduate education students that resulted in five major findings. Implications for both teacher education and study abroad programs are discussed.

Locus of Control (LOC) is measured by a brief survey designed to determine an 'internal' or 'external' locus. Internal LOC signifies ownership of the consequences of one's actions. Individuals with a more internal LOC tend to have higher determents of positive mental health. This study investigated the impact on the LOC of university students after a 25-day program focused on adventure-based eco-tourism where the participants hiked, camped, white water rafted and took part in other adventure-based activities. We found the results further support previous studies that determined adventure programs enhanced internality measured quantitatively through Locus of Control. Qualitative responses indicated greater self-reliance due to enhanced belief in ability.

This study's research aim is to discover how the COVID-19 pandemic impacts early career researchers' work lives, prospects, and scholarly communication behavior. Early career researchers (ECRs), including doctoral students, post-docs, and pre-tenure faculty, are the next generation of scientists, researchers, scholars, teachers, and academic leaders, and are considered "vulnerable" when compared to their more senior colleagues. Part of an eight-country study, we present findings from long semi-structured interviews of 22 ECRs within the sciences and social sciences from a variety of regions in the United States. Transcripts were approved by the participants and responses were coded into a project-approved spreadsheet for analysis. The coding sheets were multi-faceted, containing both quantitative and qualitative data. Key findings include loss of research productivity due to lab closures and/or human subject research. The most recurring negative impact is the loss of formal and informal in-person meetings. For the majority, the pandemic has not deterred ECRs to deviate from their chosen academic career paths.

The inclusion of First Nations health curricula in programs is critical for the development of culturally safe graduates, however, less is known about how to embed content into curriculum in ways that reflect best practice and pedagogy. The aim of this scoping review was to describe methods and processes of First Nations health curriculum development in nursing, medical, dentistry, and allied health entry-level programs in international peer-reviewed journals. Systematic searches of databases were completed including CINAHL, Proquest, Medline, and Informit; with additional searches in Google Scholar and First Nations-led journals. A total of 104 articles met inclusion criteria; the majority relating to medicine (n = 38) and nursing/midwifery (n = 17) student cohorts. Methods and processes for embedding First Nations health content are described, including First Nations-led development and co-leadership, resulting in a suggested model for curriculum development. Evidence-informed curriculum development is critical to ensure effective methods and processes are adopted and cultural safety learning outcomes are achieved.

A 21st-century challenge for educators is to promote meaningful engagement in online courses, and student development of critical thinking skills is an essential aspect of higher order learning. Evaluation of critical thinking in online discussions is often facilitated by the use of rubrics; however, it is not unusual for rubrics to either omit critical thinking as a component of the rubric or to reference it in a vague way. For the purposes of this study, quantitative and qualitative data were collected from faculty to identify their attitudes about critical thinking attributes as performance measures for evaluation rubrics. Factor analysis revealed that the response patterns clustered for each factor represented the themes (1) "demonstrates logic and reasoning" (described as offering accurate supporting evidence and strategies and solutions); and (2) "creative critical thought processes" (described as novel perceptions, bias refutation, and alternative-seeking). From this study, we would suggest that faculty should use an evaluation rubric that encompasses these two dimensions.

Women who attain more education tend to have children with more educational opportunities, a transmission of educational advantages across generations that is embedded in the larger structures of families' societies. Investigating such country-level variation with a life-course model, this study estimated associations of mothers' educational attainment with their young children's enrollment in early childhood education and engagement in cognitively stimulating activities in a pooled sample of 36,400 children (n = 17,900 girls, 18,500 boys) drawn from nationally representative data sets from Australia, Ireland, U.K., and U.S. Results showed that having a mother with a college degree generally differentiated young children on these two outcomes more in the U.S., potentially reflecting processes related to strong relative advantage (i.e., maternal education matters more in populations with lower rates of women's educational attainment) and weak contingent protection (i.e., it matters more in societies with less policy investment in families).

The New Mexico jumping mouse (Zapus luteus) is a federally endangered species that relies on riparian sites of the southwestern United States. Only isolated populations occur throughout its range and detecting potential suitable environments and identifying new populations are important for long‐term conservation of genetic diversity and habitat restoration by management agencies. We used a presence‐only data approach compiled from multiple surveys since 2000 in Arizona, Colorado, and New Mexico with bioclimatic and vegetation variables to generate species distribution models for the species. Our models predicted environmentally suitable areas outside the current species management units that could be prioritized in surveys. Our models also highlighted opportunities for collaboration among federal, state, tribal, and private landowners and managers to secure habitat and connectivity for the species and its long‐term survival. [ABSTRACT FROM AUTHOR]

Simple Summary: The purpose of the present study was to determine the role of changes in the stage of colorectal cancer (CRC, Stage 0 to 4, with 0 be very early stage and 4 late stage) at diagnosis over time, and its impact on overall survival (OS) in our Health Network system. Two datasets were used, the Health Network (n = 1385) and a national dataset (n = 202,391). There was a significant increase in early CRC stages at diagnosis (Stage 0–1), and late diagnosis (Stage 4) with a concomitant decrease in the diagnosis of CRC Stage 2. The present findings confirmed CRC stage migration in our Health Network System, along with a national trend conducive to an increased OS for early CRC stages. Background/Objectives: Due to an increased rate of surveillance colonoscopy, we aim to determine the impact of stage migration on the incidence and overall survival (OS) of patients who underwent pathological staging of colorectal cancer (CRC) at our Health Network System. Methods: Two datasets were included: subjects from the tumor registry at a regional Comprehensive Cancer Center (n = 1385) and subjects from the Surveillance, Epidemiology, and End Results (SEER) national database (n = 202,391). Results: A significant increase in the diagnosis of CRC Stage 1 and 4 was observed, with a decrease in stage 2, and no change in Stage 3 in the National datasets (p < 0.01). There was an increase in Stage 4 CRC diagnosis, with a concurrent decrease in stage 2, and no changes in stages 1 and 3 in the regional dataset (p < 0.05). OS followed the expected and progressive decrease in OS by stage (from 1 to 4, p < 0.01). Conclusions: The present findings confirmed CRC stage migration in our Health Network System, along with a national trend conducive to an increased OS for early CRC stages. [ABSTRACT FROM AUTHOR]

The article focuses on the potential pitfalls of integrating Equity, Diversity and Inclusion (EDI) principles into bioethics, emphasizing the importance of learning from the mistakes of other fields. Topics include the risks of adopting dogmatic EDI approaches without context; the challenges of balancing diverse normative frameworks in bioethical discourse; and the necessity for thorough review and consideration of existing academic norms to foster inclusive environments.

This paper explores the different epistemologies that define the Professional Doctorate, paying close attention to how Postgraduate Researchers (PGRs) doing a Professional Doctorate reconcile academic and professional knowledge. Through a narrative exploration of the literature published since the first UK Professional Doctorates were awarded in 2000, the paper situates the Professional Doctorate within the confluence of the workplace, the profession and the university. From this stance, the paper explores distinct knowledge terrains between knowledge generated by Professional Doctorates in the context of application and knowledge generated in the context of disciplinary laws applied to sites of practice. The purpose of this discussion is to understand if, how and to what extent Professional Doctorates reconcile competing knowledge terrains. This study draws towards two broad conclusions. The first conclusion suggests that in the literature identified, the distinction between academic and professional epistemologies has little resonance. Instead of the dichotomous knowledge generated in the context of practice in contrast to knowledge generated in the context of disciplinary laws, Professional Doctorates were ensconced within several competing epistemologies. The literature identified focuses on impact and identity, concepts the study employs as lenses to guide a discussion. The paper thus views the process of reconciliation first through the lens of impact and then through the lens of identity. The investigation then draws a second conclusion: The epistemic landscape occupied by the Professional Doctorate is involved in a reconciliation of more significance that the putative academic and professional binary. The paper is compelled towards a diffractive re-reading of this academic-professional knowledge tension. This new reading allows a full recognition of both difference and mutual entanglement between knowledge generated in the context of practice and knowledge generated in the context of disciplinary laws. [ABSTRACT FROM AUTHOR]

When domestic violence first became recognized as a social problem, services (e.g., hotlines, medical accompaniment, and emergency shelters) focused largely on meeting victims' needs during crisis. Research documenting the process survivors go through to end abusive relationships and to establish a new, safe life shows that the challenges they face go well beyond the initial crisis. In contrast to standard practices, the Chesapeake Crisis to Self-Sufficiency Model (CCSSM) provides a continuum of holistic, survivor-centered services to support the transition from crisis to self-sufficiency. Staff interviews reveal that the CCSSM grew out of recognizing clients' needs postcrisis. Establishing service continuums in critical areas such as housing, legal assistance, and economic empowerment creates customizable pathways for clients to follow. Administrative data for 464 survivors receiving services under the traditional model and 607 served under the CCSSM show that the CCSSM cohort worked with the agency for significantly more months and received a broader array of services. These data suggest that the comprehensive service model provides survivors with much needed services beyond the initial crisis and may ultimately increase their chances of leaving an abusive relationship. Future research should explore if the CCSSM leads to increased survivor safety and movement toward self-sufficiency and if the model decreases the odds that survivors will return to an abusive partner. [ABSTRACT FROM AUTHOR]

Purpose: This study investigates changes in the prevalence and practice of simulation in communication sciences and disorders (CSD) education. It is a follow-up to a 2015 survey on the same topic. Given the changes in program certification standards and the impact of the COVID-19 pandemic on clinical education programs across the United States, re-examination of simulation in CSD is warranted. Method: An online questionnaire was developed to survey university programs accredited by the Council on Academic Accreditation of the American Speech-Language-Hearing Association. University program directors and clinical directors received recruitment e-mails using QuestionPro, an online survey platform. The recruitment e-mail contained the purpose of the study and a link to the online questionnaire along with instructions to forward the survey to the appropriate designee. The consent form was then embedded in the questionnaire. Results: The results of this survey indicated changes in patterns and the use of simulation in clinical education for CSD. Results indicated an overall increase in the use of simulations, specifically in computer-based simulations. Distance simulation as a hybrid technology proved a major addition to clinical education programs during the COVID-19 pandemic. External and internal factors affecting the use of simulations in CSD were identified. Conclusions: The use of simulation to supplement clinical education in CSD has evolved in recent years. These changes are likely due in part to changes in certification standards in the profession, an increase in awareness and training, and reliance on distance simulation during the COVID-19 pandemic. [ABSTRACT FROM AUTHOR]

Objective: Attachment style and social support networks (SSN) are associated with suicide ideation (SI) and suicide attempt (SA). How these two factors interact is important to understanding the mechanisms of risk for suicidal behaviors and identifying interventions. Method: Using the Army Study to Assess Risk and Resilience in Servicemembers New Soldier Study (N = 38,507 soldiers), we examined how three attachment styles (preoccupied, fearful, and secure) and SSN (smaller vs larger) were associated with lifetime SI, SA, and SA among soldiers with SI. The interaction of each attachment style by SSN was examined. Results: All three attachment styles were associated with SI and SA in the total sample (for SA: preoccupied OR = 2.82, fearful OR = 2.84, and secure OR = 0.76). Preoccupied and fearful attachment were associated with SA among suicide ideators. Smaller SSN was associated with a higher risk for all three outcomes (range of ORs = 1.23–1.52). The association of SSN with SI and with SA among suicide ideators was significantly modified by the presence or absence of preoccupied attachment style. Among soldiers without preoccupied attachment, larger SSN was associated with lower risk of SI. Among suicide ideators with preoccupied attachment, a larger SSN was associated with lower risk of SA. Conclusion: This study highlights the need for increased understanding of the role of attachment style and social networks in suicide risk, in particular preoccupied attachment among soldiers with SI. A critical next step is to explore these relationships prospectively to guide intervention development. [ABSTRACT FROM AUTHOR]

Background: Intestinal failure-associated liver disease (IFALD) is a complication of long-term PN use, attributed to the use of ω-6 injectable lipid emulsions (ILE). Fish oil (FO) ILE have been successful in reversing liver injury in neonates. Evidence for pure FO ILE use in adult patients is limited. Methods: Case series of the use of FO lipid emulsions in adults with IFALD from the University of Chicago PN registry. Analysis of medical charts and PN formulations was performed. Results: Three cases of IFALD treated with FO ILE were identified. The first case was a 30-year-old man with short bowel syndrome (SBS), hyperbilirubinemia, and biopsy-proven IFALD. Following a change from a soy lipid emulsion to FO lipid emulsion, his liver tests rapidly improved and remained stable over 202 weeks of use. The second case was a 76-year-old woman with intestinal failure (IF) due to a frozen bowel. A change from a soy ILE to a composite lipid and later to a pure FO ILE did not result in improvement in her liver tests. The third case was a 28-year-old man with SBS and biopsy-proven IFALD. Change to a composite ILE and subsequently FO lipid emulsion resulted in a gradual improvement in liver tests. No clinical essential fatty acid (EFA) deficiencies were identified during treatment. Conclusion: FO ILE may be effective in the treatment of adult patients with cholestatic IFALD. Use is safe with no EFA deficiencies detected in up to 4 years of use. [ABSTRACT FROM AUTHOR]

PURPOSE: Routine collection of sexual orientation (SO) and gender identity (GI; collectively SOGI) in cancer clinics advances cancer care equity. METHODS: In 2022, NCI Community Oncology Research Program (NCORP) practice groups were asked about routine collection of SOGI data in the electronic health record. The proportions of practice groups reporting collection of SO and/or GI data were calculated, and practice group characteristics were assessed for associations. RESULTS: Of 271 practice groups nationwide, 42% (n = 112) collect SO data, 58% (n = 157) collect GI data, and 35% (n = 96) collect both. In multivariate analyses, SO data collection was associated with practice groups having minority outreach staff (odds ratio [OR], 2.07 [95% CI, 1.12 to 3.81]; P =.02); GI data collection was associated with practice groups located in the Northeastern United States (OR, 2.08 [95% CI, 0.73 to 5.91]; P =.045), and those with a higher proportion of new patients who were White (OR, 1.02 [95% CI, 1.01 to 1.04]; P <.001). Practice groups in the South were least likely to collect SOGI data (OR, 0.49 [95% CI, 0.26 to 0.94]; P =.004). There were no statistically significant differences in SO and/or GI collection on the basis of the practice group's proportion of Medicaid/Medicare patients, number of new patients with cancer per year, or practice ownership. CONCLUSION: Slightly over one third of NCORP practice groups report routinely collecting SOGI data. There are regional differences in data collection, underscoring the need to craft targeted, region-specific interventions focused on boosting the capture and recording of SOGI data in an affirming manner. [ABSTRACT FROM AUTHOR]

Heart disease, cancer, stroke, diabetes, and respiratory diseases are the leading chronic diseases worldwide. For American college students, specifically, behavioral risk factors for chronic disease include: insufficient sleep, inactivity, unhealthy eating habits, poor mental health, substance abuse, unhealthy relationships, and unsafe sexual practices. Although little has been reported in the literature, and no national assessment was conducted of college-aged students in India; there is some evidence that that this population may also engage in the behavioral risk factors of alcohol and tobacco use. A convenience sample of English-speaking, college-aged students from a medium-sized, rural university in India and a medium-sized, rural university in the United States participated in a survey about their behavioral health risks for chronic disease. The chronic disease risk factors of substance abuse, physical inactivity, and poor nutrition were similar between the two respondent groups; however, choice of substance to abuse (US- alcohol, India- tobacco) significantly differed between the groups. Health promotion intervention programming for college-age students in both countries would be similar and should focus on decreasing personal risk factors and promoting protective factors for chronic disease prevention.

Background: Verbal bullying is often reported by students. However, little is known about the exact things that bullies say to students or the immediate emotional reactions elicited by verbal bullying. Objective: This study examined verbal bullying to determine what specific taunts are used in bullying, how students feel when they hear these taunts, if there is a relationship between particular taunts and feelings, and gender differences among these variables. Method: Participants in this field study included a sample of middle school students, grades 6–8, with data collected over three years (N = 339) from a large school district in the United States. Using an open-ended format, students wrote things they thought bullies might say and how they would feel if they heard these taunts. Results: Individual taunts such as "ugly" and "fat" and those falling into the categories of Stupid, Name Calling, and Personal Insults were most common. Frequent emotional responses were Sad, Angry/Hatred, and Depressed. Gender differences in both taunts and feelings were few, but females were more likely than males to be sensitive to issues of appearance, sexual propriety, and genuineness. Conclusions: These data expand the literature by specifying the content of verbal bullying and immediate emotional reactions to it. They identify appearance as well as competence and warmth, key factors in the Stereotype Content Model, as underlying much of the content of verbal bullying. [ABSTRACT FROM AUTHOR]

Objectives: This qualitative study aimed to understand the experiences, information and support needs of family members of cancer patients and their satisfaction with the services provided to them as a family member. Design: Inductive qualitative and critical realist approach to data collection and analysis. Methods: Purposive sampling was used to identify family members of cancer patients. We conducted semi-structured interviews with 10 participants by means of email, enabling us to explore sensitive topics at a pace appropriate for each participant and gain rich sources of information. We analysed the data using an inductive thematic approach. Results: Three superordinate themes were identified: information acquisition, seeking support and family members' experiences of cancer. Needs were high, and a complex relationship between information and support was apparent. Many participants felt dissatisfied with the support and information received as it was sometimes inconsistent, incorrect or vague, and some reported deterioration in their own health as a consequence. Online communities were reported as being informative and supportive as the participants felt they could relate to the firsthand experience of the other members. Conclusion: Improving healthcare professionals' awareness of the type of information and support the family members need is vital for both family members and patients. There is a need for the development of educational and psychological interventions to assist family members in coping when a loved one is diagnosed with cancer, is undergoing or recovering from treatment, or is receiving palliative care.

Aims The atherosclerotic profile and advanced plaque subtype burden in symptomatic patients ≤45 years old have not been established. This study aimed to assess the prevalence and predictors of coronary artery calcium (CAC), plaque subtypes, and plaque burden by coronary computed tomography angiography (CCTA) in symptomatic young patients. Methods and results We included 907 symptomatic young patients (18–45 years) from Montefiore undergoing CCTA for chest pain evaluation. Prevalence and predictors of CAC, plaque subtypes, and burden were evaluated using semi-automated software. In the overall population (55% female and 44% Hispanic), 89% had CAC = 0. The likelihood of CAC or any plaque by CCTA increased with >3 risk factors {RFs, odds ratio [OR] 7.13 (2.14–23.7) and OR 10.26 (3.36–31.2), respectively}. Any plaque by CCTA was present in 137 (15%); the strongest independent predictors were age ≥35 years [OR 3.62 (2.05–6.41)] and family history of premature coronary artery disease (FHx) [OR 2.76 (1.67–4.58)]. Stenosis ≥50% was rare (1.8%), with 31% of those having CAC = 0. Significant non-calcified plaque (NCP, 37.2%) and low-attenuation plaque (LAP, 4.24%) burdens were seen, even in those with non-obstructive stenosis. Among patients with CAC = 0, 5% had plaque, and the only predictor of exclusively NCP was FHx [OR 2.29 (1.08–4.86)]. Conclusion In symptomatic young patients undergoing CCTA, the prevalence of CAC or any coronary atherosclerosis was not negligible, and the likelihood increased with RF burden. The presence of coronary stenosis ≥50% was rare and most often accompanied by CAC >0, but there was a significant burden of NCP and LAP even within the non-obstructive group. [ABSTRACT FROM AUTHOR]

Family caregivers to persons living with a chronic or disabling condition often report disruption to their employment. Employment disruption can cause long-term financial difficulty and psychological distress for caregivers, high costs for employers, and exacerbates social inequities. In this commentary, we describe a community initiative to better support employees who are caregivers conducted with nonprofit employers in San Antonio, located in the central Texas region of the United States. This initiative aimed to raise awareness among local employers about the challenges employees face in balancing employment and caregiving. This led to the co-development of a pledge to guide employer efforts to support employees who are caregivers. This initiative represents a first step to mobilize employers as stakeholder allies to improve workplace support for family caregivers. The authors draw on the Shilton Model of Policy Advocacy to make the case that the mobilization of employers as advocacy stakeholders can hasten the advancement of policies that enable family caregivers to balance both roles. Further, the implementation of organization-level changes, in addition to state and federal policy changes, to support employed caregivers by employers is consistent with recommendations of the recently published National Strategy to Support Family Caregivers. [ABSTRACT FROM AUTHOR]

Background: Interpersonal communication is a crucial component of the cancer experience that can contribute to managing cancer care and improving cancer survivors' and caregivers' quality of life. Cultural and contextual factors may impact Hispanic childhood cancer survivor (CCS) and parent caregiver relationships and communication. This study sought to describe the healthcare communication experiences of Hispanic parents with CCS, families, and medical providers. Methods: We conducted 15 semi-structured interviews with Hispanic caregivers from a safety-net hospital in Los Angeles County. Interviews were conducted in English and Spanish, audio-recorded and professionally transcribed, and analyzed using a thematic approach. Results: Caregivers shared the importance and impact of medical communication when exploring the "first big talk" of the diagnosis, uncertainty about treatment, navigating multiple providers, therapeutic communication (i.e., providing emotional reassurance), and current and lingering effects of cancer. All caregivers shared "good communication" experiences, while others shared various barriers to communication, including a lack of understanding of the cancer diagnosis and caregiver experience, psychological challenges impacting communication, cultural and language differences, physical factors that limit communication, and young age of child impacting communication with caregivers. Conclusions: Our findings suggest that a strong interpersonal communication skill set for clinicians can contribute to managing cancer care and improving caregivers' psychological adjustment. [ABSTRACT FROM AUTHOR]

This study reports on food insecurity (FI) amidst the COVID-19 pandemic. College students in four regions of the US completed the two-item validated Hunger Vital Sign™ screening tool on Qualtrics. FI increased significantly after March 2020 among US students (worry about food running out: 25% to 35%; food did not last: 17% to 21%) with significant regional increase in the Midwest and South. An adjusted multivariable logistic regression model indicated students that ran out of food were significantly at greater odds of experiencing hardship with paying bills (AOR: 5.59, 95% CI =3.90-8.06). The findings identified an increase in the prevalence of FI among college students during the pandemic. Suggestions of how to address FI are discussed. [ABSTRACT FROM AUTHOR]

Simple Summary: We evaluated the repurposing of a class of non-cancer drugs, phosphodiesterase inhibitors, to increase the potency of an anti-folate chemotherapy drug against non-small-cell lung cancer. We showed that this approach represents a double-edged strategy. While the use of phosphodiesterase inhibitors potentiated the killing of lung cancer cells by combination low-dose anti-folate chemotherapy, in half of the tumors evaluated, the benefit was lost when using higher doses of chemotherapy. Phosphosidesterases (PDEs) are key regulators of cyclic nucleotide signaling, controlling many hallmarks of cancer and playing a role in resistance to chemotherapy in non-small-cell lung cancer (NSCLC). We evaluated the anti-tumor activity of the anti-folate agent pemetrexed (PMX), alone or combined with biochemical inhibitors of PDE5, 8, 9, or 10, against squamous and non-squamous NCSLC cells. Genomic alterations to PDE genes (PDEmut) or PDE biochemical inhibition (PDEi) can sensitize NSCLC to PMX in vitro (observed in 50% NSCLC evaluated). The synergistic activity of PDEi with PMX required microdosing of the anti-folate drug. As single agents, none of the PDEis evaluated have anti-tumor activity. PDE biochemical inhibitors, targeting either cAMP or cGMP signaling (or both), resulted in significant cross-modulation of downstream pathways. The use of PDEi may present a new strategy to overcome PMX resistance of PDEwt NSCLC tumors but comes with important caveats, including the use of subtherapeutic PMX doses. [ABSTRACT FROM AUTHOR]

Background: Simulation-based learning activities have become more prevalent in prelicensure nursing curricula. When following the Simulation Standards of Best Practice, optimal learning conditions can be achieved, including the creation of a psychologically safe learning environment. Yet, the process of how students come to feel psychologically safe during a simulation experience remains unknown. Method: A grounded theory approach was used to conceptualize the basic social process by which nursing students feel psychologically safe during a simulation learning experience. Results: Six categories emerged from the data: (1) being nervous; (2) having a good instructor; (3) learning; (4) coming together; (5) being in debriefing; and (6) leaving on a positive note. The core category of putting myself out there emerged as the basic social process. Conclusion: The social process of psychological safety in simulation develops within nursing students as the result of interplay among several dimensions of the learning experience. [J Nurs Educ. 2024;63(7):427–433.] [ABSTRACT FROM AUTHOR]

Estimation of human water withdrawals is more important now than ever due to uncertain water supplies, population growth, and climate change. Fourteen percent of the total water withdrawal in the United States is used for public supply, typically including deliveries to domestic, commercial, and occasionally including industrial, irrigation, and thermoelectric water withdrawal. Stewards of water resources in the USA require estimates of water withdrawals to manage and plan for future demands and sustainable water supplies. This study compiled the most comprehensive conterminous United States water withdrawal data set to date and developed a machine learning framework for estimating public supply withdrawals and associated uncertainty for the period 2000–2020. The modeling approach provides service area resolution estimates to allow for annual and monthly water withdrawal estimation while incorporating a complex array of driving factors that include hydroclimatic, demographic, socioeconomic, geographic, and land use factors. Model results reveal highly variable and lognormally distributed per‐capita water withdrawal, spanning from 30 to 650 gallons per capita per day (GPCD), across community, regional, and national scales, with pronounced seasonal variations. Analysis of estimated withdrawal trends indicates that the national annual average withdrawal experienced a decline at a rate of 0.58 GPCD/year during the period from 2000 to 2020. Model interpretation reveals a complex interplay between public supply withdrawal and key predictors, including population size, warm‐season precipitation, counts of large buildings and houses, and areas of urban and commercial land use. The developed models can forecast future public supply driven by various climate, demographic, and socioeconomic scenarios. Key Points: Consistent, reproducible estimates of monthly water withdrawals were generated at the spatial resolution of USA water service areasSpatial and temporal variability of public supply withdrawal is driven by a complex array of explanatory featuresAn operational machine learning framework was developed to estimate water withdrawals, prediction uncertainty, and feature importance [ABSTRACT FROM AUTHOR]

Objectives Custodial grandparents are grandparents who raise grandchildren on a full-time basis in absence of the grandchild's birth parents. Compared to noncaregiving grandparents, custodial grandparents report poorer mental and physical health and stronger changes in daily well-being when experiencing negative and positive events. We examine whether an online social intelligence training (SIT) program improves custodial grandmothers' (CGM) daily well-being, socioemotional skills, and changes in well-being when confronted with daily negative and positive events. Methods Multilevel models were applied to 200 CGM who were recruited from across the United States and completed a daily survey for 14 consecutive days prior to and following participation in a randomized clinical trial. Participants were randomized into the SIT program or an attention control condition focusing on healthy living habits. The outcomes of interest were daily well-being, social connectedness, emotional awareness, and perspective-taking. Results Multilevel analyses revealed that participants who participated in the SIT program, compared to the attention control condition, exhibited stronger emotional responsiveness (i.e. improvements) to daily positive events in the outcomes of positive affect, social engagement, and perspective-taking. Discussion Our findings illustrate that SIT improves key components of daily functioning in CGM, which may serve as a pathway linking the demands of custodial grandparenting to poorer mental and physical health. Our discussion focuses on the utility and accessibility of the SIT program for helping improve outcomes for this disadvantaged population. Clinical Trials Registration Number: NCT03239977 [ABSTRACT FROM AUTHOR]

Introduction A surge of human influenza A(H7N9) cases began in 2016 in China from an antigenically distinct lineage. Data are needed about the safety and immunogenicity of 2013 and 2017 A(H7N9) inactivated influenza vaccines (IIVs) and the effects of AS03 adjuvant, prime-boost interval, and priming effects of 2013 and 2017 A(H7N9) IIVs. Methods Healthy adults (n = 180), ages 19–50 years, were enrolled into this partially blinded, randomized, multicenter phase 2 clinical trial. Participants were randomly assigned to 1 of 6 vaccination groups evaluating homologous versus heterologous prime-boost strategies with 2 different boost intervals (21 vs 120 days) and 2 dosages (3.75 or 15 μg of hemagglutinin) administered with or without AS03 adjuvant. Reactogenicity, safety, and immunogenicity measured by hemagglutination inhibition and neutralizing antibody titers were assessed. Results Two doses of A(H7N9) IIV were well tolerated, and no safety issues were identified. Although most participants had injection site and systemic reactogenicity, these symptoms were mostly mild to moderate in severity; injection site reactogenicity was greater in vaccination groups receiving adjuvant. Immune responses were greater after an adjuvanted second dose, and with a longer interval between prime and boost. The highest hemagglutination inhibition geometric mean titer (95% confidence interval) observed against the 2017 A(H7N9) strain was 133.4 (83.6–212.6) among participants who received homologous, adjuvanted 3.75 µg + AS03/2017 doses with delayed boost interval. Conclusions Administering AS03 adjuvant with the second H7N9 IIV dose and extending the boost interval to 4 months resulted in higher peak antibody responses. These observations can broadly inform strategic approaches for pandemic preparedness. Clinical Trials Registration. NCT03589807. [ABSTRACT FROM AUTHOR]

Haitian immigrant women living in the U.S. have a higher rate of cervical cancer mortality than any other ethnic group, primarily due to lower rates of screening test utilization. Therefore, it is important to understand the issues affecting their pap smear screening behaviors. We conducted a narrative review of articles from PubMed, SCOPUS, Embase, CINAHL/Nursing, and Psych Info. Inclusion criteria: U.S. Haitian immigrant, screening, cervical cancer, health beliefs/perceptions. Exclusion criteria: HPV-vaccine. Primary barriers: (1) lack of knowledge of cervical cancer, HPV, and pap smears; (2) lack of culturally appropriate dissemination of information; and (3) difficulty obtaining the test. Primary facilitators: (1) provider recommendations, (2) Haitian media to disseminate health information, and (3) having health insurance. This review highlights the points for intervention by health professionals and policy makers to address this group's low pap smear utilization. [ABSTRACT FROM AUTHOR]

The article explores the historical roots of executive clemency in the U.S. and its connection to the concept of mercy. It highlights the decline of clemency, particularly in capital cases, since the revival of the death penalty in 1976. It argue that this decline is linked to the constitutional regulation of capital punishment but suggest that clemency still plays a vital role in addressing deficiencies in the capital system.

In the United States, direct support professionals (DSPs) support people with intellectual and developmental disabilities (IDD) so they can live in the community. Thirty years of deinstitutionalization and the development of community living options would not have been possible without DSPs. Although life for people with IDD improved greatly, working conditions, wages/benefits, demands, stress/burnout, and trauma experienced by DSPs have worsened. Turnover and vacancy rates threaten the availability of community supports for too many people with IDD. DSPs from diverse racial, ethnic, linguistic, and cultural backgrounds face significant workplace disparities. These issues were discussed during the Research and Training Center on Community Living's 2022 State of the Science Conference. We propose important research questions needing solutions to continue constructively addressing these critical issues. [ABSTRACT FROM AUTHOR]

Objective: Responding to the National Institutes of Health Working Group's call for research on the psychological impact of stillbirth, we compared coping-related behaviors by outcome of an index birth (surviving live birth or perinatal loss – stillbirth or neonatal death) and, among individuals with loss, characterized coping strategies and their association with depressive symptoms 6–36 months postpartum. Methods: We used data from the Stillbirth Collaborative Research Network follow-up study (2006–2008) of 285 individuals who experienced a stillbirth, 691 a livebirth, and 49 a neonatal death. We conducted a thematic analysis of coping strategies individuals recommended following their loss. We fit logistic regression models, accounting for sampling and inverse probability of follow-up weights to estimate associations between pregnancy outcomes and coping-related behaviors and, separately, coping strategies and probable depression (Edinburgh Postnatal Depression Scale > 12) for those with loss. Results: Compared to those with a surviving live birth and adjusting for pre-pregnancy drinking and smoking, history of stillbirth, and age, individuals who experienced a loss were more likely to report increased drinking or smoking in the two months postpartum (adjusted OR: 2.7, 95% CI = 1.4–5.4). Those who smoked or drank more had greater odds of probable depression at 6 to 36 months postpartum (adjusted OR 6.4, 95% CI = 2.5–16.4). Among those with loss, recommended coping strategies commonly included communication, support groups, memorializing the loss, and spirituality. Discussion: Access to a variety of evidence-based and culturally-appropriate positive coping strategies may help individuals experiencing perinatal loss avoid adverse health consequences. Significance: What Is Already Known on this Subject?: Experiencing a perinatal loss (stillbirth or neonatal death) is a traumatic event with potential long term psychologic consequences. Effective coping strategies can prevent complicated grief; yet little is known about current practices and preferences among parents who experience perinatal loss. What this Study Adds?: In a population-based study, individuals who experienced perinatal loss reported higher maladaptive coping (increased smoking and drinking) compared to those with healthy live birth. Individuals who experienced perinatal loss recommended a wide range of coping including communication, memorializing the loss, spirituality, and support groups. [ABSTRACT FROM AUTHOR]

Background Customized and standard automated insulin delivery (AID) systems for use in pregnancies of women with preexisting type 1 diabetes (T1D) are being developed and tested to achieve pregnancy appropriate continuous glucose monitoring (CGM) targets. Guidance on the use of CGM for treatment decisions during pregnancy in the United States is limited. Methods Ten pregnant women with preexisting T1D participated in a trial evaluating at-home use of a pregnancy-specific AID system. Seven-point self-monitoring of blood glucose (SMBG) was compared to the closest sensor glucose (Dexcom G6 CGM) value biweekly to assess safety and reliability based on the 20%/20 mg/dL criteria. Results All participants completed the study with 7 participants satisfying the safety and reliability criteria with a mean absolute relative difference of 10.3%. Three participants did not fulfill the criteria, mainly because the frequency of SMBG did not meet the requirements. Conclusion Dexcom G6 CGM is safe and accurate in the real-world setting for use in pregnant women with preexisting T1D with reduced SMBG testing as part of a pregnancy-specific AID system. [ABSTRACT FROM AUTHOR]

Approximately 356 million limb amputations are performed globally every year. In 2005, the prevalence of limb loss in the United States was 1.6 million people; and it is estimated to increase to 3.6 million by 2050. Many postamputation patients experience chronically altered sensations and pain associated with the amputation, such as phantom limb pain. The risk factors for phantom limb pain are widely debated in the literature due to the heterogeneity of the population being studied. This review will highlight both the non-operative and operative risk factors for phantom limb pain. [ABSTRACT FROM AUTHOR]

This study compared word recognition for words written in a traditional flat font to the same words written in a three-dimensional appearing font determined to create a right hemispheric stimulation. The participants were emergent readers enrolled in Montessori schools in the United States learning to read basic CVC (consonant, vowel, consonant) words and who were being taught with similar educational methodology. Analysis of error types for readers in the lower 20th percentile showed that vowel or consonant substitutions were more frequent for males than females (p less than 0.07), errors in which the students rhymed the word incorrectly with the previous word were more frequent in males (p less than 0.026), and word guessing errors were more frequent in older students (p less than 0.022). Letter/word transpositions (e.g., b/p; t/f; whole word, such as nap/pan were moderately more frequent for traditional flat print words (p less than 0.043). Among the 23 students who scored in the lowest 10th percentile (fewer than 42 out of 52 traditional flat print words read correctly), 9 increased their score by at least 10% in the three-dimensional appearing font when compared to their traditional flat print score; 5 of them increased by at least 20%. The largest improvement was from 35 traditional flat print words to 44 three-dimensional appearing prints, which translates to a 25.7% gain. For the student at risk for either a specific learning disability in reading or dyslexia, the use of three-dimensional font may provide enough a right hemispheric catalyst to increase the number of words recognized and read correctly. (Contains 2 tables and 2 figures.)

This study reports the progress of a project in a teacher education program designed to deliver professional development to rural teachers through an online format addressing ESOL (English for speakers of other languages). Funded by a Professional Development Grant from the OELA (Office of English Language Acquisition) of the United States Department of Education, the project was conceived in response to a number of factors, commencing with the perceptions of teacher candidates in the program that they had not received sufficient coursework or field experience to prepare them to teach the growing numbers of ELLs (English language learners) they were encountering in their internship classrooms. While this signaled the need for curriculum revision, it also pointed out the need to improve the clinical classroom. Project LEAP (Leading Exceptional Annual Progress) was crafted to provide in-service teachers with professional development in ESOL, so that services to ELLs in the region would be improved and so that clinical placements for teacher candidates would model and support best practices for a diverse student body. Ongoing inquiry is reported, reflecting both baseline data and interim findings for the project. (Contains 2 tables.)

This article discusses the impact of the Standards for Foreign Language Teaching in the 21st Century on language programs at American universities. Surveys were administered to American students and to faculty at a university in Spain asking questions about the five goal areas of the standards. Responses from these groups were analyzed and compared with responses of faculty at American institutions. Although most faculty informants in the U.S. and in Spain said they were familiar with the goals of the standards, findings indicate that grammatical accuracy is perceived to be the primary focus of language programs in the U.S. Faculty in the U.S. reported that they felt underprepared to teach culture and communication skills and unsure of the role of linguistics in the development of students' language proficiency.

Trends in International Mathematics and Science Study raised the concern that the United States (US) mathematics teachers place less emphasis on topics and teach a variety of content strands (Goldsmith, Mark & Kantrov, 2000; Kerachsky, 2008). The overall pattern in the US mathematics classrooms today is that primary and upper elementary teachers cover numerous topics before students achieve mastery (Cogan & Schmidt, 1999; National Center for Education Statistics, 1997). To solve this problem, US teachers need to find ways to focus fewer curriculum and study topics with a more in-depth agenda. Curriculum Focal Points for pre-kindergarten through grade 8 mathematics: a quest for coherence (National Council of Teachers of Mathematics, 2006) provides a strong framework that may assist teachers in creating a more coherent and focused mathematics program for students. In this article, the authors discuss example lessons that were implemented and observed in pre-kindergarten, fourth grade and sixth grade classrooms during a year-long professional development program. The overarching goal of this program was to provide appropriate instruction for teachers to organize mathematics standards-based curriculum in geometry, algebra and measurement, using a curriculum that emphasizes a strong conceptual framework. As an outcome of this exploratory research agenda, the authors' intentions were to circulate "best practices" and encourage international connections and discussion when using Curriculum Focal Points (CFP) in global classrooms.

Jane Barker--poet, novelist, farm manager, student and practitioner of medical arts--was not allowed to attend university because she was a woman. Yet she was Oxford-educated in the most modern of medical theories of her time. By the end of her life, unmarried by choice, Barker was writing for pay under her own name in an emerging genre--the novel--and publicly challenging the dominance of male authors. Aspects of her life prompt reflection upon women in higher education leadership today: assumptions about women's competence in a male-dominated domain, personal decisions about marriage and childbearing, and the consequences and rewards of choosing the difficult career path. This essay is based on printed sources such as American Council of Education data (2009) and recent interviews with seventeen women leaders in private colleges and universities in the United States. The stories of these provosts and presidents illuminate challenges faced by women seeking and living in positions of authority and influence. These leaders negotiated suspicions that women could be decisive or have expertise in finance, and they were faced with difficult decisions as institutions responded to the late-2008 economic downturn. Women in this pool made a wide range of decisions about marriage, childbearing, and gender roles in a marriage. Generational and racial differences influenced their approaches to their work. Administrators, especially presidents, negotiated the isolation inherent in their positions. Concerns have arisen, in fact, that the constant scrutiny or "fishbowl" life of a president has decreased the traditional applicant pipeline of provosts. The essay concludes with an overview of women's choices about leadership in higher education today. (Contains 11 footnotes.)

In 1993, the first study of outcomes of auditory-verbal graduates was published in the Journal of the American Academy of Audiology (JAAA). The stated purpose of the research at that time "was to document the status of graduates of one aural habilitation option; auditory-verbal" (p. 190, Goldberg & Flexer). A follow-up study was published in 2001, also in JAAA, and findings of both studies revealed that the majority of the participants were integrated into regular/typical learning and living environments. The latter study suggested that the early fitting of sensory aids and cochlear implant technology, coupled with family-focused early intervention emphasizing auditory learning, helped to provide for even greater independence and community participation of these later graduates. Now, over 25 years after the initial auditory-verbal graduate study, this current research project replicates and provides an update of graduates of auditory-verbal teaching from around the world. (Participants in the earlier studies were solely from the United States and Canada.) Results from over 200 graduates continue to reinforce the positive outcomes reported in the earlier studies.

High on any required reading list for college-level student affairs officers and high school counselors is "Millennials Rising: The Next Great Generation" by Neil Howe and William Strauss (2000). Experts on generational change in the United States, the authors contend that the current generation of college-age and pre-college-age students possesses many unique qualities that will both delight and challenge professionals working at various stages of the educational continuum. According to Howe and Strauss (2000), members of five generations comprise the vast majority of the current U.S. population (with birth dates listed): the G.I. generation (1901-1924), the Silent generation (1925-1942), the Boom generation (1943-1960), Generation X (1961-1981), and the Millennial generation (1982-2002). This newest generational cohort, the Millennials, builds upon the values instilled by the Baby Boomers while also filling the cultural void left by the departing G.I. generation.