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Objective The United States carries a diverse Latinx population. This population largely consists of Mexicans however, there has been a population decrease since 2010. Though, the Guatemalan population has increased since 2010 and has become the third most growing population in the United States. Previous research shows that level of acculturation influences neuropsychological test performance. The Córdoba Naming Test (CNT) is a confrontation naming test created for Spanish-speakers. We examined the relationship between acculturation and CNT performance in a Latinx sample that immigrated to the United States. Method The sample consisted of 44 Mexicans and 14 Guatemalans that were neurologically and psychologically healthy residents. All the participants completed the CNT and the Abbreviated Multidimensional Acculturation Scale (AMAS) in Spanish. ANOVAs were used to examine CNT performance and acculturation on the AMAS subscales. Results Results revealed the Guatemalan immigrant group outperformed the Mexican immigrant group on the CNT, p = 0.035, ηp2 = 0.08. Additionally, we found that on the English language subscale of the AMAS, the Mexican immigrant group reported higher English language levels than the Guatemalan immigrant group, p = 0.002, ηp2 = 0.16. Conclusion Our findings showed that Guatemalans demonstrated better CNT performance compared to Mexicans. To our knowledge, this is the first study to examine confrontation naming performance in a Latinx immigrant sample. Furthermore, we found that Mexicans reported higher English language compared to Guatemalans. Future research on the CNT with larger samples should investigate possible interactions between acculturation and other cultural variables (e.g. bilingualism) in the interpretation of test performance in a Latinx immigrant population. [ABSTRACT FROM AUTHOR]