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Background The evidence that influenza vaccination programs regularly provide protection to unvaccinated individuals (ie, indirect effects) of a community is lacking. We sought to determine the direct, indirect, and total effects of influenza vaccine in the Household Influenza Vaccine Evaluation (HIVE) cohort. Methods Using longitudinal data from the HIVE cohort from 2010–11 through 2017–18, we estimated direct, indirect, and total influenza vaccine effectiveness (VE) and the incidence rate ratio of influenza virus infection using adjusted mixed-effect Poisson regression models. Total effectiveness was determined through comparison of vaccinated members of full or partially vaccinated households to unvaccinated individuals in completely unvaccinated households. Results The pooled, direct VE against any influenza was 30.2% (14.0–43.4). Direct VE was higher for influenza A/H1N1 43.9% (3.9 to 63.5) and B 46.7% (17.2 to 57.5) than A/H3N2 31.7% (10.5 to 47.8) and was higher for young children 42.4% (10.1 to 63.0) than adults 18.6% (−6.3 to 37.7). Influenza incidence was highest in completely unvaccinated households (10.6 per 100 person-seasons) and lower at all other levels of household vaccination coverage. We found little evidence of indirect VE after adjusting for potential confounders. Total VE was 56.4% (30.1–72.9) in low coverage, 43.2% (19.5–59.9) in moderate coverage, and 33.0% (12.1 to 49.0) in fully vaccinated households. Conclusions Influenza vaccines may have a benefit above and beyond the direct effect but that effect in this study was small. Although there may be exceptions, the goal of global vaccine recommendations should remain focused on provision of documented, direct protection to those vaccinated. [ABSTRACT FROM AUTHOR]

There is growing evidence for the adverse health effects of structural and individual forms of discrimination in multiple religious, ethnic, and racial groups. Since the September 11, 2001 terrorist attacks, Arab Americans have experienced increasingly more frequent and visible forms of discrimination. However, the impact of these experiences on their mental well-being requires further investigation. This study examines the association between perceived discrimination and several markers of mental health and well-being, using cross-sectional data from a convenience sample of 279 Arab American adults from southeast Michigan. After adjustment for a series of relevant confounders, perceived discrimination was significantly associated with depressive symptoms (estimate 0.93, 95% CI 0.53, 1.34, p < 0.01), anxiety symptoms (estimate 0.48, 95% CI 0.19, 0.77, p < 0.01), and poor self-rated health (OR 1.31, 95% CI 1.08, 1.58, p < 0.01). The study highlights the need to address and mitigate health disparities among individuals of Arab descent and improves awareness of the potential health effects of ongoing structural and interpersonal discrimination toward this population.