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The California Psychological Inventory's Dominance scale was investigated for inconsistencies in item-trait associations across four samples (one American normative and three culturally dissociated manager groupings). The Kim, Cohen, and Park procedure was used, enabling simultaneous multigroup comparison in addition to the traditional differential item functioning focus on paired-group contrasts. Framing comparisons within Hofstede's cultural dimensions, Dominance construct-item association inconsistencies were predicted to occur across Indian manager responses (when contrasted relatively with U.S. and U.K. responses). Results are consistent with the Hofstede predictions and have particular implications for empirically keyed assessments, multigroup contrasts, the cross-cultural expression of individual differences, and the generalizability of trait definitions across cultures. (Contains 1 figure and 1 table.)

Background Monoclonal antibodies (mAbs) against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are a promising treatment for limiting the progression of coronavirus disease 2019 (COVID-19) and decreasing strain on hospitals. Their use, however, remains limited, particularly in disadvantaged populations. Methods Electronic health records were reviewed from SARS-CoV-2 patients at a single medical center in the United States that initiated mAb infusions in January 2021 with the support of the US Department of Health and Human Services' National Disaster Medical System. Patients who received mAbs were compared with untreated patients from the time period before mAb availability who met eligibility criteria for mAb treatment. We used logistic regression to measure the effect of mAb treatment on the risk of hospitalization or emergency department (ED) visit within 30 days of laboratory-confirmed COVID-19. Results Of 598 COVID-19 patients, 270 (45%) received bamlanivimab and 328 (55%) were untreated. Two hundred thirty-one patients (39%) were Hispanic. Among treated patients, 5/270 (1.9%) presented to the ED or required hospitalization within 30 days of a positive SARS-CoV-2 test, compared with 39/328 (12%) untreated patients (P  < .001). After adjusting for age, gender, and comorbidities, the risk of ED visit or hospitalization was 82% lower in mAb-treated patients compared with untreated patients (95% CI, 56%–94%). Conclusions In this diverse, real-world COVID-19 patient population, mAb treatment significantly decreased the risk of subsequent ED visit or hospitalization. Broader treatment with mAbs, including in disadvantaged patient populations, can decrease the burden on hospitals and should be facilitated in all populations in the United States to ensure health equity. [ABSTRACT FROM AUTHOR]

ABSTRACT: In the final decades of the nineteenth century, concern was building about the status of migratory bird populations in North America. In this literature review, we describe how that concern led to a landmark conservation agreement in 1916, between the United States and Great Britain (on behalf of Canada) to conserve migratory birds shared by Canada and the United States. Drawing on published literature and our personal experience, we describe how subsequent enabling acts in both countries gave rise to efforts to better estimate population sizes and distributions, assess harvest rates and demographic impacts, design and fund landscape‐level habitat conservation initiatives, and organize necessary political and regulatory processes. Executing these steps required large‐scale thinking, unprecedented regional and international cooperation, ingenuity, and a commitment to scientific rigor and adaptive management. We applaud the conservation efforts begun 100 years ago with the Migratory Bird Treaty Convention. The agreement helped build the field of wildlife ecology and conservation in the twentieth century but only partially prepares us for the ecological and social challenges ahead. © 2017 The Wildlife Society. [ABSTRACT FROM AUTHOR]

Overhydration is reported to be the main cause of hypertension (HTN) and to have no association with HTN in hemodialysis (HD) population. This is the first report of the relationship between interdialytic weight gain (IDWG) and pre-HD blood pressure (BP) in pediatric patients in relation to residual urine output (RUO). We studied 170 HD sessions and interdialytic periods performed during a 12-week period in 5 patients [age 4–17 years, weight 20.8–66 kg, 3 anuric (102 HD sessions), and 2 nonanuric (68 HD sessions)] were studied. BP is presented as systolic BP index (SBPI) and diastolic BP index (DBPI), calculated as systolic or diastolic BP/95th percentile for age, height, and gender. IDWG did not differ (P>0.05) between anuric and nonanuric pts. There was a positive but not significant correlation between IDWG and both pre-HD SBPI (r=0.833, P=0.080) and pre-HD DBPI (r=0.841, P=0.074). Pre-HD SBPI (1.01±0.12 versus 1.13±0.18) and DBPI (0.92±0.16 versus 1.01±0.24) were higher in nonanuric patents (P<0.001 and P<0.01, resp.). Pre-HD HTN may not be solely related to IDWG and therapies beyond fluid removal may be needed. Individualized approach to HTN management is necessary in pediatric dialysis population. [ABSTRACT FROM AUTHOR]

Objective: To determine macronutrients and micronutrients in foods served to and consumed by children at child-care centres in Oklahoma, USA and compare them with Dietary Reference Intakes (DRI).Design: Observed lunch nutrients compared with one-third of the age-based DRI (for 1-3 years-olds and 4-8-year-olds). Settings Oklahoma child-care centres (n 25), USA.Subjects: Children aged 3-5 years (n 415).Results: Regarding macronutrients, children were served 1782 (sd 686) kJ (426 (sd 164) kcal), 22·0 (sd 9·0) g protein, 51·5 (sd 20·4) g carbohydrate and 30·7 (sd 8·7) % total fat; they consumed 1305 (sd 669) kJ (312 (sd 160 kcal), 16·0 (sd 9·1) g protein, 37·6 (sd 18·5) g carbohydrate and 28·9 (sd 10·6) % total fat. For both age-based DRI: served energy (22-33 % of children), protein and carbohydrate exceeded; consumed energy (7-13 % of children) and protein exceeded, while carbohydrate was inadequate. Regarding micronutrients, for both age-based DRI: served Mg (65·9 (sd 24·7) mg), Zn (3·8 (sd 11·8) mg), vitamin A (249·9 (sd 228·3) μg) and folate (71·9 (sd 40·1) µg) exceeded; vitamin E (1·4 (sd 2·1) mg) was inadequate; served Fe (2·8 (sd 1·8) mg) exceeded only in 1-3-year-olds. Consumed folate (48·3 (sd 38·4) µg) met; Ca (259·4 (sd 146·2) mg) and Zn (2·3 (sd 3·0) mg) exceeded for 1-3-year-olds, but were inadequate for 4-8-year-olds. For both age-based DRI: consumed Fe (1·9 (sd 1·2) mg) and vitamin E (1·0 (sd 1·7) mg) were inadequate; Mg (47·2 (sd 21·8) mg) and vitamin A (155·0 (sd 126·5) µg) exceeded.Conclusions: Lunch at child-care centres was twice the age-based DRI for consumed protein, while energy and carbohydrate were inadequate. Areas of improvement for micronutrients pertain to Fe and vitamin E for all children; Ca, Zn, vitamin E and folate for older pre-schoolers. Adequate nutrients are essential for development and the study reveals where public health nutrition experts, policy makers and care providers should focus to improve the nutrient density of foods. [ABSTRACT FROM AUTHOR]

In this article, the author introduces defenders of the battle of Alamo, a part of Texas's war 1836, including David Crockett, James Bowie and James Butler Bonham, discusses their contribution in the war and highlights the impact of Mexican immigration law on the war.

The article discusses several developments involving anti-money laundering laws in the U.S. as of 2015, and it mentions statutory history, organized crime-related laws, and legislation such as America's Bank Secrecy Act and the country's Comprehensive Crime Control Act of 1984.

The article offers information on the significance of the Leahy-Smith America Invents Act (AIA), which enhances the value of U.S. provisional and non-provisional patent applications (PPAs and NPAs) to foreign applicants in the U.S. It discusses traditional benefits to foreign filers of PPAs including term extension, cost-efficiency and secrecy of applicants. Topics discussed include the implementation for the GATT, patent laws and the significance of the European Patent Office (EPO).

Background: Single-center studies suggest an increasing incidence of acute pancreatitis (AP) in children. Our specific aims were to (i) estimate the recent secular trends, (ii) assess the disease burden, and (iii) define the demographics and comorbid conditions of AP in hospitalized children within the United States. Methods: We used the Healthcare Cost and Utilization Project Kids’ Inpatient Database, Agency for Healthcare Research and Quality for the years 2000 to 2009. Extracted data were weighted to generate national-level estimates. We used the Cochrane-Armitage test to analyze trends; cohort-matching to evaluate the association of AP and in-hospital mortality, length of stay, and charges; and multivariable logistic regression to test the association of AP and demographics and comorbid conditions. Results: We identified 55,012 cases of AP in hospitalized children (1–20 years of age). The incidence of AP increased from 23.1 to 34.9 (cases per 10,000 hospitalizations per year; P<0.001) and for all-diagnoses 38.7 to 61.1 (P<0.001). There was an increasing trend in the incidence of both primary and all-diagnoses of AP (P<0.001). In-hospital mortality decreased (13.1 to 7.6 per 1,000 cases, P<0.001), median length of stay decreased (5 to 4 days, P<0.001), and median charges increased ($14,956 to $22,663, P<0.001). Children with AP compared to those without the disease had lower in-hospital mortality (adjusted odds ratio, aOR 0.86, 95% CI, 0.78–0.95), longer lengths of stay (aOR 2.42, 95% CI, 2.40–2.46), and higher charges (aOR 1.62, 95% CI, 1.59–1.65). AP was more likely to occur in children older than 5 years of age (aORs 2.81 to 5.25 for each 5-year age interval). Hepatobiliary disease was the comorbid condition with the greatest association with AP. Conclusions: These results demonstrate a rising incidence of AP in hospitalized children. Despite improvements in mortality and length of stay, hospitalized children with AP have significant morbidity. [ABSTRACT FROM AUTHOR]

Heavier vehicles are safer for their own occupants but more hazardous for other vehicles. Simple theory thus suggests that an unregulated vehicle fleet is inefficiently heavy. Using three separate identification strategies we show that, controlling for own-vehicle weight, being hit by a vehicle that is 1000 pounds heavier generates a 40–50% increase in fatality risk. These results imply a total accident-related externality that exceeds the estimated social cost of US carbon emissions and is equivalent to a gas tax of $0.97 per gallon ($136 billion annually). We consider two policies for internalizing this external cost, a weight-varying mileage tax and a gas tax, and find that they are similar for most vehicles. The findings suggest that European gas taxes may be much closer to optimal levels than the US gas tax. [ABSTRACT FROM PUBLISHER]

We offer insights on how distance-related trade costs may best be inferred from price-dispersion measures. Using a simple spatial model of price dispersion, we argue that measures of price dispersion that are not spatially informed can mislead researchers into concluding that distance-related costs are small even when such costs are the major determinant of price dispersion. With intra-United States data on eleven goods, we find that distance-related costs are large and are indeed underestimated when inferred from standard, non-spatial, price dispersion measures. Our empirical findings have implications for studies of market integration policies (such as trade liberalization and currency unions) and the significance of economic geography. [ABSTRACT FROM AUTHOR]

Respiratory syncytial virus (RSV) infection of the lower respiratory tract is the leading cause of respiratory failure among infants in the United States of America and annually results in >300,000 deaths worldwide. Despite the importance of RSV, there is no licensed vaccine, and no specific form of therapy. This is largely due to the absence of an appropriate animal model for the evaluation of vaccines and therapeutic agents. We inoculated anesthetized infant (4 wk) baboons (Papio anubis) with a human strain of RSV intranasally or intratracheally. Baboons were monitored daily for clinical changes. Anesthetized baboons were intubated at various intervals, and bronchoalveolar lavage (BAL) was performed for viral culture and determination of leukocyte counts. Sham-infected baboons served as controls. Necropsies were performed on infected baboons on days 1, 3, 5, 8, or 13 after inoculation, with pathological analysis and immunohistochemical staining of lung tissues to detect RSV antigen. Infected baboons developed tachypnea and reduced oxygenation peaking from 4 to 8 days after infection and persisting for ≥14 days. Virus was recoverable in BAL fluid up to 8 days following infection. Necropsy revealed intense interstitial pneumonia, sloughing of the bronchiolar epithelium, and obstruction of the bronchiolar lumen with inflammatory cells and sloughed epithelial cells. RSV antigen was identified in bronchiolar and alveolar epithelium. We conclude that RSV-infected infant baboons develop clinical and pathological changes that parallel those observed in human infants with RSV infection. The infant baboon represents a much-needed model for studying the pathogenesis of RSV infection and evaluating antivirals and vaccines. [ABSTRACT FROM AUTHOR]

The nematode community inhabiting the mantle cavity of quagga mussels, Dreissena rostriformis bugensis, in Copper Basin Reservoir and Lake Skinner was quantified and compared for the first time with the nematode community from the periphyton surrounding the mussels. Nematode species inhabiting the mantle cavity were also found in the periphyton, while the periphyton community always contained more species than the mantle cavity. Chromadorina bioculata was the dominant species in the mantle cavity and periphyton community in Lake Skinner and Copper Basin Reservoir. Our results suggest that nematodes found inside the mantle cavity of the mollusc do not have obligate symbiotic relationship with quagga mussels, but that they are free-living, entering from the periphyton community into the mantle cavity of the mussel, exhibiting neutralism. [ABSTRACT FROM AUTHOR]

Bermudagrass ( Cynodon spp.) is extensively cultivated for forage and turf in the the southern United States and in parts of Asia, Africa, southern Europe, Australia and South America. However, few simple sequence repeat (SSR) markers are available for bermudagrass genetics research. Accordingly, the objective of this study was to develop SSR markers in bermudagrass by transferring sorghum genomic SSR primers and by exploring bermudagrass expressed sequence tags (ESTs) from the National Center for Biotechnology Information (NCBI) database. The transferability of 354 tested sorghum SSRs was 57% to C. transvaalensis T577 (2n = 2 x = 18), 27% to C. dactylon Tifton 10 (2n = 6 x = 54) and 22% to Zebra (2n = 4 x = 36). Among the transferred SSRs, 65 primer pairs generated reproducible SSR bands across the three genotypes. From 20,237 Cynodon ESTs at NCBI, 303 designed SSR primer pairs amplified target bands in at least one of C. dactylon var. aridus (2n = 2 x = 18), C. transvaalensis T577, C. dactylon cv. Tifton 10, and C. dactylon var. dactylon Zebra. Of the effective EST SSRs, 230 primer pairs produced reproducible bands in all four genotypes. The study demonstrated that EST sequences and sorghum SSR primers are useful sources for the development of SSR markers for bermudagrass. The developed SSR markers will make a valuable contribution to the molecular identification of commercial cultivars, construction of genetic maps, and marker-assisted breeding in bermudagrass. [ABSTRACT FROM AUTHOR]

The article focuses on the Americans with Disabilities Act (ADA) and how issues concerning the Internet are affecting the elderly population. It argues that although the ADA guarantees equal access to employment, retail and other places of public accommodation to the elderly and disabled, its legal interpretation does not consider the Internet as a place. Challenges are also faced by elderly Internet users because of age-related disabilities like age vision impairment.

The understanding of Cd impacts to avian species has been improved by recent studies and the extensive literature review completed as part of the development of the U.S. Environmental Protection Agency's Ecological Soil Screening Levels (Eco-SSLs). Therefore, we sought to update the Cd toxicity reference value (TRV) for birds used by regulatory agencies and resource trustees in California for predictive ecological risk assessments. We surveyed the available literature sources, particularly TRVs between the currently used TRV (0.08 mg/kg/d) and the Eco-SSL TRV (1.47 mg/kg/d) to identify the lowest, ecologically relevant no observed adverse effect levels (NOAELs) for oral exposure of birds to Cd. As a result, we identified an ecologically protective NOAEL TRV of 0.7 mg/kg/d, based primarily on renal effects in wood ducks, but supported by another study with both renal and reproductive endpoints. In addition, a lowest observed adverse effect level (LOAEL) of 1.0 mg/kg/d was selected based on kidney nephrosis in mallards. Overall, these updated TRVs incorporate more recent studies on Cd toxicity in birds while establishing thresholds based on ecologically relevant endpoints. [ABSTRACT FROM AUTHOR]

The article presents a profile and examination into the life and active involvement of Lorraine Hansberry with the African American journal "Freedom" and her political activism. It discusses the early career of Hansberry in the publication, highlighting its role in her personal transition from a political activist to an artist, and her shift from communist advocacy to the international human rights movement. Further attention is given to the contributions of Hansberry in the field of advocacy journalism in the mid 20th-century.

In this article the author considers an aspect of the motion picture "Déjà Vu," directed by Tony Scott. The central focus of the article is the narrative structure of the film, in which Scott allows the plot to unfold through diegesis, that is, the use of a narrator to described the action, rather than letting the images speak for themselves. In addition, the action depicted in "Déjà Vu," is analyzed with reference to traumatic events that have taken place in the United States such as the Oklahoma City bombing, the September 11, 2001 terror attacks, and Hurricane Katrina.

Light trucks have doubled their share of the vehicle fleet from 1980 to 2004. This paper examines the effects of this increase on traffic safety, combining estimates from a state-level panel data set with an accident-level micro-data set. The results suggest that a one-percentage point increase in light truck share raises annual traffic fatalities by 0.34%, or 143 deaths per year. Of this increase, approximately one-fifth accrue to the light trucks' own occupants, and the remaining four-fifths accrue to the occupants of other vehicles and pedestrians. Using standard value of life figures, the implied Pigovian tax is approximately 3850 dollars per light truck sold. Overall, light trucks pose a significant hazard to other users of the highway system but on average provide no additional protection to their own occupants. [ABSTRACT FROM AUTHOR]

Thirty faculty in randomly selected Commission on Accreditation for Marriage and Family Therapy Education (COAMFTE) programs representing four geographical regions of the United States were asked to respond to a survey that included seven brief vignettes depicting gatekeeping and remediation challenges supervisors may face when working with therapists-in-training. Research participants were asked to select from among a range of 17 response options and were also asked to provide a rationale for the selection of their responses. The response rate for the mailed survey was 34%. Telephone interviews were conducted with three respondents who had provided especially detailed responses to the open-ended portions of the mailed survey and who also volunteered to be questioned regarding how supervision decisions are made. Results support the conclusion that COAMFTE faculty take their gatekeeping function seriously as they balance commitments to multiple stakeholders. When presented with hypothetical “bare-bones” vignettes, the supervisors in our study consistently recommended talking with the student in order to more fully understand the context of the student’s performance problem before deciding how to proceed. Supervisors recommended a variety of remediation efforts, but reserved the most severe consequences, such as probation, dismissal, and filing an ethics complaint, for the vignette involving dishonesty and lack of personal integrity. [ABSTRACT FROM AUTHOR]

Declining fall flows are limiting the ability of the Cosumnes River to support large fall runs of Chinook salmon. Management scenarios linking surface water and groundwater alternatives to provide sufficient fall flows are examined using groundwater flow and channel routing models. Results show that groundwater overdraft in the basin has converted the river to a predominantly losing stream, practically eliminating base flows. Management alternatives to increase net recharge (for example, pumping reductions) were examined along with surface water augmentation options. Using a minimum depth standard for fish passage, average surface water flow deficits were computed for the migration period of Chinook salmon. Groundwater deficits were evaluated by comparing simulated current groundwater conditions with conditions under various scenarios. Increases in net recharge on the order of 200 to 300 million m3/year would be required to reconnect the regional aquifer with the channel and in turn reestablish perennial base flows. Options that combine surface water augmentation with groundwater management are most likely to ensure sufficient river flows in the short term and to support long-term restoration of regional groundwater levels. [ABSTRACT FROM AUTHOR]

As a part of a study examining alternatives for flow augmentation for fall run Chinook salmon migration on the Cosumnes River, California, two models were constructed to simulate channel flow combined with seepage losses. The first model is a numerical, one-dimensional diffusion wave approximation of the St. Venant equations coupled to a seepage routine that uses either a Green and Ampt infiltration routine or a head-based seepage routine that can handle seepage to or from the channel. The second model uses an analytical solution to the diffusion wave approximation of the St. Venant equations and also incorporates the Green and Ampt method to represent losses due to seepage for the simulation of flow over a dry riverbed. The two models are used to simulate low flow periods in the Michigan Bar to McConnell reach of the Cosumnes River in order to determine flows associated with a minimum depth necessary for fall run Chinook salmon migration. These computed flows were compared against historical data in order to determine volumes of flow augmentation for the time period October through December which corresponds to the spawning period of fall run Chinook salmon. Computed flow augmentation volumes were compared with available reservoir storage in the watershed in order to determine if such flow augmentation would be possible. Both models proved capable of simulating low flow periods on the Cosumnes River. During dry years, the computed flow augmentation volumes represent a significant percentage of the available reservoir storage, indicating that augmentation flows may not always be possible for the entire time period from this source alone. [ABSTRACT FROM AUTHOR]

Investigates why manufacturing employment contracted more rapidly in New York and New Jersey than in the rest of the United States between 1969 and 1999. Likely explanation for the region's weak manufacturing performance; Statistical model to examine whether manufacturing dispersion can account for the steep job losses; Local industry trends.

Presents a study on the Canada-United States (U.S.) border's effect on trade. Estimation of the size of the border effect with a dataset for 1990 province-U.S. trade; Model specification; Results and conclusion.

Presents a study which assessed two United States aerospace companies in order to examine technology strategy in defence industry acquisitions. Identification of the companies; What were the companies' motivates and rationale behind their acquisitions; Comparison of the companies' strategies.

Objectives The objective was to estimate emergency department ( ED) visits for Clostridium difficile infection in the United States for the years 2006 through 2010. Methods Estimates of ED visits for C. difficile infection were calculated in patients 18 years and older using the Nationwide Emergency Department Sample. Results During the calendar years 2006 through 2010, there were an estimated total of 491,406,018 ED visits. Of these, 462,160 ED visits were associated with a primary International Classification of Diseases, Ninth Revision, Clinical Modification diagnosis of C. difficile. The C. difficile infection ED visit rate (visits/100,000 census population) increased from 34.1 in 2006 to 42.3 in 2010, an increase of 24% (p < 0.01). There was also a significant overall increased trend in the number of ED visits for C. difficile from 2006 through 2010 (p < 0.01). The highest ED visit rate for C. difficile was observed for patients 65 years and older (163.18 per 100,000), while the lowest visit rate was for patients aged 18 to 24 years (5.10 per 100,000). The greatest increase in C. difficile infection visits occurred in the age group 18 to 24 years. Conclusions These results indicate an increased trend of ED visits for C. difficile in the period 2006 through 2010 with an overall population-adjusted increase of 24%. This represents important complementary data to previous studies reporting an increase in the rate of C. difficile infections in the U.S. hospitalized population. [ABSTRACT FROM AUTHOR]

Discusses the benefits of U.S. Department of Agriculture Forest Service's administrative appeals process. Role in giving Forest Service officials in reviewing and correcting controversial decisions be lower-level agency managers; Role in reducing the need for litigation by providing an alternative means of dispute resolution.

Although most health care providers will go through their careers without experiencing a major disaster in their local communities, if one does occur, it can be life and career altering. The American Academy of Pediatrics has been at the forefront of providing education and advocacy on the critical importance of disaster preparedness. From experiences over the past decade, new evidence and analysis have broadened our understanding that the concept of preparedness is also applicable to addressing the unique professional liability risks that can occur when caring for patients and families during a disaster. In our recommendations in this policy statement, we target pediatric health care providers, advocates, and policy makers and address how individuals, institutions, and government can work together to strengthen the system of liability protections during disasters so that appropriate and timely care can be delivered with minimal fear of legal reprisal or confusion. [ABSTRACT FROM AUTHOR]

Abstract: The Mid-Atlantic region in the United States (US) is composed of a diverse range of gradients across its natural and human systems. These gradients encompass heavily urbanized population centers, agriculture dominated valleys, reforested headwaters, and some of the most important estuaries in North America. The Mid-Atlantic Watershed Atlas (MAWA) portal has been developed to encourage public access and use of a wide range of freely available data resources. Moreover, the system has been designed to facilitate emergent geospatial tagging to identify the individuals, groups, and agencies shaping the region''s water resources. The goal of the system is to facilitate improved regional watershed knowledge, provide information to individual stakeholders, and support broad regional initiatives. [Copyright &y& Elsevier]

The article discusses several considerations governing the generation, transportation, storage and release of hazardous substances in the U.S. The purchase of transportation service requires an expertise in both Environmental Protection Agency (EPA) and Department of Transportation (DOT) regulations. Traffic managers are usually well versed in DOT provisions and in the purchase of transportation service but not in environmental regulations. For these reasons, the most efficient purchase of waste transportation service occurs through a team effort with the traffic manager utilizing transportation knowledge and expertise with those trained in EPA regulatory compliance.

Lung cancer is one of the most deadly cancers in the USA, and despite multiple modalities of treatment, the 5 year survival rate remains <20%. Given these outcomes, new treatment options that selectively kill cancer cells, as well as hypoxic cells and early progenitor cancer stem cells, are urgently needed. Disulfiram (DSF) is an FDA approved redox active Cu chelating drug that may be repurposed for cancer therapy. Clonogenic survival assays showed that low concentrations of DSF (50-150 nM) combined with physiologically relevant concentrations of copper (15 µM CuSO 4 ) are selectively toxic to lung cancer cells versus normal bronchial epithelial cells. Furthermore, the cancer cell toxicity of DSF is exacerbated at 1% O 2 , relative to 4 or 21% O 2 . DSF acts as a copper ionophore, and DSF treatment significantly increased total Cu levels, with higher Cu levels present in tumor versus normal cells and in cancer cells at 1% O 2 versus 21% O 2 . Treatment of cancer cells with a copper chelator [bathocuproinedisulfonic acid (BCS)] as well as a superoxide dismutase (SOD) mimetic (GC4419) was shown to inhibit DSF toxicity, suggesting that redox cycling of Cu contributed to toxicity. DSF was also shown to enhance radiation and chemotherapy-induced cancer cell killing and reduce chemotherapy resistance under hypoxia. DSF also inhibited increases in %ALDH+ cancer stem cells in bulk populations exposed to radiation and enhanced radiation toxicity in both ALDH+ and ALDH- cells. Finally, DSF caused decreased lung cancer xenograft growth and protected mice from weight loss during treatment with carboplatin and radiation. These results suggest that DSF is a promising adjuvant for cancer therapy based on its ability to selectively target fundamental differences in oxidative metabolism of Cu in cancer versus normal cells. [ABSTRACT FROM AUTHOR]

Adaptive management (AM) is being employed in a number of programs in the United States to guide actions to restore aquatic ecosystems because these programs are both expensive and are faced with significant uncertainties. Many of these uncertainties are associated with prioritizing when, where, and what kind of actions are needed to meet the objectives of enhancing ecosystem services and recovering threatened and endangered species. We interviewed nine large-scale aquatic ecosystem restoration programs across the United States to document the lessons learned from implementing AM. In addition, we recorded information on ecological drivers (e.g., endangered fish species) for the program, and inferred how these drivers reflected more generic ecosystem services. Ecosystem services (e.g., genetic diversity, cultural heritage), albeit not explicit drivers, were either important to the recovery or enhancement of the drivers, or were additional benefits associated with actions to recover or enhance the program drivers. Implementing programs using AM lessons learned has apparently helped achieve better results regarding enhancing ecosystem services and restoring target species populations. The interviews yielded several recommendations. The science and AM program must be integrated into how the overall restoration program operates in order to gain understanding and support, and effectively inform management decision-making. Governance and decision-making varied based on its particular circumstances. Open communication within and among agency and stakeholder groups and extensive vetting lead up to decisions. It was important to have an internal agency staff member to implement the AM plan, and a clear designation of roles and responsibilities, and long-term commitment of other involved parties. The most important management questions and information needs must be identified up front. It was imperative to clearly identify, link and continually reinforce the essential components of an AM plan, including objectives, constraints, uncertainties, hypotheses, management actions, decision criteria and triggers, monitoring, and research. Some employed predictive models and the results of research on uncertainties to vet options for actions. Many relied on best available science and professional judgment to decide if adjustments to actions were needed. All programs emphasized the need to be nimble enough to be responsive to new information and make necessary adjustments to management action implementation. We recommend that ecosystem services be explicit drivers of restoration programs to facilitate needed funding and communicate to the general public and with the global efforts on restoring and conserving ecosystems. [ABSTRACT FROM AUTHOR]

Background: Without highly qualified nurse anesthesia educators and administrators, the health care system will be threatened by the inadequate supply of certified registered nurse anesthetists (CRNAs)., Purpose: American Association of Nurse Anesthesiologists' Faculty Stabilization Task Force (FSTF) analyzed reasons for high faculty turnover and developed recommendations to support nurse anesthesia faculty and administrators., Methods: A survey evaluated participants' current role, leadership development opportunities, mentorship experiences, and resource needs., Results: Of 109 respondents, 87 (80%) were program administrators or assistant administrators with less than 5 years of experience in their role. Despite academic experience, 51% felt adequately prepared for their role., Conclusions: The FSTF provided 2 recommendations: to create a robust faculty development program for all faculty at all levels of CRNA education and a repository of information needed for program administrators and faculty to oversee and educate students in a high-quality CRNA program., Competing Interests: The authors declare no conflicts of interest., (Copyright © 2023 The Authors. Published by Wolters Kluwer Health, Inc.)

Background: High-need, high-cost Medicare patients can have difficulties accessing office-based primary care. Home-based primary care (HBPC) can reduce access barriers and allow a clinician to obtain valuable information not obtained during office visit, possibly leading to reductions in hospital use., Objective: To determine whether HBPC for high-need, high-cost patients reduces hospitalizations and Medicare inpatient expenditures., Design: We conducted a matched retrospective cohort study using a difference-in-differences analysis to examine patients 2 years before and 2 years after their first home visit (HBPC group)., Participants: The study included high-need, high-cost fee-for-service Medicare patients without prior HBPC use, of which 55,303 were new HBPC recipients and 156,142 were matched comparison patients., Intervention: Receipt of at least two HBPC visits and, within 6 months of the index HBPC visit, a majority of a patient's primary care visits in the home., Main Measures: Total and potentially avoidable hospitalizations and Medicare inpatient expenditures., Key Results: HBPC reduced total hospitalization rates, but the marginal effects were not statistically significant: a reduction of 11 total hospitalizations per 1000 patients in the first year (- 0.6%, p = 0.19) and 14 in the second year (- 0.7%, p = 0.16). However, HBPC reduced potentially avoidable hospitalization rates in the second year. The estimated marginal effect was a reduction of 6 potentially avoidable hospitalizations per 1000 patients in the first year (- 1.6%, p = 0.16) and 11 in the second (- 3.1%, p = 0.01). The estimated effect of HBPC was a small decrease in inpatient expenditures of $24 per patient per month (- 1.1%, p = 0.10) in the first year and $0 (0.0%, p = 0.99) in the second., Conclusions: After high-need, high-cost patients started receiving HBPC, they did not experience fewer total hospitalizations or lower inpatient spending but may have had lower rates of potentially avoidable hospitalizations after 2 years., (© 2023. The Author(s), under exclusive licence to Society of General Internal Medicine.)

Competing Interests: We declare no competing interests.

Coronavirus disease 2019 (COVID-19) is an ongoing pandemic caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) virus. More than 5 million children have been infected in the United States. Risk factors for more severe disease progression include obesity, pulmonary disease, gastrointestinal disorders, and neurologic comorbidities. Children with COVID-19 are admitted to the pediatric intensive care unit because of severe acute COVID-19 illness or COVID-19-associated multisystem inflammatory syndrome in children. The delta surge of 2021 was responsible for an increased disease burden in children and points to the key role of vaccinating children against this sometimes-deadly disease., Competing Interests: Disclosure The authors have nothing to disclose., (Copyright © 2022 Elsevier Inc. All rights reserved.)

The COVID-19 pandemic accelerated the uptake of digital health worldwide and highlighted many benefits of these innovations. However, it also stressed the magnitude of inequalities regarding accessing digital health. Using a scoping review, this article explores the potential benefits of digital technologies for the global population, with particular reference to people living with disabilities, using the autism community as a case study. We ultimately explore policies in Sweden, Australia, Canada, Estonia, the United Kingdom, and the United States to learn how policies can lay an inclusive foundation for digital health systems. We conclude that digital health ecosystems should be designed with health equity at the forefront to avoid deepening existing health inequalities. We call for a more sophisticated understanding of digital health literacy to better assess the readiness to adopt digital health innovations. Finally, people living with disabilities should be positioned at the center of digital health policy and innovations to ensure they are not left behind., (©Robin van Kessel, Rok Hrzic, Ella O'Nuallain, Elizabeth Weir, Brian Li Han Wong, Michael Anderson, Simon Baron-Cohen, Elias Mossialos. Originally published in the Journal of Medical Internet Research (https://www.jmir.org), 22.02.2022.)

Monoclonal antibody therapeutics to treat coronavirus disease (COVID-19) have been authorized by the US Food and Drug Administration under Emergency Use Authorization (EUA). Many barriers exist when deploying a novel therapeutic during an ongoing pandemic, and it is critical to assess the needs of incorporating monoclonal antibody infusions into pandemic response activities. We examined the monoclonal antibody infusion site process during the COVID-19 pandemic and conducted a descriptive analysis using data from 3 sites at medical centers in the United States supported by the National Disaster Medical System. Monoclonal antibody implementation success factors included engagement with local medical providers, therapy batch preparation, placing the infusion center in proximity to emergency services, and creating procedures resilient to EUA changes. Infusion process challenges included confirming patient severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positivity, strained staff, scheduling, and pharmacy coordination. Infusion sites are effective when integrated into pre-existing pandemic response ecosystems and can be implemented with limited staff and physical resources.