1. Dose-Dependent Infectivity of Aseptic, Purified, Cryopreserved Plasmodium falciparum 7G8 Sporozoites in Malaria-Naive Adults.
- Author
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Laurens, Matthew B, Berry, Andrea A, Travassos, Mark A, Strauss, Kathy, Adams, Matthew, Shrestha, Biraj, Li, Tao, Eappen, Abraham, Manoj, Anita, Abebe, Yonas, Murshedkar, Tooba, Gunasekera, Anusha, Richie, Thomas L, Lyke, Kirsten E, Plowe, Christopher V, Kennedy, Jessie K, Potter, Gail E, Deye, Gregory A, Sim, B K L, and Hoffman, Stephen L
- Subjects
PLASMODIUM falciparum ,SPOROZOITES ,ADULTS ,MALARIA ,VACCINATION ,MALARIA prevention ,IMMUNITY ,IMMUNIZATION ,INTRAVENOUS therapy ,PROTOZOA ,VACCINES ,SPORES - Abstract
Direct venous inoculation of 3.2 × 103 aseptic, purified, cryopreserved, vialed Plasmodium falciparum (Pf) strain NF54 sporozoites, PfSPZ Challenge (NF54), has been used for controlled human malaria infection (CHMI) in the United States, 4 European countries, and 6 African countries. In nonimmune adults, this results in 100% infection rates. We conducted a double-blind, randomized, dose-escalation study to assess the infectivity of the 7G8 clone of Pf (PfSPZ Challenge [7G8]). Results showed dose-dependent infectivity from 43% for 8 × 102 PfSPZ to 100% for 4.8 × 103 PfSPZ. PfSPZ Challenge (7G8) will allow for more complete assessment by CHMI of antimalarial vaccines and drugs. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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