1. Serum Levels of Proinflammatory Cytokines in Painful Knee Osteoarthritis and Sensitization.
- Author
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Imamura, Marta, Ezquerro, Fernando, Marcon Alfieri, Fábio, Vilas Boas, Lucy, Tozetto-Mendoza, Tania Regina, Chen, Janini, Özçakar, Levent, Arendt-Nielsen, Lars, and Rizzo Battistella, Linamara
- Subjects
KNEE disease treatment ,OSTEOARTHRITIS diagnosis ,OSTEOARTHRITIS treatment ,PAIN diagnosis ,CYTOKINES ,INFLAMMATION ,INTERLEUKINS ,JOINT diseases ,KNEE diseases ,MEDICAL care costs ,OSTEOARTHRITIS ,DATA analysis ,DESCRIPTIVE statistics ,DISEASE complications ,DIAGNOSIS - Abstract
Osteoarthritis (OA) is the most common joint disorder in the world. Among the mechanisms involved in osteoarthritis, biomarkers (cytokines profile) may be related to pain and pain intensity, functional capacity, and pressure pain thresholds (PPT). Thus, the study of these relationships may offer useful information about pathophysiology and associated mechanisms involved in osteoarthritis. Therefore, the objective of this study was to investigate the seric concentration of pro (IL-6, IL-8, and TNF-α) and anti-inflammatory (IL-10) cytokines in patients with painful knee osteoarthritis and to correlate the levels of these biomarkers with the patients’ functional capacity and pressure pain threshold (PPT) values. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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