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Objective To explore the relationship between hormone replacement therapy (HRT) and the time period when postmenopausal women received HRT and accelerated biological aging. Methods Based on the biochemical and anthropometric data collected from the UK Biobank baseline survey, the biological age (BA) and BA acceleration index were constructed by Klemera Doubal method (KDM). The subjects were divided into 5 groups according to the status of receiving HRT: no, 10 years before menopause, 0-10 years before menopause, 0-10 years after menopause, and 10 years after menopause. Multivariate linear regression model was used to explore the relationship between HRT and BA acceleration. The characteristic factors of the population were taken as stratified factors for stratified analysis. Results A total of 96 889 subjects were included. Compared with people who did not receive HRT, there was a correlation for starting HRT 0-10 years before menopause (3=-0.28, 95%CI: -0.36 to -0.19) and starting HRT postmenopausal 0-10 years (j8=-0.39, 95%CI: -0.46 to -0.31) with the delayed accelerated aging. The effect of HRT on delaying and accelerating aging was more obvious in postmenopausal women less than 60 years old. Conclusion Receiving HRT slows biological aging and is more effective when used within 10 years of menopause in postmenopausal women under 60 years of age. [ABSTRACT FROM AUTHOR]