1. Plasma IgA, IgG and IgM and their relationship to breast cancer in British, Japanese and Hawaiian-Japanese women.
- Author
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Wang DY, Goodwin PR, Bulbrook RD, Hayward JL, Abe O, Utsunomiya J, Kumaoka S, Greenwood FC, Glober G, and Stemmerman G
- Subjects
- Breast Neoplasms immunology, Female, Hawaii, Humans, Japan ethnology, Risk, United Kingdom, Asian People, Breast Neoplasms etiology, Immunoglobulin A analysis, Immunoglobulin G analysis, Immunoglobulin M analysis, White People
- Abstract
The plasma levels of immunoglobulins IgA, IgG and IgM have been measured in 35 British, 44 Hawaiian-Japanese and 37 Japanese healthy adult women. Previous investigations showed that the mean levels of all three immunoglobulins were higher in Japanese than in British normal women. The present study finds that Hawaiian-Japanese women have "Japanese" levels of IgA, "British" levels of IgM and are intermediate for IgG. Thus, plasma IgM concentrations correlate with breast cancer incidence rates in the three racial groups and the reduced amounts of plasma IgM found in Japanese patients with breast cancer support this association.
- Published
- 1979
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