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Background: Although a number of health outcomes such as CVDs, metabolic-related outcomes, neurological disorders, pregnancy outcomes, and cancers have been identified in relation to B vitamins, evidence is of uneven quality and volume, and there is uncertainty about putative causal relationships., Objectives: To explore the effects of B vitamins and homocysteine on a wide range of health outcomes based on a large biorepository linking biological samples and electronic medical records., Methods: First, we performed a phenome-wide association study (PheWAS) to investigate the associations of genetically predicted plasma concentrations (genetic component of the circulating concentrations) of folate, vitamin B6, vitamin B12, and their metabolite homocysteine with a wide range of disease outcomes (including both prevalent and incident events) among 385,917 individuals in the UK Biobank. Second, 2-sample Mendelian randomization (MR) analysis was used to replicate any observed associations and detect causality. We considered MR P <0.05 as significant for replication. Third, dose-response, mediation, and bioinformatics analyses were carried out to examine any nonlinear trends and to disentangle the underlying mediating biological mechanisms for the identified associations., Results: In total, 1117 phenotypes were tested in each PheWAS analysis. After multiple corrections, 32 phenotypic associations of B vitamins and homocysteine were identified. Two-sample MR analysis supported that 3 of them were causal, including associations of higher plasma vitamin B6 with lower risk of calculus of kidney (OR: 0.64; 95% CI: 0.42, 0.97; P = 0.033), higher homocysteine concentration with higher risk of hypercholesterolemia (OR: 1.28, 95% CI: 1.04, 1.56; P = 0.018), and chronic kidney disease (OR: 1.32, 95% CI: 1.06, 1.63; P = 0.012). Significant nonlinear dose-response relationships were observed for the associations of folate with anemia, vitamin B12 with vitamin B-complex deficiencies, anemia and cholelithiasis, and homocysteine with cerebrovascular disease., Conclusions: This study provides strong evidence for the associations of B vitamins and homocysteine with endocrine/metabolic and genitourinary disorders., (Copyright © 2023 American Society for Nutrition. All rights reserved.)

Recent findings highlight two facets of the two fundamental stereotype content dimensions of agency (i.e., 'dominance' and 'competence') and communality (i.e., 'morality' and 'sociability'; e.g., Abele et al., 2016) with implications for understanding gender inequality in the workplace (e.g., Prati et al., 2019). Extending this research and contributing to the facial first impressions literature, we examined how these facets of agency and communality when inferred from White men's and women's faces, along with attractiveness, influence their leadership suitability. In three studies in the United Kingdom (total N = 424), using student and working samples and two managerial descriptions, we found an unexpected pattern of results, supported by an internal meta-analysis: attractiveness and competence were the most important predictors of hirability for all candidates. For women, dominance was the next most important predictor; for men, morality and sociability were more important than dominance. Moreover, morality and sociability were more important in evaluating men than women, while dominance was more important in evaluating women than men. Findings are discussed in terms of a 'deficit bias', whereby the qualities women and men are considered to lack - dominance for women, morality, and sociability for men - may be given more weight when evaluating their leadership suitability., (© 2021 The Authors. British Journal of Social Psychology published by John Wiley & Sons Ltd on behalf of British Psychological Society.)