1. Urolithiasis is prevalent and associated with reduced bone mineral density in β-thalassaemia major.
- Author
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Wong, Phillip, Milat, Frances, Fuller, Peter J., Kerr, Peter G., Doery, James C. G., Oh, Danielle H., Jackson, Dana, Gillespie, Matthew T., Bowden, Donald K., Pasricha, Sant‐Rayn, and Lau, Ken K.
- Subjects
BETA-Thalassemia ,OSTEOPOROSIS ,TOMOGRAPHY ,BONE density ,URINARY calculi ,DISEASE prevalence ,DIAGNOSIS - Abstract
Asymptomatic urolithiasis is common and of mixed composition in patients with β-thalassaemia major. Twenty-seven subjects were imaged using dual-energy computer tomography to determine the presence and composition of urolithiasis. The prevalence of urolithiasis was 59% and affected patients generally had multiple stones, often with more than one component: struvite (33%), calcium oxalate (31%) and cystine (22%). Hypercalciuria was present in 78% of subjects and calcium-containing urolithiasis was associated with reduced femoral neck Z scores. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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