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The article focuses on birth prevalence of Down's syndrome in Wales and England from 1990 t0 1997. In a study on this subject, it is determined that between 1990 and 1997 the birth prevalence of this disease which would have been expected in the absence of selective termination and antenatal screening has increased from 1.44 per 1000 births in 1996. This trend was studied by using the data gathered by the National Down's Syndrome Cytogenetic Register (NDSCR).