1. Assessment of the appropriateness of antibiotic prescribing in an acute UK hospital using a national audit tool: a single centre retrospective survey.
- Author
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Owens R, Bamford K, Pinion S, Garry E, Cranmer E, Pearce C, Wint HH, Gill S, Philips R, Khan A, Roy Bentley S, Roberts N, Keating B, Askaroff N, Morphew M, Orr C, Mouket T, Pope K, and Powell N
- Subjects
- Humans, Retrospective Studies, Female, Male, Middle Aged, Aged, England, Practice Patterns, Physicians' standards, Practice Patterns, Physicians' statistics & numerical data, United Kingdom, Adult, Antimicrobial Stewardship standards, Aged, 80 and over, Anti-Bacterial Agents therapeutic use, Anti-Bacterial Agents administration & dosage, Inappropriate Prescribing statistics & numerical data, Inappropriate Prescribing prevention & control
- Abstract
Introduction: Antibiotic use drives antibiotic resistance. The UK antimicrobial resistance (AMR) strategy aims to reduce antibiotic use. We aimed to quantify excess antibiotic use in a district general hospital in south-west England., Methods: Medical patients discharged in August 2020 who had received antibiotics were included. An audit tool of antibiotic prescribing appropriateness was used to collect relevant clinical information regarding each patient case. The appropriateness of antibiotic use was then determined by two infection specialists and excess days of therapy (DOTs) calculated., Results: 647 patients were discharged in August 2020. Of the 1658 antibiotic DOTs for the 184 patients reviewed, 403 (24%) were excess DOTs. The excess antibiotic DOTs were prescribed in 92 patients (50%); 112/403 (27.8%) excess DOTs originated at the initiation of antibiotic therapy (time point A); 184/403 (45.7%) of excess DOTs occurred at the antibiotic review pre-72 hours (time point B); and 107/403 (26.6%) of excess DOTs were due to protracted antibiotic courses (time point C)., Conclusion: 24% of antibiotic DOTs were deemed unnecessary. The greatest opportunity to reduce antibiotic use safely was the pre-72 hours antibiotic review, which may provide a target for reducing excess antimicrobial therapy in line with the national AMR strategy., Competing Interests: Competing interests: None declared., (© European Association of Hospital Pharmacists 2024. No commercial re-use. See rights and permissions. Published by BMJ.)
- Published
- 2024
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