1. Associations of Intrapancreatic Fat Deposition With Incident Diseases of the Exocrine and Endocrine Pancreas: A UK Biobank Prospective Cohort Study.
- Author
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Dong X, Zhu Q, Yuan C, Wang Y, Ma X, Shi X, Chen W, Dong Z, Chen L, Shen Q, Xu H, Ding Y, Gong W, Xiao W, Wang S, Li W, and Lu G
- Subjects
- Humans, Female, Male, Middle Aged, Prospective Studies, United Kingdom epidemiology, Aged, Adult, Magnetic Resonance Imaging, Pancreatitis epidemiology, Risk Factors, Biological Specimen Banks, Incidence, Pancreatic Neoplasms epidemiology, Pancreatic Neoplasms pathology, Intra-Abdominal Fat diagnostic imaging, Prevalence, Diabetes Mellitus epidemiology, Pancreas, Exocrine metabolism, Proportional Hazards Models, Pancreas diagnostic imaging, Pancreas pathology, Pancreas metabolism, UK Biobank, Pancreatic Diseases epidemiology, Pancreatic Diseases metabolism, Pancreatic Diseases diagnostic imaging
- Abstract
Introduction: To investigate whether increased intrapancreatic fat deposition (IPFD) heightens the risk of diseases of the exocrine and endocrine pancreas., Methods: A prospective cohort study was conducted using data from the UK Biobank. IPFD was quantified using MRI and a deep learning-based framework called nnUNet. The prevalence of fatty change of the pancreas (FP) was determined using sex- and age-specific thresholds. Associations between IPFD and pancreatic diseases were assessed with multivariate Cox-proportional hazard model adjusted for age, sex, ethnicity, body mass index, smoking and drinking status, central obesity, hypertension, dyslipidemia, liver fat content, and spleen fat content., Results: Of the 42,599 participants included in the analysis, the prevalence of FP was 17.86%. Elevated IPFD levels were associated with an increased risk of acute pancreatitis (hazard ratio [HR] per 1 quintile change 1.513, 95% confidence interval [CI] 1.179-1.941), pancreatic cancer (HR per 1 quintile change 1.365, 95% CI 1.058-1.762) and diabetes mellitus (HR per 1 quintile change 1.221, 95% CI 1.132-1.318). FP was also associated with a higher risk of acute pancreatitis (HR 3.982, 95% CI 2.192-7.234), pancreatic cancer (HR 1.976, 95% CI 1.054-3.704), and diabetes mellitus (HR 1.337, 95% CI 1.122-1.593, P = 0.001)., Discussion: FP is a common pancreatic disorder. Fat in the pancreas is an independent risk factor for diseases of both the exocrine pancreas and endocrine pancreas., (Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology.)
- Published
- 2024
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