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This article examines the evolution of long-term trends in the prioritization of environmental protection in Britain over a period of four decades. It does so by compiling comparable questions tapping into the same underlying environmental dimension from a range of sources, including historical polling data that has only recently been made available to the research community. At the aggregate level, prioritization largely tracks changing economic conditions as well as key environmental events, with the winter of 2019 showing the highest recorded levels. Furthermore, trends in individuals' willingness to prioritize the environment may not always go in tandem with trends in environmental salience. At the individual level, educational attainment is the only consistently significant demographic correlate over time. However, there is evidence of increasing politicization of the environment, with left–right orientations only becoming an important correlate of environmental prioritization in recent years, in line with rising divergence on the issue at the elite level. [ABSTRACT FROM AUTHOR]

British and English national identities have long been considered to have porous boundaries whereby English individuals consider the terms more or less interchangeable. However, there is no empirical evidence to demonstrate whether primary feelings of either Britishness or Englishness are highly fluid within-individuals or whether individuals are consistent in their perceptions of their British or English identity. This is especially relevant in the post-Brexit referendum context where national identity is highly correlated with Brexit attitudes. Using panel data, we demonstrate that there is a notable degree of fluidity between identifying as British or English. This is higher than the fluidity between other national identities in the UK as well as more fluid than moving between any partisan or EU referendum identities. Remainers are more fluid than Leavers in their Englishness, whereas they are similar in the fluidity of their Britishness. [ABSTRACT FROM AUTHOR]

Objectives Juvenile-onset systemic lupus erythematosus (jSLE) affects 15–20% of lupus patients. Clinical heterogeneity between racial groups, age groups and individual patients suggests variable pathophysiology. This study aimed to identify highly penetrant damaging mutations in genes associated with SLE/SLE-like disease in a large national cohort (UK JSLE Cohort Study) and compare demographic, clinical and laboratory features in patient sub-cohorts with 'genetic' SLE vs remaining SLE patients. Methods Based on a sequencing panel designed in 2018, target enrichment and next-generation sequencing were performed in 348 patients to identify damaging gene variants. Findings were integrated with demographic, clinical and treatment related datasets. Results Damaging gene variants were identified in ∼3.5% of jSLE patients. When compared with the remaining cohort, 'genetic' SLE affected younger children and more Black African/Caribbean patients. 'Genetic' SLE patients exhibited less organ involvement and damage, and neuropsychiatric involvement developed over time. Less aggressive first line treatment was chosen in 'genetic' SLE patients, but more second and third line agents were used. 'Genetic' SLE associated with anti-dsDNA antibody positivity at diagnosis and reduced ANA, anti-LA and anti-Sm antibody positivity at last visit. Conclusion Approximately 3.5% of jSLE patients present damaging gene variants associated with younger age at onset, and distinct clinical features. As less commonly observed after treatment induction, in 'genetic' SLE, autoantibody positivity may be the result of tissue damage and explain reduced immune complex-mediated renal and haematological involvement. Routine sequencing could allow for patient stratification, risk assessment and target-directed treatment, thereby increasing efficacy and reducing toxicity. [ABSTRACT FROM AUTHOR]

Background: Campylobacter jejuni is the most common bacterial cause of human infectious intestinal disease. Methods: We genome sequenced 601 human C. jejuni isolates, obtained from two large prospective studies of infectious intestinal disease (IID1 [isolates from 1993–1996; n = 293] and IID2 [isolates from 2008–2009; n = 93]), the INTEGRATE project [isolates from 2016–2017; n = 52] and the ENIGMA project [isolates from 2017; n = 163]. Results: There was a significant increase in the prevalence of the T86I mutation conferring resistance to fluoroquinolone between each of the three later studies (IID2, INTEGRATE and ENIGMA) and IID1. Although the distribution of major multilocus sequence types (STs) was similar between the studies, there were changes in both the abundance of minority STs associated with the T86I mutation, and the abundance of clones within single STs associated with the T86I mutation. Discussion: Four population-based studies of community diarrhoea over a 25 year period revealed an increase over time in the prevalence of the T86I amongst isolates of C. jejuni associated with human gastrointestinal disease in the UK. Although associated with many STs, much of the increase is due to the expansion of clones associated with the resistance mutation. [ABSTRACT FROM AUTHOR]