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Objectives: To investigate the correlation between sarcopenia and arterial stiffness in Caucasians, centering on the relationship between skeletal mass index (SMI) and the cardio-ankle vascular index (CAVI) to assess the use of CAVI in predicting sarcopenia., Design Cross-Sectional Setting: United Kingdom., Participants: UK adults aged 45 years and over (N = 366, n = 177 male, n = 189 female)., Measurements: Bioimpedance analysis was used to derive SMI. CAVI score was calculated using a vascular screening system. Handgrip strength was measured using a standard dynamometer., Results: Average CAVI was significantly correlated with SMI (correlation coefficient (r) = -0.285, p < .001), with higher correlation in women (r = -0.416, p < .001) than men (r = -0.214, p = .01). CAVI had the highest correlation with SMI from appendicular muscle (fat-free mass in men, r = -0.253, p = .002; predicted muscle mass in women, r = -0.436, p < .001). There was a significant difference in average CAVI between groups, with participants who were not sarcopenic having lower CAVI (8.98) than those who were sarcopenic (9.80) (p < .001, t-test). Linear regression was performed using SMI as the dependent variable. After adjustment for age, average CAVI was a significant predictor of SMI in women (beta = -0.332, p < .001) but not men., Conclusion: Indices of sarcopenia are independently associated with a higher CAVI, with greater correlation in women than men. The CAVI can be used to assess overall vascular compliance and may be a useful operator-independent tool that can be used to measure sarcopenia and its cardiovascular implications in older adults. J Am Geriatr Soc 67:317-322, 2019., (© 2018, Copyright the Authors Journal compilation © 2018, The American Geriatrics Society.)