1. Genome-wide association study in 176,678 Europeans reveals genetic loci for tanning response to sun exposure.
- Author
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Visconti A, Duffy DL, Liu F, Zhu G, Wu W, Chen Y, Hysi PG, Zeng C, Sanna M, Iles MM, Kanetsky PA, Demenais F, Hamer MA, Uitterlinden AG, Ikram MA, Nijsten T, Martin NG, Kayser M, Spector TD, Han J, Bataille V, and Falchi M
- Subjects
- Adult, Aged, Chromosome Mapping, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Hair Color genetics, Humans, Male, Melanoma etiology, Melanoma genetics, Middle Aged, Neoplasms, Radiation-Induced genetics, Phenotype, Polymorphism, Single Nucleotide, Prospective Studies, Radiation Exposure, Risk Factors, Sex Factors, Skin Neoplasms etiology, Skin Neoplasms genetics, United Kingdom, Carrier Proteins genetics, Genetic Loci, Neoplasm Proteins genetics, Receptors, Aryl Hydrocarbon genetics, Sunburn genetics, Suntan genetics, White People genetics
- Abstract
The skin's tendency to sunburn rather than tan is a major risk factor for skin cancer. Here we report a large genome-wide association study of ease of skin tanning in 176,678 subjects of European ancestry. We identify significant association with tanning ability at 20 loci. We confirm previously identified associations at six of these loci, and report 14 novel loci, of which ten have never been associated with pigmentation-related phenotypes. Our results also suggest that variants at the AHR/AGR3 locus, previously associated with cutaneous malignant melanoma the underlying mechanism of which is poorly understood, might act on disease risk through modulation of tanning ability.
- Published
- 2018
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