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1. Neutralization Heterogeneity of UK and South African Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Variants in BNT162b2-Vaccinated or Convalescent Coronavirus Disease 2019 (COVID-19) Healthcare Workers.

Author

Marot, Stéphane, Malet, Isabelle, Leducq, Valentin, Abdi, Basma, Teyssou, Elisa, Soulie, Cathia, Wirden, Marc, Rodriguez, Christophe, Fourati, Slim, Pawlotsky, Jean-Michel, Boutolleau, David, Burrel, Sonia, Calvez, Vincent, Marcelin, Anne-Geneviève, and Jary, Aude

Subjects
SARS-CoV-2, IMMUNIZATION, COVID-19, IMMUNOGLOBULINS, COVID-19 vaccines, SERUM, SICK people, MEDICAL personnel, NEUTRALIZATION tests, DESCRIPTIVE statistics, VIRAL antibodies
Abstract

There are concerns about neutralizing antibodies' (NAbs') potency against severe acute respiratory syndrome coronavirus 2 variants. Despite decreased NAb titers elicited by BNT162b2 vaccine against VOC202012/01 and 501Y.V2 strains, 28/29 healthcare workers (HCWs) had an NAb titer ≥1:10. In contrast, 6 months after coronavirus disease 2019 mild forms, only 9/15 (60%) of HCWs displayed detectable NAbs against 501Y.V2 strain. [ABSTRACT FROM AUTHOR]

Published
2022
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