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Purpose: This study set out to identify the extent of the relationships between subsections of the Movement Assessment Battery for Children 2nd Edition - MABC2 (manual dexterity, aiming and catching, and balance) to PA, CRF and BMI in adolescents. Methods: Height, BMI, the MABC2, a 20m shuttle run test and wrist-worn accelerometery PA levels (mins) were measured. Multivariable linear regression models, adjusting for sex, height and BMI were used to assess the relationship of the three subsections of the MABC2 with PA, CRF and BMI. Results: A total of 155 adolescents, aged 13-14 years, took part in this study (77 girls, 78 boys). Balance reported significant relationships with moderate to vigorous PA (unstandardised Beta B=0.15, 95%CI 0.02-0.28), vigorous PA (B=0.06, 95%CI 0.02-0.09) and BMI (B=-0.01, 95%CI -0.02-0.005). Balance in addition to aiming and catching skills were both significantly related to adolescent CRF (B=0.30, 95%CI 0.17-0.42 and B=0.29, 95%CI 0.14-0.45, respectively). Conclusion: This study suggests that balance is the strongest correlate skill to achieving the highest intensities of PA and healthier BMI status in adolescents. [ABSTRACT FROM AUTHOR]

Pathological placental inflammation increases the risk for several adult disorders, but these mediators are also expressed under homeostatic conditions, where their contribution to adult health outcomes is unknown. Here we define an inflammation-related expression signature, primarily expressed in Hofbauer cells of the term placenta and use expression quantitative trait loci to create a polygenic score (PGS) predictive of its expression. Using this PGS in the UK Biobank we conduct a phenome-wide association study, followed by Mendelian randomization and identify protective, sex-dependent effects of the placental module on cardiovascular and depressive outcomes. Genes differentially regulated by intra-amniotic infection and preterm birth are over-represented within the module. We also identify aspirin as a putative modulator of this inflammation-related signature. Our data support a model where disruption of placental Hofbauer cell function, due to preterm birth or prenatal infection, contributes to the increased risk of depression and cardiovascular disease observed in these individuals. Placental inflammation is sometimes associated with health outcomes later in life. Here, the authors find that expression of genes associated with the homeostatic function of Hofbauer cells, a placenta-specific macrophage, are associated with protection from adult cardiovascular and depressive disorders [ABSTRACT FROM AUTHOR]

Gestures have been shown to reflect speakers' embodied thinking about mathematical concepts and play a role in conveying understandings in teaching/learning interactions. However little research has been done to consider the similarities and differences in the functions that a particular gesture might have in mathematics classrooms in different parts of the world. In this paper, the occurrence of a metaphorical gesture to do with addition in a bilingual mathematics classroom in the UK and two Spanish-speaking classrooms in Chile is investigated. To do this, we elaborate on Systemic Functional Linguistics to consider how the gesture is integrated with other modes of communication to reflect the immediate context of situation as well as a wider mathematics education context of culture. An analysis of the interactions in three classrooms illustrates how the gesture seemed to convey extra meanings, sometimes complementary and sometimes contradictory, to what was expressed through other modes. Besides adding meaning to the mathematical ideas conveyed verbally, the gesture could potentially convey meanings to participants in the interactions about interpersonal relationships which were not as evident in the verbal communication. [ABSTRACT FROM AUTHOR]

Objective: To test the extent to which initial walking speed influences dual-task performance after walking intervention, hypothesising that slow walking speed affects automatic gait control, limiting executive resource availability. Design: A secondary analysis of a trial of dual-task (DT) and single-task (ST) walking interventions comparing those with good (walking speed ⩾0.8 m s−1, n = 21) and limited (walking speed <0.79 m s−1, n = 24) capacity at baseline. Setting: Community. Subjects: Adults six-months post stroke with walking impairment. Interventions: Twenty sessions of 30 minutes treadmill walking over 10 weeks with (DT) or without (ST) cognitive distraction. Good and limited groups were formed regardless of intervention received. Main measures: A two-minute walk with (DT) and without (ST) a cognitive distraction assessed walking. f NIRS measured prefrontal cortex activation during treadmill walking with (DT) and without (ST) Stroop and planning tasks and an f MRI sub-study used ankle-dorsiflexion to simulate walking. Results: ST walking improved in both groups (∆baseline: Good = 8.9 ± 13.4 m, limited = 5.3±8.9 m, Group × time = P < 0.151) but only the good walkers improved DT walking (∆baseline: Good = 10.4 ± 13.9 m, limited = 1.3 ± 7.7 m, Group × time = P < 0.025). f NIRS indicated increased ispilesional prefrontal cortex activation during DT walking following intervention (P = 0.021). f MRI revealed greater DT cost activation for limited walkers, and increased resting state connectivity of contralesional M1 with cortical areas associated with conscious gait control at baseline. After the intervention, resting state connectivity between ipsilesional M1 and bilateral superior parietal lobe, involved in integrating sensory and motor signals, increased in the good walkers compared with limited walkers. Conclusion: In individual who walk slowly it may be difficult to improve dual-task walking ability. Registration: ISRCTN50586966 [ABSTRACT FROM AUTHOR]

Background: Research indicates that the internet is used to source health-related information, including pregnancy-related information. The aim of this study was to examine websites targeted at the pregnant population and to assess the content therein relating to stillbirth and modifiable risk factors. Methods: The study was limited to websites hosted in Ireland and the UK, and results organized by provider and topic. A codebook was designed to record the information found on the websites. Data were collected on different website characteristics, and a search was undertaken for basic information related to stillbirth (prevalence, causes, procedures, consequences, etc.), and information relating to modifiable risk factors (smoking, alcohol/drug use, medicines use, sleep position, attendance at antenatal care, and weight management). Results: 92 websites were included in the study, of which 39.1% (n = 36) contained basic information about stillbirth and 29.3% (n = 27) contained information related to modifiable risk factors. Only one website (1.1%) contained all the information that was sought. Websites hosted by charities were more likely to contain basic information related to stillbirth, (39.3%, n = 11 of the 28 websites hosted by charities) whereas the commercial sites were more likely to contain information about modifiable risk factors (53.3%, n = 8 of the 15 commercial sites). Conclusion: The results of this study illustrate that websites directed at the pregnant population are a poor source for information related to stillbirth. Some stillbirth risk factors are modifiable; therefore, it is crucial that women and stakeholders can avail of reliable sources of information to make informed decisions. [ABSTRACT FROM AUTHOR]

Background: Encephalitis is an acute clinical syndrome of the central nervous system (CNS), often associated with fatal outcome or permanent damage, including cognitive and behavioural impairment, affective disorders and epileptic seizures. Infection of the central nervous system is considered to be a major cause of encephalitis and more than 100 different pathogens have been recognized as causative agents. However, a large proportion of cases have unknown disease etiology. Methods: We perform hierarchical cluster analysis on a multicenter England encephalitis data set with the aim of identifying sub-groups in human encephalitis. We use the simple matching similarity measure which is appropriate for binary data sets and performed variable selection using cluster heatmaps. We also use heatmaps to visually assess underlying patterns in the data, identify the main clinical and laboratory features and identify potential risk factors associated with encephalitis. Results: Our results identified fever, personality and behavioural change, headache and lethargy as the main characteristics of encephalitis. Diagnostic variables such as brain scan and measurements from cerebrospinal fluids are also identified as main indicators of encephalitis. Our analysis revealed six major clusters in the England encephalitis data set. However, marked within-cluster heterogeneity is observed in some of the big clusters indicating possible sub-groups. Overall, the results show that patients are clustered according to symptom and diagnostic variables rather than causal agents. Exposure variables such as recent infection, sick person contact and animal contact have been identified as potential risk factors. Conclusions: It is in general assumed and is a common practice to group encephalitis cases according to disease etiology. However, our results indicate that patients are clustered with respect to mainly symptom and diagnostic variables rather than causal agents. These similarities and/or differences with respect to symptom and diagnostic measurements might be attributed to host factors. The idea that characteristics of the host may be more important than the pathogen is also consistent with the observation that for some causes, such as herpes simplex virus (HSV), encephalitis is a rare outcome of a common infection. [ABSTRACT FROM AUTHOR]

This article explores the conceptual problems and contextual assumptions found in the treatment of Britishness in Australian history, especially as it has affected the understanding of Australia's relations with the world. It examines firstly the problem of the teleology of nationalism and its uses in Australian history, secondly the notion of Britishness in Australian identity, thirdly the Australian view of Britain and the Empire/Commonwealth in the twentieth century and lastly the implications of this for tensions between the community of culture and the community of interest in Australia. [ABSTRACT FROM AUTHOR]

• Microglia function is not directly associated with sex-dependent depression risk. • Microglial function during adulthood interacts with environmental stressors to affect sex-dependent depression risk. • Microglial function during the perinatal period interacts with exposure to prenatal maternal depression to affect sex-dependent depression risk of offspring. There is a two-fold higher incidence of depression in females compared to men with recent studies suggesting a role for microglia in conferring this sex-dependent depression risk. In this study we investigated the nature of this relation. Using GWAS enrichment, gene-set enrichment analysis and Mendelian randomization, we found minimal evidence for a direct relation between genes functionally related to microglia and sex-dependent genetic risk for depression. We then used expression quantitative trait loci and single nucleus RNA-sequencing resources to generate polygenic scores (PGS) representative of individual variation in microglial function in the adult (UK Biobank; N = 54753–72682) and fetal (ALSPAC; N = 1452) periods. The adult microglial PGS moderated the association between BMI (UK Biobank; beta = 0.001, 95 %CI 0.0009 to 0.003, P = 7.74E-6) and financial insecurity (UK Biobank; beta = 0.001, 95 %CI 0.005 to 0.015, P = 2E-4) with depressive symptoms in females. The fetal microglia PGS moderated the association between maternal prenatal depressive symptoms and offspring depressive symptoms at 24 years in females (ALSPAC; beta = 0.04, 95 %CI 0.004 to 0.07, P = 0.03). We found no evidence for an interaction between the microglial PGS and depression risk factors in males. Our results illustrate a role for microglial function in the conferral of sex-dependent depression risk following exposure to a depression risk factor. [ABSTRACT FROM AUTHOR]

Social withdrawal behavior has been linked to internalizing problems and increased risk of anxiety disorders and depression later in life. It is known that inhibition of pyramidal neurons in the ventral hippocampus impairs normal social behavior (Murugan et al., 2017; Okuyama et al., 2016; Brumback et al., 2017). To identify the biological underpinnings of social withdrawal behavior, we used ventral hippocampus RNA sequencing data from rats that naturally varied in their willingness to interact with a co-specific. Data was processed through weighted gene co-expression network analysis (WGCNA), and we identified one co-expression network that significantly correlated with social interaction behavior. We used functional enrichment analysis (Metacore®, Clarivate Analytics, https://portal.genego.com) to identify the significant gene ontology processes associated with the genes comprising this network. The network was associated with gene ontology processes related to immune system response and cytokine production. Human ortholog genes from these networks were used to inform the calculation of expression-based polygenic scores (ePRS) in adolescents (ALSPAC) and adults (UK Biobank). Variations in these ePRS scores were significantly associated with mood disorders in adults and emotional symptoms in adolescents in response to early life adversity. To test the specificity of ePRS for interacting with early adversity on these outcomes, we additionally calculated the traditional polygenic risk scores using the major depression GWAS 2018 (Wray, Ripke et al. 2018) and anxiety GWAS 2020 (Levey, Gelernter et al. 2020). PRSs were calculated to be comparable in size to ePRS in terms of SNPs for each cohort (ASLPAC and UK Biobank). Testing both PRSs in models of gene x environment interaction, no significant effects were observed. Functional genomics translational tools like the one used in this study can help in the identification of individual differences in child behavior that map onto adult psychopathology, especially in response to early adversity. [ABSTRACT FROM AUTHOR]