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Background: One of the major reasons to stop antibiotic prophylaxis (AP) to prevent infective endocarditis (IE) in the United Kingdom but not in the rest of the world was that it would result in more deaths from fatal adverse drug reactions (ADRs) than the number of IE deaths. The main aim of this study was to quantify and describe the ADRs with amoxicillin or clindamycin for IE AP. The second aim was to infer a crude incidence of anaphylaxis associated with amoxicillin for IE AP. Material and Methods: The Medical Dictionary for Regulatory Activities (MedDRA) was used to group ADRs for IE AP using the broad Standardized MedDRA Queries "Anaphylactic reaction, Amoxicillin, Clindamycin, Clostridium Difficile infection" to the French Pharmacovigilance Database System. From this first-line collection, we selected all cases occurring for IE AP and ultimately, the cases for IE AP for a dental procedure. Then, each case was analyzed. Results: Of 11639 first-line recorded ADRs, 100 were for IE AP but no fatal anaphylaxis to amoxicillin or clindamycin and no C. difficile infection associated with clindamycin were identified. Only 17 cases of anaphylaxis to amoxicillin related to dental procedures were highlighted. The estimation of the crude incidence rate of anaphylaxis associated with amoxicillin for IE AP for invasive dental procedure was 1/57 000 (95% CI 0.2-0.6). Conclusions: Fatal or severe ADRs with amoxicillin or clindamycin is not a rational argument to stop IE AP before invasive dental procedures. [ABSTRACT FROM AUTHOR]

The article presents information on the Telford Toothpaste cycling competition held through the Shropshire countryside in England. Topics discussed include the history of the competition, comparison between the Telford race and the Spring Classic Paris-Roubaix contest, route length, and ascent. Accommodations for participating cyclists and local bike shop available are also mentioned.

The article explores the cycling coaching sessions conducted by cycling club Kingston Wheelers, which targets to equip club members with the essentials on how to ride in a group. Topics discussed include the factors that prompted Andy Edwards to push for the sessions and the part played by the club's more experienced riders on the sessions. Also mentioned is how the club's sessions are beneficial in promoting safer riding across Great Britain.

The article talks about the meals consumed by road cyclist Tom Scully of the Pro Continental team Madison-Genesis during a stage race of the 2014 Tour of Britain. Topics discussed are the health benefits of eating poached eggs,wholemeal bread, muesli and bio-yoghurt for breakfast, the necessity of having an early meal consisting of white rice at pre-race, and the importance of taking energy bars or gels and electrolyte drink for fueling during the race and of restoring lost energy post-race.