Six children with multiple disabilities (ages 5 to 8) participated in this evaluation of the effect of sensory integration treatment on sensorimotor function and academic learning. The children had cognitive abilities ranging from sub-average to significantly sub-average, three were non-ambulatory, one had severe behavioral problems, and each displayed characteristics of sensory integrative dysfunction including tactile dysfunction, proprioceptive dysfunction, and vestibular dysfunction. The sensory integration treatment, developed with an occupational therapist, included individual activities (such as daily massage), group activities, and individual seat work. Treatment was provided for 50 minutes daily for 9 weeks. Although a statistically significant gain on a measure of sensorimotor function was found, these gains did not result in notable improvement in academic learning or sensorimotor function as observed by the teacher. (Contains 23 references.) (DB)