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Background: To evaluate the efficacy of intravitreal ranibizumab injection in wet type age-related macular degeneration. Material and Methods: Sixty eyes of 60 patients treated with intravitreal ranibizumab injection for wet type age-related macular degeneration that were followed up for at least 12 months were evaluated retrospectively between june 2009 with june 2011 in Harran University Medical School Ophthalmology Department. Before and after ranibizumab treatment, in each control, measurement of bestcorrected visual acuity and detailed ophthalmological examination were done to patients. Before treatment, color fundus photographs and fundus fluorescein angiography of patients were performed. Later, fundus fluorescein angiography was realized once in 2 months bimonths. First three months all patients were treated with intravitreal ranibizumab monthly in the treatment protocol. After the third month, chroidal neovascularization was regarded as active on the phenamenans with at least on Snellen line decrease in visual acuity, intraretinal or preretinal hemorrhage, moderate or increased leakage of fundus fluorescein angiography, and the treatment was repeated. Patients were called up to control every month. After treatment, best-corrected visual acuity, ranibizumab injection number was investigated. Results: Thirty-two patients were female (53 %) and 28 (47 %) were male. Mean age was 72.0±7.13 (56-84) years. The mean follw-up period was 16.81±7.34 (12-30) months. According to fundus fluorescein angiography findings of patients out of 60 eyes 32 (53 %) of them were determined as occult type, 20 (33 %) of them were determined as predominantly classic type and 8 (13 %) of them were determined as minimally classic type choroidal neovascularization. While the average rates of logMAR were 0.67±0.29 before the treatment, on the 12th month after the treatment they were 0.59±0.30. On the 83 % of the eyes, the visual acuity was determined as the some or incresed. It was determined that there were 10 (16.6 %) patiens with 3 logMAR sequens and over acquisition, 16 (26.6 %) patients with a less acquisition of 3 sequences, 7 (11.6 %) patients with a less loss of 3 sequences, 3 (5 %) patients with a more loss of 3 sequences. The mean best-corrected visual acuity was significantly improved (p < 0.01) in all eyes with treatment ranibizumab but there was no statistical difference between the subgroups (p > 0.05). During follow-up period, about 4.54±1.32 intravitreal ranibizumab injection was performed. The first day after injection in both eyes intraocular pressure values were determined over 40 mmHg and acute angle-closure glaucoma in a patient and reaction was observed uveitis in both eyes. None of the patients with systemic side effects were seen. Conclusion: Intravitreal ranibizumab injection was effective in increasing significantly in patients with wet type age-related macular degeneration. Unlike a fixed range of toolkid, a treatment according to the findings of activation of the disease will be more useful in terms of costs. Considering the ones applied every month, ranibizumab injection repeated as needed will reduce the side effects of drug and injection. [ABSTRACT FROM AUTHOR]

Purpose: The aim of this study was, by analyzing data from uveitis patients living in Van province or referred from the surrounding provinces (i.e. Ağrı, Mufl, Hakkari, Iğdır and Bitlis), to reveal the profile of uveitis in that district. Material and Method: In this study, we retrospectively investigated 855 eyes of 678 uveitis patients who were examined and followed in Yuzuncu Yil University, Ophthalmology Department between 1996 and 2008. Results: The mean age of the patients was 29.86±16.01 (range 1-79) years. 403 (59.4%) were male and 275 (40.6%) patients were female. Monocular involvement was present in 501 (73.9%), while binocular involvement was observed in 177 (26.1%) patients. According to the involved area, 395 (58.3%) patients had anterior, 85 (12.5%) intermediate, 33 (4.9%) posterior and 165 (24.3%) patients had panuveitis. No accompanying findings were detected in 406 (59.9%) patients. The most frequent accompanying disease was Behçet's disease seen in 109 (16.1%) patients. Discussion: In this study, the profile of uveitis of Van and the surrounding provinces was revealed. We think that this study is important, because it reflects the profile of uveitis of the Eastern part and together with data obtained from the other parts of Turkey, it will contribute to the development of uveitis map of the country. [ABSTRACT FROM AUTHOR]

Objectives: Although sarcoidosis is classically defined to be a disease of young adults, it might also be seen at older ages. There are very few clinical studies which focus on the features of patients diagnosed at older ages. In this study, we tried to determine the frequency of patients diagnosed at or above 50 years of age and to compare the clinical and demographic features of these subjects with other sarcoidosis patients.Methods: We evaluated the general clinical features of sarcoidosis patients more than 50 years of age who were diagnosed at our center within a 36-year period. We also compared the clinical features of older sarcoidosis patients with the features of other patients.Results: Of 579 sarcoidosis patients being followed up at our center, 102 (17.7%) were older than 50 years of age at the time of initial diagnosis. The female to male ratio in this group was higher than the ratio in other sarcoidosis patients (3.43 versus 1.85, P = 0.015). When the features of older patients were compared with other sarcoidosis patients, extrapulmonary involvement was observed to be more common in this group (P < 0.001). By contrast, arthritis or arthralgia (P < 0.001), clinical presentation in the form of Löfgren syndrome (P < 0.001), erythema nodosum (P < 0.001), and uveitis (P = 0.006) were less frequent.Conclusions: Although generally presenting as a disease of the young, in many subjects sarcoidosis is diagnosed at older ages, and this study indicates that the clinical features of sarcoidosis in older subjects differ from those found among younger patients. [ABSTRACT FROM AUTHOR]