1. Vascular endothelial function in patients with slow coronary flow.
- Author
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Sezgin AT, Sigirci A, Barutcu I, Topal E, Sezgin N, Ozdemir R, Yetkin E, Tandogan I, Kosar F, Ermis N, Yologlu S, Bariskaner E, and Cehreli S
- Subjects
- Adult, Brachial Artery drug effects, Brachial Artery physiopathology, Coronary Angiography, Coronary Artery Disease drug therapy, Coronary Artery Disease physiopathology, Coronary Thrombosis drug therapy, Coronary Thrombosis physiopathology, Female, Humans, Hyperemia drug therapy, Hyperemia physiopathology, Male, Middle Aged, Myocardial Infarction drug therapy, Myocardial Infarction physiopathology, Nitroglycerin therapeutic use, Statistics as Topic, Turkey, Vasodilation drug effects, Vasodilation physiology, Vasodilator Agents therapeutic use, Blood Flow Velocity physiology, Coronary Circulation physiology, Endothelium, Vascular physiopathology
- Abstract
Background: Slow coronary flow (SCF) in a normal coronary angiogram is a well-recognized clinical entity, but its etiopathogenesis remains unclear., Design: The aim of the study was to determine endothelial function in patients with SCF using a flow-mediated dilatation (FMD) technique in the brachial artery., Methods: Coronary flow was quantified using the corrected thrombosis in myocardial infarction (TIMI) frame count (CTFC) method. Endothelial function was studied in 27 patients with SCF (23 men, four women, mean age 47.6+/-8.7 years) and in 30 people with normal coronary flow (NCF) (22 men and eight women, mean age 47.5+/-7.4 years)., Results: The flow-mediated diameter increase in the SCF group was significantly smaller than that in the NCF group (3.48+/-0.10% compared with 9.11+/-0.10%, P < 0.001). The percentage of nitroglycerine (NTG)-induced dilatation was not significantly different between patients with SCF and people with NCF (16.8+/-1.1% compared with 17.1+/-1.1%, P = 0.87). Simple regression analysis showed that mean CTFC (CTFC(m)) was strongly and inversely related to the percentage of FMD (r = -0.29, P < 0.01) in all participants. When the patients with SCF were excluded, CTFC(m) was still inversely related to the percentage of FMD (r = -0.36, P < 0.05). CTFC(m) was also inversely related to NTG-induced dilatation in the 57 participants (r = -0.23, P < 0.05). Multiple regression analysis showed that CTFC(m) was inversely related to the percentage of FMD only (r = -0.37, P < 0.05)., Conclusions: These findings suggest that endothelial function is impaired in people with SCF and that CTFC correlates well with endothelial dysfunction.
- Published
- 2003
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