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Objectives: We define the profile of gallbladder diseases in recipients of a laparoscopic cholecystectomy. Patients and Methods: Pathological features of cholecystectomy specimens of 404 patients were reviewed. Microslides and pathology reports of the patients were reevaluated. Results: Three hundred and two (74.75%) of patients were female, 102 (25.25%) were male. The age range of patients was 16- 80 and mean age was 47.68±12.93. Most common diseases were cholelithiasis in 393 cases and chronic cholecystitis in 363 cases. The gallbladder of one of the patients with xanthogranulomatous cholecystitis has been suggestive of malignancy. Metaplasia in 46 patients, dysplasia in 4 patients and adenocarcinoma in just one patient were detected. Conclusion: The incidence of malignant tumors in the gallbladder of recipients of a laparoscopic cholecystectomy is very low (0.24%). We suggest that, cholecystectomy specimens must be routinely examined histopathologically with an adequate number of samples for detection of malignancies without clinical signs and for the exclusion of findings of likely malignancies such as xanthogranulomatous cholecystitis. [ABSTRACT FROM AUTHOR]