1. Incidence and risk factors of contrast-induced nephropathy after transcatheter arterial chemoembolization in hepatocellular carcinoma.
- Author
-
Aoe M, Kanemitsu T, Ohki T, Kishi S, Ogura Y, Takenaka Y, Hashiba T, Ambe H, Furukawa E, Kurata Y, Ichikawa M, Ohara K, Honda T, Furuse S, Saito K, Toda N, and Mise N
- Subjects
- Aged, Aged, 80 and over, Carcinoma, Hepatocellular blood, Carcinoma, Hepatocellular diagnostic imaging, Contrast Media administration & dosage, Female, Humans, Incidence, Kidney Diseases diagnosis, Kidney Diseases epidemiology, Liver Neoplasms blood, Liver Neoplasms diagnostic imaging, Male, Middle Aged, Retrospective Studies, Risk Assessment, Risk Factors, Serum Albumin, Human analysis, Time Factors, Tokyo epidemiology, Treatment Outcome, Tumor Burden, Carcinoma, Hepatocellular therapy, Chemoembolization, Therapeutic adverse effects, Contrast Media adverse effects, Kidney Diseases chemically induced, Liver Neoplasms therapy
- Abstract
Background: Transcatheter arterial chemoembolization (TACE) is widely used for unresectable hepatocellular carcinoma (HCC). The purpose of this study was to investigate incidence and risk factors of contrast-induced nephropathy (CIN) after TACE in patients with HCC., Methods: In this single-center retrospective study, we examined 461 consecutive TACE sessions in 260 patients between January 2003 and October 2015. CIN was defined as an increase in serum creatinine levels by ≥ 0.5 mg/dl or ≥ 25% from baseline within 72 h after TACE. We calculated incidence rate of CIN and tried to identify its risk factors by logistic regression analysis., Results: Twenty-one cases of CIN (5%) were observed in 461 TACE sessions. One patient required subsequent hemodialysis transiently. In univariate analysis, tumor size > 5 cm [odds ratio (OR) 5.76, 95% confidence interval (CI) 2.34-14.14, p < 0.001], chronic kidney disease (OR 2.54, 95% CI 1.05-6.14, p = 0.04), serum hemoglobin level [OR 0.79 (per 1 g/dl increase), 95% CI 0.64-0.98, p = 0.03] and serum albumin level [OR 0.44 (per 1 g/dl increase), 95% CI 0.19-1.02, p = 0.05] were associated with the development of CIN. Stepwise logistic regression methods showed that tumor size > 5 cm (OR 7.81, 95% CI 2.99-20.46, p < 0.001) and serum albumin [OR 0.29 (per 1 g/dl increase), 95% CI 0.11-0.75, p = 0.01] were risk factors of CIN., Conclusions: In this study, HCC tumor size and lower serum albumin level were independent predictors of CIN after TACE.
- Published
- 2019
- Full Text
- View/download PDF