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Background: Estrogen have many important functions regarding the genital tract, central nervous system, the breast, the development of the secondary sex characteristics and many other functions the most important here is its effect on the bone by increasing deposition of bone and its role in epiphysial closure. Aims: The aim of the study is to determine serum estrogen concentration in normal healthy non pregnant women in Tikrit city. Subjects & Methods: This study was carried out during a period extending from January to July 2012 in Tikrit University. Two hundred normal healthy women were participated in this study, their ages from 20 up to 65 years. About five ml blood was drawn from each participant using a tourniquet, and then blood sample was put into plan tube without anticoagulant for serum separation. Serum estrogen was measured by using kit from Roche (Germany) which was used on cobas e 411 analyzers -disk system. Results: The first group aged 20 to 29 years has a serum estrogen concentration of 939 ± 78 pg/ml, this group of women have the highest serum estrogen concentration as compare with other groups (P≤0.01). Also, there is significant reduction in serum estrogen concentration in group aged 30-39 years (377.42 ± 28.4 pg/ml) as compare with group 20-29 years (939 ± 78 pg/ml). Moreover, there is significant reduction in serum estrogen concentration in group aged 40-49 years (168.07 ± 29.3 pg/ml) as compare with group 20-29 years (939 ± 78 pg/ml). Furthermore, there is significant reduction in serum estrogen concentration in group aged 50-59 years (53.16 ± 13.4 pg/ml) as compare with group 20-29 years (939 ± 78 pg/ml). Meanwhile, there is significant reduction in serum estrogen concentration in women group aged above 60 years (28.4 ± 7.4 pg/ml) as compare with group 20-29 years (939 ± 78 pg/ml). Conclusion: The present study concludes that there is significant reduction in serum estrogen in women as advance in age. The most sever reduction in age group above 50 years. The present study recommend the followings;- Regular assessment of serum estrogen in women above 45 years & study the relation between reduction in serum estrogen & bone density in women. [ABSTRACT FROM AUTHOR]